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Contents volumes 43–44 (1997)
P ELSEVIER
~
~]
European Journal of Pharmaceutics and Biopharmaceutics 44 (1997) 351-354
Contents Volumes 43-44 (1997) Vol. 43, No. 1 (JANUARY 1997) Publisher's Note Editorial
Tableting of coated pellets R. Bodmeier (German)') Doxorubicin induces aggregation of small negatively charged liposomes M.J. Fonseca, E.C.A. van Winden, D.J.A. Crommelin (The Netherlands) Biocompatibility of ABA triblock copolymer microparticles consisting of poly(L-lactic-co-glycolic-acid) A-blocks attached to central poly(oxyethylene) B-blocks in rats after intramuscular injection B. Ronneberger, T. Kissel, J.M. Anderson (Germany, USA) Microencapsulation of rh-erythropoietin, using biodegradable poly(D,L-lactide-co-glycolide): protein stability and the effects of stabilizing excipients M. Morlock, H. Koll, G. Winter, T. Kissel (Germany) Delivery of a hydrophilic solute through the skin from novel microemulsiou systems M. Bego~a Delgado-Charro, G. lglesias-Vilas, J. Blanco-M~ndez, M. Arturo L6pez-Quintela, J.-P. Marry, R.H. Guy (Spain, France, USA) Electroperturbation of the human skin barrier in vitro (1): the influence of current density on the thermal behaviour of skin impedance W.H.M. Craane-van Hinsberg, J.C. VerhoeJ~ H.E. Junginger, H.E. BoddO (The Netherlands) Ultrapure poly(vinyl alcohol) hydrogels with mucoadhesive drug delivery characteristics N.A. Peppas, N.K. Mongia (USA) In vivo evaluation of hydrophilic and hydrophobic mucoadhesive semi-solid formulations containing sucralfate and lidocaine for intraoral use Y. Jacques, T. Nguyen-Xuan, E. lonescu, G.P. Ravelli, P. Buri, P. Baehni, R. Gurny (Switzerland, France) Factors affecting in vitro gastric mucoadhesion: IV. Influence of tablet excipients, surfactants and salts on the observed mucoadhesion of polymers M.J. Tobyn, J.R. Johnson, P.W. Dettmar (UK) Interaction and translocation of cysteamine (mercaptoethylamine) with model membranes: a ]SN-NMR and ]H-NMR study C. Lagoueyte, G. Subra, P.-A. Bonnet, J.-P. Chapat, J.-C. Debouzy, F. Fauvelle, F. Berleur, V. Roman, M. Fatome, J.-P. Fernandez (France) Aqueous pseudolatex of zein for film coating of solid dosage forms P.B. O'Donnell, C. Wu, J. Wang, L. Wang, B. Oshlack, M. Chasin, R. Bodmeier, J.W. McGinity (USA, Germany) The effect of V-mixer scale-up on the mixing of magnesium stearate with direct compression microcrystalline cellulose J.G. Van der Watt, M.M. de Villiers (South Africa) Influence of micronization on the compaction properties of an investigational drug using tableting index analysis M.O. Omelczuk, C.-C. Wang, D.G. Pope (USA) Book reciews Doctoral Theses A P V News Cah'ndar Instructions to Authors
v vii
1 9
19 29 37 43 51 59 65 73 83 91 95 101 103 109 111 113
l'ol. 43, No. 2 (APRIL 1997)
Controlled and/or prolonged parental delivery of peptides from the hypothalmic pituitary axis A. Rothen-Weinhold, R. Gurny (Switzerland, France) 0939-6411/97/$17.00 © 1997 Elsevier Science B.V. All rights reserved. P l l S0939-6411 (97)00144-6
115
352
Contents of Volumes 43-44
Acute effects of iontophoresis on human skin in vivo: cutaneous blood flow and transepidermal water loss measurements R.M. Brand, P. Singh, E. Aspe-Carranza, H.L Maibach, R.H. Guy (USA) Preparation of the glucosylamines of procainamide and evaluation of the pharmacokinetics of the fl-glucosylamine of procainamide in the conscious rabbit J.E. Parkin, K.F. llett (Australia) Kaliuretic effect of short-term theophylline in healthy subjects S. Samaan, S.L. Markantonis (USA, Greece) Influence of process parameters on sustained-release theophylline pellets coated with aqueous polymer dispersions and organic solvent-based polymer solutions C.A. Lorck, P.C. Grunenberg, H. Jiinger, A. Laicher (Germany) The influence of thermal neutron irradiation on the in vitro characteristics of ASA oral dosage forms: Validation of neutron activation T. Waaler, S.A. Sande, B.W. Miiller, G. Schiiller Lisether (Norway, Germany) Prevention of the sticking tendency of floating minitablets filled into hard gelatin capsules N. Rouge, J.