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GENDER DIFFERENCE IN REGRESSION OF MYOCARDIAL HYPERTROPHY AFTER AORTIC VALVE REPLACEMENT
A1334 JACC March 17, 2015 Volume 65, Issue 10S
Non Invasive Imaging (Echocardiography, Nuclear, PET, MR and CT) Gender Difference in Regression of Myocardial Hypertrophy After Aortic Valve Replacement Poster Contributions Poster Hall B1 Monday, March 16, 2015, 9:45 a.m.-10:30 a.m. Session Title: Non Invasive Imaging: Advances in Clinical Non-Invasive Imaging Abstract Category: 17. Non Invasive Imaging: Echo Presentation Number: 1243-046 Authors: Kumiko Hirata, Makoto Orii, Yasutsugu Shiono, Takashi Yamano, Yoshiki Matsuo, Yasushi Ino, Tomoyuki Yamaguchi, Takashi Kubo, Atsushi Tanaka, Takashi Akasaka, Wakayma Medical University, Wakayama, Japan
Background: In patients with aortic stenosis (AS), pressure overload induces cardiac hypertrophy and fibrosis. Although male sex influences cardiac remodeling and fibrosis in animal models, sex differences in left ventricular (LV) hypertrophy regression after aortic valve replacement (AVR) have not yet been fully studied. Methods: We prospectively performed echocardiography before and 2 weeks, 3 and 6 months after AVR in 47 patients, 28 women and 19 men, undergoing AVR for isolated AS. Magnetic resonance imaging (MRI) was also performed before surgery to assess delayed enhancement (DE) as myocardial fibrosis.
Results: Preoperatively, women and men had similar LV ejection fraction (56 and 59%) and mass index (142 and 148g/m²). Postoperatively, there was no difference in effective valvular orifice area index and transvalvular pressure gradient between men and women. Two weeks after operation, LV mass in women quickly regressed to 119 g/m², while increased LV mass in men still persisted (131g/m²). LV mass in men was gradually decreased (121g/m²) to the same level of women 6 months after operation. Cardiac MRI revealed that DE was more frequently found in men (12, 43%) compared with women (4, 21%, p=0.045). Atrial fibrillation was more frequently appeared in men (13, 68%) compared with women (12, 36%, p=0.028) during hospitalization.
Conclusion: Women adapt to pressure regression quickly, while men caught up to women 6 months after operation, resulting in a lower frequency of atrial fibrillation in women.
Non Invasive Imaging (Echocardiography, Nuclear, PET, MR and CT) Gender Difference in Regression of Myocardial Hypertrophy After Aortic Valve Replacement Poster Contributions Poster Hall B1 Monday, March 16, 2015, 9:45 a.m.-10:30 a.m. Session Title: Non Invasive Imaging: Advances in Clinical Non-Invasive Imaging Abstract Category: 17. Non Invasive Imaging: Echo Presentation Number: 1243-046 Authors: Kumiko Hirata, Makoto Orii, Yasutsugu Shiono, Takashi Yamano, Yoshiki Matsuo, Yasushi Ino, Tomoyuki Yamaguchi, Takashi Kubo, Atsushi Tanaka, Takashi Akasaka, Wakayma Medical University, Wakayama, Japan
Background: In patients with aortic stenosis (AS), pressure overload induces cardiac hypertrophy and fibrosis. Although male sex influences cardiac remodeling and fibrosis in animal models, sex differences in left ventricular (LV) hypertrophy regression after aortic valve replacement (AVR) have not yet been fully studied. Methods: We prospectively performed echocardiography before and 2 weeks, 3 and 6 months after AVR in 47 patients, 28 women and 19 men, undergoing AVR for isolated AS. Magnetic resonance imaging (MRI) was also performed before surgery to assess delayed enhancement (DE) as myocardial fibrosis.
Results: Preoperatively, women and men had similar LV ejection fraction (56 and 59%) and mass index (142 and 148g/m²). Postoperatively, there was no difference in effective valvular orifice area index and transvalvular pressure gradient between men and women. Two weeks after operation, LV mass in women quickly regressed to 119 g/m², while increased LV mass in men still persisted (131g/m²). LV mass in men was gradually decreased (121g/m²) to the same level of women 6 months after operation. Cardiac MRI revealed that DE was more frequently found in men (12, 43%) compared with women (4, 21%, p=0.045). Atrial fibrillation was more frequently appeared in men (13, 68%) compared with women (12, 36%, p=0.028) during hospitalization.
Conclusion: Women adapt to pressure regression quickly, while men caught up to women 6 months after operation, resulting in a lower frequency of atrial fibrillation in women.