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DNA amplificationand sequence-specific oligonucleotide probe hybridization
Fermentation and Recovery Process for Lactic Acid Production Coleman et al. University of Chicago US 5464760; November 7, 1995 A method of converting starch to glucose and fermenting glucose to lactic acid including simultaneous saccharification and fermentation through the use of a novel consortium of bacterial strains.
Plants Needles for Cell Transformation of Monocotyledons Coffee et al. Zeneca Ltd. US 5464765; November 7, 1995 Plant cells are transformed by bringing them into contact with a multiplicity of needle-like bodies on which the cells may be impaled. This causes a rupture in the cell wall which allows entry of transforming DNA either from a surrounding liquid medium or of DNA previously bound to or otherwise entrapped in the needlelike projections.
Immunology Isolated DNA Molecule Encoding SHET2 of Shigella jlexnen’ 2A Fasano et al. University of Maryland US 5468639; November 21, 1995 Substantially pure enterotoxins of Shigella _fZexneri2a along with a method for obtaining them, antibodies having binding specificity to the enterotoxins, and a method for use of the enterotoxins to develop a nonreactogenic Shigella jlexneri 2a vaccine candidate. Immunogenic Compositions against Human Gastrin 17 Gevas et al. Aphton Corporation US 5468494; November 21, 1995 An improved immunogenic composition against human gastrin 17 comprising the peptide pGlu-Gly-Pro-Trp-Leu-Glu-Glu-GluGlu-SerSer-Pro-Pro-Pro-Pro-Cys coupled to an immunogenic carrier.
Method for the Determination of Antigens or Antibodies in the Presence of an Immune Complex Toth Behringwerke AG US 5466611; November 14, 1995 The invention relates to a latex agglutination method for the detection or determination of one partner of an antigen-antibody reaction wherein in order to suppress nonspecific reactions to, for example, Clq and rheumatoid factors, the immunochemical reaction takes place in the presence of an immune complex which does not contain any antibody or antigen that is specific for one of the partners.
methods for screening compounds for their ability to inhibit formation of syncytia between cells that express HIV-l gp160 and cells that express CD4.
Immune System Modulation Using Psoralens Activated with Visible Light Edelson et al. Yale University US 5462733; October 31, 1995 Methods and pharmaceutical compositions for modifying the immune response of a mammal. The pharmaceutical compositions include a pharmaceutically acceptable carrier and a plurality of cells containing psoralen-DNA monoadducts and substantially no psoralen-DNA cross-links. The preparation is formed by irradiating a suspension of cells with visible light radiation in the presence of psoralen.
Genetics AXL Oncogene Liu University of North Carolina US 5468634; November 21, 1995 Isolated DNA sequences encoding a mammalian ax1 receptor which exhibits ax1 oncogene activity, vectors containing such DNA sequences, host cells containing such DNA sequences, ax1 receptor proteins, and soluble ax1 receptors. Chimeric proteins including the extracellular domain of the ax1 receptor and DNA sequences encoding such chimeric proteins, and antibodies which specifically bind the ax1 receptor are also discussed.
cDNA Clone for Human-Inducible Nitric Oxide Synthase and Process for Preparing Same Billiar et al. Universie of Pittsburgh US 5468630; November 21, 1995 A human tissue-inducible nitric oxide synthase cDNA clone and a process for preparing this cDNA clone coding for human tissueinducible nitric oxide synthase and for expressing the human tissue inducible nitric oxide synthase protein.
DNA Amplification and Sequence-Specific Oligonucleotide Probe Hybridization Baxter-Lowe et al. The Blood Center Research Foundation US 5468611; November 21, 1995 A method for HLA typing by amplification of a sample followed by sequence-specific oligonucleotide hybridization with a labelled oligonucleotide probe provides for both positive and negative controls. Control sequences representing known allelic polymorphisms at the locus in question are subjected to the labelled probe along with the sample. The method reduces errors and improves the chance of obtaining a successful tissue match which is vital in the case of tissue transplants, in particular bone marrow transplants.
Protein Ligand Binding Region Mapping System Human Lymphoid Cells Expressing Human Immunodeficiency Virus Envelope Protein GP160 Clark et al. Smithkline Beecham Corporation US 5462872; October 3 1, 1995 Mammalian cells modified to stably express at least the entire human immunodeficiency virus-l envelope protein gp160, and
76
Enzyme Microb.