-C. Leroux, E.T. Cole, E. Doelker, P. Buri (Switzerland) Influence of the viscosity grade and the particle size of HPMC on metronidazole release from matrix tablets M.E. Campos-Aldrete, L. Villafuerte-Robles (MOxico) Development and characterization of microemulsions for ocular application A. Hare, S. Keipert (Germany) Interactions between bendroflumethiazide and water soluble polymers. I. Solubility of bendroflumethiazide in water from solid dispersions and formation of associates under climatic stress R. Frontini, J.B. Mielck (Germany) Pharmacokinetics and bioavailability of pentoxifylline in healthy volunteers-a comparative study of three oral formulations M. Pokrajac, B. MzTjkovi~, D. Simi~, B. Brzakovi~, A. Galetin (Yugoslavia) PKC, a new pharmacokinetic software using SAS® J.-M. Cardot, A. Jaouen, J. Godbillon (France)
Book reviews Doctoral Theses AP V News Calendar Instructions to Authors
133
139 145
149
159 165 173 179
185 193 197 201 203 209 211 213
Vol. 43 No. 3 (JUNE 1997) Residual solvents in pharmaceutical products: acceptable limits, influences on physicochemical properties, analytical methods and documented values C. Witschi, E. Doelker (Switzerland) Trends in the organization of drug research: interfacing industry and universities D.K.F. Meijer, J. Wilting (The Netherlands) Bioconversion of estradiol esters in the skin of various animal models in vitro K. Yamada, K. Tojo (Japan) Simple method of in vitro diffusion of nicotine across porcine palatine mucosa A.-L. Cornaz Gudet, A.F. Ganem-Quintanar, P. Buri (Switzerland, France) Intestinal absorption of the quaternary trospium chloride: permeability-lowering factors and bioavailabilities for oral dosage forms P. Langguth, A. Kubis, G. Krumbiegel, IV. Lang, H.P. Merkle, W. Wdchter, H. Spahn-Langguth, R. Weyhenmeyer (Switzerland, Poland, Germany) Serotonin antagonists for use as antiglaucoma agents and their ocular penetration R.D. Schoenwald, R. R. Gadiraju, C.F. Barfknecht (USA) Influence of traces of surfactants on nifedipine bioavailability in rats after neomycin-induced malabsorption syndrome H. Wojdak (Poland) Development and characterization of protein-loaded poly(lactide-co-glycolide) nanospheres M.D. Blanco, M.J. Alonso (Spain) Long term stability of freeze-dried, lyoprotected doxorubicin liposomes E.C.A. van Winden, D.J.A. Crommelin (The Netherlands) Interactions between bendroflumethiazide and water soluble polymers. II. Factors promoting drug-polymer association R. Frontini, J.B. Mielck (Germany)
215 243 253 259
265 273 283 287 295 309
Contents of Volumes 43-44
353
Crushing strength, disintegration time and weight variation of tablets compressed from three Avicel® PH grades and their mixtures E. Lahdenpgiii, M. Niskanen, J. Yliruusi (Finland)
315
Book reviews Recently Published Doctoral Theses A P V Veranstaltungen in Deutschland/APV Courses in Germany Calendar of events Announcement
323 327 S1 $3 $4
