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IgG IN BRAIN CELLS IN SLE
1304 " XBD=1285 XBD=314 XBD=366 XBD=612 XBD=745 XBD=796 XBD=1098 XBD=1145 XHG=227 XHG=324 XHG=375 XHG=622 XHG=805 XHG=1108 XHG=1155 XHG=1201 YBD=359 YBD=365 YBD=364 YBD=358 YBD=359 YHG=336>LACK YHG=337>ANTIDIABETIC YHG=337>EFFECT YHG=337>(-)-EPICATECHIN YHG=337>(E) YHG=337>IN YHG=337>HIGH " XBD=1190 XBD=1494XHG=755 XBD=1630 XBD=1729 XBD=1822 XBD=1956 XBD=2022 XBD=2136 XBD=2194 XBD=2231 XBD=2265 XBD=2369 XBD=2441 XBD=2540 XHG=1423YBD=358 XHG=1506 XHG=1641 XHG=1741 XHG=1833 XHG=1968 XHG=2035 XHG=2151 XHG=2207 XHG=2243 XHG=2278 XHG=2379 XHG=2453 YBD=371YHG=337>OF YBD=370 YBD=362 YBD=369 YBD=360 YHG=342>may YHG=333>depend YHG=342>upon YHG=333>their YHG=332>smaller YHG=341>age YHG=341>range. YHG=331>Or YHG=331>is YHG=332>it YHG=331>really YHG=330>that YHG=331>much XBD=337 XHG=524 XBD=420 XBD=514 XBD=821 XBD=865 XBD=1106 XBD=1152 XBD=1244 XHG=831 XHG=268 XHG=348 XHG=431 XHG=874YBD=411 XHG=1117 XHG=1161 YBD=404 YBD=405 YBD=404 YBD=403 YHG=382>AND YHG=382>LOW YHG=382>DOSE YHG=382>STREPTOZOTOCIN YHG=383>(S) YHG=382>EXPERIMENTS YHG=382>IN YHG=381>MICE " XBD=2539 XBD=1562 XBD=1769 XBD=1860 XBD=1920 XBD=2029 XBD=2127 XBD=2205 XBD=2352 XBD=2421 XHG=1423 XHG=1572 XHG=1778 XHG=1867 XHG=1928 XHG=2037 XHG=2136 XHG=2215 XHG=2359 XHG=2430 YBD=408 YBD=407 YBD=414 YBD=405 YBD=412 YHG=378>smaller? YHG=378>Calculation YHG=378>from YHG=378>the YHG=378>stated YHG=386>mean YHG=386>ages YHG=383>suggests YHG=376>that YHG=376>subject
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XBD=2539 XBD=1473 XBD=1527 XBD=1601 XBD=1653 XBD=1751 XBD=1825 XBD=1991 XBD=2041 XBD=2106 XBD=2210 XBD=2259 XBD=2367 XBD=2442 XBD=2501 XBD=1475 XBD=1569 XBD=1716 XBD=1793 XBD=1904 XBD=2054 XBD=2147 XBD=2237 XBD=2463 XBD=2539 XBD=1496 XBD=1670 XBD=1751 XBD=1886 XBD=1951 XBD=2022 XBD=2232 XBD=2408 XBD=2458 XBD=2539 XBD=1589 XBD=1650 XBD=1731 XBD=1875 XBD=2036 XBD=2247 XBD=2314 XBD=2393 XBD=2501 XBD=2538 XBD=1593 XBD=1641 XBD=1707 XBD=1954 XBD=2000 XBD=2154 XBD=2232 XBD=2306 XBD=2386 XBD=2539 XBD=1497 XBD=1559 XBD=1589 XBD=1709 XBD=1822 XBD=1910 XBD=1975 XBD=2157 XBD=1549 XBD=1614 XBD=1738 XBD=1799 XBD=2177 XBD=2310 XBD=2424 XBD=2539 XBD=1457 XBD=1725 XBD=1771 XBD=1857 XBD=1928 XBD=2051 XBD=2191 XBD=2232 XBD=2293 XBD=2375 XBD=2421 XBD=2538 XBD=1589 XBD=1682 XBD=1754 XBD=1965 XBD=2039 XBD=2168 XBD=2407 XBD=2494 XBD=2538 XBD=1765 XBD=1911 XBD=1956 XBD=2029 XBD=2177 XBD=1510
