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Fluorine and its compounds. By R. N. haszeldine and A. G. Sharpe. John Wiley & Sons, Inc., New York, 1951. 153 pp. 11 × 17 cm. Price $1.75
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Book Reviews
Medicinal Chemistry. Vol. 11. By ALFRED BURGER. Interscience Publishers, Inc., Kew York, 1951. xv 4-506 pp. 16 x 23.5 cm. Price $10. This is the second of two volumes of a treatise on medicinal chemistry by Alfred Burger of the Department of Chemistry of the University of Virginia. The first volume, published in 1951, was described and reviewed earlier [THIS JOURNAL, 40,417(1951)]. The second volume is a continuation of the first, in which the major part is devoted to drugs used in the chemotherapy of diseases caused by pathogenic organisms. In addition, however, chapters on the chemistry of the hormones and their uses in medicine, chemotherapy, and theories of metabolite antagonism are included. The chapter on theories of metabolite antagonism is written with unusual clarity and conciseness. The chapters on dyestuffs in chemotherapy, the sulfonamide drugs, antimalarials, metal-free drugs used in tropical diseases, antibiotics, antifungal agents, anthelmintics, organometallic chemotherapeutic compounds of arsenic, antimony and bismuth, and antiseptics, are all handled adequately and with Professor Burger’s customary skill. In the several fields covered, the available literature relating thereto was reviewed completely up to 1951. Thus with the publication of the second volume of MedicinaE Chemistry. a modern, usable, and essentially upto-date treatise on the subject has been made available. One of the greatest technical difficulties in the preparation of a book of the type of dsfedicinal Chemistry is the preparation of an adequate subject index. The subject index to Volumes I and I1 represents a real accomplishment. This index, consisting of 57 pages, includes a sufficient number of entries so that no difficulty is experienced in quickly locating information on any phase of the subject covered. Professor Burger’s book should have ready acceptance, both as a textbook and a reference, by all who are interested in any phase of medicinal chemistry.
A Study o j Antimetabolztcs. By D. W. WOOLLEE‘. John Wiley & Sons, Inc., New York, 1952. xiii 269 pp. 15 5 x 23.5 cm. Price $5. The author of this book, Dr. D. W. Woolley of the Rockefeller Institute for Medical Research, has presented a logical, modern, and thoroughly intelligible account of experimental rcsults which have been accumulated during the past ten or fifteen years on antimetabolites. A knowledge of this subject may contribute to an understanding of many unanswered problems in pharmacology, chemotherapy, and biochemistry. For this reason the book should be of special interest to pharmaceutical chemists and pharmacologists. The introduction alone serves admirably to orient the reader to the subject of antimetabolites. The book presents a thorough discussion of the antagonisms between structurally related compounds and original concepts concerning the nature of antimetabolic action, and points the way to the application of that concept to solve problems in chemotherapy, biochemistry, and pharmacology. Among other features, the book includes a tabulation of antiIIletdbOliteS acting against many constituents of living cells, The value of the book is enhanced by a bibliography of 500 references to the original literature. It is also provided with an index of structural formulas and an adequate subject index. The printing and binding are of excellent quality.
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Substances Naturelles de Syntkese. Vol. 111. By LEON VELLUZ. Masson e t Cie, Paris, 1951. 156 pp. 16 x 23.3 cm. Price 1500 fr. The same authors (J. Mathieu, A. Petit, and P. Poirier) have collaborated with Dr. Velluz in the three volumes of this series and the same style is carried on. The review of the first two volumes [THIS JOURNAL, 40, 534(1951)] described the arrangement of the text. Detailed descriptions of the important methods of syntheses with summaries of other methods are given for the following compounds : m-glutamic acid, DL-dihydroxyphenylalanine (DOPA), estradiol. DL-ornithine, and thiamine. The syntheses of equiIenine, estrone, and oxythiamine are discussed. Fluorine and Its Compounds. By R. N. HASZELDINE Rcdctions involving the thiazole ring, especially and A. G. SHARPE.John Wiley & Sons, Inc., the mono- and dimolecular condensations, and parNew York, 1951. 153 pp. 11 x 17 em. Price ticularly the benzothiazoles, are discussed. Reac$1.75. tion schemes and references are tabulated. Methods of syntheses of amino-acids are discussed and the reThis little book is a convenient review of the history and development of the chemistry of fluorine actions and references are tabulated. The procedures used in the determination of meltup to 1950. The authors compiled this concise ing points and the practical utilization of this physimonograph during the same period that a much more comprehensive treatise was being prepared by C. cal property are discussed. Slesser and S. R. Schram [reviewed in THISJOURNAL, A more detailed table of contents giving the ititermediate compounds in the detailed syntheses, in 41,58( 1952)]. Dr. Haszeldine’s intimate association with the subject matter covered in his text is indi- addition to author and subject indexes, is appended. This series of books should be available to everycated by the fact that 13 of the 91 references are to one interested in the synthesis of organic compounds. his publications. An index is appended. 167
