- Email: [email protected]
DO LOW HDL CHOLESTEROL LEVELS HAVE ROLE IN ASPIRIN RESISTANCE?
96
Poster Sessions PO22 Epidemiology of CVD risk factors
pendent factors for development of atherosclerosis. Therefore, monitoring glycemia levels in blood should start as early as in childhood. Aim of our study was to evaluate glycemia levels in school children during five years period both in boys and girls. Methods: We evaluated 5768 children age of 10 years (48.74% were girls, 51.26% were boys) and 3737 children age of 15 years (48.70% girls, 51.30% boys). In these groups of children we analyzed glicemia levels in blood by standard laboratory tests. Results were presented in form of percentiles. Results: 5% of boys age 10 years had glycemia levels beyond 3.70mmol/l, 50% beyond 4.80mmol/l and 5% had values above 5.90mmol/l. 5% of girls age 10 years had glycemia levels beyond 3.60mmol/l, 50% beyond 4.70mmol/l and 5% had values above 5.70mmol/l. 5% of boys age 15 years had glycemia levels beyond 3.90mmol/l, 50% beyond 5.00mmol/l and 5% had values above 6.00mmol/l. 5% of girls age 15 years had glycemia levels beyond 3.80mmol/l, 50% beyond 4.70mmol/l and 5% had values above 5.72mmol/l. Conclusions: We found statistical difference (p<0.001) when genders where compared in same age population. Statistical difference was found also (p<0.01) when boys and girls were compared separately due to age groups. According to our study, we can conclude that boys have greater risk for development of atherosclerosis in adulthood. PO22-322
PO22-323
EVALUATION OF BLOOD PRESSURE LEVELS AND USE OF ANTIHYPERTENSIVE MEDICATION IN ICEBERG STUDY PATIENTS
G. Kabakci 1 , N. Koylan 2 , O. Kozan 3 , B. Ilerigelen 4 , K. Buyukozturk 2 . Cardiology, Hacettepe Univ. School of Medicine, Ankara, Turkey; Univ. Istanbul School of Medicine, Istanbul, Turkey; 3 Dept. of Cardiology, Dokuz Eylul Univ. School of Medicine, Izmir, Turkey; 4 Dept. of Cardiology, Istanbul Univ. Cerrahpasa School of Medicine, Istanbul, Turkey
1 Dept. of 2 Istanbul
Background and aims: The “Intensive/Initial Cardiovascular Examination regarding Blood pressure levels: Evaluation of Risk Groups (ICEBERG)” study aimed to evaluate cardiovascular risk of subjects with high normal or high blood pressure and impact of various different laboratory tests on risk stratification. This report presents patients’ blood pressure levels and antihypertensive drug use. Methods: ICEBERG was a non-interventional epidemiological study including patients diagnosed with hypertension and receiving antihypertensive medication or not. Results: Table 1 demonstrates classification of patients according to their blood pressure levels and antihypertensive medication use.
EVALUATION OF SOCIODEMOGRAPHIC CHARACTERISTICS AND MEDICAL CONDITIONS OF THE ICEBERG STUDY POPULATIONS
B. Ilerigelen 1 , G. Kabakci 2 , N. Koylan 3 , O. Kozan 4 , K. Buyukozturk 3 . of Cardiology, Istanbul Univ. Cerrahpasa School of Medicine, Istanbul, Turkey; 2 Dept. of Cardiology, Hacettepe Univ. School of Medicine, Ankara, Turkey; 3 Dept. of Cardiology, Istanbul Univ. Istanbul School of Medicine, Istanbul, Turkey; 4 Dept.of Cardiology, Dokuz Eylul Univ. School of Medicine, Izmir, Turkey 1 Dept.
Background and aim: The “Intensive/Initial Cardiovascular Examination regarding Blood pressure levels: Evaluation of Risk Groups (ICEBERG)” study aimed to evaluate cardiovascular risk status of subjects with high normal or high blood pressure and the impact of different laboratory tests on risk stratification. This report focuses on the description of ICEBERG cohort of approximately 10,000 hypertensive patients regarding their sociodemographic status and medical conditions. Methods: ICEBERG was a non-interventional epidemiological study, and patients were either on anti-hypertensive medication or not upon the decision of their physicians.
