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Hepatoprotective effects of polygonum bistorta (LINN) and its active principle against acetaminophen -induced toxicity in rats
ABSTRACTS
(median 282, 5). The median ALT level was 2100 IU/L(2004000). Drug-induced hepatotoxicity occurred more frequently due to the followings: chemotherapy 20 (48%), Halotan 8 (20%), antituberculous, analgetics 4 (10%), and antidiabetics 2 (5%) respectively and others 6 (12%). Out of 42 in 34 (80%) patients were diagnosed hepatocellural injury, with elevation of aminotransferase levels as predominant symptom, in the rest of them was found cholestatic injury with elevated ALP levels. Ascit was found in 10 (23%) patients, 2 (4.8%) died from acute liver failure. The recovery period of 40 patients lasted for 4-12 weeks. Conclusions: Drug-induced hepatotoxicity was 7.8% among the patients with acute hepatitis.Risk factors of drug-induced hepatotoxicity were: age, gender and large BMI/obesity.The most frequent cause of drug-induced hepatitis was chemotherapy with compatibility of several drugs.
21ST ANNUAL CONFERENCE—2013
idation level however reduced glutathione content was decreased. A concomitant fall was observed in the enzymatic activities of adenosine triphosphatase, glucose-6-phosphatase and histopathological findings. Plant extract and its active principle prevent the development of acute liver damage, thus supported these biochemical and histopathological findings. Conclusion: The results of this study clearly indicate that PB and TA have a potent hepatoprotective action; whereas tannic acid is showed protective effect compare to Polygonumbistorta against Acetaminophen-induced toxicological profile. Corresponding Author. Deepak Kumar Mittal. E-mail: [email protected]
Corresponding Author. Hasmik Ghazinyan. E-mail: [email protected]
DILI
HEPATOPROTECTIVE EFFECTS OF POLYGONUM BISTORTA (LINN) AND ITS ACTIVE PRINCIPLE AGAINST ACETAMINOPHEN -INDUCED TOXICITY IN RATS Deepak Kumar Mittal,1 Deepmala Joshi,2 Sangeeta Shukla1 1
Jiwaji University, Gwalior, India, 2Deen Dayal Upadhyay University, Gorakhpur, India
Background and Objectives: Many herbal preparations have been recommended in alternative system of medicine for the treatment of hepatic disorder. Drug-induced hepatotoxicity is still a significant unresolved clinical problem as liver is the most common site of damage. It is well known that overdoses of acetatminophen are hepatotoxic. The goal of the present work is to evaluate and compare the efficacy of root extract of Polygonumbistorta and tannic acid against toxicant induced damage in liver and kidney. Methods: Male rats (15010g b.w.) were administered a single bolus dose of acetaminophen (2 g/kg, p.o.). Plant extract (PB) and its active principle (TA) was given at the dose of 100 mg/kg and 25 mg/kg, respectively (p.o.) after 24 h of toxicant administration. Results: The hepatotoxicity produced by acute paracetamol administration was found to be inhibited by Polygonumbistorta and tannic acid with evidence of decreased levels of serum transaminases, alkaline phosphatase, protein, albumin, bilirubin, urea, creatinine, triglycerides and cholesterol concentration whereas increase was found in blood sugar. A significant rise was observed in lipid peroxS40
© 2013, INASL
(median 282, 5). The median ALT level was 2100 IU/L(2004000). Drug-induced hepatotoxicity occurred more frequently due to the followings: chemotherapy 20 (48%), Halotan 8 (20%), antituberculous, analgetics 4 (10%), and antidiabetics 2 (5%) respectively and others 6 (12%). Out of 42 in 34 (80%) patients were diagnosed hepatocellural injury, with elevation of aminotransferase levels as predominant symptom, in the rest of them was found cholestatic injury with elevated ALP levels. Ascit was found in 10 (23%) patients, 2 (4.8%) died from acute liver failure. The recovery period of 40 patients lasted for 4-12 weeks. Conclusions: Drug-induced hepatotoxicity was 7.8% among the patients with acute hepatitis.Risk factors of drug-induced hepatotoxicity were: age, gender and large BMI/obesity.The most frequent cause of drug-induced hepatitis was chemotherapy with compatibility of several drugs.
21ST ANNUAL CONFERENCE—2013
idation level however reduced glutathione content was decreased. A concomitant fall was observed in the enzymatic activities of adenosine triphosphatase, glucose-6-phosphatase and histopathological findings. Plant extract and its active principle prevent the development of acute liver damage, thus supported these biochemical and histopathological findings. Conclusion: The results of this study clearly indicate that PB and TA have a potent hepatoprotective action; whereas tannic acid is showed protective effect compare to Polygonumbistorta against Acetaminophen-induced toxicological profile. Corresponding Author. Deepak Kumar Mittal. E-mail: [email protected]
Corresponding Author. Hasmik Ghazinyan. E-mail: [email protected]
DILI
HEPATOPROTECTIVE EFFECTS OF POLYGONUM BISTORTA (LINN) AND ITS ACTIVE PRINCIPLE AGAINST ACETAMINOPHEN -INDUCED TOXICITY IN RATS Deepak Kumar Mittal,1 Deepmala Joshi,2 Sangeeta Shukla1 1
Jiwaji University, Gwalior, India, 2Deen Dayal Upadhyay University, Gorakhpur, India
Background and Objectives: Many herbal preparations have been recommended in alternative system of medicine for the treatment of hepatic disorder. Drug-induced hepatotoxicity is still a significant unresolved clinical problem as liver is the most common site of damage. It is well known that overdoses of acetatminophen are hepatotoxic. The goal of the present work is to evaluate and compare the efficacy of root extract of Polygonumbistorta and tannic acid against toxicant induced damage in liver and kidney. Methods: Male rats (15010g b.w.) were administered a single bolus dose of acetaminophen (2 g/kg, p.o.). Plant extract (PB) and its active principle (TA) was given at the dose of 100 mg/kg and 25 mg/kg, respectively (p.o.) after 24 h of toxicant administration. Results: The hepatotoxicity produced by acute paracetamol administration was found to be inhibited by Polygonumbistorta and tannic acid with evidence of decreased levels of serum transaminases, alkaline phosphatase, protein, albumin, bilirubin, urea, creatinine, triglycerides and cholesterol concentration whereas increase was found in blood sugar. A significant rise was observed in lipid peroxS40
© 2013, INASL