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Enterovirus associated placental morphology: A light, virological, electron microscopic and immunohistologic study
340
Citations from the Literature
Pregnancy in a cohort of long-term partners of human immunodefiiiency virus-seropositive hemophiliacs
Kraus EM; Brettler DB; Forsberg AD, Sullivan JL Department
of
Medicine,
Massachusetts-Memorial, 01605, USA
Medical
Center
119 Belmont Street,
of
Central
(2) direct virus-induced injury is not the only possible cause for the lesions: (3) placental enteroviral infection occurred with placental pathology but the virus did not cross the organ as the newborn had no signs of infection.
Worcester, MA
OBSTET GYNECOL 1991 78/5 I (735-738) Since 1981, there have been 17 pregnancies in 12 long-term female sexual partners of human immunodeficiency virus (HIV-1)-seropositive hemophilic men at the New England Hemophilia Center. Eleven of 12 women were seronegative for HIV antibody and one was seropositive. Six of the women followed a specific antibody testing schedule for nine pregnancies. This involved antibody testing at specific points before, during and after pregnancy. All of the seronegative women had at least one negative antibody test at the conclusion of each pregnancy. Fourteen of 16 pregnancies in the seronegative women resulted in live-born infants. The children now range in age from 7 months to 7 years and 8 months and have no signilicant medical problems. The woman found to be seropositive at 8 weeks’gestation of her first pregnancy subsequently delivered an infected infant. In this small group, 11 of 12 women at risk for HIV transmission were able to become pregnant and remain seronegative for HIV antibody. Antibody testing during pregnancy gave the women information on which to base reproductive choices.
Enterovirus associated placental morphology: A light, virological, electron microscopic aad immunohistologic study
Garcia AGP; Da Silva Basso NG, Fonseca MEF; Zuardi JAT; Outanlfi HN
Human T-cell lymphotropic virus type I infection sod pregoancy: A case-control study and U-month follow-up of 135 women and their infants
Ville Y; Delaporte E; Peeters M; Leruez M; Glowaczower E; Femandez H Service de Gynecologie Obstetrique, Departement de Gynecologie-Obstetrique, Hopital Antoine Beclere, 157, Rue de la Porte de Trivaux. 92141 Clamart, FRA
AM J OBSTET GYNECOL 1991 165/5 I (1438-1443) Human T-cell lymphotropic virus type I (HTLV-I) infection is common in Gabon, but its influence on pregnancy is unknown. A single case of acute T-cell leukemia in a pregnant woman has been reported in the literature, but, as far as we know, we present the first case-control study analyzing the relationship between HTLV-I seropositivity and the course and outcome of pregnancy. The study concerned 45 HTLV-I seropositive pregnant women matched with 90 seronegative pregnant women. None has clinical features of HTLV-I infection during pregnancy or during the year after delivery. HTLVI seropositivity did not significantly affect the course or outcome of pregnancy. After losing maternal antibodies to HTLVI, none of the infants had seroconversion to HTLV-I 1 year after birth. Filaria infection was correlated with HTLV-I seropositivity, but confounding factors may account for this observation. Systemic ol-interferon (Wellferon) treatment of genital haman papillomavlrus (HPV) type 6, 11, 16 and 18 infectiolls: Dooble-
Institute Fernandes Figueira. Avenida Ruy Barbosa 716, Rio de
blind, placebo-controlled trial
Janeiro, CEP 22.250, BRA
Yliskoski M; Syrjanen K; Syrjanen S; Saarikoski S; Nethersell A
PLACENTA 1991 12/5 (533-547) The purpose of this study was to identify the possible effect of enteroviruses on placental tissue. Seventy-eight pregnant women were studied throughout their pregnancy: enteroviral infection was detected by fecal viral isolation and seric neutralization of previously identified virus in cell culture. In 19 cases of confirmed maternal infection placentae were examined grossly by optical microscopy immunohistochemical and electron microscopic methods. Ten term placentae from women included in the study with no clinical serological or virological evidence of enteroviral infection were used as control and examined by gross and optical microscopy. In 17 specimens (echoviruscoaxsackievirus) an hematogenous placentitis was suspected on the basis of gross observation. Microscopic lesions were similar to those found in other viral infections with specific features. The nature of the inflammatory reaction pointed to the presence of an acute type of hematogenous placentitis not present in placentae of the control group. The authors (AA) comment on the results and present the hypotheses about the available data: (1) maternal enteroviremia and fecal virus shedding without placental invasion placental damage being an unspecific consequence of infection; Int J Gynecol Obstet 38
Department
of Obstetrics
and Gynecology,
Kuopio
University
Central Hospital, SF-70210 Kuopio, FIN
GYNECOL ONCOL 1991 43/l (55-60) The efficacy of systemic interferon-o! (IFN-onl; Wellferon) treatment on genital human papillomavirus (HPV) infections was studied in a double-blind, placebo-controlled trial. A total of 120 women were randomly allocated to receive either interferon (IFN, n = 60) or placebo (n = 60). In both treatment groups, 15 patients with lesions induced by each of the four HPV types (HPV 6, 11, 16 and 18) were included. The dose of IFN was 1.5 x lo6 IU subcutaneously three times for the first week followed by 3 x lo6 IU three times weekly for a further 6 weeks. The control patients received matching placebo injections. Ten patients (three IFN-treated and seven placebotreated) were lost to follow-up. As determined by colposcopy, cytological and histological examinations and HPV typing (in situ hybridization, ISH), 8 IFN-treated patients (14%) and 11 placebo-treated patients (18%) showed complete response (CR) at the 8th week. The corresponding figures were 22 (37%) and 25 (43%) at the 24th week and 28 (49%) and 25 (49%) at the 52nd week, respectively. The total number of HPV DNA
Citations from the Literature
Pregnancy in a cohort of long-term partners of human immunodefiiiency virus-seropositive hemophiliacs
Kraus EM; Brettler DB; Forsberg AD, Sullivan JL Department
of
Medicine,
Massachusetts-Memorial, 01605, USA
Medical
Center
119 Belmont Street,
of
Central
(2) direct virus-induced injury is not the only possible cause for the lesions: (3) placental enteroviral infection occurred with placental pathology but the virus did not cross the organ as the newborn had no signs of infection.
