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HEMOSTATIC SAFETY OF STRONTIUM RANELATE TREATMENT IN OSTEOPOROTICPATIENTS
8th European Congress on Menopause (EMAS) / Maturitas 63, Supplement 1 (2009) S1–S136
S95
Conclusions: Data from the present study indicate that patients with premature ovarian failure present significantly lower values of bone mineral density than premenopausal women of similar age and have higher prevalence of osteopenia/osteoporosis than women after natural menopause. These young women need early medical strategies to maintain their bone mass and compliance with the treatment. Keywords: premature menopause; osteoporosis; bone mineral density.
strontium ranelate in osteoporotic patients can be determined by longer follow up periods with larger population and more hemostatic parameters. Keywords: Hemostasis, osteoporosis, strontium ranelate.
372
S.I.A. Vilariño 1 , C. Vilariño 1 , A. Schwartz 2 , O. Contreras Ortiz 1 , J. Dotto 1 . 1 Institutos Atención Ginecológica (IAG, Cooperative Private Group), Gynecology, Buenos Aires, Argentina; 2 Institutos Atención Ginecológica (IAG, Cooperative Private Group), Epidemiology, Buenos Aires, Argentina
OSTEOPOROSIS IN INDIANS: ROLE OF NURSES IN PREVENTION S. Kaur. Post Graduate Institute of Medical Education and Research, National Institute of Nursing Education, Chandigarh, India Background: Osteoporosis is a growing public health problem affecting both men and women. The disease is highly prevalent in India. An expected 61 million people in India are reported to be affected with osteoporosis currently. Studies have shown a lower BMD in Indians. Osteoporosis, although not a curable disease can be prevented partly by adopting certain healthy habits in the form of healthy life style, nutritional issues, exercise, and fall prevention. Knowledge of the disease correlates with engaging in health related behaviors. Nurses have been identified as important players in osteoporosis prevention. Objectives: This paper is intended to sensitize nurses to the magnitude of osteoporosis and to identify the nurses’ role in its prevention and its related complications. Methods: An extensive review of literature was carried regarding the risk factors, prevention and treatment of osteoporosis, and the important contributions nurses can make in preventing this debilitating condition. Results: Evidence exists that osteoporosis educational programmes conducted by nurses were effective in promoting knowledge and prevention behaviors. Information provided in the form of leaflet was also found to be efficient in elevating the knowledge among elderly. Nurses in fact are one of those health care professionals who are with the patients for most of the time. They are expected to dedicate time in counseling patients and the patients’ attendants as well in certain very important aspects such as healthy diet, engaging in exercises, reducing the risk of falls and osteoporotic complications. Conclusion: Awareness helps in prevention of osteoprosis. Keywords: Osteoporosis, prevention, nurses’ role.
373 HEMOSTATIC SAFETY OF STRONTIUM RANELATE TREATMENT IN OSTEOPOROTICPATIENTS I. Bayhan 1 , D. Uygur 2 , N. Ugurlu 2 , N. Yilmaz 2 , L. Mollamahmutoglu 2 , G. Ozaksit 2 . 1 Dr. Lutfi Kirdar Research and Education Hospital, Orthopedics and Traumatology, Istanbul, Turkey; 2 Zekai Tahir Burak Woman Health Care Education and Research Hospital, Menopause, Ankara, Turkey Objectives: There are some data showing an association between strontium ranelate treatment and increased incidence of venous thromboembolism (VTE). We studied the effect of stontium ranelate on hemostasis. Methods: Forty-nine postmenopausal osteoporotic women aged 40-70 were included in the study. Women using medications known to have an effect on the hemostatic system, or with a history of VTE were excluded. Patients received strontium ranelate 2 g/day with additional calcium carbonate (1,500mg/day) and alpha-calcidiol (1-alpha hydroxy vitamin D3)(0.50g/day). Hemostatic parameters including protrombin time, international