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Effectiveness of music intervention on the anxiety and salivary physiological indicators of patients with breast cancer undergoing chemotherapy
15th St.Gallen International Breast Cancer Conference / The Breast 32S1 (2017) S78–S132
this was 1.7% (95% CI, 0.9–3.1) in those who did not receive and 3.2% (95% CI, 1.8–5.4) amongst those who did receive aCT. Table 1 describes the patients who did not receive and who did receive aCT. Conclusion: Omission of aCT based on clinicopathological results, in “MINDACT clinical high risk”, ER positive, grade 1–2 tumors, resulted in a low 5-year cumulative DRFI (1.7%). Clinicopathological factors may contribute to the most cost-effective use of gene expression profiles. Disclosure of Interest: No significant relationships. Table 1 Description of patients with and without adjuvant chemotherapy (aCT) Variable
Age (years), median (IQR) Size (mm), median (IQR) Grade 1, N (%) pN1, N (%)
With aCT (n = 392) 50(45–54) 30(22–45) 20(5%) 318(81%)
Without aCT (n = 550) 60(53–65) 26(22–35) 44(8%) 260(47%)
P328 Effectiveness of music intervention on the anxiety and salivary physiological indicators of patients with breast cancer undergoing chemotherapy H. Tsai1 *, K. Chou2. 1New Taipei, Taiwan (R.O.C), 2Taipei, Taiwan (R.O.C) Aims: This study investigated the effectiveness of music intervention on the anxiety and salivary physiological indicators of patients with breast cancer who are undergoing chemotherapy. Methods: This study used a randomized, double blind, parallelgroup, controlled trial design. A total of 36 patients with breast cancer who were undergoing chemotherapy were recruited at a teaching hospital in New Taipei City. The experimental group and the control group were each assigned 18 participants. The participants in the experimental group listened to music for 30 minutes, whereas the control group participants listened to ambient sounds for the same interval. The research instruments employed were the state anxiety inventory (SAI) and a handheld salivary α-amylase (SAA) analyzer. The Mann–Whitney U test and the Wilcoxon signed-rank test were used for inferential statistical analysis. Results: The results showed that the experimental group participants presented a significant decline in state anxiety level from 40.1 to 36.8 ( p = .03) after undergoing music intervention. Significant difference in state anxiety level was found between the experimental and control groups ( p < .01). Similarly, concerning the salivary indicator, the SAA level of the experimental group declined significantly from 203.6 U/mL to 131.6 U/mL ( p = .02). Significant difference in SAA level between the experimental and control groups was also found ( p = .001), indicating a clear post intervention decline and rise of SAA level in the experimental group and the control group, respectively. Conclusion: Music intervention is nonthreatening and non-invasive, and is thus suitable for patients with breast cancer, who are experiencing physical and mental distress. Clinical nurses are suggested to incorporate music listening into routine care programs as anxiety-reduction and stress-relief measures, which could improve nursing quality during chemotherapy and thereby increase patient satisfaction. Disclosure of Interest: No significant relationships.
S131
P329 Aesthetic and functional results of quality of life after breast conserving surgery evaluated by Portuguese/Brazil version of breast cancer treatment outcome scale (BCTOS) R. Costa Vieira*, F. Brandini Silva, J. da Silva, L. Ferreira, J. Santos Paulista, M. Alves de Lima, A. Sarri, C. Paiva. Hospital de Câncer de Barretos, Barretos, Brazil Aims: Validate for Portuguese/Brazil language and evaluate the quality of life questionnaire BCTOS. Methods: A prospective cohort study was performed evaluating 300 breast cancer patients, submitted to breast conservative surgery (BCS) and radiotherapy. The inclusion criteria were the end of radiotherapy at last one year and absence of recurrence or metastatic disease. The quality of life questionnaire (QLQ) BCTOS had been initially translated for Portuguese/Brazil using Beaton’s methodology. It has 22 questions and four domains (functional, cosmetic, pain and edema). The patients completed the QLQ BCTOS, EORTC QLQ-C30 and QLQ-BR23. We evaluated the internal consistency, reliability, factorial analysis, and convergent/divergent validation. For questionnaire and domain evaluation the Cronback’s α was used. For reliability the index of interclass correlation was used. For validation convergent and divergent process a Spearman’s analysis was performed. Ethics committee approval was performed (782/2014). Results: The mean elapsed time of the end of treatment was 7.4 years (1.2 to 20.6). Evaluating the QLQ BCTOS answers we observed missing information lower than 1%. The item Cronback’s α were higher than 0.4 in all questions, and after