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Heterotopic Oral Gastrointestinal Cyst: Case Report
OOOO Volume 119, Number 3 GLANDULAR ODONTOGENIC CYST OF MAXILLA: A CASE REPORT Alen Palancioglu1, Cemil Isler1, Merva Soluk Tekkes¸in2, Mehmet Yaltirik1, Zerrin Cebi1, 1Department of Oral and Maxillofacial Surgery, Istanbul University Faculty of Dentistry, Istanbul, Turkey; 2Department of Tumour Pathology, Institute of Oncology, Istanbul University, Istanbul, Turkey Glandular odontogenic cyst (GOC) is a rare aggressive developmental cyst of the jaw. GOC occurs more commonly in middle-aged people and has a predilection for the anterior mandible. Radiographically, the lesion presents as either a unilocular or multilocular radiolucency and has high recurrence rate. Histopathologically, the cyst is lined by stratified squamous epithelium that exhibits focal thickenings in which the epithelial cells become a swirled appearance. The cells of the epithelium lining are cuboidal, often with cilia. The clusters of mucous cells are also present. There is considerable overlap between the histomorphologic features of the GOC and the cystic low-grade mucoepidermoid carcinoma, which makes its diagnosis challenging. Because of its potentially aggressive nature and tendency for recurrence, long-term follow-up is essential. This case report represents radiologic-pathologic features and surgical treatment of GOC of the anterior maxilla in a 31-years-old male patient. Keywords: Odontogenic, Cyst, Glandular, Maxilla
ASSOCIATION OF IMMUNOLOCALIZATION OF EZRIN AND PODOPLANIN IN BENIGN EPITHELIAL AND MIXED ODONTOGENIC TUMOURS Diego Mauricio Bravo-Calderón1, Laís Priscila De Santis1, Paula Nascimento Antonio1, Kellen Cristine Tjioe1, Cléverson Teixeira Soares2, Denise Tostes Oliveira1, 1Department of Stomatology, Area of Pathology, Bauru School of Dentistry University of São Paulo, Bauru, Brazil; 2Lauro de Souza Lima Institute, Bauru, Brazil Objective: To investigate the association of ezrin and podoplanin expressions in benign odontogenic tumours with and without ectomesenchyme. Study Design: Immunohistochemistry of ezrin and podoplanin was analyzed in 52 benign odontogenic tumours including 8 ameloblastomas, 12 adenomatoid odontogenic tumours, 18 keratocyst odontogenic tumours (KCOT), 2 calcifying epithelial odontogenic tumours, 3 ameloblastic fibromas, 5 ameloblastic fibro-odontomas and 4 calcifying cystic odontogenic tumours. The association between membranous and cytoplasmic ezrin and podoplanin expressions by epithelial odontogenic cells was determined by Wilcoxon’s test. Results: Strong cytoplasmic ezrin and membranous podoplanin expressions was found on peripheral epithelial cells in all the odontogenic tumours. Significant differences relative to cytoplasmic ezrin and membranous podoplanin were observed (p¼0.002) in KCOT. Conclusions: These findings suggest that ezrin and podoplanin are regularly expressed by epithelial cells of the odontogenic tumours. Further studies are warranted to elucidate the role of this molecular association on the odontogenic tumor progression. Financial support: FAPESP #2012/13411-6; #2013/16036-4; CNPq #142790/2011-7 Keywords: odontogenic tumours, ezrin, podoplanin
HETEROTOPIC ORAL GASTROINTESTINAL CYST: CASE REPORT Irem Hicran Ozbudak1, Havva Serap Toru1, Neslihan Yaprak2, Kenan Guney2, Gulay Ozbilim1,
ABSTRACTS Abstracts e193 1 Department of Pathology, Akdeniz University School of Medicine, Antalya, Turkey; 2Department of Ear Nose Throat Head and Neck Surgery, Akdeniz University School of Medicine, Antalya, Turkey