Vol. 44 No. 1 (JULY 1997) Editor&l Lectins and bacterial invasion factors for controlling endo- and transcytosis of bioadhesive drug carrier systems E. Haltner, J.H. Easson, C.-M. Lehr (Germany) Bioadhesion of solid oral dosage forms, why and how? D. Duchdne, G. Ponchel (France) Mucoadhesion of colloidal particulate systems in the gastro-intestinal tract G. Ponchel, M.-J. Montisci, A. Dembri, C. Durrer, D. Duchdne (France) The influence of in-vivo carbonation on GI physiological processes and drug permeability J.D. Eichman, A.E.-D.B. Yassin, J.R. Robinson (USA, Egypt) An in vitro-in vivo investigation of oral bioadhesive controlled release furosemide formulations G. Santus, C. Lazzarini° G. Bottoni, E.P. SandeJer, R.C. Page, W.J. Doll, U.Y. Ryo, G.A. Digenis (Italy, USA) Preparation and in vitro characterisation of mucoadhesive polymeric microspheres as intra-nasal delivery systems M.D.A. El-Hameed, I.W. Kellaway (UK) Dielectric analysis of bioadhesive gel systems D.Q.M. Craig, S. Tamburic (UK) Ocular pharmacokinetics/pharmacodynamics N. W~rakul, J.R. Robinson (USA, Thailand) Interactions between bendroflumethiazide and water-soluble polymers, lII. Chemical degradation R. Frontini, J.B. Mielck (Germany) Pharmacological modulation of the tissue response to implanted polylactic-co-glycolic acid microspheres A.L. Daugherty, J.L. Cleland, E.M. Duenas, R.J. Mrsny (USA) Book reviews A P V News Calendar of events
I
3 15 25 33 39 53 6l 71 85 89 103 S1 $2
Vol. 44 No. 2 (SEPTEMBER 1997) Contribution of lipid components to the permeability barrier of oral mucosa A. Ganem-Quintanar, F. Falson-Rieg, P. Buri (France, Switzerland) The use of small volume ocular sprays to improve the bioavailability of topically applied ophthalmic drugs L.G. Martini, J.K. Embleton, R.J. Malcolmson, C.G. Wilson (UK) Body distribution of azidothymidine bound to nanoparticles after oral administration R. L6benberg, L. Araujo, J. Kreuter (Germany) Increase of polypeptide transport by lectin conjugation across rabbit Peyer's patches T. Isoda, E. Watanabe, M. Haga, S. Haseto, S. Awazu, M. Hayashi (Japan) Buccoadhesive oxycodone hydrochloride disks: plasma pharmacokinetics in healthy volunteers and clinical study B. Parodi, E. Russo, G. Caviglioli, M. Vallarino, F. Fuseo, F. Henriquet (Italy) Dose linearity of quinine in healthy human subjects C.P. Babalola, 0.0. Bolaji, F.A. Ogunbona, A. Sowunmi, O. Walker (Nigeria) Comparative in vitro biocompatibility testing of polycyanoacrylates and poly(D,L-lactide-co-glycolide) using different mouse fibroblast (L929) biocompatibility test models R. Zange, T. Kissel (Germany) A comparison of different in vitro methods for measuring mucoadhesive performance S. Tamburic, D.Q.M. Craig (UK)
107 121 127 133 137 143
149 159
354
Contents o f Volumes 43-44
Comparison between a twin-screw extruder and a rotary ring die press. I. Influence of formulation variables C. Schmidt, H. Lindaer, P. Kleinebudde (Germany) Formulation of proteins in vacuum-dried glasses. I: Improved vacuum-drying of sugars using crystallising amino acids M. Mattern, G. Winter, R. Rudolph, G. Lee (Germany) Decrease of the stage-2 deposition in the twin impinger during storage of beclomethasone dipropionate dry powder inhalers in controlled and uncontrolled humidities E.R.M. Geuns, J.S. Toren, D.M. Barends, A. Bult (The Netherlands) A study of an epoxy aerosol can lining exposed to hydrofluoroalkane propellants R.O. Williams II1, C. Hu (USA) Application of mercury porosimetry in evaluation of extrusion-spheronisation process A.M. Juppo, L. HellOn, V. Pullinen-Strander, K. Kalsta, J. Yliruusi, E. Kristoffersson (Finland) A method for modeling in vitro dissolution profiles of drugs using gamma distribution A. Djordjevi~, I. Menda~ (Yugoslavia) Book reviews Recently Published Doctoral Theses A P V News Calendar of events
169 177
187 195 205 215 219 223 S1 $3
