Dermatomyositis Patients and Healthy Controls

Neurodegenerative Diseases Conclusions: CareCall improved depression, healthcare access, and participation in adults with spinal cord dysfunction, particularly for those with a diagnosis of MS. Future research should aim to enhance adherence and efficacy with participants with SCI. Key Words: Telemedicine, Multiple sclerosis, Spinal cord injuries, Pressure ulcer, Depression Disclosure(s): None Disclosed. Poster 85 An Event-Related Potential Study of Recognition Memory with Famous and Unknown Faces James Pau (University of Auckland), Claire Davies, Stephen Jacobs, Paul Michael Corballis, Ian Kirk, Prasadarao Podugu Objective: To determine the characteristics of event-related potential (ERP) components elicited by unknown faces and famous faces taken from an everyday context. Design: Pilot cross-sectional study. Setting: University of Auckland Electroencephalogram Lab. Participants: 11 healthy participants (7 males; aged 21-49 years; mean age 29.1 years) with normal or corrected-to-normal vision. Interventions: A 128 EEG electrode system collected brain activity when participants were presented with600 greyscale images of famous and unknown faces (face on black background to avoid contextual influence) displayed for 0.5 sec. 240 unique famous faces featured individuals commonly portrayed in the media and unknown faces were taken from existing face databases. Participants viewed the image, then actively identified the face as either “unknown”, “familiar” or “known”. Main Outcome Measure(s): Mean amplitudes of the N170, N250, and P600f potentials; with comparisons using a grand average ERP study and N-way ANOVA. Results: When comparing familiar and known to unknown responses, the N170 had no evidence that showed it was influenced by face type across hemispheres (p>0.1). In contrast the N250 mean amplitude strongly differed between occipito-temporal locations (p<0.05), and the P600f demonstrated higher positivities at centro-frontal electrode locations. These locations also had higher P600f positivities when comparing familiar to known responses. Conclusions: Without priming or study phase, the ERPs of the N250 and P600f are face dependent and can be linked to the identification of faces and the subsequent retrieval processes required to recognise a face. The ability to identify face recognition within individuals may be a useful tool for incorporating into more effective reminiscence therapy for Alzheimer’s disease. Key Words: Recognition (Psychology), Electroencephalography, Memory Disclosure(s): None Disclosed. Poster 86 Do Acoustic Features From Everyday Speech Reflect Aphasia in Individuals With Alzheimer’s Disease? James Yungjen Tung (University of Waterloo), Frank Rudzicz, Alex Mihailidis, Sandra E. Black, Eric Roy, Pascal Poupart Objective: To examine the concurrent validity of acoustic features of everyday speech as a reflection of language difficulties associated with Alzheimer’s disease (AD). Design: Criterion standard.Acoustic features extracted from 5 days of spontaneous everyday speech are compared to a standard aphasia instrument (Western Aphasia battery, WAB). Setting: General community and university laboratory. Participants: Community-dwelling individuals with mild-to-moderate AD (nZ14) and cognitively-intact age-matched controls (CTL, nZ14). This study was conducted with the approval of the Research Ethics Boards of the University of Waterloo and Sunnybrook Health Sciences Centre. Interventions: Not applicable. Main Outcome Measure(s): Acoustic features of speech extracted from 5 days of spontaneous speech gathered using a smartphone collection system: mean instantaneous power, mean and max first autocorrelation

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e35 coefficient, kurtosis, shimmer, zero-crossing rate, mean and variance of formants (F0, F1, F2, F3). Criterion standard of aphasia was measured using the Aphasia Quotient (AQ) of the Western Aphasia Battery (WAB). Results: Preliminary analyses focused on examining the relationship between acoustic features and AQ in the AD group (AQ: range Z 71.1-99.1, meanZ90.8, SDZ8.7). Correlation analysis shows significant correlations between mean instantaneous power (rZ-0.59, p-0.03), shimmer (rZ0.65, pZ0.01), and variance in F2 (rZ-0.65, pZ0.02) and criterion standard AQ. Conclusions: The initial findings indicate a correlation between everyday speech features and AQ in a sample of community-dwelling individuals with mild-to-moderate AD. On-going analyses are focused on distinguishing acoustic features from AD and CTL groups. This research will inform the development of mobile health technology to assist in the screening and assessment of aphasia related to AD. Key Words: Telemedicine, Alzheimer’s disease, Aphasia, Ambulatory monitoring Disclosure(s): None disclosed. Poster 87 Cardiorespiratory Fitness in Subacute Polymyositis/Dermatomyositis Patients and Healthy Controls Masaaki Nagashima (Hamamatsu University School of Medicine) Objective: To investigate (1) cardiorespiratory fitness, 6-minute walk test (6MWT) and muscle strength in patients with subacute polymyositis (PM) or dermatomyositis (DM), compared with matched healthy controls, and (2) the correlation between cardiorespiratory fitness and 6MWT in subacute PM/DM. Design: Cross-sectional. Setting: Rehabilitation section in the university hospital. Participants: Eight patients (PM/DM, 2/6) and 9 age- and gender-matched healthy controls were participated. Interventions: Not applicable. Main Outcome Measure(s): Target parameters were cardiorespiratory fitness (peak oxygen uptake [PeakVO2] and anaerobic threshold [AT]), 6MWT and peak isometric torque in knee extension. Results: Mean peak VO2 was 18.66.6ml/kg/min, mean AT was 10.33.1ml/kg/min, mean 6MWT was 511110m, and mean peak isometric torque divided by the weight was 1.350.40Nm/kg in patients with PM/DM. They were thus significantly reduced at 70%, 68%, 80%, 54% of the control value, respectively (p < .05). There was a significant relationship between peak VO 2 (r Z .76) or AT (r Z .71) and 6MWT (p < .05) in patients with PM/DM. Conclusions: Cardiorespiratory fitness and muscle strength were significantly diminished in patients with subacute PM/DM, compared with ageand gender-matched controls. The 6MWT may be useful to assess exercise capacity in patients with subacute PM/DM. Key Words: dermatomyositis, polymyositis, fitness Disclosure(s): None Disclosed. Poster 88 Development of an Interactive Fatigue Education Resource for Persons with Multiple Sclerosis Nadine Akbar (The Hospital for Sick Children), Karen Turpin, Marcia Finlayson Objective: Fatigue is one of the most common and disabling symptoms of multiple sclerosis (MS). The management of MS fatigue requires active engagement of the person with MS. The objective was to develop a self-guided, evidence-based fatigue self-management resource for persons with MS. Design: Literature on factors contributing to fatigue and evidence-based strategies for managing fatigue was reviewed. Findings were incorporated into an interactive Microsoft PowerPointÒ presentation with the following features: (a) ways to monitor fatigue; (b) ways to identify how five secondary factors contribute to MS fatigue (depression, sleep disorders, medications, lack of physical activity, mental exertion), and specific strategies; (c) description of the four most useful energy management