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Ethylene dodecanedioate
Fragrance raw materials monographs
31S
ETHYLENE DODECANEDIOATE Synonyms: Cyclic ethylene dodecanedioate; Arova 16; Musk 144. CAS Registry No. 54982-83-1 CAS Registry Name: 1,4-Dioxacyclohexadecane-5,16-dione Structure: H2C -- (CH2) s -- CH 2 I l O~C--O--(CH2)2--O--C~O Description: A colourless to pale yellowish oily liquid with a natural mild musk odour. Physical properties: Vapour pressure
< 0.001 mmHg 20°C
[FMA]
Analytical data on the material as tested by RIFM: Acid value Ester value after acetylation Refractive index Specific gravity
1.0 max 420--445 1.462-1.482 (20°C) 1.048-1.068 (25/25°C)
Preparation: By catalytic depolymerization of the linear polyester of ethylene glycol 1,12 dodecane dioic acid. Natural occurrence: Has apparently not been reported to occur in nature.
Biological data Irritation. A 48-hr closed patch test with 20% in petrolatum on the forearms or backs of 25 volunteers produced no irritation (Kligman, 1978). Sensitization. A maximization test (Kligman, 1966; Kligman and Epstein, 1975) was carried out with 20% in petrolatum on 25 volunteers. No reactions were produced (Kligman, 1978). This test concentration was based on a reported maximum concentration of 2.0% in consumer products. Concentrations of 1 and 5% in petrolatum were applied to the forearms of 25 male and female broncho-asthmatic patients for 24 hr under occlusion. No reactions were observed (Takasago, 1977). References Kligman A. M. (1966) The identification of contact allergens by human assay. IIl. The maximization test. A procedure for screening and rating contact scnsitizers. Journal of Investigative Dermatology 47, 393-409. Kligman A. M. (1978) Report to RIFM, 28 February. Kligman A. M. and Epstein W. (1975) Updating the maximization test for identifying contact allergens. Contact Dermatitis 1, 231-239. Takasago Inc. (1977) Private communication to RIFM, 6 December.
31S
ETHYLENE DODECANEDIOATE Synonyms: Cyclic ethylene dodecanedioate; Arova 16; Musk 144. CAS Registry No. 54982-83-1 CAS Registry Name: 1,4-Dioxacyclohexadecane-5,16-dione Structure: H2C -- (CH2) s -- CH 2 I l O~C--O--(CH2)2--O--C~O Description: A colourless to pale yellowish oily liquid with a natural mild musk odour. Physical properties: Vapour pressure
< 0.001 mmHg 20°C
[FMA]
Analytical data on the material as tested by RIFM: Acid value Ester value after acetylation Refractive index Specific gravity
1.0 max 420--445 1.462-1.482 (20°C) 1.048-1.068 (25/25°C)
Preparation: By catalytic depolymerization of the linear polyester of ethylene glycol 1,12 dodecane dioic acid. Natural occurrence: Has apparently not been reported to occur in nature.
Biological data Irritation. A 48-hr closed patch test with 20% in petrolatum on the forearms or backs of 25 volunteers produced no irritation (Kligman, 1978). Sensitization. A maximization test (Kligman, 1966; Kligman and Epstein, 1975) was carried out with 20% in petrolatum on 25 volunteers. No reactions were produced (Kligman, 1978). This test concentration was based on a reported maximum concentration of 2.0% in consumer products. Concentrations of 1 and 5% in petrolatum were applied to the forearms of 25 male and female broncho-asthmatic patients for 24 hr under occlusion. No reactions were observed (Takasago, 1977). References Kligman A. M. (1966) The identification of contact allergens by human assay. IIl. The maximization test. A procedure for screening and rating contact scnsitizers. Journal of Investigative Dermatology 47, 393-409. Kligman A. M. (1978) Report to RIFM, 28 February. Kligman A. M. and Epstein W. (1975) Updating the maximization test for identifying contact allergens. Contact Dermatitis 1, 231-239. Takasago Inc. (1977) Private communication to RIFM, 6 December.