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Correlation of antistaphylococcal antibody titers with severity of Staphylococcal disease
Multiple endocrine adenomatosis Type I lnsullnoma
Pltultary tumor
Hypothyroidism Water dluresls
Counterimmunoelectrophoresis (CIE) was utilized to determine antistaphylococcal precipitin antibody titers in various staphylococcal disease states and control groups. Patients with staphylococcal disease comprised five cases of endocarditis, 22 of deep tissue infection (including seven cases of osteomyelitis), six of bacteremia and six of skin infection. Controls consisted of 31 patlents with nonstaphylococcal bacteremias, 29 hospitalized patients without infection and 30 healthy subjects. Antistaphylococcal antibodies were present in all patients with staphylococcal endocarditis and deep tissue staphylococcal infection, and all but three had titers 2 1:4. No significant difference in titers was found between these two groups of patients. Antibodies, although present in some patients in the other categories, were deteoted less frequently and only two patients had titers 11:4. Thus, an antistaphylococcal antfbody titer by CIE of 1:4 or greater may be an additional diagnostic parameter.
Jackson W, Sottile MI, Aguilar-Torres FG, Dee TH, Rytel MW: Correlation of antistaphylococcal antibody titers with seventy of staphylococcal disease. Am J h4ed 64: 629-633, 1978.
Staphylococcal disease Antibodies Counterlmmunoelectrophoresls Endocardltls Deep tissue Infection Preclpttln antibody tlters
The response of plasma vasopressin to acute water ingestion was evaluated in 20 patients with myxedema prior to treatment and in eight following thyroid medication. Vasopressin was increased and failed to suppress after oral water ingestion in 15 hypothyroid patients, two of whom had a normal renal response suggesting end organ resistance. Three patients with suppressable vasopressin showed a defect in water excretion suggestinga renal mechanism. E&&t patients restudied when euthyroid had normal inhibition of vasopressin and a normal urinary excretion following the oral water load.
Skowsky WR, Kikuchi TA: The role of vasopressin in the impaired water excretion of myxedema Am J Med 64: 613-621. 1978.
Vasopressln Hyponatremla Renal water transport Myxedema
Contrnuedon page A89
Tha adequacy of emergency room treatment of patients with acute severe asthma was assessed by analyzing the course of 127 vrsits to the emergency room by 102 patients. Using conventional clinrcal criteria as an end point the patients in 85.4 per cent of these episodes responded sufficiently to emergency room treatment to allow their discharge. However, the relief of airway obstruction measured directly was modest. Approximately onequarter of those episodes that ended in the patient’s discharge from the emergency room were followed by equally severe episodes within 10 days (relapse); 6 per cent of the patients initially discharged who returned to the emergency room required hospitalization. We conckrde that the success of emergency room treatment depends on the degree of improvement in pulmonary function achieved; objective measures (e.g., FEV,) of the degree of airway obstruction are helpful in predicting the outcome of emergency room treatment of patients with acute asthma
Kelsen SG, Kelsen DP, Fleegler BF, Jones RC, Rodman T: Emergency room assessment and treatment of patients with acute asthma Adequacy of the conventional approach. Am J Med 64: 622-628, 1978.
Pulmonary function Emergency room treatment Asthma Sternomastoid muscle contraction Airway obstruction
Endocrinologic investigation of 10 patients wrth the Zollinger-Ellison syndrome revealed coexisting endocrine disease in seven of them. Six of these patients probably suffered from multiple endocrine adenomatosis type I, whereas the remaining patient presumably had a mixed pancreatic tumor. The six patients with multiple endocnne adenomatosis all had relatives with endocrine abnormalities, whereas no endocrine abnormalities were found in the families of the other four patients with the Zolllnger-Ellison syndrome. During this study, four previously undiagnosed cases of pituitary tumor, 17 of hyperparathyroidism, seven of the Zollinger-Ellison syndrome and one of insulinoma were detected. The endocrine disorders were often asymptomatic.
Lamers CB, Stadil F, van Tongeren JH: Prevalence of endocrine abnormalities in patients wlth the Zollrnger-Ellison syndrome and in their families. Am J Med 64: 607612,1978.
