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Decreased IL-3 production by peripheral blood mononuclear cells in patients with M.S.
DEVELOPMENT OF EXPPRIMBmAL ALLWGIC l3NCePHALOMYEUTI.S AFIXX NtKX’OR’l#:.AL BRAIN ABLATIONS IN LEFT AND RIGHTBIASED RATS
DECREASED MONONUCLEAR
IL-3 PRODUCTION CELLS IN PATIENTS
BY
PERIPHERAL WITH M.S.
BLOOD
M.Huberman*,F.Shalit#,I.Roth-Deri#, B.Gutman*, *Dept.of Neurology,Meir Hosp. B.Sredni#,E.Kott*. Tel-Aviv Univ. #CAIR Inst,Bar-Ilan Univ. Israel.
The production of Interleukin-3 by peripheral blood mononuclear cells (MNC) was assessed in patients with relapsing multiple sclerosis (MS) in both the active and the stable state, and in healthy controls. IL-3 levels were compared to levels of production of interleukin-2 (IL-2), tumor necrosis factor (TNF) and X interferon ( C-IFN). No significant differences in IL-3 observed between stable-state levels were patients and controls. When levels of cytokine production of patients in the inactive phase were compared to those of the same patients during relapse a significant decrease in IL-3 as opposed to significant levels was observed, increases in X-IFN and TNF levels,and an though a non-significant, in IL-2 increase, The functional significance of lowered levels. unknown. However, the IL-3 production is findings support the hypoyhesis of a highly complex interaction of overlapping regulatory influences within the cytokine network which parallels MS disease activity
NEURODPHTHALh4DLDGlCAL SCLEROSIS : ANALYSIS
FINDINGS IN MULTIPLE OF 354 PATIENTS
MULTIPLE SCLEROSIS ASSOCIATED MEDITERRANEAN FEVER
Fethi IDIMAN, Egemen IDIMAN, KOryd GENC, BariS BAKLAN, Sermin GENC, KOr.qad KUTLUK Dokuz Eylut University, Department of Neurology. lzmir, TURKEY
WITH
FAMILIAL
Eaemen IDIMAN, Fethi IDIMAN, I Ethem TANRIKURT, Kur$ad KUTLUK, Cengiz TATARMLU. Raif GAKMUR &lc~z Ed1 !zmjr, TURKEY , -11 I- Jniversitv . . -. -. ., Hospit&, --
Famlllal Mediterranean Fever (FMF) IS an autosomal recessive disorder occumng most commonly in Sephardrc Jews Armenrans, Turkish. and Arab famrlres The dtsease usually begins wrth fever followed by self-llmrted eprsode of pentonitts, pleurrbs 01 synovms The pathogenem of FMF remams obscure but its typrcal acute transient Intense mflammatory response has suggested on uncontrolled release of Inflammatory mediators, In partrcular the tumor necrosrs factor (TNF) to be involved In the other hand Mulbple Sclerosis (MS) IS an mflammatory demyelinatmg disease of the centrat nervous system Despite an enormous amount of research, the cause of MS remams unknown However, several reports lndrcate that It IS lrkely to be an immune mediated dsorder Many studies have suggested a role of T cells rn the pathogenesis of MS The cytokmes. partrcularly TNF. may play an important role I” the Initiation and maintenance of the mflammatory reactlon In MS In thts paper we present two patrents wrth relapsing remrtbng defmrte multiple sclerosrs who had familial Medrterranean fever beginnmg rn childhood A revrew of the literature revealed no report of an assocratlon of these two conditrons Because of the rare assoclatron the possrble role of TNF m pathogenesrs of both diseases has been drscussed
Symptoms and signs due to demyelination of visual snd oculomotor systenrs in multiple tclerosla (MS) W. common and well k-. However, the al= which Investigate the frequency end va!w of these various Rndings hl Crtiolqfkal diagnosis are few end did nc4 consls( 01 large populations. Thh shtdy pressnls the results of 354 MS patients (137 malo, 217 fwle) evalrphd in our neurwphthalm&gy untl and outpatknt chic of rnuiiiple sclerorb. Neurwphthalmdoglcal findings were m In 260 (73.44%) cam. Involvement of aftwent vhual system was W with logalher ,fundoseqpk and biomlcroscoplc slgrn such Is uv&ls-reUnlUr (1 .I2 U). papi(2.54 %) optic abophy and lempor~l pallor ( 52.25 )o. In &Rbn kr amaurosls (056 %), decreased vlslan (6 49 %). vhtml fiekt defer& (1.08 %) On ths dha hand. there worn nculnr motor dlsturbsnws in many pall&s md tha meal Imp&ant complnlnl due to oculomdor sys@m Invdvrm& wm dipk@t (18.35 W) .&ubmdor nerve parnlysls 13 muuliva factor hr been soan in 11 U d cam. la addltion. IN0 ma de&ted In a ratlo of 18.3 % tforlzontal and vwtial m p&e6 ( 10.4 U) woe found as a resuti 01 brainstem gaze contr, lwbns. Involunb~ ocular movements included horizontal (31 .B W). vertical ( 18 % ) r&tory ( 2.8 %) and othst types of nystagmus.