Conclusions: (1) Untreated patients are in higher grade strata of hypertension, and (2) ARB+diuretics are most frequently used drugs in Treated Group, ARBs are mostly recommended to Untreated patients. PO22-324
DO LOW HDL CHOLESTEROL LEVELS HAVE ROLE IN ASPIRIN RESISTANCE?
S. Aytekin 1 , A. Catakoglu 2 , M. Sener 1 , H. Kurtoglu 1 , H. Celebi 2 , I. Demiroglu 2 , V. Aytekin 1 . 1 Istanbul Bilim University, Florence Nightingale Hospital, Department of Cardiology; 2 Florence Nightingale Hospital, Department of Cardiology
Results and conclusion: Table 1 summarizes the sociodemographics, hematology and medical status of the study populations. The evaluation of this population regarding cardiovascular risk status has been published elsewhere.
Background: Both HDL cholesterol (HDL-C) and LDL cholesterol receptors were shown on platelet membrane in previous studies. Low HDL-C levels have been demonstrated to effect platelet aggregation, by both direct and indirect mechanisms in several studies. The aim of our study was to investigate the relationship between low HDL-C and AR, in coronary artery disease (CAD) patients with a previous percutaneous coronary intervention (PCI) history. Methods: Lipid profile analysis and aspirin resistance determination was performed in 100 consecutive CAD patients with a previous PCI history. All patients were on regular aspirin treatment. Aspirin resistance was measured by PFA-100 Analyser and HDL-C was measured by enzymatic procedures. Results: Aspirin resistance was documented in 14 patients (%14) (Group A). The mean value of HDL-C was 31.43±4.45 mg/dl in patients who were aspirin resistant, whereas in the aspirin responsive group, the mean level of HDL-C was 35.06±6.17 mg/dl, which was significantly lower (p=0.037). Patients were divided into two groups acording to HDL-C ≤30
77th Congress of the European Atherosclerosis Society, April 26–29, 2008, Istanbul, Turkey
Poster Sessions PO22 Epidemiology of CVD risk factors mg/dl (Group A)(n=26)and >30 mg/dl (Group B) (n=74). No significant differences were found between groups regarding gender, age, medications, hypertension, family history, obesity, smoking, and comorbid conditions. In Group A, the incidence of aspirin resistance was %26.9, whereas %9.5 in Group B. The difference was statistically significant (p=0.045). Conclusion: This study shows that aspirin resistance is more frequent in patients who have low HDL-C levels, which may be a result of the direct and indirect effects of HDL-C on platelets. PO22-325
AN ANALYSIS OF THE RESIDUAL RISK OF CARDIOVASCULAR EVENTS IN PATIENTS AT LOW DENSITY LIPOPROTEIN (LDL-C) TARGET LEVELS
R. Simko 1 , S. Balu 1 , M. Cziraky 2 , C. Sarawate 2 . 1 Abbott, Chicago, IL USA; 2 HealthCore, Wilmington, DE, USA
PO22-326
CARDIOVASCULAR DISEASE AND GAMMA-GLUTAMYLTRANSFERASE LEVELS
Yu. Nikitin, S. Burakova, G. Simonova, S. Maluytina. Institute of Internal Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirskm Russia Purpose: To investigate association between gamma-glytamiltransferase levels (GGTP) and the development of cardiovascular disease (CVD). The data were taken from materials of the epidemiological study “Determinants of cardiovascular disease in Eastern Europe”, the HAPPIE project. We investigated representative samples from non-organized population of men and women 45-69 years old living in Novosibirsk – 9361 subjects (4275 men and 5086 women). The program of study included: questionnaire of previous CVD, smoking status and alcohol consumption; two blood pressure measurements; anthropometry, biochemical analysis (GGTP, total cholesterol, HDL cholesterol, and triglycerides) and rest echocardiography. Among all subjects we distinguished three groups: first – patients with diagnosed ischemic heart disease (angina pectoris or myocardial infarction) and without previous cerebral stroke; second – patients with previous cerebral stroke (without ischemic heart disease); third – patients without previous ischemic heart disease and cerebral stroke (control group). We revealed reliable data on sex-dependent difference of GGTP levels: men have higher GGTP levels compared with women in all age groups. Subjects who didn’t take alcoholic drinks during the last year have noticeably lower GGTP level than those who took alcoholic drinks during that period. GGTP activity was higher both in men and women in group with ischemic heart disease, than in control group. We did not reveal the difference of GGTP activity in group with cerebral stroke compared to control group. The similar patterns were revealed in subjects who didn’t take alcoholic drinks during the last year.
