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HLA system — New aspects
Journal of Immunological Methods, 17 (1977) 389
389
© Elsevier/North-Holland Biomedical Press
Book review
HLA System -- New Aspects, edited by G.B. Ferrara. North-Holland, Ams t e r d a m - N e w York, 1977 (170 pp., illus.) $ 23.50 (Dfl. 57.00). Since the discovery by P.A. Gorer of the mouse H-2 complex and the detection by J. Dausset of the first HLA antigen in 1958, the field of histocompatibility testing has become an almost autonomous biomedical discipline. To mark the 40th foundation anniversay of the I m m u n o h a e m a t o l o g y Research Center in Bergamo, Italy, the International Symposium on I-tLA System was held at that institution in September 1976. The symposium proceedings have been published in a book under the above title. The book contains eleven papers variously presenting reviews and original experimental and clinical findings related to H-2 and HLA systems. The first paper reviews the present knowledge of the genetic control of human tissue antigens, the mapping of HLA loci in chromosome 6, and the polymorphism of these genetic loci. The second paper discusses the target and recognitive functions as well as the cellular distribution of HLA gene products in mice and in man. The subsequent three papers deal with the biochemistry and genetics of murine tumor-associated transplantation antigens. The sixth paper summarizes results of chessboard c y t o t o x i c i t y tests with human multispecific antisera vs. lymphocytes of HLA-A and B identical and compatible panel-donors, shows the correlation between HLA compatibilities and the survival of renal and corneal grafts, and examines the diagnostic value of the direct cell-mediated lympholysis in predicting transplantation results. The remaining 5 papers survey respectively the application of MLC typing to human family studies, the medical significance of human B-cell alloantigens, the analogy between human HLA-D/B and murine Ia antigens, HLA-associated susceptibility to certain infections and autoimmune diseases, and the histocompatibility testing for clinical bone marrow transplantation. Each of the abovementioned papers offers a wealth of data and interpretation of the given subject. The text, in conjunction with tables, diagrams and bibliographic references, is presented in an accessible form. This book should be of considerable interest to those specializing in immunogenetics as well as to biologists in general. F. Borek
389
© Elsevier/North-Holland Biomedical Press
Book review
HLA System -- New Aspects, edited by G.B. Ferrara. North-Holland, Ams t e r d a m - N e w York, 1977 (170 pp., illus.) $ 23.50 (Dfl. 57.00). Since the discovery by P.A. Gorer of the mouse H-2 complex and the detection by J. Dausset of the first HLA antigen in 1958, the field of histocompatibility testing has become an almost autonomous biomedical discipline. To mark the 40th foundation anniversay of the I m m u n o h a e m a t o l o g y Research Center in Bergamo, Italy, the International Symposium on I-tLA System was held at that institution in September 1976. The symposium proceedings have been published in a book under the above title. The book contains eleven papers variously presenting reviews and original experimental and clinical findings related to H-2 and HLA systems. The first paper reviews the present knowledge of the genetic control of human tissue antigens, the mapping of HLA loci in chromosome 6, and the polymorphism of these genetic loci. The second paper discusses the target and recognitive functions as well as the cellular distribution of HLA gene products in mice and in man. The subsequent three papers deal with the biochemistry and genetics of murine tumor-associated transplantation antigens. The sixth paper summarizes results of chessboard c y t o t o x i c i t y tests with human multispecific antisera vs. lymphocytes of HLA-A and B identical and compatible panel-donors, shows the correlation between HLA compatibilities and the survival of renal and corneal grafts, and examines the diagnostic value of the direct cell-mediated lympholysis in predicting transplantation results. The remaining 5 papers survey respectively the application of MLC typing to human family studies, the medical significance of human B-cell alloantigens, the analogy between human HLA-D/B and murine Ia antigens, HLA-associated susceptibility to certain infections and autoimmune diseases, and the histocompatibility testing for clinical bone marrow transplantation. Each of the abovementioned papers offers a wealth of data and interpretation of the given subject. The text, in conjunction with tables, diagrams and bibliographic references, is presented in an accessible form. This book should be of considerable interest to those specializing in immunogenetics as well as to biologists in general. F. Borek