normalized ratio, activated partial thromboplastin time, fibrinogen, antithrombin III were assessed before therapy and at 3, 6, and 12 months of therapy. Results: There was no statistically significant changes in hemostatic parameters except in fibrinogen levels. However, there was a significant increase in fibrinogen levels at 6. months of treatment compared to levels before the treatment (p<0.001)(321.46 vs 396.15mg/dl). Fibrinogen level (435.19 mg/dl) at 12 months of treatment was also significantly higher compared to the basal fibrinogen levels (321.46 mg/dl)(p<0.001). None of the subjects developed clinical VTE during the study. Conclusions: Our study showed that there was no significant changes in hemostatic parameters during the 1 year follow up of strontium ranelate treatment except the fibrinogen levels. However, the clinical significance of the increase in fibrinogen level as well as the hemostatic safety of
374 COMPARISON OF DIFFERENT TREATMENTS ON POSTMENOPAUSAL PATIENTS (POSTM)
Objectives: to compare alendronate (Ale), risendronate (Ris), and ibandronate (Iba) treatment on bone mineral densitometry (BMD) of osteoporotic and osteopenic patients. Material and Methods: a prospective and randomized study was done. 122 patients were studied with BMD on lumbar spine (LS) and femoral neck (FN) and treated: 69 with Ale. 10mg/d, 31 with Ris 5 mg/d, and 22 with 5 mg/d, during 1 year. Average age = 62 years old. Last period was in 76% of patients between 40-50 years old. BMI was 24 Student test was done. Results: BMD value improved in 60,65% of patients after the treatment (percentage of improvement were LS= 0,324; FN = 0,33) There wasn’t statistical significance difference in each one of treatments on LS (CH12=31243, GL=4; p 0,5373) or FN (CH12= 0,2339, GL=4; p 0,0037). Conclusions: In our sample we didn’t find any difference among each treatment in osteopenic and osteoporotic PostM patients according with BMD. Keywords: Osteoporosis, Alendronate, Risendronate, Ibandronate
375 RELATIONSHIP BETWEEN SERUM LEPTIN LEVEL AND BONE BIOCHEMICAL MARKERS IN POSTMENOPAUSAL WOMEN Y. You 1 , S. Lee 1 , M. Kim 2 , J. Kim 3 . 1 St.Vincent Hospital, Obstetrics and Gynecology, Suwon, Korea, Republic of; 2 Kangnam St. Mary’s Hospital, Obstetrics and Gynecology, Seoul, Korea, Republic of; 3 St. Mary’ Hospital, Obstetrics and Gynecology, Suwon, Korea, Republic of Objectives: This study was performed to prove the relatioship betweeen serum leptin and bone mineral density of lumbar spine, femur neck and bone markers in postmenopausal women. Methods: We measured serum leptin, osteocalcin, urine deoxypyridinoline levels and BMD of lumbar spine, femur neck in 88 premenopausal and 118 postmenopausal women who visited St. Vincent’s Hospital of the Catholic Uni versity of Korea from March 1st, 2007 to December 31th, 2007. Results: Significant correlation were shown between serum leptin and BMI in premenopausal (r=0.343, p<0.0001). and postmenopausal women (r=0.360, p<0.0001). And no significant correlation were observed between leptin and BMD in premenopausal women (r=0.013, p=0.017 and r=0.004, p=0.425), but in postmenopausal women, there was a positve correlation between leptin and lumbar spine BMD (r=0.085, p=0.02). But after adjustment with age and BMI, leptin and BMD of lumbar spine did not showed any correlation in the same group (r=0.088, p=0.939). Also, no significant correlation were observed between lepin and osteocalcin, urine deoxypyridinoline in premenopausal (r=0.004, p=0.566 and r=0.002, p=0.707) and postmenopausal women (r=0.026, p=0.096 and r=0.000, p=0.933). Conclusion: In our study, there is no significant correlation between leptin and BMD and bone markers in premenopausal and postmenopausal women. Our own data would suggest that leptin has both negative and positive effects in bone mass regulation. Furthermore, larger clinical studies are necessary to clarify the contribution of the central and peripheral role of leptin in bone overall maintenance of bone turnover. Keywords: Leptin, BMD, Bone markers.
