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F282 IMPACT OF CHRONIC LOW BACK PAIN ON BACK MUSCLES PERFORMANCE, FEAR BELIEFS, AND DEPRESSIVE SYMPTOMS: COMPARATIVE STUDY OF TURKISH ELDERLY
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POSTER SESSIONS / European Journal of Pain Supplements 5 (2011) 15–295
F282 IMPACT OF CHRONIC LOW BACK PAIN ON BACK MUSCLES PERFORMANCE, FEAR BELIEFS, AND DEPRESSIVE SYMPTOMS: COMPARATIVE STUDY OF TURKISH ELDERLY E.A. Telci, N. Yagci, T. Can, U. Cavlak *. School of Physiotherapy, Pamukkale University, Denizli, Turkey
Conclusion: MSEP was effective in reducing pain, enhancing psychological parameters and mobility for older persons; use of center-based and home-based modules also encouraged the older people to participate in the self-management of their pain situations. Disclosure: None declared
Background and Aims: Many factors affecting, including chronic low back pain (CLBP) older adults’ activity participation have been established. Back performance is very important factor helping older adults to independently manage their daily living activities. The purposes of this study were: 1. to compare performance level, fear avoidance behaviour, and depressive symptoms in older adults with/without (CLBP); and 2. to determine the relation between pain intensity, performance level, fear avoidance behaviour, and depressive symptoms in older people with CLBP. Methods: Ninety-one participants with CLBP (n = 56; mean age: 71.2±6.4 yr.) or without CLBP (n = 35; mean age: 72.5±7.3 yr.) were evaluated in this study. The Visual Analog Scale (VAS) was used to determine pain intensity. Four tests of the Back Performance Scale (sock test, pick-up test, roll-up test and finger-tofloor test) were used to assess performance. Fear Avoidance Beliefs Questionnaire physical activity scale (FABQ-PA) was also used. Geriatric Depression Scale (GDS) was used to detect depressive symptoms. Results: Participants with CLBP (mean VAS: 5.4±1.9) had higher scores in terms of two performance tests (sock test, pick-up test), fear avoidance beliefs, and depressive symptoms compared to those without CLBP (p < 0.05). While a significant linear correlation between pain intensity and depressive symptoms were seen (p < 0.05), no correlation between pain intensity and the other parameters just evaluated in the study were found (p > 0.05). Conclusions: The findings indicate that emotional status is affected by increased pain intensity rather than back performance or fear avoidance belief in older adults with CLBP. Disclosure: None declared
F283 MULTISENSORY STIMULATION AND EXERCISE PROGRAMME FOR COMMUNITY-DWELLING OLDER PERSONS WITH CHRONIC PAIN M. Tse *. School of Nursing, The Hong Kong Polytechnic University, Hong Kong, Hong Kong S.A.R. Background and Aim: Prevalence of pain among older persons is high, every effort should be made to enhance pain management. This paper reports the pain situations among community-dwelling older adults and the effectiveness of a multisensory stimulation and exercise programme (MSEP) in improving their pain intensity, physical and psychological status. Methods: It was a quasi-experimental pre-test and post-test control study. Two elderly community centres were approached and randomized into an experimental group (with 8-week MSEP) and control group (with usual activities in the centre). The MSEP included centre-based and home-based modules. Centre-based module consisted of 1.5 hours of multisensory stimulation and physical exercise training per week for 8 weeks, while the homebased module encouraged practice of MSEP at home 3 times a week. Data were collected 1 week before and after the MSEP for both groups. Findings: A total of 65 (experimental n = 33; control n = 32) participants completed the study. Moderate pain (experimental: 4.23±1.88, control: 3.39±1.67) was reported. There was a significant reduction in pain intensity to 2.41±0.28 (p < 0.05) in the experimental group, but none in the control group (p > 0.05). Anxiety and depression were reduced, mobility and physical aspects of quality of life improved in the experimental group (p < 0.05), while no such changes in the control group (p > 0.05).