LIPID PROFILE OF GREEK HYPERTENSIVE PATIENTS: DATA FROM HYPERTENSHELL
S. Voyaki, A. Efstratopoulos, A. Baltas, L. Mourgos, V. Lekakis, M. Pagoni, M. Meikopoulos, F. Vratsistas, E. Kastritsea. Hypertension Unit of General Hospital of Athens The Hypertension Study in General Practice in Hellas (Hypertenshell) is a cross-sectional Study (much like th NHANES Study) for assessing the prevalence,level of awareness, treatment, and control of hypertension in Greece. Methods: A total of 11950 individuals participated and data for 11540 were analyzed. The prevalence of hypertension was 31.1% (total = 3590, men = 1600 and women = 1990, 15-95 year-old). Among the various parameters that were examined the lipid and metabolic profile was included (T Chol, TG, HDL-C, LDL-C, fasting blood sugar (FPG). Results: In hypertensives patients without diabetes mellitus (DM) the lipid profil was: T.Chol 236.7±48mg/dl, Tr:156.5±72mg/dl, HDL:50.3±11.5mg/dl, LDL:156.5±43.6mg/dl. In comparison to hypertensives without DM those with DM had higher Tg (185±88mg/dl, P=0.0000) and lower HDL-C levels (46.8±10.5mg/dl, P=0.0000) but similar TChol and LDL-C levels (238.2±51mg/dl, 153.4±41mg/dl, P=NS for both). Between the two sexes women had higher TChol levels in comparison to men (245±46.5mg/dl vs 234±51.5mg/dl, P=0.0008) but higher HDL-C levels (52.5±11.5 vs 47.2±10.2, P=0.0000). Conclusions: From this post-hoc analysis of Hypertenshell study we showed that Greek hypertensives have a lipid profil characterized by slightly increased values of TChol and triglycerides and low values of HDL-C. PO22-328
LONGITUDINAL FOLLOW-UP STUDY FOR CHANGES IN LIPIDS AND LIPOPROTEINS DURING THE PERIMENOPAUSE
C. Kim, H. Ko, W. Ryu. Department of Internal Medicine, Chung-Ang University Hospital, 224-1 Heukseokdong, Dongjakku, Seoul, Korea Background: The aim of this study is to quantitatively measure changes in lipids and lipoproteins during the perimenopause and to find the relationship of these changes with related variables. Methods: Among women who had 3 times regular health evaluations for 2 or 3 years, 38 women remaining in premenopausal state, 38 premenopausal women transiting to postmenopausal state, and 37 postmenopausal women were enrolled. Menopausal state was determined by both female sex hormone levels and amenorrhea history. Yearly changes in lipids were calculated by linear regression method from 3 measurements. Results: The transition from the premenopause to the postmenopause increased total cholesterol and LDL cholesterol levels by 8.7±10.0 mg/dL (4.8±5.7%) and 8.2±8.8 mg/dL (8.0±8.9%) per one year, resulting in the elevation of 21.2±21.6 mg/dL (11.9±13.6%) and 21.6±24.1 mg/dL (20.6±22.1%) respectively during the perimenopause. There were no changes in premenopausal and postmenopausal women. Body weight, blood pressure, HDL cholesterol, triglyceride were not changes in all three groups. In perimenopausal women, absolute and percent changes of LDL cholesterol per one year were associated with changes in estradiol levels (r=0.43, p=0.008 and r=0.43, p=0.037 respectively) and not with changes in body weights. In all women, absolute and percent changes of LDL cholesterol per one year were associated with perimenopausal state (r=0.33, p=0.000 and r=0.31, p=0.001 respectively) and hypertension (r=0.22, p=0.021 and r=0.26, p=0.007 respectively). Conclusion: During the perimenopause, LDL cholesterol levels increases and HDL cholesterol levels are not changed. Changes in LDL cholesterol levels are mainly dependent on changes in female sex hormones. PO22-329
INDIVIDUAL GLOBAL RISK OF POLISH POPULATION AND IT’S RELATION TO MEDICAL CARE. RESULTS OF NATIONAL MULTICENTER HEALTH SURVEY (WOBASZ)
A. Piwonska 1 , W. Piotrowski 1 , J. Piwonski 2 . 1 Dept of CVD Epidemiology, Prevention and Health Promotion; 2 on behalf of WOBASZ investigators Background and aim: The individual global risk (GR) of fatal CVD should be the basis for physician management. We want to assess GR of polish population and it’s relation to selected elements of medical care (MC) (BP measurement, stop smoking and dietary advice, higher physical activity recommendation on each visit, cholesterol measurement).
