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Effect of gamma radiation on the ferritin activity
Abstracts / Physica Medica 30 (2014) e75ee121
EFFECT OF GAMMA RADIATION ON THE FERRITIN ACTIVITY V. Kochev a, L. VladimirovaeMihaleva a, At. Papucharov b, G. Gyulchev c, G. Zlatevac c, N. Atanasova e Gesheva b. a Sofia University “St. Kliment Ohridski”, Faculty of Physics, 5 James Boucher Blvd. 1164 Sofia, Bulgaria; b Specialized hospital for active treatment in oncology, 6 Plovdivsko Pole Str., Sofia, Bulgaria; c Sofia University “St. Kliment Ohridski”, Faculty of Medicine, 1407 Sofia, 1 Kozyak Str., Sofia, Bulgaria Presenting authors: At. Papucharov, G. Gyulchev Topics: Radiation protection, monitoring and dose reduction
e121
The consequences of ferritin exposure to different doses of gamma radiation, typically used in therapy, are disclosed in this paper. Although, the ferritin is susceptible to UV and visible light, responding with a change in the redox state of its mineral core, the effect of high energy gamma photons turned out to be more subtle. However, at increased doses there is a facilitated mobilization of inorganic core Fe3 +, which is reduced to Fe2+ and released from the protein interior in the presence of ascorbic acid as exogenous reducing agent. According to a working hypothesis, this is attributed to the impact of the products of water radiolysis on the architecture of the threefold channels responsible for the transport of iron. Keywords: ferritin, gamma radiation therapy, potentiometric redox titration, radiolysis of water
EFFECT OF GAMMA RADIATION ON THE FERRITIN ACTIVITY V. Kochev a, L. VladimirovaeMihaleva a, At. Papucharov b, G. Gyulchev c, G. Zlatevac c, N. Atanasova e Gesheva b. a Sofia University “St. Kliment Ohridski”, Faculty of Physics, 5 James Boucher Blvd. 1164 Sofia, Bulgaria; b Specialized hospital for active treatment in oncology, 6 Plovdivsko Pole Str., Sofia, Bulgaria; c Sofia University “St. Kliment Ohridski”, Faculty of Medicine, 1407 Sofia, 1 Kozyak Str., Sofia, Bulgaria Presenting authors: At. Papucharov, G. Gyulchev Topics: Radiation protection, monitoring and dose reduction
e121
The consequences of ferritin exposure to different doses of gamma radiation, typically used in therapy, are disclosed in this paper. Although, the ferritin is susceptible to UV and visible light, responding with a change in the redox state of its mineral core, the effect of high energy gamma photons turned out to be more subtle. However, at increased doses there is a facilitated mobilization of inorganic core Fe3 +, which is reduced to Fe2+ and released from the protein interior in the presence of ascorbic acid as exogenous reducing agent. According to a working hypothesis, this is attributed to the impact of the products of water radiolysis on the architecture of the threefold channels responsible for the transport of iron. Keywords: ferritin, gamma radiation therapy, potentiometric redox titration, radiolysis of water