- Email: [email protected]
Contents volume 272 (1992)
Mutation Research, 272 (1992) 297-298 © 1992 Elsevier Science Publishers B.V. All rights reserved 0165-1161/92/$05.00
297
Contents Volume 272 (1992) Editorial
Research Papers Consideration of CASE predictions of genotoxic carcinogenesis for omeprazole, methapyrilene and azathioprine J. Ashby (UK) Grain counting in the in vitro hepatocyte DNA-repair assay G. Brambilla and A. Martelli (Italy) Development of a flow-cytometric HLA-A locus mutation assay for human peripheral blood lymphocytes J.-i. Kushiro, Y. Hirai, Y. Kusunoki, S. Kyoizumi, Y. Kodama, A. Wakisaka, A. Jeffreys, J.B. Cologne, K. Dohi, N. Nakamura and M. Akiyama (Japan, UK) Time-saving in biological dosimetry by using the automatic metaphase finder Metafer2 J. Weber, W. Scheid and H. Traut (Germany) Assessing overdispersion and dose-response in the male dominant lethal assay A.-M.C. Lockhart, W.W. Piegorsch and J.B. Bishop (USA) Testing by artificial intelligence: Computational alternatives to the determination of mutagenicity G. Klopman and H.S. Rosenkranz (USA) Significance testing in mutagen screening: the dependence of statistical power on the control sample size H. Traut and W. Scheid (Germany) Letter to the Editor Comment on the US EPA recommendation for genotoxicity guidelines on chemicals M. lshidate Jr. (Japan)
17 31 35 59 73
79
Conference Report First International Conference on Environmental Mutagens in Human Populations at Risk: Cairo, 1992 Preface F.H, Sobels (The Netherlands) Summary recommendations that have an impact on genetic toxicology research in developing countries W, Anwar, W,W. Au, A. Massoud, J.M. Gentile and J. Ashby (Egypt, USA, UK)
81
Anno~ancement
89
Research Papers A sensitive umu test system for the detection of mutagenic nitroarenes in Salmonella typhimurium NMI011 having a high nitroreductase activity Y. Oda, T. Shimada, M. Watanabe, M. Ishidate Jr. and T. Nohmi (Japan) Description of a new amplifiable shuttle vector for mutagenesis studies in human cells: application to N-methyI-N'nitro-N-nitrosoguanidine-induced mutation spectrum A. Stary, C.F.M. Menck and A. Sarasin (France, Brazil) Structural basis of the in vivo induction of micronuclei W.-L Yang, G. Klopman and H.S. Rosenkranz (USA) Some factors affecting sister-chr3matid differentiation (SCD) and sister-chromatid exchange (SCE) in Hordeum t,ulgare Y. Hongyu ano Z. Zili (China) Overdispersion of aggregated genetic data K.O. Bowman and M.A. Kastenbaum (USA) Mutation of V79 cells by N-dialkylnitrosamines after activation by hamster pancreas duct cells T. Lawson and C. Kolar (USA)
83
101 111
125 133 139
298 An evaluation of the E. coli K-12 ucrB/rec,4 DNA repair host-mediated assay. I. In vitro sensitivity of the bacteria to 61 compounds L. HellmSr and G. Bolcsfoldi (Sweden) An evaluation of the E. coli K-12 urrB/recA DNA repair host-mediated assay. II. In vivo results for 36 compounds tested in the mouse L. Helim{~rand G. Bolcsfoldi (Sweden) Genotoxic potential of the organochlorine insecticide lindane (y-BHC): an in vivo study in chicks S.P. Bhunya and G.B. Jena (India) Use of a newly developed tester strain Salmonella typhimurium NM2009 for the study of metabolic activation of carcinogenic aromatic amines by rat liver microsomal cytochrome P-450 enzymes H. Yamazaki, Y. Oda and T. Shimada (Japan)
Letter to the Editor A.T. Natarajan, E.W. Vogel and A.A. Van Zeeland (Netherlands)
145
161 175
183
193
Research Papers Detection of somatic mutations in vivo in lung fibroblasts, I. Spontaneous frequencies in Chinese hamsters and F344 rats J.A. Heddle, J.D. Gingerich, C. Urlando, M. Pagura, P. Shepson and M.A. Khan (Canada) Mutagenicity testing of protein-containing and biological samples using the Ames/Salmonella plate incorporation test and the fluctuation test L. Nylund and P. Einist6 (Finland) In rive fate of MMS-induced DNA lesions that elicit SCE P. Morales-Ramfrez, R. Rodrlguez-Reyes and T. Vallarino-Kelly (Mexico) Evaluation of the micronucleus test using a Chinese hamster cell line as an alternative to the conventional in vitro chromosomal aberration test A. Matsuoka, N. Yamazaki, T, Suzuki, M. Hayashi and T. Sofuni (Japan) The mouse splenocyte assay, an in rive/in vitro system for biological monitoring: studies with X-rays, fssion neutrons and bleomycin F, Darroudi, Z, Farooqi, D, Benova and A.T. Natarajan (Netherlands, Bulgaria)
237
Enrironmetual Mutagen Society of Japan Selected Abstracts of the 20th Annual Meeting 6=8 November 1991, Tokyo, Japan
249