77th Congress of the European Atherosclerosis Society, April 26–29, 2008, Istanbul, Turkey
POSTER SESSIONS
Background and Aims: Reduction of LDL-C reduces cardiovascular (CV) disease morbidity and mortality. Patients with controlled LDL-C levels continue to be at risk for CVD events. We assessed the risk of CV events in patients who meet the LDL-C goal set by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines. Methods: Systematic review of randomized controlled trials (RCT) published in English language between January 1, 1996 and November 30, 2006. Outcomes of interest included stroke, myocardial infarction, peripheral vascular disease, and mortality. Results: Of 1,899 citations 1642 abstracts and 137 papers were rejected during screening. Papers were rejected due to absence of outcomes (k=59), non-RCT design (k=25), follow-up <1 year (k=15), and <100 patients per arm (k=22). Studies contributed a patient cohort of 137,738 patients with mean age of 61 and 73% males. Patients with LDL-C < 100 mg/dL (target LDL-C) suffered from adverse CV events such as 2.5 MI, 0.8 strokes, 0.9 PVD events, and 2.2 all-cause mortality per 100 patients-years of follow-up. Patients with large increase in HDL (>5%) and patients with decrease in TG levels were associated with lower incidence of MI and fatal stroke as compared to patients with decreased HDL and/or increased TG levels. Patients on fibrate therapy increased HDL (13.73%) and reduced triglyceride (24.63%) at a higher rate than statin therapy. Conclusions: There is risk of cardiovascular event and mortality in patients at target levels of LDL-C. Control of HDL-C and TG may offer additional benefits.
PO22-327
97
Poster Sessions PO22 Epidemiology of CVD risk factors
pendent factors for development of atherosclerosis. Therefore, monitoring glycemia levels in blood should start as early as in childhood. Aim of our study was to evaluate glycemia levels in school children during five years period both in boys and girls. Methods: We evaluated 5768 children age of 10 years (48.74% were girls, 51.26% were boys) and 3737 children age of 15 years (48.70% girls, 51.30% boys). In these groups of children we analyzed glicemia levels in blood by standard laboratory tests. Results were presented in form of percentiles. Results: 5% of boys age 10 years had glycemia levels beyond 3.70mmol/l, 50% beyond 4.80mmol/l and 5% had values above 5.90mmol/l. 5% of girls age 10 years had glycemia levels beyond 3.60mmol/l, 50% beyond 4.70mmol/l and 5% had values above 5.70mmol/l. 5% of boys age 15 years had glycemia levels beyond 3.90mmol/l, 50% beyond 5.00mmol/l and 5% had values above 6.00mmol/l. 5% of girls age 15 years had glycemia levels beyond 3.80mmol/l, 50% beyond 4.70mmol/l and 5% had values above 5.72mmol/l. Conclusions: We found statistical difference (p<0.001) when genders where compared in same age population. Statistical difference was found also (p<0.01) when boys and girls were compared separately due to age groups. According to our study, we can conclude that boys have greater risk for development of atherosclerosis in adulthood. PO22-322
PO22-323
EVALUATION OF BLOOD PRESSURE LEVELS AND USE OF ANTIHYPERTENSIVE MEDICATION IN ICEBERG STUDY PATIENTS
G. Kabakci 1 , N. Koylan 2 , O. Kozan 3 , B. Ilerigelen 4 , K. Buyukozturk 2 . Cardiology, Hacettepe Univ. School of Medicine, Ankara, Turkey; Univ. Istanbul School of Medicine, Istanbul, Turkey; 3 Dept. of Cardiology, Dokuz Eylul Univ. School of Medicine, Izmir, Turkey; 4 Dept. of Cardiology, Istanbul Univ. Cerrahpasa School of Medicine, Istanbul, Turkey
1 Dept. of 2 Istanbul
Background and aims: The “Intensive/Initial Cardiovascular Examination regarding Blood pressure levels: Evaluation of Risk Groups (ICEBERG)” study aimed to evaluate cardiovascular risk of subjects with high normal or high blood pressure and impact of various different laboratory tests on risk stratification. This report presents patients’ blood pressure levels and antihypertensive drug use. Methods: ICEBERG was a non-interventional epidemiological study including patients diagnosed with hypertension and receiving antihypertensive medication or not. Results: Table 1 demonstrates classification of patients according to their blood pressure levels and antihypertensive medication use.
