Correlation of Adherence to Quality of Life in Patients Receiving Anti Retro Viral Medication

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affect the treatment adherence. The likelihood of having high treatment adherence increased monotonically over age 34: 50~64 years (OR= 1.768, 95% CI= 1.317-2.372), ≥  65 years (OR= 3.823, 95% CI= 1.802-8.107).  Conclusions: Patients having more non-ART drugs per day are less likely to achieve a high ART adherence. This could be due to the increased comorbid status or the complex daily drug-taken frequencies. ART tabs per day will affect the treatment adherence. Elder patients shows a higher compliance to ART than young patients in general. PIN47 Factors Related to Hpv Vaccine Uptake and 3-Dose Completion Among Adult Women: The Importance of a Physcian Recommendation Wilson A, Bailey N Anolinx, Murray, UT, USA

Objectives: Human papillomavirus (HPV) is the most common sexually transmitted disease in the United States and is the primary cause of cervical cancer. Fortunately, there are safe and effective vaccines to prevent HPV, however uptake is low in Utah with only 24.7% of Utah adolescents completing the series. The objective of this study was to assess the demographic and attitudinal factors associated with HPV vaccine initiation and completion among 18–26-year-old women in Utah.  Methods: Between January 2013 and December 2013, we surveyed 325 women from the University of Utah Community Clinics about their HPV vaccine related beliefs and behaviors. Odds ratios (ORs) were estimated from logistic regression models to identify variables related to HPV vaccine initiation and series completion. Additionally, a meta-analysis was performed on 74 articles to support findings related to intention to vaccinate.  Results: Of the 325 participants, 204 (62.8%) had initiated the vaccine and 159 (48.9%) had completed the 3-dose series. The variables of interest associated with HPV vaccine initiation included the strength of doctor recommendation (OR =  1.86 per scale unit); and whether a doctor’s recommendation was influential (OR = 1.70 per scale unit). These variables were also significantly associated with HPV vaccine completion. Our findings are in-line with the results of the Meta-analysis, that vaccine uptake increases significantly with physician recommendation, when accounting for potential confounders.  Conclusions: Our findings show that there is a tremendous opportunity to create a program to support physicians as champions of the HPV vaccination, which would increase HPV vaccination rates among young women in Utah. PIN48 Correlation of Adherence to Quality of Life in Patients Receiving Anti Retro Viral Medication Chakka G1, G H1, Krupa S1, Y N1, M PK1, Giri Raja S1, TS MS1, SCb 2 1Annamacharya College of Pharmacy, YSR Kadapa, India, 2Rajiv Gandhi institute of medical sciences, Kadapa, India

Objectives: The aim of the study was to analyse the correlation between Quality of Life and adherence in patients receiving (ART) anti retroviral therapy.  Methods: It is a prospective observational study conducted in Rajiv Gandhi Institute of Medical sciences, for 8 months Aug-2014 to March-2015with a sample size of 195 outpatients diagnosed with (HIV/AIDS) human immunodeficiency virus/acquired immune deficiency syndrome and on ART. Study subjects were aged between 18-60years the mean age group of males was 34.5 ± 2.12 years and females was 33.5 ± 2.12 years. Patients were followed up for 5 months.  Results: The overall (QOL) Quality of life was score calculated with WHO-HIVBREF questionnaire scored from 0-100 and was found to be 75.15. The proportion of respondents with high was seen in the environmental domain (78.6%), followed by physical domain (76.22%), and social domains (75.7%). Lowest was observed in the psychological domain (74.59%). Total mean adherence scores by using Morisky-8-item medication adherence questionnaire were scored as a High-77.22%, Medium-22.66%, Low-0.12%. In males and females total mean scores were 62.36±36.83, 50.09±41.06 respectively-value for adherence was 0.034 which was significant. Pearson’s correlation coefficient value r =  0.98 which shows the linear relationship between and adherence. Conclusions: Males with income more than 5000, no formal education, married, coolis, living with spouse and on ART had high scores of adherence correlates to higher than to females with no formal education, married and income more than 3000 widowed, illiterates, unemployed and adherence were found to be related to education, income, occupation, ART status, duration of taking ART. PIN49 Ecodevelopmentally Based Study of Epidemiological and SelfPerceived Indices of Hiv Risk among Young African Americans: A Comparative Analysis Li Y1, Mgbere O2, Abughosh S1, Chen H1, Cuccaro P3, Essien EJ1 1University of Houston, Houston, TX, USA, 2Houston Department of Health and Human Services, Houston, TX, USA, 3University of Texas School of Public Health, Houston, TX, USA

Objectives: This study examined the association between epidemiological and self-perceived risks of contracting the human immunodeficiency virus (HIV) among young African Americans (AA) and the multi-level factors (micro-, meso-, exo-, and macro-systems) identified based on the ecodevelopmental theory. Methods: A retrospective cross-sectional study was conducted using 1,619 AA youth ages 14.2-17.8 years in wave 1 of the National Longitudinal Study of Adolescent Health. Epidemiological and self-perceived indices of HIV risk were developed and their associations between and within the ecodevelopmental systems were evaluated using Chi-square and Cohen’s Kappa statistics.  Results: Findings revealed significant discordance (p< 0.0001) in young AAs’ risk status based on the two assessment methods, with a Cohen’s Kappa coefficient of 0.1443 (95% CI: 0.1434-0.1452). Using the epidemiological index as the “gold standard”, 55.72% of the study sample was able to accurately assess their risk levels through self-perception with significant variations noted cross the ecodevelopmental systems. Inaccurate risk estimates were generally associated with being male, low parents’ function (not having a mother, feeling less close to their father), and low academic performance.

