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ID 45 – Central and autonomic activity during emotion processing: A multi-method approach with hemodynamic (fNIRS), electrocortical (EEG) and autonomic measures
Abstracts / Clinical Neurophysiology 127 (2016) e18–e132
ID 30 – Influence of M1 hand knob ischemic stroke on motor activation: An fMRI study in chronic stage—E. Kallioniemi a,b, M. Könönen a,c, L. Säisänen a,d, P. Julkunen a,b, R. Vanninen c,d, P. Jäkälä e,f, S. Määttä a,d, S. Vaalto g (a Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio Finland, b Department of Applied Physics, University of Eastern Fin1land, Kuopio, Finland, c Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland, d Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland, e Department of Neurology, Kuopio University Hospital, Kuopio, Finland, f Brain Research Unit, University of Eastern Finland, Kuopio, Finland, g Department of Clinical Neurophysiology, Helsinki University Hospital, Helsinki, Finland) Objective: To evaluate whether stroke lesion focused on the primary motor cortex hand knob re-localizes the hand motor area in the affected hemisphere. Methods: The study included 8 right-handed chronic ischemic stroke patients (2 females, age range: 48–68 years) with hand knob localized lesion (2 left hemisphere, 6 right hemisphere, at least 2 years from stroke). Block-design fMRI was performed using a 3T MR scanner during finger tapping task to both hemispheres. For the analysis, images with left hemisphere lesions were flipped. Differences between affected and unaffected hemispheres were tested with a paired t-test using a threshold of p < 0.001 (T = 4.79), uncorrected for multiple comparisons. Results: Significantly reduced motor activation in the affected hemisphere versus unaffected hemisphere was observed in the posterior part of precentral gyrus (hand-knob), pars opercularis and pars triangularis of the inferior frontal gyrus, inferior parietal cortex, intraparietal sulcus and lobule VI in cerebellum. Conclusions: Reduction in the hand motor activation was observed in M1 in the affected hemisphere. Key message: fMRI is capable to detect abnormal motor activation after focal stroke on hand knob area. doi:10.1016/j.clinph.2015.11.249
ID 45 – Central and autonomic activity during emotion processing: A multi-method approach with hemodynamic (fNIRS), electrocortical (EEG) and autonomic measures—M.E. Vanutelli a,b, E. Grippa a, M. Balconi a,b (a Psychology, Catholic University of Milan, Milan, Italy, b Research Unit in Affective and Social Neuroscience, Catholic University of Milan, Milan, Italy) Objective: Because of its sudden temporal evolution and representation among different levels and complex neural networks, emotion processing should be examined by means of a multi-method approach. The possibility to acquire autonomic (arousal-related) and central (cortical-related) activities allows to better elucidate the reciprocal interplay of the two compartments. Methods: 20 subjects were submitted to emotional stimuli while functional near-infrared spectroscopy (fNIRS), frequency bands (EEG) and skin conductance response (SCR) were simultaneously recorded as biological markers of emotions. Subjective measures were also considered (Self-Assessment Manikin; SAM). Results: As shown by oxyhemoglobin (O2Hb) increasing within the right hemisphere, the contribution of the prefrontal cortex was elucidated, by pointing out a right-lateralized effect induced by the negative valence of the stimuli. Moreover EEG activity was associated with the cortical hemodynamic responsiveness to negative emotional patterns, within the right side. SCR increased in response
e75
to negative patterns and was related to explicit (SAM) and cortical (fNIRS; EEG) measures. Conclusions: Cortical, autonomic and subjective measures were intrinsically associated. Specifically, negative valence was more relevant to process emotional cue in relation to the hemispheric lateralization. Key message: Results suggest the importance of central and peripheral measures to explore subjects’ response to emotions. doi:10.1016/j.clinph.2015.11.250
