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Developmental origins of aging in the brain and blood vessels
Neurobiology of Aging 26 (2005) 279
Introduction
Developmental origins of aging in the brain and blood vessels For several decades vascular disease and Alzheimer disease have been considered as largely independent pathological processes. However, there is a recent potential convergence of mechanisms, risk factors, and interventions shared across Alzheimer disease and vascular disease. This emergent interface stimulated the organization of a special workshop, perhaps the first, which convened many leaders from both fields. This Special Issue represents most of the talks presented at the Workshop before the 33rd Annual Meeting of the Society for Neuroscience (November 2003, New Orleans). We are grateful for the generous financial support of Elsevier and the enthusiastic staff who made the meeting work so well. On both sides of the aisle, Alzheimer and vascular, new dialogues were begun, with increased realization that the long-term processes
0197-4580/$ – see front matter © 2004 Elsevier Inc. All rights reserved. doi:10.1016/j.neurobiolaging.2004.11.004
at work might share fundamental factors in blood lipids, inflammation, nutrition, and of course, genetics. After all, apoE4 was the first recognized genetic polymorphism modulating blood cholesterol (Sing CF, Davignon J. Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am J Hum Genet 1985; 37:268-85). C. Finch University of California Andrus Gerontology Center and Department of Biological Sciences Los Angeles, CA 90089-0191, USA Tel.: +1 213 740 1758; fax: +1 213 740 0853 E-mail address: [email protected]
Introduction
Developmental origins of aging in the brain and blood vessels For several decades vascular disease and Alzheimer disease have been considered as largely independent pathological processes. However, there is a recent potential convergence of mechanisms, risk factors, and interventions shared across Alzheimer disease and vascular disease. This emergent interface stimulated the organization of a special workshop, perhaps the first, which convened many leaders from both fields. This Special Issue represents most of the talks presented at the Workshop before the 33rd Annual Meeting of the Society for Neuroscience (November 2003, New Orleans). We are grateful for the generous financial support of Elsevier and the enthusiastic staff who made the meeting work so well. On both sides of the aisle, Alzheimer and vascular, new dialogues were begun, with increased realization that the long-term processes
0197-4580/$ – see front matter © 2004 Elsevier Inc. All rights reserved. doi:10.1016/j.neurobiolaging.2004.11.004
at work might share fundamental factors in blood lipids, inflammation, nutrition, and of course, genetics. After all, apoE4 was the first recognized genetic polymorphism modulating blood cholesterol (Sing CF, Davignon J. Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am J Hum Genet 1985; 37:268-85). C. Finch University of California Andrus Gerontology Center and Department of Biological Sciences Los Angeles, CA 90089-0191, USA Tel.: +1 213 740 1758; fax: +1 213 740 0853 E-mail address: [email protected]