Additionally, high epidemiologic risk status was associated with age at sexual debut, weak family function (living alone, having a loose bond with their biological father), loose connection in schools and to their neighborhoods (having difficulty getting along with teachers, and having fewer social interactions), and having more sexually active friends (who contracted sexually transmitted diseases, and frequently using condoms).  Conclusions: The disparity noted between self-perceived and epidemiological risks for contracting HIV in our study underscore the need for effective HIV educational programs targeting young AA and their parents. The implication of ecosystemic processes at different levels within the risk status particularly family and school functioning, and parental social support indicate that ecodevelopmentally-based interventions may be valuable in preventing the risk of HIV transmission among AA adolescents. PIN50 Understanding the Hepatitis C Patient Journey: Insights from a Patient Panel in the United States Abdel-Sattar M1, Donne L1, Wees J2, Rugani M2, McLaughlin T1, Jackson J1 Harbor, FL, USA, 2Xcenda, San Bruno, CA, USA

1Xcenda, Palm

Objectives: To gain a better understanding of the Hepatitis C (HCV) patient journey by gathering patients’ insights about their experience with healthcare providers, treatment successes and failures, and sources of information and support.  Methods: A 20-minute, web-based survey was administered in July 2015 to 267 non-incarcerated American HCV patients within Xcenda’s Health & Lifestyle Patient Market Research Panel.  Results: Of the 50 HCV patients who completed the survey, 62% were female, 46% were unemployed, and 68% were diagnosed with HCV genotype 1. Respondents had a mean age of 57, with 40 being the mean age at diagnosis. Although 84% had private insurance, Medicare, or dual coverage, 12% ranked out-of-pocket costs as the most important attribute for new HCV treatments. Three-fourths (76%) felt they were “very knowledgeable” about HCV and nearly half (48%) participated in HCV support programs. When asked to identify the most important attribute for HCV support programs, 50% selected education on HCV and its treatments, and 33% chose communication and interaction with other HCV patients. 89% of respondents reported seeing a physician at least once a year. Of those who underwent a liver biopsy (64%), 97% knew their F-score. 61% had only one previous treatment, 21% had two, and 18% tried three or more treatments, including interferon, peginterferon, ribavirin, Sovaldi®, Harvoni®, Olysio®, and others. 96% reported being able to take all doses of their HCV medications in a typical week, 78% completed at least one full course of treatment, 84% achieved a sustained virologic response with 64% remaining free of the virus, and 50% expressed they were “extremely satisfied” with their treatment experience.  Conclusions: HCV patients in the United States are increasingly knowledgeable and engaged in their healthcare. They often participate in support programs to gain more information on HCV and its treatments, and to be part of a shared patient experience. PIN51 A Review of Discrete Choice Experiment Studies of Preferences for Vaccine Features Poulos C RTI Health Solutions, Research Triangle Park, NC, USA

Objectives: Studies that quantify preferences for vaccination features help vaccine producers and policymakers understand what drives decisions to vaccinate. This literature review summarizes published discrete choice experiment (DCE) studies of preferences for vaccination features, reports key findings and identifies gaps in the literature.  Methods: A PubMed literature search was conducted to identify published original English-language DCE studies articles reporting preferences for vaccinations. For each study, information on study features was extracted and summarized.  Results: Using the search terms, 450 abstracts were identified for review. A total of 40 studies published since 2004 were included in the review. The studies focused on vaccines against HPV (number of studies [n]= 11), HIV (n= 7), influenza (n= 5), rotavirus (n= 2), and meningococcal disease (n= 2). Five studies focused on multiple or unidentfied vaccines. Fourteen studies were conducted in the United States; 7 in The Netherlands; 3 in Thailand; 3 in Canada; 2 in Vietnam; 2 in Germany; 1 each in Belgium, The Phillipines, Japan, and the United Kingdom (some studies were conducted in multiple countries). The study population varied and included parents evaluating vaccines for their children (n= 11), physicians or other health care providers (n= 5), general population adults (n= 7), girls (n= 4), and high-risk adults (n= 3). Ten studies used ratings of hypothetical vaccine profiles, while most of the remaining studies used discrete choice question formats. Ratings studies evaluated the acceptability of vaccines and the stated intention to vaccinate. The data from the discrete choice format studies were used to calculate predicted uptake and willingness to pay. The types and defintitions of vaccination features included in the studies varied signficantly across studies.  Conclusions: DCE studies of vaccine preferences have been diverse. Study findings can help stakeholders understand the features that may drive vaccination decisions. Additional analysis of existing studies is required to facilitate direct comparisons of the findings. PIN52 Evaluation of the Performance Properties of the Influenza PatientReported Outcomes Instrument (Flu-Pro) Powers JH1, Bacci ED2, Leidy NK3, Stringer S3, Kim K3, Memoli MJ4, Han A4, Fairchok MP5, Chen W6, Arnold JC7, Danaher PJ8, Lalani T9, Hansen EA10, Ridore M11, Burgess TH6, Millar EV6, Hernández A12, Rodríguez-Zulueta P13, Ortega-Gallegos H14, Galindo-Fraga A14, Ruiz-Palacios GM14, Pett S15, Fischer W16, Gillor D17, Macias LM18, DuVal A19, Rothman R19, Dugas A19, Guerrero ML14 1Leidos Biomedical Research in support of NIH, George Washington University School of Medicine, Rockville, MD, USA, 2Evidera, Seattle, WA, USA, 3Evidera, Bethesda, MD, USA, 4National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA, 5Madigan Army Medical Center; Infectious Disease Clinical Research Program, Uniformed Services University, Tacoma, WA, USA, 6Infectious Disease Clinical Research Program, Uniformed Services University, Rockville, MD, USA, 7Naval