EVALUATION OF SOCIODEMOGRAPHIC CHARACTERISTICS AND MEDICAL CONDITIONS OF THE ICEBERG STUDY POPULATIONS
B. Ilerigelen 1 , G. Kabakci 2 , N. Koylan 3 , O. Kozan 4 , K. Buyukozturk 3 . of Cardiology, Istanbul Univ. Cerrahpasa School of Medicine, Istanbul, Turkey; 2 Dept. of Cardiology, Hacettepe Univ. School of Medicine, Ankara, Turkey; 3 Dept. of Cardiology, Istanbul Univ. Istanbul School of Medicine, Istanbul, Turkey; 4 Dept.of Cardiology, Dokuz Eylul Univ. School of Medicine, Izmir, Turkey 1 Dept.
Background and aim: The “Intensive/Initial Cardiovascular Examination regarding Blood pressure levels: Evaluation of Risk Groups (ICEBERG)” study aimed to evaluate cardiovascular risk status of subjects with high normal or high blood pressure and the impact of different laboratory tests on risk stratification. This report focuses on the description of ICEBERG cohort of approximately 10,000 hypertensive patients regarding their sociodemographic status and medical conditions. Methods: ICEBERG was a non-interventional epidemiological study, and patients were either on anti-hypertensive medication or not upon the decision of their physicians.
Conclusions: (1) Untreated patients are in higher grade strata of hypertension, and (2) ARB+diuretics are most frequently used drugs in Treated Group, ARBs are mostly recommended to Untreated patients. PO22-324
DO LOW HDL CHOLESTEROL LEVELS HAVE ROLE IN ASPIRIN RESISTANCE?
S. Aytekin 1 , A. Catakoglu 2 , M. Sener 1 , H. Kurtoglu 1 , H. Celebi 2 , I. Demiroglu 2 , V. Aytekin 1 . 1 Istanbul Bilim University, Florence Nightingale Hospital, Department of Cardiology; 2 Florence Nightingale Hospital, Department of Cardiology
Results and conclusion: Table 1 summarizes the sociodemographics, hematology and medical status of the study populations. The evaluation of this population regarding cardiovascular risk status has been published elsewhere.
Background: Both HDL cholesterol (HDL-C) and LDL cholesterol receptors were shown on platelet membrane in previous studies. Low HDL-C levels have been demonstrated to effect platelet aggregation, by both direct and indirect mechanisms in several studies. The aim of our study was to investigate the relationship between low HDL-C and AR, in coronary artery disease (CAD) patients with a previous percutaneous coronary intervention (PCI) history. Methods: Lipid profile analysis and aspirin resistance determination was performed in 100 consecutive CAD patients with a previous PCI history. All patients were on regular aspirin treatment. Aspirin resistance was measured by PFA-100 Analyser and HDL-C was measured by enzymatic procedures. Results: Aspirin resistance was documented in 14 patients (%14) (Group A). The mean value of HDL-C was 31.43±4.45 mg/dl in patients who were aspirin resistant, whereas in the aspirin responsive group, the mean level of HDL-C was 35.06±6.17 mg/dl, which was significantly lower (p=0.037). Patients were divided into two groups acording to HDL-C ≤30
77th Congress of the European Atherosclerosis Society, April 26–29, 2008, Istanbul, Turkey
Poster Sessions PO22 Epidemiology of CVD risk factors mg/dl (Group A)(n=26)and >30 mg/dl (Group B) (n=74). No significant differences were found between groups regarding gender, age, medications, hypertension, family history, obesity, smoking, and comorbid conditions. In Group A, the incidence of aspirin resistance was %26.9, whereas %9.5 in Group B. The difference was statistically significant (p=0.045). Conclusion: This study shows that aspirin resistance is more frequent in patients who have low HDL-C levels, which may be a result of the direct and indirect effects of HDL-C on platelets. PO22-325
AN ANALYSIS OF THE RESIDUAL RISK OF CARDIOVASCULAR EVENTS IN PATIENTS AT LOW DENSITY LIPOPROTEIN (LDL-C) TARGET LEVELS
R. Simko 1 , S. Balu 1 , M. Cziraky 2 , C. Sarawate 2 . 1 Abbott, Chicago, IL USA; 2 HealthCore, Wilmington, DE, USA
