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GW27-e0451 Protein Z plasma levels in patients with myocardial infarction
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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, VOL. 68, NO. 16, SUPPL S, 2016
collected between January 2013 and December 2014 in Shanghai, China. Poisson regression models incorporating natural spline smooth functions (generalized linear models, GLM) were used to adjust for long-term, seasonal trends and weekend effect, public holiday, as wells as other confounding factors. The associations among particulate air pollution and the number of cardiovascular diseases stratified by temperature were identified. RESULTS A total of 9, 906, 835 hospital patients of cardiovascular diseases were identified during study period. The primary pollutants were PM2.5, PM10, SO2 and NO2, and their average daily concentrations were 56.3 mg/m3, 76 mg/m3, 20.6 mg/m3 and 46.7 mg/m3, respectively. Cardiovascular incidence showed an association with temperature, the relative risks (RR) of cardiovascular incidence is 1.016 (95% CI: 1.013, 1.018) (-18 C versus 18 C). Significant correlations were showed between hospital patients and concentrations of each primary pollutant, respectively. In warm-season, with a 10-mg/m3 increase in concentrations of PM2.5, PM10, SO2 or NO2, percentages of outpatient and emergency patient of cardiovascular diseases increased by 0.502% (95% CI: 0.464%, 0.545%), 0.251% (95% CI: 0.221%, 0.282%), 2.716% (95% CI: 2.558%, 2.874%), 1.496% (95% CI: 1.421%, 1.571%), respectively. In those cold-season, the corresponding values were 0.543%(95% CI: 0.521%,0.570%), 0.568% (95% CI: 0.548%, 0.587%), 1.607%(95%CI:1.528%,1.685%), 1.923%(95%CI: 1.868%, 1.978%), respectively. Furthermore, each primary pollutant had different lag effect on hospital patients. CONCLUSIONS Low temperature increased daily numbers of hospital patients of cardiovascular diseases; Daily numbers of hospital patients increased with the increases in concentrations of daily primary air pollutants after adjusting some confounding factors. GW27-e0894 Combination of Blood pressure, left atrium size and serum total bilirubin level at admission predicts risk of 3-year’s clinical outcomes in nonischemic cardiomyopathy patients Li Xiaofei, Sun Wei, Yao Yan, Lu Minjie, Hua Wei, Zhang Shu, Fan Xiaohan State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences OBJECTIVES The present study aimed to determine whether the combination of clinical risk factors may improve the prognostic value for clinical outcomes in non-ischemic cardiomyopathy (NICM) patients. METHODS A total of 215 NICM patients in Fuwai hospital from December 2010 to April 2013 were prospectively enrolled in this cohort. Patients with known obstructive coronary heart disease, valvar heart disease, and hypertensive heart disease were excluded from this study. Baseline blood pressure, blood samples and left atrium size (by echocardiography) were obtained at admission. Patients were followed up by phone and clinical visits. The primary endpoint was defined as the composite of cardiovascular death, deterioration of heart failure (HF) for hospitalization heart transplantation and appropriate ICD therapy. RESULTS Of all the patients with NICM, 78.6% was male, the mean age was 3712 years; and 73.9% was NYHA heart function III and IV. After three years’ follow up, 95 patients (44.2%) met the primary endpoint (40 for cardiac death [18.6%], 45 for HF hospitalization [20.9%], 13 for appropriate ICD therapy [6.0%] and 8 for heart transplants [3.7%]). After adjusted age, sex and NYHA cardiac function by multivariate Cox analysis, the increased risk of clinical events were independently associated with Low systolic blood pressure (SBP)(SBP<90 mmHg, hazard ratio[HR] 3.92, 1.87-8.24), large left atrium(LA >51 mm, HR 2.38,1.45-3.93) and higher serum total bilirubin concentration(>36umol/L,1.95,1.25-3.03). Kaplan-Meier curves showed that individuals with three risk factors suffered higher clinical events as compared to those with 0-2 risk factors(76% vs 32%, log rank c2¼52.09, p<0.001). CONCLUSIONS Low systolic blood, large left atrium and higher serum total bilirubin concentration might be predictors for clinical events in patients with NICM, and patients with all of them might experience increased risk of 3-year cumulative clinical events. GW27-e1164 The trend of Young Coronary Artery Disease From 2010 to 2014: A retrospective observational study in China Liu Yuqi, Yundai Chen Department of Cardiology, PLA General Hospital