Vol. 44, No. 3 (NOVEMBER 1997) Editorial Principles, tenets and notions of tablet bonding and measurements of strength E.N. Hiestand (USA) Effect of particle size and compaction load on interparticulate bonding structure for some pharmaceutical materials studied by compaction and strength characterisation in butanol ~. Adolfsson, H. Olsson, C. Nystrrm (Sweden) Effect of water on deformation and bonding of pregelatinized starch compacts K. Van der Voort Maarschalk, H. Vromans, W. Groenendijk, G.K. Bolhuis, C. F. Lerk (The Netherlands) Evaluation of pharmaceutical beam bending tests using double-exposure holographic interferometry P. Raatikainen, R. Silvennoinen, J. Ketolainen, Pertti Ketolainen, P. Paronen (Finland) Percolation theory and physics of compression H. Leuenberger, L. Ineichen (Switzerland) Indices of tableting performance and application of percolation theory to powder compaction C. Imbert, P. Tchoreloff, B. Leclerc, G. Couarraze (France) The repeated compression of powders M.R.A.K. Al-Aghbar, N.A. Armstrong (UK) Associations of parameters characterizing the time course of the tabletting process on a reciprocating and on a rotary tabletting machine for high-speed production P. Konkel, J.B. Mielck (Germany) Compression force/time-profiles of microcrystalline cellulose, dicalcium phosphate dihydrate and their binary mixtures--a critical consideration of experimental parameters P.C. Schmidt, M. Leitritz (Germany) Compressibility and compactibility of powdered polymers: poly(vinyl chloride) powders A.-F. Rime, D. Massuelle, F. Kubel, H.-R. Hagemann, E. Doelker (Switzerland) A new practical index to predict capping occurring during the tableting process K.-i. Sugimori, Y. Kawashima (Japan) Scale-up of adhesive transdermal drug delivery systems G.A. Van Buskirk, M.A. Gonzhlez, V.P. Shah, Scott Barnhardt, C. Barrett, S. Berge, G. Cleary, K. Chan, G. Flynn, T. Foster, R. Gale, R. Garrison, S. Gochnour, A. Gotto, S. Govil, V.A. Gray, J. Hammar, S. Harder, C. Hoiberg, A. Hussain, C. Karp, H. Llanos, J. Mantelle, P. Noonan, D. Swanson, H. Zerbe (USA, Ireland) Book reviews Recently published doctoral theses Author index 1997 Subject index 1997 Reviewers 1997 Contents 1997 A P V News Calendar of events
227 229
243 253 261 269 273 283
289
303 315 323
327 333 337 341 345 349 351 SI $2
~
~]
European Journal of Pharmaceutics and Biopharmaceutics 44 (1997) 351-354
Contents Volumes 43-44 (1997) Vol. 43, No. 1 (JANUARY 1997) Publisher's Note Editorial
Tableting of coated pellets R. Bodmeier (German)') Doxorubicin induces aggregation of small negatively charged liposomes M.J. Fonseca, E.C.A. van Winden, D.J.A. Crommelin (The Netherlands) Biocompatibility of ABA triblock copolymer microparticles consisting of poly(L-lactic-co-glycolic-acid) A-blocks attached to central poly(oxyethylene) B-blocks in rats after intramuscular injection B. Ronneberger, T. Kissel, J.M. Anderson (Germany, USA) Microencapsulation of rh-erythropoietin, using biodegradable poly(D,L-lactide-co-glycolide): protein stability and the effects of stabilizing excipients M. Morlock, H. Koll, G. Winter, T. Kissel (Germany) Delivery of a hydrophilic solute through the skin from novel microemulsiou systems M. Bego~a Delgado-Charro, G. lglesias-Vilas, J. Blanco-M~ndez, M. Arturo L6pez-Quintela, J.-P. Marry, R.H. Guy (Spain, France, USA) Electroperturbation of the human skin barrier in vitro (1): the influence of current density on the thermal behaviour of skin impedance W.H.M. Craane-van Hinsberg, J.C. VerhoeJ~ H.E. Junginger, H.E. BoddO (The Netherlands) Ultrapure poly(vinyl alcohol) hydrogels with mucoadhesive drug delivery characteristics N.A. Peppas, N.K. Mongia (USA) In vivo evaluation of hydrophilic and hydrophobic mucoadhesive semi-solid formulations containing sucralfate and lidocaine for intraoral use Y. Jacques, T. Nguyen-Xuan, E. lonescu, G.P. Ravelli, P. Buri, P. Baehni, R. Gurny (Switzerland, France) Factors affecting in vitro gastric mucoadhesion: IV. Influence of tablet excipients, surfactants and salts on the observed mucoadhesion of polymers M.J. Tobyn, J.R. Johnson, P.W. Dettmar (UK) Interaction and translocation of cysteamine (mercaptoethylamine) with model membranes: a ]SN-NMR and ]H-NMR study C. Lagoueyte, G. Subra, P.