XHG=2511 XHG=1424 XHG=1492 XHG=1539 XHG=1614 XHG=1664 XHG=1763 XHG=1838 XHG=2002 XHG=2052 XHG=2118 XHG=2221 XHG=2268 XHG=2379 XHG=2454 XHG=1423 XHG=1488 XHG=1581 XHG=1727 XHG=1805 XHG=1915 XHG=2066 XHG=2157 XHG=2248 XHG=2476 XHG=1422 XHG=1523 XHG=1696 XHG=1778 XHG=1912 XHG=1970 XHG=2050 XHG=2256 XHG=2435 XHG=2482 XHG=1423 XHG=1618 XHG=1678 XHG=1759 XHG=1902 XHG=2064 XHG=2275 XHG=2341 XHG=2420 XHG=2525 XHG=1423 XHG=1607 XHG=1654 XHG=1849 XHG=1969 XHG=2014 XHG=2167 XHG=2246 XHG=2319 XHG=2401 XHG=1423 XHG=1510 XHG=1572 XHG=1601 XHG=1722 XHG=1835 XHG=1923 XHG=1988 XHG=1458 XHG=1561 XHG=1627 XHG=1750 XHG=1939 XHG=2189 XHG=2322 XHG=2436 XHG=1423 XHG=1468 XHG=1737 XHG=1781 XHG=1868 XHG=1937 XHG=2062 XHG=2200 XHG=2241 XHG=2303 XHG=2385 XHG=2425 XHG=1423 XHG=1609 XHG=1701 XHG=1775 XHG=1985 XHG=2058 XHG=2188 XHG=2426 XHG=2511 XHG=1647 XHG=1776 XHG=1923 XHG=1968 XHG=2042 XHG=1423
YBD=453 YBD=462 YBD=461 YBD=452 YBD=451 YBD=459 YBD=460 YBD=499 YBD=500 YBD=507 YBD=498 YBD=504 YBD=496 YBD=553 YBD=552 YBD=551 YBD=544 YBD=550 YBD=541 YBD=543 YBD=598 YBD=590 YBD=596 YBD=589 YBD=587 YBD=588 YBD=635 YBD=634 YBD=639 YBD=641 YBD=690 YBD=688 YBD=681 YBD=680 YBD=726 YBD=727 YBD=725 YBD=734 YBD=781 YBD=780 YBD=772 YBD=771 YBD=778 YBD=824 YBD=817 YBD=826 YBD=825 YBD=818 YBD=872 YBD=863 YBD=871
YHG=422>in YHG=433>no. YHG=424>19 YHG=433>was YHG=425>77 YHG=433>years YHG=424>old, YHG=423>implying YHG=432>an YHG=431>age YHG=432>range YHG=422>of YHG=423>10-77 YHG=421>(not YHG=421>57) YHG=470>the YHG=469>table YHG=469>(though YHG=469>that YHG=478>seems YHG=468>unlikely YHG=467>from YHG=468>their YHG=466>relationship). YHG=466>The YHG=525>very YHG=514>different YHG=524>age YHG=524>ranges YHG=514>of YHG=514>the YHG=514>&dquo;unrelated YHG=512>subjects&dquo; YHG=512>is YHG=513>also YHG=560>worrying, YHG=570>as YHG=560>the YHG=560>related YHG=560>subjects YHG=559>themselves YHG=558>do YHG=565>not YHG=557>show YHG=568>a YHG=605>difference YHG=606>in YHG=605>the YHG=605>values YHG=615>as YHG=605>between YHG=604>UU