Worcester, MA
OBSTET GYNECOL 1991 78/5 I (735-738) Since 1981, there have been 17 pregnancies in 12 long-term female sexual partners of human immunodeficiency virus (HIV-1)-seropositive hemophilic men at the New England Hemophilia Center. Eleven of 12 women were seronegative for HIV antibody and one was seropositive. Six of the women followed a specific antibody testing schedule for nine pregnancies. This involved antibody testing at specific points before, during and after pregnancy. All of the seronegative women had at least one negative antibody test at the conclusion of each pregnancy. Fourteen of 16 pregnancies in the seronegative women resulted in live-born infants. The children now range in age from 7 months to 7 years and 8 months and have no signilicant medical problems. The woman found to be seropositive at 8 weeks’gestation of her first pregnancy subsequently delivered an infected infant. In this small group, 11 of 12 women at risk for HIV transmission were able to become pregnant and remain seronegative for HIV antibody. Antibody testing during pregnancy gave the women information on which to base reproductive choices.
Enterovirus associated placental morphology: A light, virological, electron microscopic aad immunohistologic study
Garcia AGP; Da Silva Basso NG, Fonseca MEF; Zuardi JAT; Outanlfi HN
Human T-cell lymphotropic virus type I infection sod pregoancy: A case-control study and U-month follow-up of 135 women and their infants
Ville Y; Delaporte E; Peeters M; Leruez M; Glowaczower E; Femandez H Service de Gynecologie Obstetrique, Departement de Gynecologie-Obstetrique, Hopital Antoine Beclere, 157, Rue de la Porte de Trivaux. 92141 Clamart, FRA
AM J OBSTET GYNECOL 1991 165/5 I (1438-1443) Human T-cell lymphotropic virus type I (HTLV-I) infection is common in Gabon, but its influence on pregnancy is unknown. A single case of acute T-cell leukemia in a pregnant woman has been reported in the literature, but, as far as we know, we present the first case-control study analyzing the relationship between HTLV-I seropositivity and the course and outcome of pregnancy. The study concerned 45 HTLV-I seropositive pregnant women matched with 90 seronegative pregnant women. None has clinical features of HTLV-I infection during pregnancy or during the year after delivery. HTLVI seropositivity did not significantly affect the course or outcome of pregnancy. After losing maternal antibodies to HTLVI, none of the infants had seroconversion to HTLV-I 1 year after birth. Filaria infection was correlated with HTLV-I seropositivity, but confounding factors may account for this observation. Systemic ol-interferon (Wellferon) treatment of genital haman papillomavlrus (HPV) type 6, 11, 16 and 18 infectiolls: Dooble-
Institute Fernandes Figueira. Avenida Ruy Barbosa 716, Rio de
blind, placebo-controlled trial
Janeiro, CEP 22.250, BRA
Yliskoski M; Syrjanen K; Syrjanen S; Saarikoski S; Nethersell A
PLACENTA 1991 12/5 (533-547) The purpose of this study was to identify the possible effect of enteroviruses on placental tissue. Seventy-eight pregnant women were studied throughout their pregnancy: enteroviral infection was detected by fecal viral isolation and seric neutralization of previously identified virus in cell culture. In 19 cases of confirmed maternal infection placentae were examined grossly by optical microscopy immunohistochemical and electron microscopic methods. Ten term placentae from women included in the study with no clinical serological or virological evidence of enteroviral infection were used as control and examined by gross and optical microscopy. In 17 specimens (echoviruscoaxsackievirus) an hematogenous placentitis was suspected on the basis of gross observation. Microscopic lesions were similar to those found in other viral infections with specific features. The nature of the inflammatory reaction pointed to the presence of an acute type of hematogenous placentitis not present in placentae of the control group. The authors (AA) comment on the results and present the hypotheses about the available data: (1) maternal enteroviremia and fecal virus shedding without placental invasion placental damage being an unspecific consequence of infection; Int J Gynecol Obstet 38
Department
of Obstetrics
and Gynecology,
Kuopio
University
Central Hospital, SF-70210 Kuopio, FIN
GYNECOL ONCOL 1991 43/l (55-60) The efficacy of systemic interferon-o! (IFN-onl; Wellferon) treatment on genital human papillomavirus (HPV) infections was studied in a double-blind, placebo-controlled trial. A total of 120 women were randomly allocated to receive either interferon (IFN, n = 60) or placebo (n = 60). In both treatment groups, 15 patients with lesions induced by each of the four HPV types (HPV 6, 11, 16 and 18) were included. The dose of IFN was 1.5 x lo6 IU subcutaneously three times for the first week followed by 3 x lo6 IU three times weekly for a further 6 weeks. The control patients received matching placebo injections. Ten patients (three IFN-treated and seven placebotreated) were lost to follow-up. As determined by colposcopy, cytological and histological examinations and HPV typing (in situ hybridization, ISH), 8 IFN-treated patients (14%) and 11 placebo-treated patients (18%) showed complete response (CR) at the 8th week. The corresponding figures were 22 (37%) and 25 (43%) at the 24th week and 28 (49%) and 25 (49%) at the 52nd week, respectively. The total number of HPV DNA