- Email: [email protected]
Decreased resting state functional connectivity at baseline predicts subjective memory complaints after 1 year in cognitively normal individuals and individuals with mild cognitive impairment
P110
Alzheimer’s Imaging Consortium Poster Presentations: IC-P
(ADAS-cog), completed within 14 days of neuroimaging. All images were evaluated applying the same BALI rating schema, to assess lesions in the deep white matter, periventricular, basal ganglia and the infratentorial regions, deficits in the cortical gray matter, the extent of dilated small vessels, and global atrophy. Maximum possible BALI¼25; higher scores indicate greater damage. Results: The inter-rater agreement rate was consistently high, ranging from 0.96 to 0.98. Under each field-strength and image-type condition, the BALI scores differed significantly between diagnosis (p<0.05): people in the AD group had the greatest BALI on average (12.763.0), whereas those in the healthy control group had the lowest (10.562.6). Under each condition, the BALI score was significantly correlated with age (r>0.35, p<0.001), MMSE (r>0.40, p<0.001), and ADAS-cog (r>0.36, p<0.001). The BALI score at 3.0T was slightly greater than that at 1.5T (F>3.90, p<0.06), so as with T2WI comparing to T1WI (F>3.99, p<0.05) without interaction (F<0.06, p>0.80). The BALI scores at 1.5T and 3.0T were significantly correlated, for both T1WI (r¼0.94, p<0.001) and T2WI (r>0.95, p<0.001). Conclusions: T1WI and T2WI based BALI scores at 1.5T can be used to capture global brain structural changes and their relations to cognition.
IC-P-195
REGION-SPECIFIC ASSOCIATIONS OF BRAIN GLUCOSE METABOLISM WITH AGE AND BETA-AMYLOID IN NORMAL AGING
Hwamee Oh1, Cindee Madison2, Suzanne Baker3, William Jagust2, 1 University of California, Berkeley, Berkeley, California, United States; 2 University of California, Berkeley, Berkeley, California, United States; 3 Lawrence Berkeley National Laboratory, Berkeley, California, United States. Contact e-mail: [email protected] Background: Although hypometabolism is commonly seen in aging and Alzheimer’s disease (AD), the relationship between glucose metabolism and A b deposition in cognitively normal older adults remains unclear. In this study, we examined changes in glucose metabolism due to aging and A b deposition across healthy young people (Y) and cognitively normal older adults (ON) with varying degrees of A b deposition. Methods: 104 subjects (9 Y, 95 ON) underwent [11 C]PIB-PET, [18 F]FDG-PET and structural MRI scans. FreeSurfer-based parcellation was applied to MRI, FDG, and PIB data. ON subjects were categorized as PIB- or PIB+ based on averaged PIB DVR values across multiple cortical regions. We compared young and PIB-ON groups and PIB- and PIB+ON groups to assess aging and A b- related changes in glucose metabolism in 40 cortical and 6 subcortical regions, respectively. In addition, among 40 cortical regions, we selected the top and bottom 10 regions reflecting highest and lowest glucose use in the Y group. These regions were also used to examine the effects of aging and A b on relationships between glucose use and A b deposition. Results: Aging-related hypometabolism was found in frontal, parietal, temporal, and anterior cingulate cortices while glucose metabolism in posterior cingulate, precuneus and subcortical regions was preserved. A b-related hypermetabolism was found in the right precuneus with no significant changes in metabolism in other regions related to A b.The pattern of glucose metabolism across cortical regions was the same in PIB+, PIB- ON and Y subjects. Brain regions that showed the highest metabolism in the Y subjects were associated with higher A b deposition in ON adults. Conclusions: A b-related changes in glucose metabolism in cognitively normal elderly seem to occur in high-metabolism brain regions that do not undergo aging-related hypometabolism. Furthermore, brain regions that start with higher baseline glucose metabolism are the same regions that show A b deposition during aging.