YHG=604>and YHG=603>UL, YHG=603>although YHG=651>they YHG=660>are YHG=660>a YHG=651>bigger YHG=660>group YHG=651>than YHG=651>the YHG=650>unrelated. YHG=696>Were YHG=696>the YHG=696>bloods YHG=696>for YHG=697>determination YHG=696>usually YHG=696>drawn YHG=694>fasting YHG=751>or YHG=742>postprandially, YHG=752>or YHG=742>with YHG=752>any YHG=742>special YHG=742>relation YHG=748>to YHG=742>the YHG=741>time YHG=740>of YHG=741>glucose YHG=788>injection? YHG=788>Was YHG=788>the YHG=788>81-year-old YHG=788>LL YHG=788>female YHG=787>(contributing YHG=787>only YHG=795>to YHG=833>values) YHG=834>unusual YHG=834>in YHG=833>this YHG=834>respect? YHG=833>these
HbAlc HbAlc HbA1c Radcliffe Infirmary, Oxford OX2 6HE
XBD=2542 XHG=2373 XBD=1553 XBD=1655 XBD=1724 XBD=1816 XBD=1940 XBD=1985 XBD=2044 XBD=2229 XBD=2302 XBD=2361 XHG=1430 XHG=1566 XHG=1669 XHG=1737 XHG=1831 XHG=1952 XHG=1998 XHG=2058 XHG=2242 XHG=2314 YBD=1045 YHG=1015>colleagues, YBD=1046 YBD=1053 YHG=1016>** This YHG=1016>letter YHG=1016>has YHG=1016>been YHG=1017>shown YHG=1023>to YHG=1016>Dr YHG=1016>Owerbach YHG=1016>and YHG=1016>his n= 10YBD=1083 mice; XBD=274 XBD=513 XBD=558 XBD=646 XBD=847 XHG=190 XHG=472 XHG=523 XHG=569 YBD=1076 YBD=1077 YHG=1052>*n=9 YHG=1050>for YHG=1051>all YHG=1051>other YHG=1051>experiments. XBD=1534XHG=657 XBD=1635 XBD=1876 XBD=1925 XHG=1429 XHG=1547 XHG=1646 XHG=1890 YBD=1099 YBD=1091 YBD=1092 YHG=1062>whose YHG=1061>reply YHG=1061>follows.-ED. YHG=1061>L. XBD=294 XHG=883 XBD=453 XBD=548 XBD=777 XBD=851 XBD=936 XBD=1156 XBD=1326 XHG=193 XHG=327 XHG=487 XHG=583 XHG=809 XHG=969YBD=1151 XHG=1190 YBD=1152 YBD=1160 YBD=1159 YBD=1151 YBD=1151 YHG=1122>Blood YHG=1122>glucose YHG=1130>was YHG=1121>determined YHG=1121>by YHG=1121>the YHG=1121>hexokinase YHG=1121>method. XBD=1707 XBD=1755 XBD=1849 XBD=1890 XBD=1956 XBD=2060 XBD=2110 XBD=2150 XBD=2230 XBD=2309 XBD=2405 XBD=2464 XBD=2507 XBD=2543 XHG=1682 XHG=1717 XHG=1765 XHG=1858 XHG=1899 XHG=1965 XHG=2068 XHG=2119 XHG=2161 XHG=2241 XHG=2318 XHG=2414 XHG=2473 XHG=2510 YBD=1166 YBD=1165 YBD=1157 YBD=1158 YHG=1128>is YHG=1138>an YHG=1137>error YHG=1127>in YHG=1137>our YHG=1137>paper YHG=1137>on YHG=1138>p. YHG=1128>882. YHG=1127>The YHG=1137>mean YHG=1137>age YHG=1127>of