FREQUENCY AND PROGNOSTIC IMPORTANCE OF TRANSLOCATION (6;9) (MYB-NFIB GENES) IN HEAD AND NECK ADENOID CYSTIC CARCINOMA: A SYSTEMATIC REVIEW

OOOO Volume 129, Number 1 Study Design: MEDLINE/PubMed, EMBASE, Web of Science, and Scopus electronic databases were searched to identify relevant articles published up to December 2017. A manual search of bibliographies and reference lists of the included studies were also performed. Results: Initially, 661 studies were gathered and 11 met the inclusion criteria (10 in vitro; 1 in vivo). Evaluated outcomes of the studies were mitotic index, cell proliferation, cell cycle analysis, apoptosis assay, proteins analysis, and morphologic examination. Five (50%) out of 10 in vitro studies demonstrated increased cell proliferation or stimulatory effect; 4 demonstrated inhibition, no proliferation, or lower levels of cell viability and 1 showed a decreased pro-osteoclastogenic potential of the cell lines studied after PBM. The in vivo study concluded that PBM inhibited tumor progression. Laser parameters were poorly described in the majority of the studies. Conclusions: There are a broad variation in the methodologies and controversial results regarding the effects of PBM on HNSCC cells. No clear conclusions could be obtained because of the scarce number of publications. Clinical trials and further in vivo studies are strongly recommended.

FREQUENCY AND PROGNOSTIC IMPORTANCE OF TRANSLOCATION (6;9) (MYBNFIB GENES) IN HEAD AND NECK ADENOID CYSTIC CARCINOMA: A SYSTEMATIC REVIEW. YASMIN DIAS DE ALMEIDA PINTO, SARA FERREIRA DOS SANTOS COSTA, BRUNO AUGUSTO BENEVENUTO DE ANDRADE, ALBINA ALTEMANI, e PABLO AGUSTIN VARGAS, LUCAS GUIMARAES ABREU and, FELIPE PAIVA FONSECA Objective: To carry out a systematic review to address the prevalence and the prognostic potential of translocation (6;9) (MYB-NFIB genes) mutation in head and neck adenoid cystic carcinoma (AdCC). Study Design: Articles published were retrieved from multiple databases using specific search strategies. They were screened and articles included had their data extracted by 2 authors who latter assessed the risk of bias of each study. Quantitative analysis was done to determine the incidence of the translocation. Results: A total of 1107 articles were initially retrieved with 36 remaining for data extraction. The presence of t(6;9)(MYB-NFIB) translocation varied significantly, especially due to methodologic heterogeneity among studies. The meta-analysis revealed a range from 16% to 100% in the prevalence of the translocation. A total of 11 studies attempted to determine the prognostic importance of the mutation, but no study found any significant association with survival rates and only 3 studies observed a significant association with age, sex, tumor location, and the presence of recurrences and metastases. Conclusions: The prevalence of t(6;9)(MYB-NFIB) translocation in head and neck AdCC varies according to the laboratory methods used and the best evidence available demonstrate that t(6;9)(MYB-NFIB) is not a prognostic determinant. Support: CNPq and FAPEMIG.

ORAL CANCER EPIDEMIOLOGY IN PATIENTS ADMITTED TO AN ONCOLOGY HOSPITAL. MILENA THAYS MATIAS DOS

ABSTRACTS

e147

SANTOS, LUCAS EMMANUELL DE MORAIS NEVES, SANDRA APARECIDA MARINHO, SMYRNA LUIZA  XIMENES DE SOUZA, SERGIO HENRIQUE GONCALVES ¸ DE CARVALHO, DMITRY JOSE DE SANTANA SARMENTO and, GUSTAVO GOMES AGRIPINO Objective: The aim of this study was to verify the prevalence of oral cancer in patients admitted to a referral oncology hospital. Study Design: Cross-sectional and descriptive study, in which 166 patients diagnosed with cancer were examined. Results: Of the admitted patients, there was a prevalence of males (64.5%) with an average age of 51.7 years and nonwhite color (59%). Among the various types of cancer, acute leukemia (34.9%) was the most prevalent, followed by lymphomas (16.9%), pharynx and larynx (7.8%), mouth (6%), lung (6%), and head and neck cancer (6%). Chemotherapy was the most prescribed (58.4%) therapeutic approach, followed by its association with radiotherapy (18.7%), and only radiotherapy (9.6%). Radiotherapy was the most used treatment for oral cancer. Conclusions: In the evaluated sample, oral cancer was the fourth most prevalent type, predominating for the sixth decade of life, in a ratio of 4 males to 1 female. Radiotherapy was the most-used treatment. Financial support: PIBIC.

GENETIC RISK FACTORS FOR NONSYNDROMIC CLEFT LIP WITH OR WITHOUT CLEFT PALATE IN THE BRAZILIAN POPULATION. RENATO ASSIS MACHADO, EVELYN NAVARRO  NOGUEIRA, HERCILIO MARTELLI JUNIOR, SILVIA REGINA DE ALMEIDA REIS, DARLENE CAMATI PERSUHN and, RICARDO D. COLETTA Objective: To evaluate the reported genome-wide risk loci in a Brazilian sample of nonsyndromic cleft lip with or without cleft palate (NSCL§P). Study Design: Single nucleotide polymorphisms (SNPs) rs7552 (2 q24.2), rs8049367 (16 p13.3), rs1880646, rs7406226, rs9891446 (17 p13), rs1588366 (17 q23.2), and rs73039426 (19 q13.11) were genotyped using TaqMan allelic discrimination assays in an ancestry-structured case-control study containing 831 NSCL§P patients and 866 healthy controls. Results: Logistic regression analysis of the singlemarkers revealed rs7552 as a susceptibility risk marker for NSCL§P, yielding an odds ratio (OR) of 1.71 (95% confidence interval [CI]: 1.31-2.24, P = 9 £ 10-6) in the homozygous state. Several SNP-SNP interactions containing rs7552 reached significance after adjustment for multiple tests (both Bonferroni assumption and 1000 permutation test), with the most significant interaction involving the 3-loci among rs7552, rs9891446, and rs73039426 (P = 6.1 £ 10-9 and p1000 permutation = 0.001). Conclusion: Our study is the first to support the association of rs7552 in 2 p24.2 with NSCL§P in the highly admixed Brazilian population.

INTRAORAL LIPOMAS: A RETROSPECTIVE  STUDY OF 43 CASES. AUGUSTO CESAR LEAL DA SILVA LEONEL, MATHEUS FERREIRA LINARES, KAMILLA KARLA MAURICIO PASSOS, ELAINE JUDITE DE AMORIM CARVALHO,