Technol.,
1997, vol. 20, January
Garber et al. Novagen, Inc. US 5464745; November 7, 1995 A method for determining the nucleic acid sequence that encodes the ligand binding domain on any protein encoded by a known gene which includes the steps of nonspecifically cleaving the coding region of the known gene, size-selecting the cleavage products,
Plants Needles for Cell Transformation of Monocotyledons Coffee et al. Zeneca Ltd. US 5464765; November 7, 1995 Plant cells are transformed by bringing them into contact with a multiplicity of needle-like bodies on which the cells may be impaled. This causes a rupture in the cell wall which allows entry of transforming DNA either from a surrounding liquid medium or of DNA previously bound to or otherwise entrapped in the needlelike projections.
Immunology Isolated DNA Molecule Encoding SHET2 of Shigella jlexnen’ 2A Fasano et al. University of Maryland US 5468639; November 21, 1995 Substantially pure enterotoxins of Shigella _fZexneri2a along with a method for obtaining them, antibodies having binding specificity to the enterotoxins, and a method for use of the enterotoxins to develop a nonreactogenic Shigella jlexneri 2a vaccine candidate. Immunogenic Compositions against Human Gastrin 17 Gevas et al. Aphton Corporation US 5468494; November 21, 1995 An improved immunogenic composition against human gastrin 17 comprising the peptide pGlu-Gly-Pro-Trp-Leu-Glu-Glu-GluGlu-SerSer-Pro-Pro-Pro-Pro-Cys coupled to an immunogenic carrier.
Method for the Determination of Antigens or Antibodies in the Presence of an Immune Complex Toth Behringwerke AG US 5466611; November 14, 1995 The invention relates to a latex agglutination method for the detection or determination of one partner of an antigen-antibody reaction wherein in order to suppress nonspecific reactions to, for example, Clq and rheumatoid factors, the immunochemical reaction takes place in the presence of an immune complex which does not contain any antibody or antigen that is specific for one of the partners.
methods for screening compounds for their ability to inhibit formation of syncytia between cells that express HIV-l gp160 and cells that express CD4.
Immune System Modulation Using Psoralens Activated with Visible Light Edelson et al. Yale University US 5462733; October 31, 1995 Methods and pharmaceutical compositions for modifying the immune response of a mammal. The pharmaceutical compositions include a pharmaceutically acceptable carrier and a plurality of cells containing psoralen-DNA monoadducts and substantially no psoralen-DNA cross-links. The preparation is formed by irradiating a suspension of cells with visible light radiation in the presence of psoralen.
Genetics AXL Oncogene Liu University of North Carolina US 5468634; November 21, 1995 Isolated DNA sequences encoding a mammalian ax1 receptor which exhibits ax1 oncogene activity, vectors containing such DNA sequences, host cells containing such DNA sequences, ax1 receptor proteins, and soluble ax1 receptors. Chimeric proteins including the extracellular domain of the ax1 receptor and DNA sequences encoding such chimeric proteins, and antibodies which specifically bind the ax1 receptor are also discussed.
cDNA Clone for Human-Inducible Nitric Oxide Synthase and Process for Preparing Same Billiar et al. Universie of Pittsburgh US 5468630; November 21, 1995 A human tissue-inducible nitric oxide synthase cDNA clone and a process for preparing this cDNA clone coding for human tissueinducible nitric oxide synthase and for expressing the human tissue inducible nitric oxide synthase protein.
DNA Amplification and Sequence-Specific Oligonucleotide Probe Hybridization Baxter-Lowe et al. The Blood Center Research Foundation US 5468611; November 21, 1995 A method for HLA typing by amplification of a sample followed by sequence-specific oligonucleotide hybridization with a labelled oligonucleotide probe provides for both positive and negative controls. Control sequences representing known allelic polymorphisms at the locus in question are subjected to the labelled probe along with the sample. The method reduces errors and improves the chance of obtaining a successful tissue match which is vital in the case of tissue transplants, in particular bone marrow transplants.
Protein Ligand Binding Region Mapping System Human Lymphoid Cells Expressing Human Immunodeficiency Virus Envelope Protein GP160 Clark et al. Smithkline Beecham Corporation US 5462872; October 3 1, 1995 Mammalian cells modified to stably express at least the entire human immunodeficiency virus-l envelope protein gp160, and
76
Enzyme Microb.
Technol.,
1997, vol. 20, January
Garber et al. Novagen, Inc. US 5464745; November 7, 1995 A method for determining the nucleic acid sequence that encodes the ligand binding domain on any protein encoded by a known gene which includes the steps of nonspecifically cleaving the coding region of the known gene, size-selecting the cleavage products,