YHG=1129>all XBD=474 XBD=687 XBD=758 XBD=838 XBD=939 XBD=1089 XBD=1169 XBD=1330 XHG=194 XHG=513 XHG=726 XHG=798 XHG=978 XHG=1130 XHG=1208 YBD=1206 YBD=1204 YBD=1196 YBD=1197 YBD=1196 YBD=1197 YHG=1167>Hyperglycaemia YHG=1166>developed YHG=1167>in YHG=1167>all YHG=1173>rats YHG=1167>within YHG=1167>24 YHG=1167>h XBD=1485XHG=878 XBD=1631 XBD=1703 XBD=1806 XBD=1994 XBD=2055 XBD=2107 XBD=2178 XBD=2265 XBD=2322 XBD=2379 XBD=2544 XHG=1430 XHG=1495 XHG=1642 XHG=1716 XHG=1819 XHG=2005 XHG=2072 XHG=2117 XHG=2189 XHG=2275 XHG=2335 XHG=2389 YBD=1210 YBD=1211 YBD=1203 YBD=1202 YBD=1212 YHG=1173>LLand YHG=1173>subjects YHG=1174>36-9. YHG=1173>Individual YHG=1183>no. YHG=1174>19 YHG=1183>was YHG=1173>aged YHG=1174>31. YHG=1173>Dr YHG=1173>Hockaday 2 XBD=975 XBD=1155 XBD=1329 XHG=989 XHG=1167 YBD=1250 YBD=1250 YBD=1242 YHG=1211>4 YHG=1212>Complete YHG=1212>remission days. XBD=476 XBD=592 XBD=751 XBD=794 XHG=194 XHG=486 XHG=603 XHG=761 YBD=1251 YBD=1241 YBD=1242 YHG=1212>normoglycaemic YHG=1212>values YHG=1212>returned YHG=1212>in XBD=1571XHG=861 XBD=1651 XBD=1718 XBD=1799 XBD=1852 XBD=2036 XBD=2234 XBD=2279 XBD=2344 XBD=2409 XBD=2544 XHG=1430 XHG=1585 XHG=1665 XHG=1733 XHG=1813 XHG=1860 XHG=2051 XHG=2248 XHG=2292 XHG=2357 XHG=2422 YBD=1250 YBD=1257 YBD=1249 YBD=1248 YBD=1256 YHG=1225>suggests YHG=1219>that YHG=1218>the YHG=1219>lack YHG=1219>of YHG=1218>significant YHG=1219>correlation YHG=1219>in YHG=1219>the YHG=1219>LL YHG=1219>subjects XBD=268 XBD=457 XBD=530 XBD=647 XBD=803 XBD=905 XBD=1005 XBD=1257 XBD=1333 XHG=194 XHG=307 XHG=497 XHG=570 XHG=687 XHG=843 XHG=943 XHG=1046 XHG=1297 YBD=1288 YBD=1287 YBD=1295 YBD=1286 YBD=1287 YBD=1295 YBD=1288 YHG=1259>thus YHG=1258>occurred YHG=1258>in YHG=1257>both YHG=1266>groups YHG=1257>and YHG=1267>was YHG=1257>independent YHG=1257>of XBD=1570 XHG=2471 XBD=1643 XBD=1722 XBD=1836 XBD=1968 XBD=2079 XBD=2219 XBD=2270 XBD=2305 XBD=2406 XBD=2455 XBD=2544 XHG=1429 YBD=1304 XHG=1589 XHG=1661 XHG=1739 XHG=1854 XHG=1984 XHG=2095 XHG=2236 XHG=2287 XHG=2320 XHG=2423 YBD=1302 YHG=1265>early YBD=1294 YHG=1265>between YHG=1274>age YHG=1265>and YHG=1265>either YHG=1264>fasting YHG=1265>blood YHG=1265>glucose YHG=1264>k YHG=1265>value YHG=1274>or XBD=468 XBD=517 XBD=543 