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Cytochrome C: Intravenous administration in man
Abstracts
and Reviews
Selected Abstracts Wilson, Who
M. G., Served
Payson, in the
J. W., and Lnbschez, Armed Forces, 1942-46.
Of 268 rheumatic patients of per cent (167) were accepted for (physically unfit for military duty). of active carditis with failure. In group, the physical signs of valvular matic history was more severe and group 43 per cent had had one or
R.: Experience of Am. J. Pub. Health
Rheumatic Patients 38:398 (March), 1948.
military age in the New York Hospital Children’s Clinic, 62 the Services. One hundred one patients were classified as 4F In the Service group, 23 per cent had had one or more attacks about one-half of the Service group and one-third of the civilian lesions had regressed. In the civilian group the past rheuthe resultant cardiac damage was of greatest degree. In this more attacks of active carditis with failure during childhood.
The incidence of rheumatic fever among the patients in military service revealed that three men were hospitalized for rheumatic fever while in the Armed Forces. In the civilian group during 402 patient-years, there were seven patients with recurrent attacks, one of whom died. In addition, two patients had bacterial endocarditis and two developed auricular fibrillation. It is noteworthy that cardiac failure, bacterial endocarditis, and auricular fibrillation did not occur among the men in the Service. Of particular importance is the observation that among the men who returned to the clinic after discharge, no change in physical signs or cardiac enlargement was observed. The authors state that in their experience the risk of a recurrent attack of rheumatic fever is no greater while in the Services than while in civilian pursuits. BELLET.
Rabinovitcb, R., Administration
Elliott, in
K. Man.
A.
C., and McEachern, J. Lab. & Clin. Med.
D.: 33:294
Cytochrome (March),
C:
Intravenous
1948.
Cytochrome C was administered intravenously in doses of 50 to 512 mg. daily to thirty-one days. Subjects included one normal individual and eight patients diseases. The concentration was determined by the spectrophotometric method Rosenthal and Drabkin.
for periods up with various described by
Injections of 50 to 500 mg. of cytochrome C, administered intravenously at intervals of one week to the one normal adult, and single doses of 500 mg., administered to two patients suffering No changes were noted in pulse, from neuromuscular disease,‘caused no subjective symptoms. respiration, blood pressure, temperature, or basal metabolism for three hours following injection. Eight patients suffering from various neuromuscular disease and one normal control given daily intravenous doses of cytochrome C which varied from 50 to 500 milligrams. detectable changes in symptoms or signs were produced. The substance was not detected troscopically in the serum of these patients except where blood samples were collected thirty minutes after injection of single doses of 500 milligrams.
were No specwithin
KLINE. 135
and Reviews
Selected Abstracts Wilson, Who
M. G., Served
Payson, in the
J. W., and Lnbschez, Armed Forces, 1942-46.
Of 268 rheumatic patients of per cent (167) were accepted for (physically unfit for military duty). of active carditis with failure. In group, the physical signs of valvular matic history was more severe and group 43 per cent had had one or
R.: Experience of Am. J. Pub. Health
Rheumatic Patients 38:398 (March), 1948.
military age in the New York Hospital Children’s Clinic, 62 the Services. One hundred one patients were classified as 4F In the Service group, 23 per cent had had one or more attacks about one-half of the Service group and one-third of the civilian lesions had regressed. In the civilian group the past rheuthe resultant cardiac damage was of greatest degree. In this more attacks of active carditis with failure during childhood.
The incidence of rheumatic fever among the patients in military service revealed that three men were hospitalized for rheumatic fever while in the Armed Forces. In the civilian group during 402 patient-years, there were seven patients with recurrent attacks, one of whom died. In addition, two patients had bacterial endocarditis and two developed auricular fibrillation. It is noteworthy that cardiac failure, bacterial endocarditis, and auricular fibrillation did not occur among the men in the Service. Of particular importance is the observation that among the men who returned to the clinic after discharge, no change in physical signs or cardiac enlargement was observed. The authors state that in their experience the risk of a recurrent attack of rheumatic fever is no greater while in the Services than while in civilian pursuits. BELLET.
Rabinovitcb, R., Administration
Elliott, in
K. Man.
A.
C., and McEachern, J. Lab. & Clin. Med.
D.: 33:294
Cytochrome (March),
C:
Intravenous
1948.
Cytochrome C was administered intravenously in doses of 50 to 512 mg. daily to thirty-one days. Subjects included one normal individual and eight patients diseases. The concentration was determined by the spectrophotometric method Rosenthal and Drabkin.
for periods up with various described by
Injections of 50 to 500 mg. of cytochrome C, administered intravenously at intervals of one week to the one normal adult, and single doses of 500 mg., administered to two patients suffering No changes were noted in pulse, from neuromuscular disease,‘caused no subjective symptoms. respiration, blood pressure, temperature, or basal metabolism for three hours following injection. Eight patients suffering from various neuromuscular disease and one normal control given daily intravenous doses of cytochrome C which varied from 50 to 500 milligrams. detectable changes in symptoms or signs were produced. The substance was not detected troscopically in the serum of these patients except where blood samples were collected thirty minutes after injection of single doses of 500 milligrams.
were No specwithin
KLINE. 135