AIIIIOIIIlClJIIi¢tll
293
Errattotl
295
Contents. Vol, 272 (1992)
297
195
205 215
223
297
Contents Volume 272 (1992) Editorial
Research Papers Consideration of CASE predictions of genotoxic carcinogenesis for omeprazole, methapyrilene and azathioprine J. Ashby (UK) Grain counting in the in vitro hepatocyte DNA-repair assay G. Brambilla and A. Martelli (Italy) Development of a flow-cytometric HLA-A locus mutation assay for human peripheral blood lymphocytes J.-i. Kushiro, Y. Hirai, Y. Kusunoki, S. Kyoizumi, Y. Kodama, A. Wakisaka, A. Jeffreys, J.B. Cologne, K. Dohi, N. Nakamura and M. Akiyama (Japan, UK) Time-saving in biological dosimetry by using the automatic metaphase finder Metafer2 J. Weber, W. Scheid and H. Traut (Germany) Assessing overdispersion and dose-response in the male dominant lethal assay A.-M.C. Lockhart, W.W. Piegorsch and J.B. Bishop (USA) Testing by artificial intelligence: Computational alternatives to the determination of mutagenicity G. Klopman and H.S. Rosenkranz (USA) Significance testing in mutagen screening: the dependence of statistical power on the control sample size H. Traut and W. Scheid (Germany) Letter to the Editor Comment on the US EPA recommendation for genotoxicity guidelines on chemicals M. lshidate Jr. (Japan)
17 31 35 59 73
79
Conference Report First International Conference on Environmental Mutagens in Human Populations at Risk: Cairo, 1992 Preface F.H, Sobels (The Netherlands) Summary recommendations that have an impact on genetic toxicology research in developing countries W, Anwar, W,W. Au, A. Massoud, J.M. Gentile and J. Ashby (Egypt, USA, UK)
81
Anno~ancement
89
Research Papers A sensitive umu test system for the detection of mutagenic nitroarenes in Salmonella typhimurium NMI011 having a high nitroreductase activity Y. Oda, T. Shimada, M. Watanabe, M. Ishidate Jr. and T. Nohmi (Japan) Description of a new amplifiable shuttle vector for mutagenesis studies in human cells: application to N-methyI-N'nitro-N-nitrosoguanidine-induced mutation spectrum A. Stary, C.F.M. Menck and A. Sarasin (France, Brazil) Structural basis of the in vivo induction of micronuclei W.-L Yang, G. Klopman and H.S. Rosenkranz (USA) Some factors affecting sister-chr3matid differentiation (SCD) and sister-chromatid exchange (SCE) in Hordeum t,ulgare Y. Hongyu ano Z. Zili (China) Overdispersion of aggregated genetic data K.O. Bowman and M.A. Kastenbaum (USA) Mutation of V79 cells by N-dialkylnitrosamines after activation by hamster pancreas duct cells T. Lawson and C. Kolar (USA)
83
101 111
125 133 139
298 An evaluation of the E. coli K-12 ucrB/rec,4 DNA repair host-mediated assay. I. In vitro sensitivity of the bacteria to 61 compounds L. HellmSr and G. Bolcsfoldi (Sweden) An evaluation of the E. coli K-12 urrB/recA DNA repair host-mediated assay. II. In vivo results for 36 compounds tested in the mouse L. Helim{~rand G. Bolcsfoldi (Sweden) Genotoxic potential of the organochlorine insecticide lindane (y-BHC): an in vivo study in chicks S.P. Bhunya and G.B. Jena (India) Use of a newly developed tester strain Salmonella typhimurium NM2009 for the study of metabolic activation of carcinogenic aromatic amines by rat liver microsomal cytochrome P-450 enzymes H. Yamazaki, Y. Oda and T. Shimada (Japan)
Letter to the Editor A.T. Natarajan, E.W. Vogel and A.A. Van Zeeland (Netherlands)
145
161 175
183
193
Research Papers Detection of somatic mutations in vivo in lung fibroblasts, I. Spontaneous frequencies in Chinese hamsters and F344 rats J.A. Heddle, J.D. Gingerich, C. Urlando, M. Pagura, P. Shepson and M.A. Khan (Canada) Mutagenicity testing of protein-containing and biological samples using the Ames/Salmonella plate incorporation test and the fluctuation test L. Nylund and P. Einist6 (Finland) In rive fate of MMS-induced DNA lesions that elicit SCE P. Morales-Ramfrez, R. Rodrlguez-Reyes and T. Vallarino-Kelly (Mexico) Evaluation of the micronucleus test using a Chinese hamster cell line as an alternative to the conventional in vitro chromosomal aberration test A. Matsuoka, N. Yamazaki, T, Suzuki, M. Hayashi and T. Sofuni (Japan) The mouse splenocyte assay, an in rive/in vitro system for biological monitoring: studies with X-rays, fssion neutrons and bleomycin F, Darroudi, Z, Farooqi, D, Benova and A.T. Natarajan (Netherlands, Bulgaria)
237
Enrironmetual Mutagen Society of Japan Selected Abstracts of the 20th Annual Meeting 6=8 November 1991, Tokyo, Japan
249
AIIIIOIIIlClJIIi¢tll
293
Errattotl
295
Contents. Vol, 272 (1992)
297
195
205 215
223