OBJECTIVES To compare the clinical characteristics, risk factors and prognosis of young patients (45) with coronary heart disease from 2010 to 2014, and to provide evidence for the second prevention of young patients with coronary heart disease. METHODS According to the inclusion and exclusion criteria, from Jan 1, 2010 to Dec 31, 2014, in the cardiac department of General Hospital of Chinese PLA Hospital, 5288 patients (45) were diagnosed as coronary heart disease (CHD) by coronary angiography. From 2010 to 2014, the trends of clinical conditions were compared for 5 years, including onset age, body mass index, heart rate, blood pressure, smoking, drinking, hypertension, diabetes, hyperlipidemia and clinical medication, laboratory examination, cardiac ultrasound, coronary artery lesions and prognosis for one year. RESULTS From 2010 to 2014, the incidence of young coronary heart disease increased, especial the young men (91.2%w94.2%), the stable type angina pectoris increased from 46.9% to 57% and ST segment elevation myocardial infarction increased from 4.4% to 11.9% the nonST segment elevation myocardial infarction decreased from 38.7% to 28.7% (P<0.05). There is no significant change in the blood pressure, the heart rate is still high (72bmp, P<0.05) and body mass index show rising trend (from 27.93.1 to 27.63.4, P>0.05), hypertension increased from 40.7% to 47.5%, diabetes from 20.3% to 26.1%, hyperlipidemia from 27.3% to 35.7%, while the smoking (61.8%w 57.4%) and drinking (31.1%w25.0%) showed a downward trend (P < 0.05). Total cholesterol (from 4.541.26 to 4.351.26), glycerin three fat (from 3.126.26 to 2.496.83) showed a downward trend (P<0.05), LDL cholesterol showed a downward trend without statistical difference (P>0.05). Single vessel disease is dominant in young patients, left anterior descending, right coronary artery and circumflex artery in turn. Left main lesion was slightly declined. According to the ACC/ AHA classification, type A decreased and type C increased (P < 0.05). Aspirin, clopidogrel, ticagrelor, statins and beta blockers increased overall (P<0.05). Mortality in Hospitalization decreased significantly (P<0.05), but there was no significant improvement in the incidence of cardiac death and MACE in 1 year follow-up (P>0.05). CONCLUSIONS In the past 5 years, the overall incidence of young patients (45) with coronary heart disease increased, second prevention for coronary heart disease, including risk factors, as well as medical treatment still need to be improved. PREVENTION OF CARDIOVASCULAR DISEASE GW27-e0451 Protein Z plasma levels in patients with myocardial infarction Li Yong, Baoxin Liu, Qiqiang Jie, Yidong Wei Shanghai Tenth People’s Hospital of Tongji University OBJECTIVES The aims of this study were to find out the potential relationship between protein Z plasma levels and myocardial infarction and the impact of PCI and stent implantation on plasma protein Z concentration. METHODS We studied protein Z levels in 85 patients (48 male, 37 female) admitted to Shanghai Tenth People’s Hospital with a clinical manifestation of myocardial infarction (MI), and in 15 healthy subjects selected to be comparable to the patients group in terms of age and gender. RESULTS PZ levels of myocardial infarction patients were significantly lower compared to controls (1586.7717.6 ng/mL vs. 2518.0971.1 ng/mL P0.01) whereas the protein Z plasma levels of MI patients before and after percutaneous coronary intervention (PCI) were not significantly changed. CONCLUSIONS The results of our study suggest that myocardial infarction is related to low protein Z levels and that thrombosis is associated with low PZ concentrations. GW27-e0822 Research on Targeted Microbubbles Combined with Ultrasound Thrombolysis in Peripheral Microcirculation Mu Yuming, Guan Lina Department of Echocardiography, First Affiliated Hospital, Xinjiang Medical University, Urmuqi, China OBJECTIVES This research observes the effect of the targeted microbubbles ultrasound on the femoral artery thrombosis and microcirculation of embolism of rabbits under the different conditions. METHODS This research uses different designs of ultrasonic frequency (1.6, 2.2, 2.8 MHz), different ultrasonic irradiation time (30 and