PO22-326
CARDIOVASCULAR DISEASE AND GAMMA-GLUTAMYLTRANSFERASE LEVELS
Yu. Nikitin, S. Burakova, G. Simonova, S. Maluytina. Institute of Internal Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirskm Russia Purpose: To investigate association between gamma-glytamiltransferase levels (GGTP) and the development of cardiovascular disease (CVD). The data were taken from materials of the epidemiological study “Determinants of cardiovascular disease in Eastern Europe”, the HAPPIE project. We investigated representative samples from non-organized population of men and women 45-69 years old living in Novosibirsk – 9361 subjects (4275 men and 5086 women). The program of study included: questionnaire of previous CVD, smoking status and alcohol consumption; two blood pressure measurements; anthropometry, biochemical analysis (GGTP, total cholesterol, HDL cholesterol, and triglycerides) and rest echocardiography. Among all subjects we distinguished three groups: first – patients with diagnosed ischemic heart disease (angina pectoris or myocardial infarction) and without previous cerebral stroke; second – patients with previous cerebral stroke (without ischemic heart disease); third – patients without previous ischemic heart disease and cerebral stroke (control group). We revealed reliable data on sex-dependent difference of GGTP levels: men have higher GGTP levels compared with women in all age groups. Subjects who didn’t take alcoholic drinks during the last year have noticeably lower GGTP level than those who took alcoholic drinks during that period. GGTP activity was higher both in men and women in group with ischemic heart disease, than in control group. We did not reveal the difference of GGTP activity in group with cerebral stroke compared to control group. The similar patterns were revealed in subjects who didn’t take alcoholic drinks during the last year.
LIPID PROFILE OF GREEK HYPERTENSIVE PATIENTS: DATA FROM HYPERTENSHELL
S. Voyaki, A. Efstratopoulos, A. Baltas, L. Mourgos, V. Lekakis, M. Pagoni, M. Meikopoulos, F. Vratsistas, E. Kastritsea. Hypertension Unit of General Hospital of Athens The Hypertension Study in General Practice in Hellas (Hypertenshell) is a cross-sectional Study (much like th NHANES Study) for assessing the prevalence,level of awareness, treatment, and control of hypertension in Greece. Methods: A total of 11950 individuals participated and data for 11540 were analyzed. The prevalence of hypertension was 31.1% (total = 3590, men = 1600 and women = 1990, 15-95 year-old). Among the various parameters that were examined the lipid and metabolic profile was included (T Chol, TG, HDL-C, LDL-C, fasting blood sugar (FPG). Results: In hypertensives patients without diabetes mellitus (DM) the lipid profil was: T.Chol 236.7±48mg/dl, Tr:156.5±72mg/dl, HDL:50.3±11.5mg/dl, LDL:156.5±43.6mg/dl. In comparison to hypertensives without DM those with DM had higher Tg (185±88mg/dl, P=0.0000) and lower HDL-C levels (46.8±10.5mg/dl, P=0.0000) but similar TChol and LDL-C levels (238.2±51mg/dl, 153.4±41mg/dl, P=NS for both). Between the two sexes women had higher TChol levels in comparison to men (245±46.5mg/dl vs 234±51.5mg/dl, P=0.0008) but higher HDL-C levels (52.5±11.5 vs 47.2±10.2, P=0.0000). Conclusions: From this post-hoc analysis of Hypertenshell study we showed that Greek hypertensives have a lipid profil characterized by slightly increased values of TChol and triglycerides and low values of HDL-C. PO22-328
LONGITUDINAL FOLLOW-UP STUDY FOR CHANGES IN LIPIDS AND LIPOPROTEINS DURING THE PERIMENOPAUSE