F284 TRANSDERMAL BUPRENORPHINE (NORSPAN® ) PK IN ELDERLY SUBJECTS N. Al-Tawil1 *, H. Johansson2 , I. Odar-Cederlof ¨ 3 , A.-C. Berggren4 , 3 1 J. Persson . Karolinska Trial Alliance M62, Karolinska University Hospital, Stockholm, 2 Department of Geriatric and Medicine, S¨ odert¨ alje Hospital, S¨ odert¨ alje, 3 Karolinska University Hospital, Huddinge, 4 Mundipharma AB, G¨ oteborg, Sweden Background and Aims: The objective of the study was to verify if an elderly age group (≥75 years) has similar pharmacokinetics as a younger age group (50–60 years) treated with buprenorphine transdermal patches, Norspan® . Methods: The study was a single centre, multiple dose, open label, parallel group study in healthy subjects, who were divided into two age groups: younger (50–60 years) and elderly (≥75 years) in a 1:1 ratio. Six PK samples were collected following the second application (Day 7 (pre-dose), Days 8, 9, 10, 12 and 14). PK parameters were calculated based on the plasma concentrations of buprenorphine and norbuprenorphine. Safety was assessed by monitoring AEs and SAEs, laboratory measurements (haematology, clinical chemistry and urinalysis), vital signs, ECG and physical examinations. In total, 72 subjects (36 in each group) were enrolled and analyzed. Results: The results show a similar AUCtau (area under the plasma concentration-time curve measured from the time of dosing over one dosing interval at steady state) of buprenorphine in the ≥75 years group as that in the 50–60 years group. A relatively high level of variability was noted in the individual plasma profiles. The AEs reported during the study were in line with the AEs listed in the SPC of Norspan® . No clinically significant laboratory values or ECG aberrations were reported during the study. Conclusions: This study indicates that there is no age-related additional risk in treating elderly people with Norspan® . Disclosure: This clinical trial was funded by Mundipharma AB. Co-author Anna-Carin Berggren is employed by Mundipharma AB.
F285 EPIDEMIOLOGICAL, CROSS-SECTIONAL, MULTICENTER STUDY TO DESCRIBE THE CHARACTERISTICS OF CHRONIC PAIN AND ITS TREATMENT IN INSTITUTIONALIZED ELDERLY PATIENTS. DOLORES STUDY A. Stern1 *, P. Gil2 . 1 Medical Dpt., Gr¨ unenthal Pharma S.A., 2 Geriatric Dpt., Clinico San Carlos Hospital, Madrid, Spain Background and Aims: Chronic pain is one of the most prevalent symptoms in elderly population. Information about pain characteristics and it’s treatment is of great value for the improvement of a multidisciplinary treatment approach. Objective: To describe the characteristics of pain symptoms and it’s treatment in institutionalized elderly population. Methods: 830 patients have been included and 33 nursing homes participated in this epidemiological, cross sectional, multicenter study. Basic sociodemographic data was collected, as well as pain characteristic and treatment data. Results: Patients had a median age of 85 years and were mostly (75.3%) women. Median length of stay in nursing homes 26 months. 89.5% of patients reported nociceptive pain, mainly affecting the lower limbs (71.7%) and back (54.8%). Patients without cognitive impairment referred pain intensity as moderate (42%) or severe (38.7%), while patients with suspected cognitive impairment
POSTER SESSIONS / European Journal of Pain Supplements 5 (2011) 15–295
F282 IMPACT OF CHRONIC LOW BACK PAIN ON BACK MUSCLES PERFORMANCE, FEAR BELIEFS, AND DEPRESSIVE SYMPTOMS: COMPARATIVE STUDY OF TURKISH ELDERLY E.A. Telci, N. Yagci, T. Can, U. Cavlak *. School of Physiotherapy, Pamukkale University, Denizli, Turkey
Conclusion: MSEP was effective in reducing pain, enhancing psychological parameters and mobility for older persons; use of center-based and home-based modules also encouraged the older people to participate in the self-management of their pain situations. Disclosure: None declared
Background and Aims: Many factors affecting, including chronic low back pain (CLBP) older adults’ activity participation have been established. Back performance is very important factor helping older adults to independently manage their daily living activities. The purposes of this study were: 1. to compare performance level, fear avoidance behaviour, and depressive symptoms in older adults with/without (CLBP); and 2. to determine the relation between pain intensity, performance level, fear avoidance behaviour, and depressive symptoms in older people with CLBP. Methods: Ninety-one participants with CLBP (n = 56; mean age: 71.2±6.4 yr.) or without CLBP (n = 35; mean age: 72.5±7.3 yr.) were evaluated in this study. The Visual Analog Scale (VAS) was used to determine pain intensity. Four tests of the Back Performance Scale (sock test, pick-up test, roll-up test and finger-tofloor test) were used to assess performance. Fear Avoidance Beliefs Questionnaire physical activity scale (FABQ-PA) was also used. Geriatric Depression Scale (GDS) was used to detect depressive symptoms. Results: Participants with CLBP (mean VAS: 5.4±1.9) had higher scores in terms of two performance tests (sock test, pick-up test), fear avoidance beliefs, and depressive symptoms compared to those without CLBP (p < 0.05). While a significant linear correlation between pain intensity and depressive symptoms were seen (p < 0.05), no correlation between pain intensity and the other parameters just evaluated in the study were found (p > 0.05). Conclusions: The findings indicate that emotional status is affected by increased pain intensity rather than back performance or fear avoidance belief in older adults with CLBP. Disclosure: None declared
