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Fetal nanosomia and bone athrepsia in the newborn of a woman with a severe cyanotic cardiovascular anomaly
Volume 59 Number 3
PETAL NANOSOMIA AND BONE ATHREPSIA
661
fetus and newborn, such a relationship does not usually express itself in recognizable bone changes. The bone lesion of Case 5377 resembles, in some respects, those ascribed to experimental inanition of many types. 4 For want of a better explanation, it is suggested that the intrauterine hypoxemia may have resulted in an inability of the fetus to utilize all of its available nutrients, resulting not only in nanosomia, but also in prenatal athrepsia of bone. Summary 1. The case history and autopsy findings of a term infant weighing 1,400 grams, the child of a lifelong cyanotic woman suffering a cardiovascular anomaly, are presented. 2. A histologically nonspecific lesion, athrepsia of rib and femur, is described. 3. The nanosomia, as well as intrauterine osseous change, is ascribed to fetal hypoxemia. 4. Among 86 fetuses, stillborns and newborns, no qualitative difference in hone formation could he detected between the smallest and largest individuals of a given age group between five and nine months' gestation.
References 1. (a) Burke, B. S., Harting, V. V., and Stuart, H. C.: J. Pediat. 23: 506, 1943. (b) Stuart, H. C.: Pede ration Proc. 4: 271, 1945. (c) Stuart, H. C.: New England J. Med. 236: 507,537, 1947. 2. (a) Warkany, J., and Nelson, R. C.: Arch. Path. 34: 375, 1942. (b) Warkany, J.: J. Pediat. 25: 476, 1944. 3. Stander, H. J.: Textbook of Obstetrics, 3rd revision, New York, 1945, D. AppletonCentury Company, pp. 131, 132. 4. (a) Levy, B. M., and Silberberg, R.: Proc. Soc. Exper. Biol. & Med. 63: 355, 1946. (b) Levy, B. M., and Silberberg, R.: Proc. Soc. Exper. Bioi. & Med. 63: 380, 1946. (c) Silberberg, M., and Silberberg, R.: Arch. Path. 30: 675, 1940. (d) Harris, H. A., Neuberger, A., and Sanger, P.: Biochem. J. 37: 508 1 1943. (e) Gillespie, M., Neuberger, A., and Webster, T. A.: Biochem. J. 39: 203, 1945.
Villafane, Ignacio z.: Abdominal Puncture in the Diagnosis and Treatment of Acute Pelvic Peritonitis, Prensa med. argent. 33: 1446, 1946. The author, after classifying variations of pelvic peritonitis anent its etiology, pathology, and pathological anatomy, suggests this condition may be not only diagnosed but treated directly through abdominal puncture. He illustrates his principle with a case. After injection of 1.0 c.c. of Novocain, 0.5 per cent, midway on a line between the umbilicus and the superior border of the pubic bone, he introduces a trocar needle slowly into the pelvic region. Seropurulent material is removed for culture. The infected cavity is irrigated with a solution containing 6 to 10 Gm. of a sulfonamide. Single injections of 8 Gm. are repeated every twenty-four to forty-eight hours. Aside from a short interval of slight pain and discomfort the patients show a favorable and relatively rapid clinical response. One graphic. C. E. FOLSOME. temperature record is illustrated.
PETAL NANOSOMIA AND BONE ATHREPSIA
661
fetus and newborn, such a relationship does not usually express itself in recognizable bone changes. The bone lesion of Case 5377 resembles, in some respects, those ascribed to experimental inanition of many types. 4 For want of a better explanation, it is suggested that the intrauterine hypoxemia may have resulted in an inability of the fetus to utilize all of its available nutrients, resulting not only in nanosomia, but also in prenatal athrepsia of bone. Summary 1. The case history and autopsy findings of a term infant weighing 1,400 grams, the child of a lifelong cyanotic woman suffering a cardiovascular anomaly, are presented. 2. A histologically nonspecific lesion, athrepsia of rib and femur, is described. 3. The nanosomia, as well as intrauterine osseous change, is ascribed to fetal hypoxemia. 4. Among 86 fetuses, stillborns and newborns, no qualitative difference in hone formation could he detected between the smallest and largest individuals of a given age group between five and nine months' gestation.
References 1. (a) Burke, B. S., Harting, V. V., and Stuart, H. C.: J. Pediat. 23: 506, 1943. (b) Stuart, H. C.: Pede ration Proc. 4: 271, 1945. (c) Stuart, H. C.: New England J. Med. 236: 507,537, 1947. 2. (a) Warkany, J., and Nelson, R. C.: Arch. Path. 34: 375, 1942. (b) Warkany, J.: J. Pediat. 25: 476, 1944. 3. Stander, H. J.: Textbook of Obstetrics, 3rd revision, New York, 1945, D. AppletonCentury Company, pp. 131, 132. 4. (a) Levy, B. M., and Silberberg, R.: Proc. Soc. Exper. Biol. & Med. 63: 355, 1946. (b) Levy, B. M., and Silberberg, R.: Proc. Soc. Exper. Bioi. & Med. 63: 380, 1946. (c) Silberberg, M., and Silberberg, R.: Arch. Path. 30: 675, 1940. (d) Harris, H. A., Neuberger, A., and Sanger, P.: Biochem. J. 37: 508 1 1943. (e) Gillespie, M., Neuberger, A., and Webster, T. A.: Biochem. J. 39: 203, 1945.
Villafane, Ignacio z.: Abdominal Puncture in the Diagnosis and Treatment of Acute Pelvic Peritonitis, Prensa med. argent. 33: 1446, 1946. The author, after classifying variations of pelvic peritonitis anent its etiology, pathology, and pathological anatomy, suggests this condition may be not only diagnosed but treated directly through abdominal puncture. He illustrates his principle with a case. After injection of 1.0 c.c. of Novocain, 0.5 per cent, midway on a line between the umbilicus and the superior border of the pubic bone, he introduces a trocar needle slowly into the pelvic region. Seropurulent material is removed for culture. The infected cavity is irrigated with a solution containing 6 to 10 Gm. of a sulfonamide. Single injections of 8 Gm. are repeated every twenty-four to forty-eight hours. Aside from a short interval of slight pain and discomfort the patients show a favorable and relatively rapid clinical response. One graphic. C. E. FOLSOME. temperature record is illustrated.