S95
Conclusions: Data from the present study indicate that patients with premature ovarian failure present significantly lower values of bone mineral density than premenopausal women of similar age and have higher prevalence of osteopenia/osteoporosis than women after natural menopause. These young women need early medical strategies to maintain their bone mass and compliance with the treatment. Keywords: premature menopause; osteoporosis; bone mineral density.
strontium ranelate in osteoporotic patients can be determined by longer follow up periods with larger population and more hemostatic parameters. Keywords: Hemostasis, osteoporosis, strontium ranelate.
372
S.I.A. Vilariño 1 , C. Vilariño 1 , A. Schwartz 2 , O. Contreras Ortiz 1 , J. Dotto 1 . 1 Institutos Atención Ginecológica (IAG, Cooperative Private Group), Gynecology, Buenos Aires, Argentina; 2 Institutos Atención Ginecológica (IAG, Cooperative Private Group), Epidemiology, Buenos Aires, Argentina
OSTEOPOROSIS IN INDIANS: ROLE OF NURSES IN PREVENTION S. Kaur. Post Graduate Institute of Medical Education and Research, National Institute of Nursing Education, Chandigarh, India Background: Osteoporosis is a growing public health problem affecting both men and women. The disease is highly prevalent in India. An expected 61 million people in India are reported to be affected with osteoporosis currently. Studies have shown a lower BMD in Indians. Osteoporosis, although not a curable disease can be prevented partly by adopting certain healthy habits in the form of healthy life style, nutritional issues, exercise, and fall prevention. Knowledge of the disease correlates with engaging in health related behaviors. Nurses have been identified as important players in osteoporosis prevention. Objectives: This paper is intended to sensitize nurses to the magnitude of osteoporosis and to identify the nurses’ role in its prevention and its related complications. Methods: An extensive review of literature was carried regarding the risk factors, prevention and treatment of osteoporosis, and the important contributions nurses can make in preventing this debilitating condition. Results: Evidence exists that osteoporosis educational programmes conducted by nurses were effective in promoting knowledge and prevention behaviors. Information provided in the form of leaflet was also found to be efficient in elevating the knowledge among elderly. Nurses in fact are one of those health care professionals who are with the patients for most of the time. They are expected to dedicate time in counseling patients and the patients’ attendants as well in certain very important aspects such as healthy diet, engaging in exercises, reducing the risk of falls and osteoporotic complications. Conclusion: Awareness helps in prevention of osteoprosis. Keywords: Osteoporosis, prevention, nurses’ role.
373 HEMOSTATIC SAFETY OF STRONTIUM RANELATE TREATMENT IN OSTEOPOROTICPATIENTS I. Bayhan 1 , D. Uygur 2 , N. Ugurlu 2 , N. Yilmaz 2 , L. Mollamahmutoglu 2 , G. Ozaksit 2 . 1 Dr. Lutfi Kirdar Research and Education Hospital, Orthopedics and Traumatology, Istanbul, Turkey; 2 Zekai Tahir Burak Woman Health Care Education and Research Hospital, Menopause, Ankara, Turkey Objectives: There are some data showing an association between strontium ranelate treatment and increased incidence of venous thromboembolism (VTE). We studied the effect of stontium ranelate on hemostasis. Methods: Forty-nine postmenopausal osteoporotic women aged 40-70 were included in the study. Women using medications known to have an effect on the hemostatic system, or with a history of VTE were excluded. Patients received strontium ranelate 2 g/day with additional calcium carbonate (1,500mg/day) and alpha-calcidiol (1-alpha hydroxy vitamin D3)(0.50g/day). Hemostatic parameters including protrombin time, international normalized ratio, activated partial thromboplastin time, fibrinogen, antithrombin III were assessed