Book Reviews
Medicinal Chemistry. Vol. 11. By ALFRED BURGER. Interscience Publishers, Inc., Kew York, 1951. xv 4-506 pp. 16 x 23.5 cm. Price $10. This is the second of two volumes of a treatise on medicinal chemistry by Alfred Burger of the Department of Chemistry of the University of Virginia. The first volume, published in 1951, was described and reviewed earlier [THIS JOURNAL, 40,417(1951)]. The second volume is a continuation of the first, in which the major part is devoted to drugs used in the chemotherapy of diseases caused by pathogenic organisms. In addition, however, chapters on the chemistry of the hormones and their uses in medicine, chemotherapy, and theories of metabolite antagonism are included. The chapter on theories of metabolite antagonism is written with unusual clarity and conciseness. The chapters on dyestuffs in chemotherapy, the sulfonamide drugs, antimalarials, metal-free drugs used in tropical diseases, antibiotics, antifungal agents, anthelmintics, organometallic chemotherapeutic compounds of arsenic, antimony and bismuth, and antiseptics, are all handled adequately and with Professor Burger’s customary skill. In the several fields covered, the available literature relating thereto was reviewed completely up to 1951. Thus with the publication of the second volume of MedicinaE Chemistry. a modern, usable, and essentially upto-date treatise on the subject has been made available. One of the greatest technical difficulties in the preparation of a book of the type of dsfedicinal Chemistry is the preparation of an adequate subject index. The subject index to Volumes I and I1 represents a real accomplishment. This index, consisting of 57 pages, includes a sufficient number of entries so that no difficulty is experienced in quickly locating information on any phase of the subject covered. Professor Burger’s book should have ready acceptance, both as a textbook and a reference, by all who are interested in any phase of medicinal chemistry.
A Study o j Antimetabolztcs. By D. W. WOOLLEE‘. John Wiley & Sons, Inc., New York, 1952. xiii 269 pp. 15 5 x 23.5 cm. Price $5. The author of this book, Dr. D. W. Woolley of the Rockefeller Institute for Medical Research, has presented a logical, modern, and thoroughly intelligible account of experimental rcsults which have been accumulated during the past ten or fifteen years on antimetabolites. A knowledge of this subject may contribute to an understanding of many unanswered problems in pharmacology, chemotherapy, and biochemistry. For this reason the book should be of special interest to pharmaceutical chemists and pharmacologists. The introduction alone serves admirably to orient the reader to the subject of antimetabolites. The book presents a thorough discussion of the antagonisms between structurally related compounds and original concepts concerning the nature of antimetabolic action, and points the way to the application of that concept to solve problems in chemotherapy, biochemistry, and pharmacology. Among other features, the book includes a tabulation of antiIIletdbOliteS acting against many constituents of living cells, The value of the book is enhanced by a bibliography of 500 references to the original literature. It is also provided with an index of structural formulas and an adequate subject index. The printing and binding are of excellent quality.
+
Substances Naturelles de Syntkese. Vol. 111. By LEON VELLUZ. Masson e t Cie, Paris, 1951. 156 pp. 16 x 23.3 cm. Price 1500 fr. The same authors (J. Mathieu, A. Petit, and P. Poirier) have collaborated with Dr. Velluz in the three volumes of this series and the same style is carried on. The review of the first two volumes [THIS JOURNAL, 40, 534(1951)] described the arrangement of the text. Detailed descriptions of the important methods of syntheses with summaries of other methods are given for the following compounds : m-glutamic acid, DL-dihydroxyphenylalanine (DOPA), estradiol. DL-ornithine, and thiamine. The syntheses of equiIenine, estrone, and oxythiamine are discussed. Fluorine and Its Compounds. By R. N. HASZELDINE Rcdctions involving the thiazole ring, especially and A. G. SHARPE.John Wiley & Sons, Inc., the mono- and dimolecular condensations, and parNew York, 1951. 153 pp. 11 x 17 em. Price ticularly the benzothiazoles, are discussed. Reac$1.75. tion schemes and references are tabulated. Methods of syntheses of amino-acids are discussed and the reThis little book is a convenient review of the history and development of the chemistry of fluorine actions and references are tabulated. The procedures used in the determination of meltup to 1950. The authors compiled this concise ing points and the practical utilization of this physimonograph during the same period that a much more comprehensive treatise was being prepared by C. cal property are discussed. Slesser and S. R. Schram [reviewed in THISJOURNAL, A more detailed table of contents giving the ititermediate compounds in the detailed syntheses, in 41,58( 1952)]. Dr. Haszeldine’s intimate association with the subject matter covered in his text is indi- addition to author and subject indexes, is appended. This series of books should be available to everycated by the fact that 13 of the 91 references are to one interested in the synthesis of organic compounds. his publications. An index is appended. 167