Heterotopic gastrointestinal cyst is abnormally placed rest of gastric or intestinal mucosa which may be admixed with ciliated columnar and squamous epithelium. This lesion is rarely found in oral cavity. The ventral surface of tongue is the most common location. A 1-month-old boy was admitted to the hospital due to swelling of the sublingual area. Radiological examination revealed a 32.5 cm cystic mass. The patient underwent total excision of the cyst. Histologically, the cyst wall was lined with a mixture of gastric, squamous and ciliated columnar epithelium. The cyst wall also contained extracellular mucin beside the collagenized fibrovascular stroma and bundles of striated muscle. The patient was diagnosed as ‘Heterotopic oral gastrointestinal cyst’. Although heterotopic gastrointestinal cysts rarely occur, it should be considered in differential diagnosis of lingual swelling in the pediatric population along with epidermoid and dermoid cysts. Keywords: lingual cyst, congenital
PERIPHERAL GIANT CELL GRANULOMAS: A REVIEW OF THREE CASES Irem Hicran Ozbudak1, Havva Serap Toru1, Sinan Tozoglu2, Gulay Ozbilim1, 1Department of Pathology, Akdeniz University School of Medicine, Antalya, Turkey; 2Department of Oral and Maxillofacial Surgery, Akdeniz University Faculty of Dentistry, Antalya, Turkey Peripheral giant cell granuloma is the most common giant cell lesion of the jaws. It is a well-circumscribed lesion confined to the mucosa, originating from the connective tissue of the periosteum or the periodontal ligament. Herein, we reported three cases of peripheral giant cell granuloma. All patients were presented with painless swelling in the gingiva. Two of them were from maxillary and the rest was from mandibular region. Clinically, they were firm, red to purple sessile nodules variable in size which not exceed 2 cm in diameter. Surface epithelium of all lesions had focal areas of ulceration. Histologically, the lesions were characterized by multinucleated giant cells with a background of ovoid to spindle-shaped mesenchymal cells. Although in the clinical setting, malignancy is considered in differential diagnosis, Peripheral giant cell granuloma is a reactive lesion caused by local irritation. Treatment consisted of complete resection of the lesion. Keywords: Gingiva, oral
FOXP3 EXPRESSION IN ORAL AND LARYNGEAL DYSPLASIA Bilge Elçin1, Nil Üstünda g1, Mehmet Ali Elçin2, Batur S¸ebnem1, Övgü Aydın1, 1Department of Pathology, Cerrahpas¸a Medical Faculty, Istanbul University, Istanbul, Turkey; 2Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Bezmialem Vakif University, Istanbul, Turkey Objective: In this study, we report the Foxp3 expression levels of dysplasia in oral mucosa and larynx. Study Design: 78 patients diagnosed with mild-severe dysplasia, carcinoma in situ and squamous cell carcinoma in oral mucosa and larynx were selected. Immunostaining was performed for Foxp3. Staining at least 25% of the dysplastic cells was considered positive for Foxp3 expression. Chi-square test was used for the statistical analysis to analyze the relationship between Foxp3 expression and pathologic differentiation.
ASSOCIATION OF IMMUNOLOCALIZATION OF EZRIN AND PODOPLANIN IN BENIGN EPITHELIAL AND MIXED ODONTOGENIC TUMOURS Diego Mauricio Bravo-Calderón1, Laís Priscila De Santis1, Paula Nascimento Antonio1, Kellen Cristine Tjioe1, Cléverson Teixeira Soares2, Denise Tostes Oliveira1, 1Department of Stomatology, Area of Pathology, Bauru School of Dentistry University of São Paulo, Bauru, Brazil; 2Lauro de Souza Lima Institute, Bauru, Brazil Objective: To investigate the association of ezrin and podoplanin expressions in benign odontogenic tumours with and without ectomesenchyme. Study Design: Immunohistochemistry of ezrin and podoplanin was analyzed in 52 benign odontogenic tumours including 8 ameloblastomas, 12 adenomatoid odontogenic tumours, 18 keratocyst odontogenic tumours (KCOT), 2 calcifying epithelial odontogenic tumours, 3 ameloblastic fibromas, 5 ameloblastic fibro-odontomas and 4 calcifying cystic odontogenic tumours. The association between membranous and cytoplasmic ezrin and podoplanin expressions by epithelial odontogenic cells was determined by Wilcoxon’s test. Results: Strong cytoplasmic ezrin and membranous podoplanin expressions was found on peripheral epithelial cells in all the odontogenic tumours. Significant differences relative to cytoplasmic ezrin and membranous podoplanin were observed (p¼0.002) in KCOT. Conclusions: These findings suggest that ezrin and podoplanin are regularly expressed by epithelial cells of the odontogenic tumours. Further studies are warranted to elucidate the role of this molecular association on the odontogenic tumor progression. Financial support: FAPESP #2012/13411-6; #2013/16036-4; CNPq #142790/2011-7 Keywords: odontogenic tumours, ezrin, podoplanin