before therapy and at 3, 6, and 12 months of therapy. Results: There was no statistically significant changes in hemostatic parameters except in fibrinogen levels. However, there was a significant increase in fibrinogen levels at 6. months of treatment compared to levels before the treatment (p<0.001)(321.46 vs 396.15mg/dl). Fibrinogen level (435.19 mg/dl) at 12 months of treatment was also significantly higher compared to the basal fibrinogen levels (321.46 mg/dl)(p<0.001). None of the subjects developed clinical VTE during the study. Conclusions: Our study showed that there was no significant changes in hemostatic parameters during the 1 year follow up of strontium ranelate treatment except the fibrinogen levels. However, the clinical significance of the increase in fibrinogen level as well as the hemostatic safety of
374 COMPARISON OF DIFFERENT TREATMENTS ON POSTMENOPAUSAL PATIENTS (POSTM)
Objectives: to compare alendronate (Ale), risendronate (Ris), and ibandronate (Iba) treatment on bone mineral densitometry (BMD) of osteoporotic and osteopenic patients. Material and Methods: a prospective and randomized study was done. 122 patients were studied with BMD on lumbar spine (LS) and femoral neck (FN) and treated: 69 with Ale. 10mg/d, 31 with Ris 5 mg/d, and 22 with 5 mg/d, during 1 year. Average age = 62 years old. Last period was in 76% of patients between 40-50 years old. BMI was 24 Student test was done. Results: BMD value improved in 60,65% of patients after the treatment (percentage of improvement were LS= 0,324; FN = 0,33) There wasn’t statistical significance difference in each one of treatments on LS (CH12=31243, GL=4; p 0,5373) or FN (CH12= 0,2339, GL=4; p 0,0037). Conclusions: In our sample we didn’t find any difference among each treatment in osteopenic and osteoporotic PostM patients according with BMD. Keywords: Osteoporosis, Alendronate, Risendronate, Ibandronate
375 RELATIONSHIP BETWEEN SERUM LEPTIN LEVEL AND BONE BIOCHEMICAL MARKERS IN POSTMENOPAUSAL WOMEN Y. You 1 , S. Lee 1 , M. Kim 2 , J. Kim 3 . 1 St.Vincent Hospital, Obstetrics and Gynecology, Suwon, Korea, Republic of; 2 Kangnam St. Mary’s Hospital, Obstetrics and Gynecology, Seoul, Korea, Republic of; 3 St. Mary’ Hospital, Obstetrics and Gynecology, Suwon, Korea, Republic of Objectives: This study was performed to prove the relatioship betweeen serum leptin and bone mineral density of lumbar spine, femur neck and bone markers in postmenopausal women. Methods: We measured serum leptin, osteocalcin, urine deoxypyridinoline levels and BMD of lumbar spine, femur neck in 88 premenopausal and 118 postmenopausal women who visited St. Vincent’s Hospital of the Catholic Uni versity of Korea from March 1st, 2007 to December 31th, 2007. Results: Significant correlation were shown between serum leptin and BMI in premenopausal (r=0.343, p<0.0001). and postmenopausal women (r=0.360, p<0.0001). And no significant correlation were observed between leptin and BMD in premenopausal women (r=0.013, p=0.017 and r=0.004, p=0.425), but in postmenopausal women, there was a positve correlation between leptin and lumbar spine BMD (r=0.085, p=0.02). But after adjustment with age and BMI, leptin and BMD of lumbar spine did not showed any correlation in the same group (r=0.088, p=0.939). Also, no significant correlation were observed between lepin and osteocalcin, urine deoxypyridinoline in premenopausal (r=0.004, p=0.566 and r=0.002, p=0.707) and postmenopausal women (r=0.026, p=0.096 and r=0.000, p=0.933). Conclusion: In our study, there is no significant correlation between leptin and BMD and bone markers in premenopausal and postmenopausal women. Our own data would suggest that leptin has both negative and positive effects in bone mass regulation. Furthermore, larger clinical studies are necessary to clarify the contribution of the central and peripheral role of leptin in bone overall maintenance of bone turnover. Keywords: Leptin, BMD, Bone markers.