-A. Bonnet, J.-P. Chapat, J.-C. Debouzy, F. Fauvelle, F. Berleur, V. Roman, M. Fatome, J.-P. Fernandez (France) Aqueous pseudolatex of zein for film coating of solid dosage forms P.B. O'Donnell, C. Wu, J. Wang, L. Wang, B. Oshlack, M. Chasin, R. Bodmeier, J.W. McGinity (USA, Germany) The effect of V-mixer scale-up on the mixing of magnesium stearate with direct compression microcrystalline cellulose J.G. Van der Watt, M.M. de Villiers (South Africa) Influence of micronization on the compaction properties of an investigational drug using tableting index analysis M.O. Omelczuk, C.-C. Wang, D.G. Pope (USA) Book reciews Doctoral Theses A P V News Cah'ndar Instructions to Authors
v vii
1 9
19 29 37 43 51 59 65 73 83 91 95 101 103 109 111 113
l'ol. 43, No. 2 (APRIL 1997)
Controlled and/or prolonged parental delivery of peptides from the hypothalmic pituitary axis A. Rothen-Weinhold, R. Gurny (Switzerland, France) 0939-6411/97/$17.00 © 1997 Elsevier Science B.V. All rights reserved. P l l S0939-6411 (97)00144-6
115
352
Contents of Volumes 43-44
Acute effects of iontophoresis on human skin in vivo: cutaneous blood flow and transepidermal water loss measurements R.M. Brand, P. Singh, E. Aspe-Carranza, H.L Maibach, R.H. Guy (USA) Preparation of the glucosylamines of procainamide and evaluation of the pharmacokinetics of the fl-glucosylamine of procainamide in the conscious rabbit J.E. Parkin, K.F. llett (Australia) Kaliuretic effect of short-term theophylline in healthy subjects S. Samaan, S.L. Markantonis (USA, Greece) Influence of process parameters on sustained-release theophylline pellets coated with aqueous polymer dispersions and organic solvent-based polymer solutions C.A. Lorck, P.C. Grunenberg, H. Jiinger, A. Laicher (Germany) The influence of thermal neutron irradiation on the in vitro characteristics of ASA oral dosage forms: Validation of neutron activation T. Waaler, S.A. Sande, B.W. Miiller, G. Schiiller Lisether (Norway, Germany) Prevention of the sticking tendency of floating minitablets filled into hard gelatin capsules N. Rouge, J.-C. Leroux, E.T. Cole, E. Doelker, P. Buri (Switzerland) Influence of the viscosity grade and the particle size of HPMC on metronidazole release from matrix tablets M.E. Campos-Aldrete, L. Villafuerte-Robles (MOxico) Development and characterization of microemulsions for ocular application A. Hare, S. Keipert (Germany) Interactions between bendroflumethiazide and water soluble polymers. I. Solubility of bendroflumethiazide in water from solid dispersions and formation of associates under climatic stress R. Frontini, J.B. Mielck (Germany) Pharmacokinetics and bioavailability of pentoxifylline in healthy volunteers-a comparative study of three oral formulations M. Pokrajac, B. MzTjkovi~, D. Simi~, B. Brzakovi~, A. Galetin (Yugoslavia) PKC, a new pharmacokinetic software using SAS® J.-M. Cardot, A. Jaouen, J. Godbillon (France)
Book reviews Doctoral Theses AP V News Calendar Instructions to Authors
133
139 145
149
159 165 173 179
185 193 197 201 203 209 211 213
Vol. 43 No. 3 (JUNE 1997) Residual solvents in pharmaceutical products: acceptable limits, influences on physicochemical properties, analytical methods and documented values C. Witschi, E. Doelker (Switzerland) Trends in the organization of drug research: interfacing industry and universities D.K.F. Meijer, J. Wilting (The Netherlands) Bioconversion of estradiol esters in the skin of various animal models in vitro K. Yamada, K. Tojo (Japan) Simple method of in vitro diffusion of nicotine across porcine palatine mucosa A.