XBD=670 XBD=871 XBD=1146 XBD=1216 XBD=1328 XHG=193 XHG=480 XHG=527 XHG=554 XHG=880 XHG=1155 XHG=1226 YBD=1342 YBD=1332 YBD=1333 YBD=1341 YBD=1340 YBD=1333 YBD=1340 YHG=1303>(-)-epicatechin. YHG=1303>In YHG=1313>a YHG=1303>second YHG=1303>experiment YHG=1302>(-)-epicatechin YHG=1312>was YHG=1304>given, XBD=1548XHG=679 XBD=1709 XBD=1792 XBD=1843 XBD=1972 XBD=2015 XBD=2080 XBD=2214 XBD=2279 XBD=2382 XBD=2504 XBD=2544 XHG=1431 XHG=1561 XHG=1722 XHG=1804 XHG=1856 XHG=1983 XHG=2027 XHG=2093 XHG=2226 XHG=2292 XHG=2393 XHG=2516 YBD=1339 YBD=1347 YBD=1348 YHG=1310>insulin YHG=1319>response YHG=1320>may YHG=1310>be YHG=1310>related YHG=1317>to YHG=1310>the YHG=1310>smaller YHG=1319>age YHG=1320>range YHG=1310>(10-57 YHG=1321>vs XBD=226 XHG=775 XBD=355 XBD=433 XBD=543 XBD=647 XBD=715 XBD=754 XBD=860 XBD=1012 XBD=1048 XBD=1131 XBD=1257 XBD=1329 XHG=194 XHG=248 XHG=376 XHG=454 XHG=565 XHG=667 XHG=736 XHG=882YBD=1387 XHG=1036 XHG=1072 XHG=1150 XHG=1277 YBD=1384 YBD=1379 YBD=1378 YBD=1386 YBD=1378 YBD=1387 YBD=1379 YHG=1359>as YHG=1349>above, YHG=1348>but YHG=1349>twice YHG=1349>daily YHG=1348>for YHG=1350>6 YHG=1349>days, YHG=1349>starting YHG=1350>1 28 YHG=1349>day YHG=1348>before YHG=1349>the XBD=1560 XBD=1737 XBD=1821 XBD=1848 XBD=1912 XBD=2002 XBD=2076 XBD=2119 XBD=2186 XBD=2377 XBD=2460 XBD=2544 XHG=1435 XHG=1571 XHG=1747 XHG=1831 XHG=1858 XHG=1922 XHG=2012 XHG=2084 XHG=2127 XHG=2194 XHG=2384 XHG=2468 YBD=1393 YBD=1391 YBD=1394 YBD=1384 YBD=1385 YBD=1386 YHG=1356>10-74). YHG=1355>However, YHG=1356>only YHG=1356>3 YHG=1362>out YHG=1355>of YHG=1356>UU YHG=1365>or YHG=1355>UL YHG=1356>individuals YHG=1365>were YHG=1356>older XBD=1506 XBD=1569 XHG=1430 XHG=1521 YBD=1431 YBD=1430 YHG=1401>than YHG=1402>57. XBD=443 XHG=924 XBD=499 XBD=642 XBD=790 XBD=907 XBD=963 XBD=1035 XBD=1193 XBD=1329 XHG=194 XHG=460 XHG=509 XHG=660 XHG=807 XHG=974YBD=1424 XHG=1052 XHG=1209 YBD=1425 YBD=1429 YBD=1432 YBD=1425 YBD=1424 YHG=1394>administration YHG=1394>alloxan; YHG=1394>another YHG=1404>group YHG=1393>of YHG=1401>rats YHG=1394>received YHG=1394>alloxan XBD=277 XBD=585 XBD=783 XBD=839 XBD=942 XBD=1083 XBD=1219 XBD=1284 XBD=1330 XHG=194 XHG=305 XHG=610 XHG=807 XHG=864 XHG=967 XHG=1108 XHG=1244 XHG=1308 YBD=1479 YBD=1478 