HETEROTOPIC ORAL GASTROINTESTINAL CYST: CASE REPORT Irem Hicran Ozbudak1, Havva Serap Toru1, Neslihan Yaprak2, Kenan Guney2, Gulay Ozbilim1,
ABSTRACTS Abstracts e193 1 Department of Pathology, Akdeniz University School of Medicine, Antalya, Turkey; 2Department of Ear Nose Throat Head and Neck Surgery, Akdeniz University School of Medicine, Antalya, Turkey
Heterotopic gastrointestinal cyst is abnormally placed rest of gastric or intestinal mucosa which may be admixed with ciliated columnar and squamous epithelium. This lesion is rarely found in oral cavity. The ventral surface of tongue is the most common location. A 1-month-old boy was admitted to the hospital due to swelling of the sublingual area. Radiological examination revealed a 32.5 cm cystic mass. The patient underwent total excision of the cyst. Histologically, the cyst wall was lined with a mixture of gastric, squamous and ciliated columnar epithelium. The cyst wall also contained extracellular mucin beside the collagenized fibrovascular stroma and bundles of striated muscle. The patient was diagnosed as ‘Heterotopic oral gastrointestinal cyst’. Although heterotopic gastrointestinal cysts rarely occur, it should be considered in differential diagnosis of lingual swelling in the pediatric population along with epidermoid and dermoid cysts. Keywords: lingual cyst, congenital
PERIPHERAL GIANT CELL GRANULOMAS: A REVIEW OF THREE CASES Irem Hicran Ozbudak1, Havva Serap Toru1, Sinan Tozoglu2, Gulay Ozbilim1, 1Department of Pathology, Akdeniz University School of Medicine, Antalya, Turkey; 2Department of Oral and Maxillofacial Surgery, Akdeniz University Faculty of Dentistry, Antalya, Turkey Peripheral giant cell granuloma is the most common giant cell lesion of the jaws. It is a well-circumscribed lesion confined to the mucosa, originating from the connective tissue of the periosteum or the periodontal ligament. Herein, we reported three cases of peripheral giant cell granuloma. All patients were presented with painless swelling in the gingiva. Two of them were from maxillary and the rest was from mandibular region. Clinically, they were firm, red to purple sessile nodules variable in size which not exceed 2 cm in diameter. Surface epithelium of all lesions had focal areas of ulceration. Histologically, the lesions were characterized by multinucleated giant cells with a background of ovoid to spindle-shaped mesenchymal cells. Although in the clinical setting, malignancy is considered in differential diagnosis, Peripheral giant cell granuloma is a reactive lesion caused by local irritation. Treatment consisted of complete resection of the lesion. Keywords: Gingiva, oral
FOXP3 EXPRESSION IN ORAL AND LARYNGEAL DYSPLASIA Bilge Elçin1, Nil Üstünda g1, Mehmet Ali Elçin2, Batur S¸ebnem1, Övgü Aydın1, 1Department of Pathology, Cerrahpas¸a Medical Faculty, Istanbul University, Istanbul, Turkey; 2Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Bezmialem Vakif University, Istanbul, Turkey Objective: In this study, we report the Foxp3 expression levels of dysplasia in oral mucosa and larynx. Study Design: 78 patients diagnosed with mild-severe dysplasia, carcinoma in situ and squamous cell carcinoma in oral mucosa and larynx were selected. Immunostaining was performed for Foxp3. Staining at least 25% of the dysplastic cells was considered positive for Foxp3 expression. Chi-square test was used for the statistical analysis to analyze the relationship between Foxp3 expression and pathologic differentiation.