Zollinger-Elllson syndrome Hyperparathyroldlsm
Pltultary tumor
Hypothyroidism Water dluresls
Counterimmunoelectrophoresis (CIE) was utilized to determine antistaphylococcal precipitin antibody titers in various staphylococcal disease states and control groups. Patients with staphylococcal disease comprised five cases of endocarditis, 22 of deep tissue infection (including seven cases of osteomyelitis), six of bacteremia and six of skin infection. Controls consisted of 31 patlents with nonstaphylococcal bacteremias, 29 hospitalized patients without infection and 30 healthy subjects. Antistaphylococcal antibodies were present in all patients with staphylococcal endocarditis and deep tissue staphylococcal infection, and all but three had titers 2 1:4. No significant difference in titers was found between these two groups of patients. Antibodies, although present in some patients in the other categories, were deteoted less frequently and only two patients had titers 11:4. Thus, an antistaphylococcal antfbody titer by CIE of 1:4 or greater may be an additional diagnostic parameter.
Jackson W, Sottile MI, Aguilar-Torres FG, Dee TH, Rytel MW: Correlation of antistaphylococcal antibody titers with seventy of staphylococcal disease. Am J h4ed 64: 629-633, 1978.
Staphylococcal disease Antibodies Counterlmmunoelectrophoresls Endocardltls Deep tissue Infection Preclpttln antibody tlters
The response of plasma vasopressin to acute water ingestion was evaluated in 20 patients with myxedema prior to treatment and in eight following thyroid medication. Vasopressin was increased and failed to suppress after oral water ingestion in 15 hypothyroid patients, two of whom had a normal renal response suggesting end organ resistance. Three patients with suppressable vasopressin showed a defect in water excretion suggestinga renal mechanism. E&&t patients restudied when euthyroid had normal inhibition of vasopressin and a normal urinary excretion following the oral water load.
Skowsky WR, Kikuchi TA: The role of vasopressin in the impaired water excretion of myxedema Am J Med 64: 613-621. 1978.
Vasopressln Hyponatremla Renal water transport Myxedema
Contrnuedon page A89
Tha adequacy of emergency room treatment of patients with acute severe asthma was assessed by analyzing the course of 127 vrsits to the emergency room by 102 patients. Using conventional clinrcal criteria as an end point the patients in 85.4 per cent of these episodes responded sufficiently to emergency room treatment to allow their discharge. However, the relief of airway obstruction measured directly was modest. Approximately onequarter of those episodes that ended in the patient’s discharge from the emergency room were followed by equally severe episodes within 10 days (relapse); 6 per cent of the patients initially discharged who returned to the emergency room required hospitalization. We conckrde that the success of emergency room treatment depends on the degree of improvement in pulmonary function achieved; objective measures (e.g., FEV,) of the degree of airway obstruction are helpful in predicting the outcome of emergency room treatment of patients with acute asthma
Kelsen SG, Kelsen DP, Fleegler BF, Jones RC, Rodman T: Emergency room assessment and treatment of patients with acute asthma Adequacy of the conventional approach. Am J Med 64: 622-628, 1978.
Pulmonary function Emergency room treatment Asthma Sternomastoid muscle contraction Airway obstruction
Endocrinologic investigation of 10 patients wrth the Zollinger-Ellison syndrome revealed coexisting endocrine disease in seven of them. Six of these patients probably suffered from multiple endocrine adenomatosis type I, whereas the remaining patient presumably had a mixed pancreatic tumor. The six patients with multiple endocnne adenomatosis all had relatives with endocrine abnormalities, whereas no endocrine abnormalities were found in the families of the other four patients with the Zolllnger-Ellison syndrome. During this study, four previously undiagnosed cases of pituitary tumor, 17 of hyperparathyroidism, seven of the Zollinger-Ellison syndrome and one of insulinoma were detected. The endocrine disorders were often asymptomatic.
Lamers CB, Stadil F, van Tongeren JH: Prevalence of endocrine abnormalities in patients wlth the Zollrnger-Ellison syndrome and in their families. Am J Med 64: 607612,1978.
Zollinger-Elllson syndrome Hyperparathyroldlsm