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, VOL. 68, NO. 16, SUPPL S, 2016
collected between January 2013 and December 2014 in Shanghai, China. Poisson regression models incorporating natural spline smooth functions (generalized linear models, GLM) were used to adjust for long-term, seasonal trends and weekend effect, public holiday, as wells as other confounding factors. The associations among particulate air pollution and the number of cardiovascular diseases stratified by temperature were identified. RESULTS A total of 9, 906, 835 hospital patients of cardiovascular diseases were identified during study period. The primary pollutants were PM2.5, PM10, SO2 and NO2, and their average daily concentrations were 56.3 mg/m3, 76 mg/m3, 20.6 mg/m3 and 46.7 mg/m3, respectively. Cardiovascular incidence showed an association with temperature, the relative risks (RR) of cardiovascular incidence is 1.016 (95% CI: 1.013, 1.018) (-18 C versus 18 C). Significant correlations were showed between hospital patients and concentrations of each primary pollutant, respectively. In warm-season, with a 10-mg/m3 increase in concentrations of PM2.5, PM10, SO2 or NO2, percentages of outpatient and emergency patient of cardiovascular diseases increased by 0.502% (95% CI: 0.464%, 0.545%), 0.251% (95% CI: 0.221%, 0.282%), 2.716% (95% CI: 2.558%, 2.874%), 1.496% (95% CI: 1.421%, 1.571%), respectively. In those cold-season, the corresponding values were 0.543%(95% CI: 0.521%,0.570%), 0.568% (95% CI: 0.548%, 0.587%), 1.607%(95%CI:1.528%,1.685%), 1.923%(95%CI: 1.868%, 1.978%), respectively. Furthermore, each primary pollutant had different lag effect on hospital patients. CONCLUSIONS Low temperature increased daily numbers of hospital patients of cardiovascular diseases; Daily numbers of hospital patients increased with the increases in concentrations of daily primary air pollutants after adjusting some confounding factors. GW27-e0894 Combination of Blood pressure, left atrium size and serum total bilirubin level at admission predicts risk of 3-year’s clinical outcomes in nonischemic cardiomyopathy patients Li Xiaofei, Sun Wei, Yao Yan, Lu Minjie, Hua Wei, Zhang Shu, Fan Xiaohan State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences OBJECTIVES The present study aimed to determine whether the combination of clinical risk factors may improve the prognostic value for clinical outcomes in non-ischemic cardiomyopathy (NICM) patients. METHODS A total of 215 NICM patients in Fuwai hospital from December 2010 to April 2013 were prospectively enrolled in this cohort. Patients with known obstructive coronary heart disease, valvar heart disease, and hypertensive heart disease were excluded from this study. Baseline blood pressure, blood samples and left atrium size (by echocardiography) were obtained at admission. Patients were followed up by phone and clinical visits. The primary endpoint was defined as the composite of cardiovascular death, deterioration of heart failure (HF) for hospitalization heart transplantation and appropriate ICD therapy. RESULTS Of all the patients with NICM, 78.6% was male, the mean age was 3712 years; and 73.9% was NYHA heart function III and IV. After three years’ follow up, 95 patients (44.2%) met the primary endpoint (40 for cardiac death [18.6%], 45 for HF hospitalization [20.9%], 13 for appropriate ICD therapy [6.0%] and 8 for heart transplants [3.7%]). After adjusted age, sex and NYHA cardiac function by multivariate Cox analysis, the increased risk of clinical events were independently associated with Low systolic blood pressure (SBP)(SBP<90 mmHg, hazard ratio[HR] 3.92, 1.87-8.24), large left atrium(LA >51 mm, HR 2.38,1.45-3.93) and higher serum total bilirubin concentration(>36umol/L,1.95,1.25-3.03). Kaplan-Meier curves showed that individuals with three risk factors suffered higher clinical events as compared to those with 0-2 risk factors(76% vs 32%, log rank c2¼52.09, p<0.001). CONCLUSIONS Low systolic blood, large left atrium and higher serum total bilirubin concentration might be predictors for clinical events in patients with NICM, and patients with all of them might experience increased risk of 3-year cumulative clinical events. GW27-e1164 The trend of Young Coronary Artery Disease From 2010 to 2014: A retrospective observational study in China Liu Yuqi, Yundai Chen Department of Cardiology, PLA General Hospital