the item exclusion it was higher than 0.90. The Cronback’s α was excellent, as it was higher than 0.785 for all domains, and after domain exclusion it was higher than 0.776. Evaluating the item reliability we observed an excellent correlation (0.825 to 0.879). Exploratory factorial analysis also selected four main domains. Convergent and divergent validations between different QLQ’s were regular to moderate (Table 1). Conclusion: The QLQ BCTOS seems to be related to the quality of life for Brazilian women, independent of the time after BCS. Disclosure of Interest: No significant relationships. Grant: FAPESP 2014/08197-0. Table 1 Convergent and Divergent validation with QLQ BCTOS between EORTC QLQ C30 and QLQ BR23 in Brazilian women BCTOS
Functional
Cosmetic
EORTC C30 global health C30 functional scale C30 symptom scale BR23 functional scale BR23 symptom scale
−0.429 −0.628 0.612 −0.343 0.714
−0.379 −0.458 0.382 −0.417 0.397
Pain
Edema
0.292 −0.540 0.532 −0.353 0.618
−0.298 −0.435 0.409 −0.308 0.490
P330 Quantifying cosmetic results after breast-conserving therapy. We’re talking about the same thing? R. Costa Vieira1 *, V. Andrade1, F. Brandini da Silva1, G. Zucca-Matthes1, G. Uemura2, M. do Socorro Silva Maciel3, F. Nazima4, G. Biller1, J. da Silva1, C. Paiva1. 1Hospital de Câncer de Barretos, Barretos, Brazil, 2 Faculdade de Medicina de Botucatu/ UNESP, Botucatu, Brazil, 3 Hospital Alemão Oswaldo Cruz, São Paulo, Brazil, 4Clínica Plastiki, Londrina, Brazil Aims: Evaluate and compare multiple quantitative methodologies of cosmetic evaluation of breast-conserving therapy. Methods: 300 breast cancer patients, submitted to conservative treatment and radiotherapy were evaluated. The inclusion criteria were the end of radiotherapy at last one year and the absence of recurrence or metastatic disease. Photographs were performed for BCCT.core cosmetic evaluation.
this was 1.7% (95% CI, 0.9–3.1) in those who did not receive and 3.2% (95% CI, 1.8–5.4) amongst those who did receive aCT. Table 1 describes the patients who did not receive and who did receive aCT. Conclusion: Omission of aCT based on clinicopathological results, in “MINDACT clinical high risk”, ER positive, grade 1–2 tumors, resulted in a low 5-year cumulative DRFI (1.7%). Clinicopathological factors may contribute to the most cost-effective use of gene expression profiles. Disclosure of Interest: No significant relationships. Table 1 Description of patients with and without adjuvant chemotherapy (aCT) Variable
Age (years), median (IQR) Size (mm), median (IQR) Grade 1, N (%) pN1, N (%)
With aCT (n = 392) 50(45–54) 30(22–45) 20(5%) 318(81%)
Without aCT (n = 550) 60(53–65) 26(22–35) 44(8%) 260(47%)
P328 Effectiveness of music intervention on the anxiety and salivary physiological indicators of patients with breast cancer undergoing chemotherapy H. Tsai1 *, K. Chou2. 1New Taipei, Taiwan (R.O.C), 2Taipei, Taiwan (R.O.C) Aims: This study investigated the effectiveness of music intervention on the anxiety and salivary physiological indicators of patients with breast cancer who are undergoing chemotherapy. Methods: This study used a randomized, double blind, parallelgroup, controlled trial design. A total of 36 patients with breast cancer who were undergoing chemotherapy were recruited at a teaching hospital in New Taipei City. The experimental group and the control group were each assigned 18 participants. The participants in the experimental group listened to music for 30 minutes, whereas the control group participants listened to ambient sounds for the same interval. The research instruments employed were the state anxiety inventory (SAI) and a handheld salivary α-amylase (SAA) analyzer. The Mann–Whitney U test and the Wilcoxon signed-rank test were used for inferential statistical analysis. Results: The results showed that the experimental group participants presented a significant decline in state anxiety level from 40.1 to 36.8 ( p = .03) after undergoing music intervention. Significant difference in state anxiety level was found between the experimental and control groups ( p < .01). Similarly, concerning the salivary indicator, the SAA level of the experimental group declined significantly from 203.6 U/mL to 131.6 U/mL ( p = .02). Significant difference in SAA level between the experimental and control groups was also found ( p = .001), indicating a clear post intervention decline and rise of SAA level in the experimental group and the control group, respectively. Conclusion: Music intervention is nonthreatening and non-invasive, and is thus suitable for patients with breast cancer, who are experiencing physical and mental distress. Clinical nurses are suggested to incorporate music listening into routine care programs as anxiety-reduction and stress-relief measures, which could improve nursing quality during chemotherapy and thereby increase patient satisfaction. Disclosure of Interest: No significant relationships.