ID 65 – Magnetoencephalography (MEG) and diffusion tensor magnetic resonance imaging (DTI) of functional and effective brain connectivity in traumatic brain injury (TBI)—R. Nowak a, S. Gimenez a,b (a MEG Laboratory, Centro Médico Teknon, Barcelona, Spain, b Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain) The present study used an integrated multimodal neuroimaging approach involving MEG and DTI to assess their utility in functional and effective connectivity evaluation in TBI. The study population consisted of TBI patients (25) and a group of healthy subjects (25). All patients in the sample have been examined twice (before and after rehabilitation). All study patients completed a neurorehabilitation program adapted to each individual’s requirements. Patients and controls underwent a neuropsychological assessment, in order to establish their cognitive status in multiple cognitive functions. Traumatic white matter injury has been measured with diffusion tensor imaging (DTI), impaired cortical activation has been detected with MEG. Brain networks connectivity analysis showed: TBI patients exhibit functional connectivity alteration as compared to the control subjects; overall significant reduction of MEG connectivity activity in TBI patients compared with control subjects. Extent of functional disconnection was associated with injury severity. Reduction of MEG connectivity originates from gray matter neurons that experience de-afferentation due to axonal injury to the underlying white matter fiber tracts, which was manifested on diffusion tensor imaging (DTI) as reduced fractional anisotropy. Neuronal reorganization, as measured by brain connectivity, due to comprehensive rehabilitation process correlated with cognitive recovery as indicated by neuropsychological assessment. doi:10.1016/j.clinph.2015.11.251
ID 73 – Cortical parcellation based on local neuronal electrical activity—C. Cottone a,b, C. Porcaro a, A. Cancelli a,c, E. Olejarczyk a,e, C. Salustri a, F. Tecchio a,d (a Laboratory of Electrophysiology for Translational neuroScience (LET’S) – ISTC – CNR, Department of Neuroscience, Fatebenefratelli Hospital Isola Tiberina, Rome, Italy, b Department of Neuroscience and Imaging, G. d’Annunzio University of Chieti – Pescara, Italy, c Institute of Neurology, Cattolica del Sacro Cuore University, Rome, Italy, d Department of Neuroimaging, IRCCS San Raffaele Pisana, Rome, Italy, e Nałe˛cz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland) Brodmann’s pioneering work resulted in the classification of the cortical areas based on their cyto-architecture and topology. Here,
ID 30 – Influence of M1 hand knob ischemic stroke on motor activation: An fMRI study in chronic stage—E. Kallioniemi a,b, M. Könönen a,c, L. Säisänen a,d, P. Julkunen a,b, R. Vanninen c,d, P. Jäkälä e,f, S. Määttä a,d, S. Vaalto g (a Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio Finland, b Department of Applied Physics, University of Eastern Fin1land, Kuopio, Finland, c Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland, d Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland, e Department of Neurology, Kuopio University Hospital, Kuopio, Finland, f Brain Research Unit, University of Eastern Finland, Kuopio, Finland, g Department of Clinical Neurophysiology, Helsinki University Hospital, Helsinki, Finland) Objective: To evaluate whether stroke lesion focused on the primary motor cortex hand knob re-localizes the hand motor area in the affected hemisphere. Methods: The study included 8 right-handed chronic ischemic stroke patients (2 females, age range: 48–68 years) with hand knob localized lesion (2 left hemisphere, 6 right hemisphere, at least 2 years from stroke). Block-design fMRI was performed using a 3T MR scanner during finger tapping task to both hemispheres. For the analysis, images with left hemisphere lesions were flipped. Differences between affected and unaffected hemispheres were tested with a paired t-test using a threshold of p < 0.001 (T = 4.79), uncorrected for multiple comparisons. Results: Significantly reduced motor activation in the affected hemisphere versus unaffected hemisphere was observed in the posterior part of precentral gyrus (hand-knob), pars opercularis and pars triangularis of the inferior frontal gyrus, inferior parietal cortex, intraparietal sulcus and lobule VI in cerebellum. Conclusions: Reduction in the hand motor activation was observed in M1 in the affected hemisphere. Key message: fMRI is capable to detect abnormal motor activation after focal stroke on hand knob area. doi:10.1016/j.clinph.2015.11.249