OBJECTIVES To compare the clinical characteristics, risk factors and prognosis of young patients (45) with coronary heart disease from 2010 to 2014, and to provide evidence for the second prevention of young patients with coronary heart disease. METHODS According to the inclusion and exclusion criteria, from Jan 1, 2010 to Dec 31, 2014, in the cardiac department of General Hospital of Chinese PLA Hospital, 5288 patients (45) were diagnosed as coronary heart disease (CHD) by coronary angiography. From 2010 to 2014, the trends of clinical conditions were compared for 5 years, including onset age, body mass index, heart rate, blood pressure, smoking, drinking, hypertension, diabetes, hyperlipidemia and clinical medication, laboratory examination, cardiac ultrasound, coronary artery lesions and prognosis for one year. RESULTS From 2010 to 2014, the incidence of young coronary heart disease increased, especial the young men (91.2%w94.2%), the stable type angina pectoris increased from 46.9% to 57% and ST segment elevation myocardial infarction increased from 4.4% to 11.9% the nonST segment elevation myocardial infarction decreased from 38.7% to 28.7% (P<0.05). There is no significant change in the blood pressure, the heart rate is still high (72bmp, P<0.05) and body mass index show rising trend (from 27.93.1 to 27.63.4, P>0.05), hypertension increased from 40.7% to 47.5%, diabetes from 20.3% to 26.1%, hyperlipidemia from 27.3% to 35.7%, while the smoking (61.8%w 57.4%) and drinking (31.1%w25.0%) showed a downward trend (P < 0.05). Total cholesterol (from 4.541.26 to 4.351.26), glycerin three fat (from 3.126.26 to 2.496.83) showed a downward trend (P<0.05), LDL cholesterol showed a downward trend without statistical difference (P>0.05). Single vessel disease is dominant in young patients, left anterior descending, right coronary artery and circumflex artery in turn. Left main lesion was slightly declined. According to the ACC/ AHA classification, type A decreased and type C increased (P < 0.05). Aspirin, clopidogrel, ticagrelor, statins and beta blockers increased overall (P<0.05). Mortality in Hospitalization decreased significantly (P<0.05), but there was no significant improvement in the incidence of cardiac death and MACE in 1 year follow-up (P>0.05). CONCLUSIONS In the past 5 years, the overall incidence of young patients (45) with coronary heart disease increased, second prevention for coronary heart disease, including risk factors, as well as medical treatment still need to be improved. PREVENTION OF CARDIOVASCULAR DISEASE GW27-e0451 Protein Z plasma levels in patients with myocardial infarction Li Yong, Baoxin Liu, Qiqiang Jie, Yidong Wei Shanghai Tenth People’s Hospital of Tongji University OBJECTIVES The aims of this study were to find out the potential relationship between protein Z plasma levels and myocardial infarction and the impact of PCI and stent implantation on plasma protein Z concentration. METHODS We studied protein Z levels in 85 patients (48 male, 37 female) admitted to Shanghai Tenth People’s Hospital with a clinical manifestation of myocardial infarction (MI), and in 15 healthy subjects selected to be comparable to the patients group in terms of age and gender. RESULTS PZ levels of myocardial infarction patients were significantly lower compared to controls (1586.7717.6 ng/mL vs. 2518.0971.1 ng/mL P0.01) whereas the protein Z plasma levels of MI patients before and after percutaneous coronary intervention (PCI) were not significantly changed. CONCLUSIONS The results of our study suggest that myocardial infarction is related to low protein Z levels and that thrombosis is associated with low PZ concentrations. GW27-e0822 Research on Targeted Microbubbles Combined with Ultrasound Thrombolysis in Peripheral Microcirculation Mu Yuming, Guan Lina Department of Echocardiography, First Affiliated Hospital, Xinjiang Medical University, Urmuqi, China OBJECTIVES This research observes the effect of the targeted microbubbles ultrasound on the femoral artery thrombosis and microcirculation of embolism of rabbits under the different conditions. METHODS This research uses different designs of ultrasonic frequency (1.6, 2.2, 2.8 MHz), different ultrasonic irradiation time (30 and