F283 MULTISENSORY STIMULATION AND EXERCISE PROGRAMME FOR COMMUNITY-DWELLING OLDER PERSONS WITH CHRONIC PAIN M. Tse *. School of Nursing, The Hong Kong Polytechnic University, Hong Kong, Hong Kong S.A.R. Background and Aim: Prevalence of pain among older persons is high, every effort should be made to enhance pain management. This paper reports the pain situations among community-dwelling older adults and the effectiveness of a multisensory stimulation and exercise programme (MSEP) in improving their pain intensity, physical and psychological status. Methods: It was a quasi-experimental pre-test and post-test control study. Two elderly community centres were approached and randomized into an experimental group (with 8-week MSEP) and control group (with usual activities in the centre). The MSEP included centre-based and home-based modules. Centre-based module consisted of 1.5 hours of multisensory stimulation and physical exercise training per week for 8 weeks, while the homebased module encouraged practice of MSEP at home 3 times a week. Data were collected 1 week before and after the MSEP for both groups. Findings: A total of 65 (experimental n = 33; control n = 32) participants completed the study. Moderate pain (experimental: 4.23±1.88, control: 3.39±1.67) was reported. There was a significant reduction in pain intensity to 2.41±0.28 (p < 0.05) in the experimental group, but none in the control group (p > 0.05). Anxiety and depression were reduced, mobility and physical aspects of quality of life improved in the experimental group (p < 0.05), while no such changes in the control group (p > 0.05).
F284 TRANSDERMAL BUPRENORPHINE (NORSPAN® ) PK IN ELDERLY SUBJECTS N. Al-Tawil1 *, H. Johansson2 , I. Odar-Cederlof ¨ 3 , A.-C. Berggren4 , 3 1 J. Persson . Karolinska Trial Alliance M62, Karolinska University Hospital, Stockholm, 2 Department of Geriatric and Medicine, S¨ odert¨ alje Hospital, S¨ odert¨ alje, 3 Karolinska University Hospital, Huddinge, 4 Mundipharma AB, G¨ oteborg, Sweden Background and Aims: The objective of the study was to verify if an elderly age group (≥75 years) has similar pharmacokinetics as a younger age group (50–60 years) treated with buprenorphine transdermal patches, Norspan® . Methods: The study was a single centre, multiple dose, open label, parallel group study in healthy subjects, who were divided into two age groups: younger (50–60 years) and elderly (≥75 years) in a 1:1 ratio. Six PK samples were collected following the second application (Day 7 (pre-dose), Days 8, 9, 10, 12 and 14). PK parameters were calculated based on the plasma concentrations of buprenorphine and norbuprenorphine. Safety was assessed by monitoring AEs and SAEs, laboratory measurements (haematology, clinical chemistry and urinalysis), vital signs, ECG and physical examinations. In total, 72 subjects (36 in each group) were enrolled and analyzed. Results: The results show a similar AUCtau (area under the plasma concentration-time curve measured from the time of dosing over one dosing interval at steady state) of buprenorphine in the ≥75 years group as that in the 50–60 years group. A relatively high level of variability was noted in the individual plasma profiles. The AEs reported during the study were in line with the AEs listed in the SPC of Norspan® . No clinically significant laboratory values or ECG aberrations were reported during the study. Conclusions: This study indicates that there is no age-related additional risk in treating elderly people with Norspan® . Disclosure: This clinical trial was funded by Mundipharma AB. Co-author Anna-Carin Berggren is employed by Mundipharma AB.
F285 EPIDEMIOLOGICAL, CROSS-SECTIONAL, MULTICENTER STUDY TO DESCRIBE THE CHARACTERISTICS OF CHRONIC PAIN AND ITS TREATMENT IN INSTITUTIONALIZED ELDERLY PATIENTS. DOLORES STUDY A. Stern1 *, P. Gil2 . 1 Medical Dpt., Gr¨ unenthal Pharma S.A., 2 Geriatric Dpt., Clinico San Carlos Hospital, Madrid, Spain Background and Aims: Chronic pain is one of the most prevalent symptoms in elderly population. Information about pain characteristics and it’s treatment is of great value for the improvement of a multidisciplinary treatment approach. Objective: To describe the characteristics of pain symptoms and it’s treatment in institutionalized elderly population. Methods: 830 patients have been included and 33 nursing homes participated in this epidemiological, cross sectional, multicenter study. Basic sociodemographic data was collected, as well as pain characteristic and treatment data. Results: Patients had a median age of 85 years and were mostly (75.3%) women. Median length of stay in nursing homes 26 months. 89.5% of patients reported nociceptive pain, mainly affecting the lower limbs (71.7%) and back (54.8%). Patients without cognitive impairment referred pain intensity as moderate (42%) or severe (38.7%), while patients with suspected cognitive impairment