YBD=1470 YBD=1478 YBD=1471 YBD=1469 YHG=1441>only. YHG=1440>Hyperglycaemia YHG=1440>developed YHG=1440>in YHG=1440>both YHG=1449>groups YHG=1440>within YHG=1440>24 XBD=1552 XHG=2445 XBD=1681 XBD=1723 XBD=1783 XBD=1977 XBD=2153 XBD=2214 XBD=2310 XBD=2371 XBD=2438 XBD=2544 XHG=1465 YBD=1485 XHG=1561 XHG=1690 XHG=1731 XHG=1793 XHG=1984 XHG=2162 XHG=2222 XHG=2319 XHG=2379 YBD=1484 YHG=1440>h YBD=1476 YBD=1477 YBD=1486 YBD=1478 YHG=1447>With YHG=1453>respect YHG=1454>to YHG=1447>&dquo;unrelated YHG=1446>subjects&dquo;, YHG=1447>the YHG=1456>mean YHG=1457>age YHG=1457>was YHG=1448>higher
T. D. R. HOCKADAY
SIR,-There
274±83 XBD=333 XHG=847 XBD=442 XBD=579 XBD=833 XBD=895 XBD=1330 XHG=193 XHG=346 XHG=454 XHG=737 XHG=906YBD=1516 YBD=1525 YBD=1524 YBD=1523 YBD=1524 YHG=1486>(average YHG=1486>blood YHG=1486>glucose YHG=1485>mg/dl YHG=1485>for YHG=1485>(-)-epicatechin + alloxan (34 - 0) (43 - 4) " XBD=2542 XBD=2074 XBD=2132 XBD=2198 XBD=2353 XBD=2421 XHG=1998 XHG=2085 XHG=2144 XHG=2322 XHG=2363 XHG=2433 YBD=1521 YBD=1522 YBD=1523 YBD=1532 YHG=1493>than YHG=1493>for YHG=1492>LL YHG=1502>as YHG=1502>was YHG=1493>HbAlc XBD=1476 XBD=1539 XBD=1616 XBD=1688 XBD=1759 XBD=1870 XHG=1428 XHG=1487 XHG=1551 XHG=1627 XHG=1699 XHG=1770 YBD=1530 YHG=1494>the YHG=1493>UU YHG=1493>and YHG=1492>UL YHG=1502>group 309±80 XBD=224 XHG=839 XBD=480 XBD=542 XBD=678 XBD=790 XBD=825 XBD=913 XBD=1002 XBD=1101 XBD=1326 XHG=190 XHG=383 XHG=494 XHG=556 XHG=691 XHG=807 XHG=926YBD=1569 XHG=1016 XHG=1115 YBD=1568 YBD=1561 YBD=1560 YBD=1560 YBD=1560 YHG=1542>vs YHG=1531>mg/dl YHG=1531>for YHG=1531>alloxan YHG=1531>alone. YHG=1533>6 YHG=1531>days YHG=1531>later YHG=1540>some YHG=1537>spontaneous (5 - 74% 8107o). " XBD=2542 XBD=1642 XBD=1852 XBD=1913 XBD=2094 XBD=2164 XBD=2340 XBD=2425 XHG=1608 XHG=1758 XHG=1860 XHG=1922 XHG=2103 XHG=2173 XHG=2348 XHG=2433 YBD=1566 YBD=1567 YBD=1575 YBD=1568 YBD=1578 YHG=1539>4 YHG=1538>From YHG=1538>the YHG=1538>regression YHG=1538>line YHG=1538>calculated YHG=1538>from YHG=1538>HbA - lc ( -)-epicatechin+alloxan " XBD=895 XBD=354 XBD=425 XBD=583 XBD=839 XHG=190 XHG=363 XHG=433 XHG=742 YBD=1607 YBD=1614 YBD=1606 (292±78 YHG=1576>remission YHG=1577>had YHG=1577>occurred YHG=1576>mg/dl YHG=1576>for XBD=1596XHG=848 