-L. Cornaz Gudet, A.F. Ganem-Quintanar, P. Buri (Switzerland, France) Intestinal absorption of the quaternary trospium chloride: permeability-lowering factors and bioavailabilities for oral dosage forms P. Langguth, A. Kubis, G. Krumbiegel, IV. Lang, H.P. Merkle, W. Wdchter, H. Spahn-Langguth, R. Weyhenmeyer (Switzerland, Poland, Germany) Serotonin antagonists for use as antiglaucoma agents and their ocular penetration R.D. Schoenwald, R. R. Gadiraju, C.F. Barfknecht (USA) Influence of traces of surfactants on nifedipine bioavailability in rats after neomycin-induced malabsorption syndrome H. Wojdak (Poland) Development and characterization of protein-loaded poly(lactide-co-glycolide) nanospheres M.D. Blanco, M.J. Alonso (Spain) Long term stability of freeze-dried, lyoprotected doxorubicin liposomes E.C.A. van Winden, D.J.A. Crommelin (The Netherlands) Interactions between bendroflumethiazide and water soluble polymers. II. Factors promoting drug-polymer association R. Frontini, J.B. Mielck (Germany)
215 243 253 259
265 273 283 287 295 309
Contents of Volumes 43-44
353
Crushing strength, disintegration time and weight variation of tablets compressed from three Avicel® PH grades and their mixtures E. Lahdenpgiii, M. Niskanen, J. Yliruusi (Finland)
315
Book reviews Recently Published Doctoral Theses A P V Veranstaltungen in Deutschland/APV Courses in Germany Calendar of events Announcement
323 327 S1 $3 $4
Vol. 44 No. 1 (JULY 1997) Editor&l Lectins and bacterial invasion factors for controlling endo- and transcytosis of bioadhesive drug carrier systems E. Haltner, J.H. Easson, C.-M. Lehr (Germany) Bioadhesion of solid oral dosage forms, why and how? D. Duchdne, G. Ponchel (France) Mucoadhesion of colloidal particulate systems in the gastro-intestinal tract G. Ponchel, M.-J. Montisci, A. Dembri, C. Durrer, D. Duchdne (France) The influence of in-vivo carbonation on GI physiological processes and drug permeability J.D. Eichman, A.E.-D.B. Yassin, J.R. Robinson (USA, Egypt) An in vitro-in vivo investigation of oral bioadhesive controlled release furosemide formulations G. Santus, C. Lazzarini° G. Bottoni, E.P. SandeJer, R.C. Page, W.J. Doll, U.Y. Ryo, G.A. Digenis (Italy, USA) Preparation and in vitro characterisation of mucoadhesive polymeric microspheres as intra-nasal delivery systems M.D.A. El-Hameed, I.W. Kellaway (UK) Dielectric analysis of bioadhesive gel systems D.Q.M. Craig, S. Tamburic (UK) Ocular pharmacokinetics/pharmacodynamics N. W~rakul, J.R. Robinson (USA, Thailand) Interactions between bendroflumethiazide and water-soluble polymers, lII. Chemical degradation R. Frontini, J.B. Mielck (Germany) Pharmacological modulation of the tissue response to implanted polylactic-co-glycolic acid microspheres A.L. Daugherty, J.L. Cleland, E.M. Duenas, R.J. Mrsny (USA) Book reviews A P V News Calendar of events
I
3 15 25 33 39 53 6l 71 85 89 103 S1 $2
Vol. 44 No. 2 (SEPTEMBER 1997) Contribution of lipid components to the permeability barrier of oral mucosa A. Ganem-Quintanar, F. Falson-Rieg, P. Buri (France, Switzerland) The use of small volume ocular sprays to improve the bioavailability of topically applied ophthalmic drugs L.G. Martini, J.K. Embleton, R.J. Malcolmson, C.G. Wilson (UK) Body distribution of azidothymidine bound to nanoparticles after oral administration R. L6benberg, L. Araujo, J. Kreuter (Germany) Increase of polypeptide transport by lectin conjugation across rabbit Peyer's patches T. Isoda, E. Watanabe, M. Haga, S. Haseto, S. Awazu, M. Hayashi (Japan) Buccoadhesive oxycodone hydrochloride disks: plasma pharmacokinetics in healthy volunteers and clinical study B. Parodi, E. Russo, G. Caviglioli, M. Vallarino, F. Fuseo, F. Henriquet (Italy) Dose linearity of quinine in healthy human subjects C.P. Babalola, 0.0. Bolaji, F.A. Ogunbona, A. Sowunmi, O. Walker (Nigeria) Comparative in vitro biocompatibility testing of polycyanoacrylates and poly(D,L-lactide-co-glycolide) using different mouse fibroblast (L929) biocompatibility test models R. Zange, T. Kissel (Germany) A comparison of different in vitro methods for measuring mucoadhesive performance S. Tamburic, D.Q.M. Craig (UK)