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DECREASED MONONUCLEAR
IL-3 PRODUCTION CELLS IN PATIENTS
BY
PERIPHERAL WITH M.S.
BLOOD
M.Huberman*,F.Shalit#,I.Roth-Deri#, B.Gutman*, *Dept.of Neurology,Meir Hosp. B.Sredni#,E.Kott*. Tel-Aviv Univ. #CAIR Inst,Bar-Ilan Univ. Israel.
The production of Interleukin-3 by peripheral blood mononuclear cells (MNC) was assessed in patients with relapsing multiple sclerosis (MS) in both the active and the stable state, and in healthy controls. IL-3 levels were compared to levels of production of interleukin-2 (IL-2), tumor necrosis factor (TNF) and X interferon ( C-IFN). No significant differences in IL-3 observed between stable-state levels were patients and controls. When levels of cytokine production of patients in the inactive phase were compared to those of the same patients during relapse a significant decrease in IL-3 as opposed to significant levels was observed, increases in X-IFN and TNF levels,and an though a non-significant, in IL-2 increase, The functional significance of lowered levels. unknown. However, the IL-3 production is findings support the hypoyhesis of a highly complex interaction of overlapping regulatory influences within the cytokine network which parallels MS disease activity
NEURODPHTHALh4DLDGlCAL SCLEROSIS : ANALYSIS
FINDINGS IN MULTIPLE OF 354 PATIENTS
MULTIPLE SCLEROSIS ASSOCIATED MEDITERRANEAN FEVER
Fethi IDIMAN, Egemen IDIMAN, KOryd GENC, BariS BAKLAN, Sermin GENC, KOr.qad KUTLUK Dokuz Eylut University, Department of Neurology. lzmir, TURKEY
WITH
FAMILIAL
Eaemen IDIMAN, Fethi IDIMAN, I Ethem TANRIKURT, Kur$ad KUTLUK, Cengiz TATARMLU. Raif GAKMUR &lc~z Ed1 !zmjr, TURKEY , -11 I- Jniversitv . . -. -. ., Hospit&, --
Famlllal Mediterranean Fever (FMF) IS an autosomal recessive disorder occumng most commonly in Sephardrc Jews Armenrans, Turkish. and Arab famrlres The dtsease usually begins wrth fever followed by self-llmrted eprsode of pentonitts, pleurrbs 01 synovms The pathogenem of FMF remams obscure but its typrcal acute transient Intense mflammatory response has suggested on uncontrolled release of Inflammatory mediators, In partrcular the tumor necrosrs factor (TNF) to be involved In the other hand Mulbple Sclerosis (MS) IS an mflammatory demyelinatmg disease of the centrat nervous system Despite an enormous amount of research, the cause of MS remams unknown However, several reports lndrcate that It IS lrkely to be an immune mediated dsorder Many studies have suggested a role of T cells rn the pathogenesis of MS The cytokmes. partrcularly TNF. may play an important role I” the Initiation and maintenance of the mflammatory reactlon In MS In thts paper we present two patrents wrth relapsing remrtbng defmrte multiple sclerosrs who had familial Medrterranean fever beginnmg rn childhood A revrew of the literature revealed no report of an assocratlon of these two conditrons Because of the rare assoclatron the possrble role of TNF m pathogenesrs of both diseases has been drscussed
Symptoms and signs due to demyelination of visual snd oculomotor systenrs in multiple tclerosla (MS) W. common and well k-. However, the al= which Investigate the frequency end va!w of these various Rndings hl Crtiolqfkal diagnosis are few end did nc4 consls( 01 large populations. Thh shtdy pressnls the results of 354 MS patients (137 malo, 217 fwle) evalrphd in our neurwphthalm&gy untl and outpatknt chic of rnuiiiple sclerorb. Neurwphthalmdoglcal findings were m In 260 (73.44%) cam. Involvement of aftwent vhual system was W with logalher ,fundoseqpk and biomlcroscoplc slgrn such Is uv&ls-reUnlUr (1 .I2 U). papi(2.54 %) optic abophy and lempor~l pallor ( 52.25 )o. In &Rbn kr amaurosls (056 %), decreased vlslan (6 49 %). vhtml fiekt defer& (1.08 %) On ths dha hand. there worn nculnr motor dlsturbsnws in many pall&s md tha meal Imp&ant complnlnl due to oculomdor sys@m Invdvrm& wm dipk@t (18.35 W) .&ubmdor nerve parnlysls 13 muuliva factor hr been soan in 11 U d cam. la addltion. IN0 ma de&ted In a ratlo of 18.3 % tforlzontal and vwtial m p&e6 ( 10.4 U) woe found as a resuti 01 brainstem gaze contr, lwbns. Involunb~ ocular movements included horizontal (31 .B W). vertical ( 18 % ) r&tory ( 2.8 %) and othst types of nystagmus.
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