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Continuous combined oral oestradiol and norethisterone acetate in post-menopausal women: effect on vasomotor symptoms, plasma lipids and lipoproteins
103
32
CONTINUOUS
COMBINED
ORAL
OESTRADIOL AND
POST-MENOPAUSALWOMEN: EFFECT ON
NORETHISTERONE ACETATE IN
VASOMOTOR SYMPTOMS, PLASMA LIPIDS AND
LIPOPROTEINS
D.A. Davey, G.M. Berger, D. Yon and F.E. Hardle - Cape Town, South Africa
The
effects of
micronised oestradiol (ME) 2 cogdally for 28 days followed by
ME 2mg daily combined with either 1 tugor for
28
days were
hot flushes, the levels of biochemical and
norethisterone acetate (NET)
plasma lipids and
lipoproteins and
Thirty
56
days
(after 28
post-menopausal
women
allocated to two groups according to NET dose In a the
effects of
the
standard
endocrine profiles were measured before treatment and at 28 days
(after oestrogen alone) and progestogen).
0.5 mg
studied in a double-blind comparative trial. The incidence of
ME
alone and
of
Preliminary analysis suggests that
ME
days
with
of
plus
oestrogen
vasomotor symptoms were
randomised block design and
with the two doses of NET were compared.
(a) not
all women with
hot
flushes are
completely relieved by ME or combined ME/NET therapy, (b) ME 2 mg daily produces a fall in total cholesterol and total triglycerides,but a lipoprotein (HDL) cholesterol, (c) the in
rise in high-density
addition of NET 1 mg daily to
total cholesterol and
ME 2 mg
daily causes a
relative rise
relative fall
in HDL-cholesterol,the addition of NET 0.5 mg to ME having a less
triglycerides and
a
marked effect, and (d) differences also occur in plasma calcium, phosphorus and alkaline
phosphatase
levels.
Detailed
results
were
obtained and
their
significance assessed.
33
MID-LIFE WOMEN AND THEIR PHYSICIANS: HEALTH PERCEPTIONS
Catherine DeLorey - Boston, Massachusetts, U.S.A.
The
interest in mid-life physiological and psychological changes in women has
led to an increased awareness of and interest in their health problems and health care provided. Since the stage in women's lives and has
the
menopause is one of the major events at this
itself generated much
attention, it
has
been
realized that the physiological and psychological Influences of the menopause on the experiences of mid-life women warrant investigation.
Except for anecdotal reports, little is experiences of
mid-life women, how
known of
the health concerns and
they perceive their own health status, or
32
CONTINUOUS
COMBINED
ORAL
OESTRADIOL AND
POST-MENOPAUSALWOMEN: EFFECT ON
NORETHISTERONE ACETATE IN
VASOMOTOR SYMPTOMS, PLASMA LIPIDS AND
LIPOPROTEINS
D.A. Davey, G.M. Berger, D. Yon and F.E. Hardle - Cape Town, South Africa
The
effects of
micronised oestradiol (ME) 2 cogdally for 28 days followed by
ME 2mg daily combined with either 1 tugor for
28
days were
hot flushes, the levels of biochemical and
norethisterone acetate (NET)
plasma lipids and
lipoproteins and
Thirty
56
days
(after 28
post-menopausal
women
allocated to two groups according to NET dose In a the
effects of
the
standard
endocrine profiles were measured before treatment and at 28 days
(after oestrogen alone) and progestogen).
0.5 mg
studied in a double-blind comparative trial. The incidence of
ME
alone and
of
Preliminary analysis suggests that
ME
days
with
of
plus
oestrogen
vasomotor symptoms were
randomised block design and
with the two doses of NET were compared.
(a) not
all women with
hot
flushes are
completely relieved by ME or combined ME/NET therapy, (b) ME 2 mg daily produces a fall in total cholesterol and total triglycerides,but a lipoprotein (HDL) cholesterol, (c) the in
rise in high-density
addition of NET 1 mg daily to
total cholesterol and
ME 2 mg
daily causes a
relative rise
relative fall
in HDL-cholesterol,the addition of NET 0.5 mg to ME having a less
triglycerides and
a
marked effect, and (d) differences also occur in plasma calcium, phosphorus and alkaline
phosphatase
levels.
Detailed
results
were
obtained and
their
significance assessed.
33
MID-LIFE WOMEN AND THEIR PHYSICIANS: HEALTH PERCEPTIONS
Catherine DeLorey - Boston, Massachusetts, U.S.A.
The
interest in mid-life physiological and psychological changes in women has
led to an increased awareness of and interest in their health problems and health care provided. Since the stage in women's lives and has
the
menopause is one of the major events at this
itself generated much
attention, it
has
been
realized that the physiological and psychological Influences of the menopause on the experiences of mid-life women warrant investigation.
Except for anecdotal reports, little is experiences of
mid-life women, how
known of
the health concerns and
they perceive their own health status, or