S131
P329 Aesthetic and functional results of quality of life after breast conserving surgery evaluated by Portuguese/Brazil version of breast cancer treatment outcome scale (BCTOS) R. Costa Vieira*, F. Brandini Silva, J. da Silva, L. Ferreira, J. Santos Paulista, M. Alves de Lima, A. Sarri, C. Paiva. Hospital de Câncer de Barretos, Barretos, Brazil Aims: Validate for Portuguese/Brazil language and evaluate the quality of life questionnaire BCTOS. Methods: A prospective cohort study was performed evaluating 300 breast cancer patients, submitted to breast conservative surgery (BCS) and radiotherapy. The inclusion criteria were the end of radiotherapy at last one year and absence of recurrence or metastatic disease. The quality of life questionnaire (QLQ) BCTOS had been initially translated for Portuguese/Brazil using Beaton’s methodology. It has 22 questions and four domains (functional, cosmetic, pain and edema). The patients completed the QLQ BCTOS, EORTC QLQ-C30 and QLQ-BR23. We evaluated the internal consistency, reliability, factorial analysis, and convergent/divergent validation. For questionnaire and domain evaluation the Cronback’s α was used. For reliability the index of interclass correlation was used. For validation convergent and divergent process a Spearman’s analysis was performed. Ethics committee approval was performed (782/2014). Results: The mean elapsed time of the end of treatment was 7.4 years (1.2 to 20.6). Evaluating the QLQ BCTOS answers we observed missing information lower than 1%. The item Cronback’s α were higher than 0.4 in all questions, and after the item exclusion it was higher than 0.90. The Cronback’s α was excellent, as it was higher than 0.785 for all domains, and after domain exclusion it was higher than 0.776. Evaluating the item reliability we observed an excellent correlation (0.825 to 0.879). Exploratory factorial analysis also selected four main domains. Convergent and divergent validations between different QLQ’s were regular to moderate (Table 1). Conclusion: The QLQ BCTOS seems to be related to the quality of life for Brazilian women, independent of the time after BCS. Disclosure of Interest: No significant relationships. Grant: FAPESP 2014/08197-0. Table 1 Convergent and Divergent validation with QLQ BCTOS between EORTC QLQ C30 and QLQ BR23 in Brazilian women BCTOS
Functional
Cosmetic
EORTC C30 global health C30 functional scale C30 symptom scale BR23 functional scale BR23 symptom scale
−0.429 −0.628 0.612 −0.343 0.714
−0.379 −0.458 0.382 −0.417 0.397
Pain
Edema
0.292 −0.540 0.532 −0.353 0.618
−0.298 −0.435 0.409 −0.308 0.490
P330 Quantifying cosmetic results after breast-conserving therapy. We’re talking about the same thing? R. Costa Vieira1 *, V. Andrade1, F. Brandini da Silva1, G. Zucca-Matthes1, G. Uemura2, M. do Socorro Silva Maciel3, F. Nazima4, G. Biller1, J. da Silva1, C. Paiva1. 1Hospital de Câncer de Barretos, Barretos, Brazil, 2 Faculdade de Medicina de Botucatu/ UNESP, Botucatu, Brazil, 3 Hospital Alemão Oswaldo Cruz, São Paulo, Brazil, 4Clínica Plastiki, Londrina, Brazil Aims: Evaluate and compare multiple quantitative methodologies of cosmetic evaluation of breast-conserving therapy. Methods: 300 breast cancer patients, submitted to conservative treatment and radiotherapy were evaluated. The inclusion criteria were the end of radiotherapy at last one year and the absence of recurrence or metastatic disease. Photographs were performed for BCCT.core cosmetic evaluation.