IC-P-196
DECREASED RESTING STATE FUNCTIONAL CONNECTIVITY AT BASELINE PREDICTS SUBJECTIVE MEMORY COMPLAINTS AFTER 1 YEAR IN COGNITIVELY NORMAL INDIVIDUALS AND INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT
Patrizia Vannini1, Sarah Wigman2, Andrew Ward3, Rebecca Amariglio4, Gad Marshall5, Aaron Schultz6, Koene van Dijk7, Willem Huijbers8,
Dorene Rentz9, Keith Johnson10, Reisa Sperling11, 1Harvard Medical School, Massachusetts General Hospital and Brigham and Women’s Hospital, Boston, Massachusetts, United States; 2Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, United States; 3Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts, United States; 4Massachusetts General Hospital, Boston, Massachusetts, United States; 5Harvard Medical School, Brigham and Women’s Hospital, Boston, Massachusetts, United States; 6 Massachusetts General Hospital, Charlestown, Massachusetts, United States; 7Harvard University, Charlestown, Massachusetts, United States; 8 Harvard Medical School, Charlestown, Massachusetts, United States; 9 Center for Alzheimer Research and Treatment, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States; 10 MGH HMS, Boston, Massachusetts, United States; 11Brigham and Women’s Hospital, Boston, Massachusetts, United States. Contact e-mail: [email protected] Background: Subjective memory complaints (SMC) have been recognized as an important part in the diagnosis of mild cognitive impairment (MCI). Individuals with MCI have an increased risk of progression to Alzheimer’s disease (AD) dementia but research on the role of SMC is contradictory in terms of its prodromal prognostic value, and more studies are needed to determine its clinical and pathological correlates. Recent functional MRI studies show that specific sets of brain regions, collectively called the default mode network (DMN), including the posterior cingulate and the medial prefrontal cortex, are particularly important for accurate self-appraisal of memory. One striking possibility is that increased SMC are early indicators of progressive decline towards AD due to DMN dysfunction. Methods: To investigate this 17 cognitively normal individuals (CDR¼0, mean age¼75) and 47 individuals with impaired memory (MCI; CDR 0.5, mean age¼75) underwent a resting functional magnetic resonance imaging scan. SMC was assessed using the "general frequency of forgetting" subscale of the Memory Functioning Questionnaire at baseline and after 12 months. Objective memory was measured using delayed recall from the Rey auditory verbal learning test at baseline and after 12 months. The integrity of the DMN was estimated by correlating resting-state fMRI time courses extracted from a priori regions including the posterior cingulate, lateral parietal, and medial prefrontal cortices. Results: Results showed that lower DMN connectivity at baseline was associated with worsening SMC over time (R¼.358,p¼.014). These results remained significant when controlling for head motion, hippocampal volume and age at baseline (R¼-.404, p¼0.009). By contrast, there were no significant relationships between DMN connectivity and change in objective memory (R¼-.021, p¼.453, controlling for head motion, hippocampal volume and age at baseline). Conclusions: These results suggest that early altered resting-state functional connectivity is related to increased SMC a year later and may be a risk factor that predisposes patients to develop AD.