ID 45 – Central and autonomic activity during emotion processing: A multi-method approach with hemodynamic (fNIRS), electrocortical (EEG) and autonomic measures—M.E. Vanutelli a,b, E. Grippa a, M. Balconi a,b (a Psychology, Catholic University of Milan, Milan, Italy, b Research Unit in Affective and Social Neuroscience, Catholic University of Milan, Milan, Italy) Objective: Because of its sudden temporal evolution and representation among different levels and complex neural networks, emotion processing should be examined by means of a multi-method approach. The possibility to acquire autonomic (arousal-related) and central (cortical-related) activities allows to better elucidate the reciprocal interplay of the two compartments. Methods: 20 subjects were submitted to emotional stimuli while functional near-infrared spectroscopy (fNIRS), frequency bands (EEG) and skin conductance response (SCR) were simultaneously recorded as biological markers of emotions. Subjective measures were also considered (Self-Assessment Manikin; SAM). Results: As shown by oxyhemoglobin (O2Hb) increasing within the right hemisphere, the contribution of the prefrontal cortex was elucidated, by pointing out a right-lateralized effect induced by the negative valence of the stimuli. Moreover EEG activity was associated with the cortical hemodynamic responsiveness to negative emotional patterns, within the right side. SCR increased in response
e75
to negative patterns and was related to explicit (SAM) and cortical (fNIRS; EEG) measures. Conclusions: Cortical, autonomic and subjective measures were intrinsically associated. Specifically, negative valence was more relevant to process emotional cue in relation to the hemispheric lateralization. Key message: Results suggest the importance of central and peripheral measures to explore subjects’ response to emotions. doi:10.1016/j.clinph.2015.11.250
ID 65 – Magnetoencephalography (MEG) and diffusion tensor magnetic resonance imaging (DTI) of functional and effective brain connectivity in traumatic brain injury (TBI)—R. Nowak a, S. Gimenez a,b (a MEG Laboratory, Centro Médico Teknon, Barcelona, Spain, b Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain) The present study used an integrated multimodal neuroimaging approach involving MEG and DTI to assess their utility in functional and effective connectivity evaluation in TBI. The study population consisted of TBI patients (25) and a group of healthy subjects (25). All patients in the sample have been examined twice (before and after rehabilitation). All study patients completed a neurorehabilitation program adapted to each individual’s requirements. Patients and controls underwent a neuropsychological assessment, in order to establish their cognitive status in multiple cognitive functions. Traumatic white matter injury has been measured with diffusion tensor imaging (DTI), impaired cortical activation has been detected with MEG. Brain networks connectivity analysis showed: TBI patients exhibit functional connectivity alteration as compared to the control subjects; overall significant reduction of MEG connectivity activity in TBI patients compared with control subjects. Extent of functional disconnection was associated with injury severity. Reduction of MEG connectivity originates from gray matter neurons that experience de-afferentation due to axonal injury to the underlying white matter fiber tracts, which was manifested on diffusion tensor imaging (DTI) as reduced fractional anisotropy. Neuronal reorganization, as measured by brain connectivity, due to comprehensive rehabilitation process correlated with cognitive recovery as indicated by neuropsychological assessment. doi:10.1016/j.clinph.2015.11.251
ID 73 – Cortical parcellation based on local neuronal electrical activity—C. Cottone a,b, C. Porcaro a, A. Cancelli a,c, E. Olejarczyk a,e, C. Salustri a, F. Tecchio a,d (a Laboratory of Electrophysiology for Translational neuroScience (LET’S) – ISTC – CNR, Department of Neuroscience, Fatebenefratelli Hospital Isola Tiberina, Rome, Italy, b Department of Neuroscience and Imaging, G. d’Annunzio University of Chieti – Pescara, Italy, c Institute of Neurology, Cattolica del Sacro Cuore University, Rome, Italy, d Department of Neuroimaging, IRCCS San Raffaele Pisana, Rome, Italy, e Nałe˛cz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland) Brodmann’s pioneering work resulted in the classification of the cortical areas based on their cyto-architecture and topology. Here,