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Drug-eluting stents do not increase the risk of stent thrombosis, but longer stents may be associated with greater incidence of thrombosis
ARTICLE IN PRESS Evidence-based Cardiovascular Medicine (2005) 9, 184
Evidence-based
CARDIOVASCULAR MEDICINE www.elsevier.com/locate/ebcm
PERCUTANEOUS CORONARY INTERVENTION
Drug-eluting stents do not increase the risk of stent thrombosis, but longer stents may be associated with greater incidence of thrombosis$
Background The rate of restenosis following implantation of a drug-eluting stent is usually low, but it remains uncertain whether drug-eluting stents alter the risk of stent thrombosis.
Objective Moreno and colleagues compared the risk of stent thrombosis from bare metal versus drug-eluting stents. They assessed whether the risk of thrombosis with drug-eluting stents is related to stent length.
Method This meta-analysis included ten randomised trials comparing drug-eluting and bare metal stents among 5,030 people. The authors did not describe the search strategy or the inclusion and exclusion criteria.
Main results There was no significant difference between bare metal and drug-eluting stents in the incidence of stent thrombosis (odds ratio 1.05, 95% CI 0.51 to 2.15). Nor was there any difference in the incidence DOI of associated commentary: 10.1016/j.ebcm.2005.06.035 Abstracted from Moreno R, Fernandez C, Hernandez R, et al. Drug-eluting stent thrombosis: results from a pooled analysis including 10 randomized studies. J Am Coll Cardiol 2005; 45(6): 954–9. $
doi:10.1016/j.ebcm.2005.06.034
of stent thrombosis between sirolimus-eluting or paclitaxel-eluting stents (0.57% vs 0.58%, p ¼ 1.00). The rate of stent thrombosis was related to stent length. People receiving longer drug-eluting stents were more likely to have stent thrombosis. The mean drug-eluting stent length was 23.4 mm for those with stent thrombosis versus 21.3 mm for those without stent thrombosis (p ¼ 0.025).
Authors’ conclusions The authors concluded that drug-eluting stents do not increase the risk of stent thrombosis when used with appropriate antiplatelet therapy. However, people receiving longer drug-eluting stents are more likely to suffer stent thrombosis than those receiving shorter drug-eluting stents.
Overall quality topic importance method quality practical use Poor
Fair
Good
Excellent
The authors did not report any study sponsorship. Enquiries to [email protected] Results abstracted by Debbie Singh.
Evidence-based
CARDIOVASCULAR MEDICINE www.elsevier.com/locate/ebcm
PERCUTANEOUS CORONARY INTERVENTION
Drug-eluting stents do not increase the risk of stent thrombosis, but longer stents may be associated with greater incidence of thrombosis$
Background The rate of restenosis following implantation of a drug-eluting stent is usually low, but it remains uncertain whether drug-eluting stents alter the risk of stent thrombosis.
Objective Moreno and colleagues compared the risk of stent thrombosis from bare metal versus drug-eluting stents. They assessed whether the risk of thrombosis with drug-eluting stents is related to stent length.
Method This meta-analysis included ten randomised trials comparing drug-eluting and bare metal stents among 5,030 people. The authors did not describe the search strategy or the inclusion and exclusion criteria.
Main results There was no significant difference between bare metal and drug-eluting stents in the incidence of stent thrombosis (odds ratio 1.05, 95% CI 0.51 to 2.15). Nor was there any difference in the incidence DOI of associated commentary: 10.1016/j.ebcm.2005.06.035 Abstracted from Moreno R, Fernandez C, Hernandez R, et al. Drug-eluting stent thrombosis: results from a pooled analysis including 10 randomized studies. J Am Coll Cardiol 2005; 45(6): 954–9. $
doi:10.1016/j.ebcm.2005.06.034
of stent thrombosis between sirolimus-eluting or paclitaxel-eluting stents (0.57% vs 0.58%, p ¼ 1.00). The rate of stent thrombosis was related to stent length. People receiving longer drug-eluting stents were more likely to have stent thrombosis. The mean drug-eluting stent length was 23.4 mm for those with stent thrombosis versus 21.3 mm for those without stent thrombosis (p ¼ 0.025).
Authors’ conclusions The authors concluded that drug-eluting stents do not increase the risk of stent thrombosis when used with appropriate antiplatelet therapy. However, people receiving longer drug-eluting stents are more likely to suffer stent thrombosis than those receiving shorter drug-eluting stents.
Overall quality topic importance method quality practical use Poor
Fair
Good
Excellent
The authors did not report any study sponsorship. Enquiries to [email protected] Results abstracted by Debbie Singh.