IC-P-197
FINANCIAL LITERACY IS ASSOCIATED WITH FUNCTIONAL CONNECTIVITY BETWEEN ANTERIOR AND POSTERIOR BRAIN REGIONS
S. Duke Han1, Patricia Boyle1, Konstantinos Arfanakis2, Debra Fleischman1, David Bennett3, 1Rush University Medical Center, Chicago, Illinois, United States; 2Illinois Institute of Technology, Chicago, Illinois, United States; 3Rush University Medical Center, Chicago, Illinois, United States. Contact e-mail: [email protected] Background: Literacy has been shown to be a neurocognitive protective factor in aging, and financial literacy is important for beneficial financial decision-making in old age. Reduced functional connectivity between anterior and posterior regions of the Default Mode Network has been associated with worse cognitive outcomes in aging. We tested the hypothesis that higher financial literacy would be associated with greater functional connectivity of anterior and posterior brain regions in older persons without dementia. Methods: One hundred and thirty-nine participants without dementia (mean age¼82.08, mean education¼15.70, male/female¼27/112, mean
Alzheimer’s Imaging Consortium Poster Presentations: IC-P
(ADAS-cog), completed within 14 days of neuroimaging. All images were evaluated applying the same BALI rating schema, to assess lesions in the deep white matter, periventricular, basal ganglia and the infratentorial regions, deficits in the cortical gray matter, the extent of dilated small vessels, and global atrophy. Maximum possible BALI¼25; higher scores indicate greater damage. Results: The inter-rater agreement rate was consistently high, ranging from 0.96 to 0.98. Under each field-strength and image-type condition, the BALI scores differed significantly between diagnosis (p<0.05): people in the AD group had the greatest BALI on average (12.763.0), whereas those in the healthy control group had the lowest (10.562.6). Under each condition, the BALI score was significantly correlated with age (r>0.35, p<0.001), MMSE (r>0.40, p<0.001), and ADAS-cog (r>0.36, p<0.001). The BALI score at 3.0T was slightly greater than that at 1.5T (F>3.90, p<0.06), so as with T2WI comparing to T1WI (F>3.99, p<0.05) without interaction (F<0.06, p>0.80). The BALI scores at 1.5T and 3.0T were significantly correlated, for both T1WI (r¼0.94, p<0.001) and T2WI (r>0.95, p<0.001). Conclusions: T1WI and T2WI based BALI scores at 1.5T can be used to capture global brain structural changes and their relations to cognition.
IC-P-195
REGION-SPECIFIC ASSOCIATIONS OF BRAIN GLUCOSE METABOLISM WITH AGE AND BETA-AMYLOID IN NORMAL AGING
Hwamee Oh1, Cindee Madison2, Suzanne Baker3, William Jagust2, 1 University of California, Berkeley, Berkeley, California, United States; 2 University of California, Berkeley, Berkeley, California, United States; 3 Lawrence Berkeley National Laboratory, Berkeley, California, United States. Contact e-mail: [email protected] Background: Although hypometabolism is commonly seen in aging and Alzheimer’s disease (AD), the relationship between glucose metabolism and A b deposition in cognitively normal older adults remains unclear. In this study, we examined changes in glucose metabolism due to aging and A b deposition across healthy young people (Y) and cognitively normal older adults (ON) with varying degrees of A b deposition. Methods: 104 subjects (9 Y, 95 ON) underwent [11 C]PIB-PET, [18 F]FDG-PET and structural MRI scans. FreeSurfer-based parcellation was applied to MRI, FDG, and PIB data. ON subjects were categorized as PIB- or PIB+ based on averaged PIB DVR values across multiple cortical regions. We compared young and PIB-ON groups and PIB- and PIB+ON groups to assess aging and A b- related changes in glucose metabolism in 40 cortical and 6 subcortical regions, respectively. In addition, among 40 cortical regions, we selected the top and bottom 10 regions reflecting highest and lowest glucose use in the Y group. These regions were also used to examine the effects of aging and A b on relationships between glucose use and A b deposition. Results: Aging-related hypometabolism was found in frontal, parietal, temporal, and anterior cingulate cortices while glucose metabolism in posterior cingulate, precuneus and subcortical regions was preserved. A b-related hypermetabolism was found in the right precuneus with no significant changes in metabolism in other regions related to A b.The pattern of glucose metabolism across cortical regions was the same in PIB+, PIB- ON and Y subjects. Brain regions that showed the highest metabolism in the Y subjects were associated with higher A b deposition in ON adults. Conclusions: A b-related changes in glucose metabolism in cognitively normal elderly seem to occur in high-metabolism brain regions that do not undergo aging-related hypometabolism. Furthermore, brain regions that start with higher baseline glucose metabolism are the same regions that show A b deposition during aging.