107 121 127 133 137 143
149 159
354
Contents o f Volumes 43-44
Comparison between a twin-screw extruder and a rotary ring die press. I. Influence of formulation variables C. Schmidt, H. Lindaer, P. Kleinebudde (Germany) Formulation of proteins in vacuum-dried glasses. I: Improved vacuum-drying of sugars using crystallising amino acids M. Mattern, G. Winter, R. Rudolph, G. Lee (Germany) Decrease of the stage-2 deposition in the twin impinger during storage of beclomethasone dipropionate dry powder inhalers in controlled and uncontrolled humidities E.R.M. Geuns, J.S. Toren, D.M. Barends, A. Bult (The Netherlands) A study of an epoxy aerosol can lining exposed to hydrofluoroalkane propellants R.O. Williams II1, C. Hu (USA) Application of mercury porosimetry in evaluation of extrusion-spheronisation process A.M. Juppo, L. HellOn, V. Pullinen-Strander, K. Kalsta, J. Yliruusi, E. Kristoffersson (Finland) A method for modeling in vitro dissolution profiles of drugs using gamma distribution A. Djordjevi~, I. Menda~ (Yugoslavia) Book reviews Recently Published Doctoral Theses A P V News Calendar of events
169 177
187 195 205 215 219 223 S1 $3
Vol. 44, No. 3 (NOVEMBER 1997) Editorial Principles, tenets and notions of tablet bonding and measurements of strength E.N. Hiestand (USA) Effect of particle size and compaction load on interparticulate bonding structure for some pharmaceutical materials studied by compaction and strength characterisation in butanol ~. Adolfsson, H. Olsson, C. Nystrrm (Sweden) Effect of water on deformation and bonding of pregelatinized starch compacts K. Van der Voort Maarschalk, H. Vromans, W. Groenendijk, G.K. Bolhuis, C. F. Lerk (The Netherlands) Evaluation of pharmaceutical beam bending tests using double-exposure holographic interferometry P. Raatikainen, R. Silvennoinen, J. Ketolainen, Pertti Ketolainen, P. Paronen (Finland) Percolation theory and physics of compression H. Leuenberger, L. Ineichen (Switzerland) Indices of tableting performance and application of percolation theory to powder compaction C. Imbert, P. Tchoreloff, B. Leclerc, G. Couarraze (France) The repeated compression of powders M.R.A.K. Al-Aghbar, N.A. Armstrong (UK) Associations of parameters characterizing the time course of the tabletting process on a reciprocating and on a rotary tabletting machine for high-speed production P. Konkel, J.B. Mielck (Germany) Compression force/time-profiles of microcrystalline cellulose, dicalcium phosphate dihydrate and their binary mixtures--a critical consideration of experimental parameters P.C. Schmidt, M. Leitritz (Germany) Compressibility and compactibility of powdered polymers: poly(vinyl chloride) powders A.-F. Rime, D. Massuelle, F. Kubel, H.-R. Hagemann, E. Doelker (Switzerland) A new practical index to predict capping occurring during the tableting process K.-i. Sugimori, Y. Kawashima (Japan) Scale-up of adhesive transdermal drug delivery systems G.A. Van Buskirk, M.A. Gonzhlez, V.P. Shah, Scott Barnhardt, C. Barrett, S. Berge, G. Cleary, K. Chan, G. Flynn, T. Foster, R. Gale, R. Garrison, S. Gochnour, A. Gotto, S. Govil, V.A. Gray, J. Hammar, S. Harder, C. Hoiberg, A. Hussain, C. Karp, H. Llanos, J. Mantelle, P. Noonan, D. Swanson, H. Zerbe (USA, Ireland) Book reviews Recently published doctoral theses Author index 1997 Subject index 1997 Reviewers 1997 Contents 1997 A P V News Calendar of events
227 229
243 253 261 269 273 283
289
303 315 323
327 333 337 341 345 349 351 SI $2