C. Kim, H. Ko, W. Ryu. Department of Internal Medicine, Chung-Ang University Hospital, 224-1 Heukseokdong, Dongjakku, Seoul, Korea Background: The aim of this study is to quantitatively measure changes in lipids and lipoproteins during the perimenopause and to find the relationship of these changes with related variables. Methods: Among women who had 3 times regular health evaluations for 2 or 3 years, 38 women remaining in premenopausal state, 38 premenopausal women transiting to postmenopausal state, and 37 postmenopausal women were enrolled. Menopausal state was determined by both female sex hormone levels and amenorrhea history. Yearly changes in lipids were calculated by linear regression method from 3 measurements. Results: The transition from the premenopause to the postmenopause increased total cholesterol and LDL cholesterol levels by 8.7±10.0 mg/dL (4.8±5.7%) and 8.2±8.8 mg/dL (8.0±8.9%) per one year, resulting in the elevation of 21.2±21.6 mg/dL (11.9±13.6%) and 21.6±24.1 mg/dL (20.6±22.1%) respectively during the perimenopause. There were no changes in premenopausal and postmenopausal women. Body weight, blood pressure, HDL cholesterol, triglyceride were not changes in all three groups. In perimenopausal women, absolute and percent changes of LDL cholesterol per one year were associated with changes in estradiol levels (r=0.43, p=0.008 and r=0.43, p=0.037 respectively) and not with changes in body weights. In all women, absolute and percent changes of LDL cholesterol per one year were associated with perimenopausal state (r=0.33, p=0.000 and r=0.31, p=0.001 respectively) and hypertension (r=0.22, p=0.021 and r=0.26, p=0.007 respectively). Conclusion: During the perimenopause, LDL cholesterol levels increases and HDL cholesterol levels are not changed. Changes in LDL cholesterol levels are mainly dependent on changes in female sex hormones. PO22-329
INDIVIDUAL GLOBAL RISK OF POLISH POPULATION AND IT’S RELATION TO MEDICAL CARE. RESULTS OF NATIONAL MULTICENTER HEALTH SURVEY (WOBASZ)
A. Piwonska 1 , W. Piotrowski 1 , J. Piwonski 2 . 1 Dept of CVD Epidemiology, Prevention and Health Promotion; 2 on behalf of WOBASZ investigators Background and aim: The individual global risk (GR) of fatal CVD should be the basis for physician management. We want to assess GR of polish population and it’s relation to selected elements of medical care (MC) (BP measurement, stop smoking and dietary advice, higher physical activity recommendation on each visit, cholesterol measurement).
77th Congress of the European Atherosclerosis Society, April 26–29, 2008, Istanbul, Turkey
POSTER SESSIONS
Background and Aims: Reduction of LDL-C reduces cardiovascular (CV) disease morbidity and mortality. Patients with controlled LDL-C levels continue to be at risk for CVD events. We assessed the risk of CV events in patients who meet the LDL-C goal set by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines. Methods: Systematic review of randomized controlled trials (RCT) published in English language between January 1, 1996 and November 30, 2006. Outcomes of interest included stroke, myocardial infarction, peripheral vascular disease, and mortality. Results: Of 1,899 citations 1642 abstracts and 137 papers were rejected during screening. Papers were rejected due to absence of outcomes (k=59), non-RCT design (k=25), follow-up <1 year (k=15), and <100 patients per arm (k=22). Studies contributed a patient cohort of 137,738 patients with mean age of 61 and 73% males. Patients with LDL-C < 100 mg/dL (target LDL-C) suffered from adverse CV events such as 2.5 MI, 0.8 strokes, 0.9 PVD events, and 2.2 all-cause mortality per 100 patients-years of follow-up. Patients with large increase in HDL (>5%) and patients with decrease in TG levels were associated with lower incidence of MI and fatal stroke as compared to patients with decreased HDL and/or increased TG levels. Patients on fibrate therapy increased HDL (13.73%) and reduced triglyceride (24.63%) at a higher rate than statin therapy. Conclusions: There is risk of cardiovascular event and mortality in patients at target levels of LDL-C. Control of HDL-C and TG may offer additional benefits.
PO22-327
97