IC-P-196
DECREASED RESTING STATE FUNCTIONAL CONNECTIVITY AT BASELINE PREDICTS SUBJECTIVE MEMORY COMPLAINTS AFTER 1 YEAR IN COGNITIVELY NORMAL INDIVIDUALS AND INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT
Patrizia Vannini1, Sarah Wigman2, Andrew Ward3, Rebecca Amariglio4, Gad Marshall5, Aaron Schultz6, Koene van Dijk7, Willem Huijbers8,
Dorene Rentz9, Keith Johnson10, Reisa Sperling11, 1Harvard Medical School, Massachusetts General Hospital and Brigham and Women’s Hospital, Boston, Massachusetts, United States; 2Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, United States; 3Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts, United States; 4Massachusetts General Hospital, Boston, Massachusetts, United States; 5Harvard Medical School, Brigham and Women’s Hospital, Boston, Massachusetts, United States; 6 Massachusetts General Hospital, Charlestown, Massachusetts, United States; 7Harvard University, Charlestown, Massachusetts, United States; 8 Harvard Medical School, Charlestown, Massachusetts, United States; 9 Center for Alzheimer Research and Treatment, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States; 10 MGH HMS, Boston, Massachusetts, United States; 11Brigham and Women’s Hospital, Boston, Massachusetts, United States. Contact e-mail: [email protected] Background: Subjective memory complaints (SMC) have been recognized as an important part in the diagnosis of mild cognitive impairment (MCI). Individuals with MCI have an increased risk of progression to Alzheimer’s disease (AD) dementia but research on the role of SMC is contradictory in terms of its prodromal prognostic value, and more studies are needed to determine its clinical and pathological correlates. Recent functional MRI studies show that specific sets of brain regions, collectively called the default mode network (DMN), including the posterior cingulate and the medial prefrontal cortex, are particularly important for accurate self-appraisal of memory. One striking possibility is that increased SMC are early indicators of progressive decline towards AD due to DMN dysfunction. Methods: To investigate this 17 cognitively normal individuals (CDR¼0, mean age¼75) and 47 individuals with impaired memory (MCI; CDR 0.5, mean age¼75) underwent a resting functional magnetic resonance imaging scan. SMC was assessed using the "general frequency of forgetting" subscale of the Memory Functioning Questionnaire at baseline and after 12 months. Objective memory was measured using delayed recall from the Rey auditory verbal learning test at baseline and after 12 months. The integrity of the DMN was estimated by correlating resting-state fMRI time courses extracted from a priori regions including the posterior cingulate, lateral parietal, and medial prefrontal cortices. Results: Results showed that lower DMN connectivity at baseline was associated with worsening SMC over time (R¼.358,p¼.014). These results remained significant when controlling for head motion, hippocampal volume and age at baseline (R¼-.404, p¼0.009). By contrast, there were no significant relationships between DMN connectivity and change in objective memory (R¼-.021, p¼.453, controlling for head motion, hippocampal volume and age at baseline). Conclusions: These results suggest that early altered resting-state functional connectivity is related to increased SMC a year later and may be a risk factor that predisposes patients to develop AD.
IC-P-197
FINANCIAL LITERACY IS ASSOCIATED WITH FUNCTIONAL CONNECTIVITY BETWEEN ANTERIOR AND POSTERIOR BRAIN REGIONS
S. Duke Han1, Patricia Boyle1, Konstantinos Arfanakis2, Debra Fleischman1, David Bennett3, 1Rush University Medical Center, Chicago, Illinois, United States; 2Illinois Institute of Technology, Chicago, Illinois, United States; 3Rush University Medical Center, Chicago, Illinois, United States. Contact e-mail: [email protected] Background: Literacy has been shown to be a neurocognitive protective factor in aging, and financial literacy is important for beneficial financial decision-making in old age. Reduced functional connectivity between anterior and posterior regions of the Default Mode Network has been associated with worse cognitive outcomes in aging. We tested the hypothesis that higher financial literacy would be associated with greater functional connectivity of anterior and posterior brain regions in older persons without dementia. Methods: One hundred and thirty-nine participants without dementia (mean age¼82.08, mean education¼15.70, male/female¼27/112, mean