Hemangiolymphangioma of the Urinary Bladder in a Child

878

ONCOLOGY AND CHEMOTHERAPY

receives daily subcutaneous injections of the chemotherapeutic agent or combinations for 5 days away from the implanted area. The animal is sacrificed and the tumor is measured. In this experiment there were 4 groups for chemotherapy, including 10 rats given cyclophosphamide, 11 given doxorubicin, 11 given cis-platinum and 6 given methotrexate. Also, 10 animals had subcutaneous tumor implants and 16 received only a placebo after subrenal capsular tumor implants. The subrenal capsular assay and subcutaneous tumor implants correlated well in the rate of tumor take. The highest rate of tumor take was in the subcutaneous tumor implant group, followed in decreasing order by the cis-platinum, methotrexate, doxorubicin and cyclophosphamide groups. This method may save considerable expense and it may serve as a useful projector for potential future chemotherapeutic trials of bladder cancer. However, the disadvantage of this system in regard to the lack of metastases and lack of regression is an interval of 5 days. Therefore, the only objective parameter is the measurement of the tumor. N. J. 1 table, 6 references

Hemangiolymphangioma of the Urinary Bladder in a Child S. CHANDNA, V. BHATNAGAR, D. K. MITRA AND P. UPADHYAYA, Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India J. Ped. Surg., 22: 1051-1052 (Nov.) 1987 Hemangiolymphangioma of the bladder is a congenital malformation that usually presents with painless gross hematuria in young patients. About 25 per cent of the cases are associated with cutaneous hemangiomas over the abdomen, perineum, thighs or external genitalia. A 9-year-old boy had a history of intermittent painless gross hematuria for 2½ years. Physical examination showed multiple hemangiomas in the penis and scrotum. Excretory urography and ultrasound revealed 2 masses in the bladder. Cystoscopy was not performed for fear of traumatizing the urethra and causing bleeding. Exploration showed a large hemangioma in the fundus and posterolateral wall of the bladder extending across the wall, and infiltrating into the pelvis and perineum. A small hemangioma was seen just above the right ureteral orifice, which was resected transurethrally. The larger lesion was treated by partial cystectomy. The patient did well with minimal bleeding. This case demonstrates that partial cystectomy can be a cura tive treatment for hemangioma of the bladder. Others have used radiotherapy for hemangiomas in the bladder neck and trigone. F. T. A. 1 figure, 8 references

Transplantable Human Prostatic Carcinoma (PC-82) in Athymic Nude Mice: I. Hormone Dependence and the Concentration of Androgens in Plasma and Tumor Tissue G. J. VAN STEENBRUGGE, J. J. W. VAN DONGEN, P. J. REUVERS, F. H. DEJONG AND F. H. SCHROEDER, Departments of Urology and Biochemistry, Division of Chemical Endocrinology, Erasmus University, Rotterdam, The Netherlands Prostate, 11: 195-210, 1987 The authors used nude mice with transplanted human prostatic cancer (PC-82) to study androgen dependence. Testoster-

one-containing silicone implants were used to level off the widely variable serum testosterone levels of the mice and, furthermore, they allowed for manipulation of testosterone levels along with castration. Androgen withdrawal from mice with growing tumors caused 80 per cent regression during 10 weeks in a biphasic manner. When tumor was grafted into castrate mice and testosterone was replaced later, delayed growth resulted. Apparently, tumor will remain dormant in the absence of testosterone. Testosterone and dihydrotestosterone were detected in tumor homogenates in varying concentrations. Testosterone withdrawal from tumor-bearing female mice caused a rapid decrease in tissue testosterone and a slower decrease in tissue dihydrotestosterone levels. J. H. N. 7 figures, 3 tables, 54 references

Adenocarcinoma of the Canine Prostate: Immunohistochemical Examination for Secretory Antigens M. MCENTEE, W. ISAACS AND C. SMITH, Department of Pathology, College of Veterinary Medicine, Cornell University and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland Prostate, 11: 163-170, 1987 Prostatic glycoproteins have been studied extensively as possible tumor markers. Prostate specific acid phosphatase and prostate specific antigen, a protease, are notable. Recently, a canine prostatic secretory protease has been isolated and characterized. The authors examined 31 canine adenocarcinomas of the prostate immunochemically to detect the aforementioned 3 antigens. Of 31 tumors 8 were positive for canine prostatic secretory protease, 2 for prostate specific antigen and 3 for prostate specific acid phosphatase. Normal and hyperplastic prostatic tissues were strongly positive for all 3 agents (control). By contrast, in human studies all but the most anaplastic tumors stain equally with benign prostatic tissue for prostate specific antigen and prostate specific acid phosphatase. J. H. N. 2 figures, 1 table, 26 references

Seeding and Perinea! Implantation of Prostatic Cancer in the Track of the Biopsy Needle: Three Case Reports and a Review of the Literature F. S. HADDAD AND A. A. SOMSIN, Department of Urology and Laboratory Services, Veterans Administration Medical Center, Phoenix, Arizona J. Surg. Oncol., 35: 184-191 (July) 1987 Seeding of prostatic tumor cells in the perineal area has been reported after needle biopsy of prostatic cancer through the perineal approach. The frequency of implantation appears to depend on the type and number of tumor cells, fertility of tissue in which the cancer cells are embedded and size of the needle. The authors report 3 cases and add 12 from the literature. They advocate excision or radiation of the lesion. Also, they favor fine needle aspiration N. J. 7 figures, 8 tables, 22 references

Relationship of Testosterone, Sex Hormone Binding Globulin, and Calculated Free Testosterone to Subsequent Clinical Progress in Patients With Carcinoma of the Prostate Treated With Bilateral Orchidectomy or Estrogens