XBD=1681 XBD=1746 XBD=1804 XBD=1880 XBD=1951 XBD=2020 XBD=2137 XBD=2308 XBD=2369 XBD=2506 XBD=2548 XHG=1428 XHG=1605 XHG=1691 XHG=1756 XHG=1814 XHG=1889 XHG=1960 XHG=2029 XHG=2145 XHG=2318 XHG=2379 XHG=2514 YBD=1621 YBD=1613 YBD=1622 YBD=1619 YBD=1614 YHG=1584>compared YHG=1583>with YHG=1593>age YHG=1583>for YHG=1583>UU YHG=1584>and YHG=1583>UL YHG=1583>family YHG=1584>members, YHG=1584>the YHG=1584>increase YHG=1583>of 229±60 <0’2%. " XBD=1326 XBD=224 XBD=479 XBD=540 XBD=675 XBD=799 XBD=905 XBD=934 XBD=1110 XBD=1216 XBD=1268 XHG=191 XHG=382 XHG=493 XHG=554 XHG=688 XHG=814 XHG=918 XHG=946 XHG=1124 XHG=1230 XHG=1274 YBD=1660 YBD=1653 YBD=1661 YBD=1652 YBD=1652 YBD=1651 YHG=1633>vs YHG=1623>mg/dl YHG=1622>for YHG=1623>alloxan YHG=1622>alone). YHG=1622>Thus YHG=1632>a YHG=1621>beneficial YHG=1621>effect YHG=1621>of YHG=1622>the XBD=1550 XHG=2496 XBD=1642 XBD=1711 XBD=1809 XBD=1863 XBD=1911 XBD=1966 XBD=2069 XBD=2123 XBD=2185 XBD=2226 XBD=2482 XBD=2542 XHG=1429 YBD=1660 XHG=1565 XHG=1658 XHG=1728 XHG=1825 XHG=1879 XHG=1926 XHG=1982 XHG=2084 XHG=2131 XHG=2201 XHG=2387 YBD=1669 YHG=1630>the YBD=1667 YBD=1668 YBD=1659 YBD=1666 YHG=1629>HbA 1c YHG=1630>with YHG=1629>from YHG=1630>35 YHG=1637>to YHG=1630>45 YHG=1639>years YHG=1629>of YHG=1639>age YHG=1630>is YHG=1630>Thus, XBD=274 XHG=820 XBD=327 XBD=462 XBD=611 XBD=657 XBD=732 XBD=806 XBD=874 XBD=1047 XHG=193 XHG=285 XHG=340 XHG=475 XHG=625 XHG=671 XHG=745 XHG=888YBD=1698 YBD=1706 YBD=1699 YBD=1698 YHG=1669>drug YHG=1679>on YHG=1669>alloxan YHG=1669>diabetes YHG=1670>in YHG=1677>rats YHG=1678>was YHG=1668>observed. " XBD=2543 XBD=1597 XBD=1760 XBD=1803 XBD=1936 XBD=2062 XBD=2231 XBD=2373 XBD=2407 XHG=1428 XHG=1609 XHG=1771 XHG=1815 XHG=1948 XHG=2071 XHG=2242 XHG=2383 XHG=2416 YBD=1715YHG=1675>not YBD=1713 YBD=1712 YBD=1705 YBD=1714 YHG=1675>difference YHG=1676>observed YHG=1676>in YHG=1676>HbAlc YHG=1685>among YHG=1675>unrelated YHG=1676>subjects YHG=1676>is YHG=1676>unlikely " XBD=260 XBD=393 XBD=613 XBD=671 XBD=783 XBD=846 XBD=951 XBD=1271 XHG=223 XHG=272 XHG=405 XHG=624 XHG=683 XHG=794 XHG=963 XHG=1283 YBD=1736 YBD=1745 YBD=1737 YBD=1746 YBD=1737 YHG=1707>In YHG=1707>further YHG=1708>experiments YHG=1717>we YHG=1707>tested YHG=1708>the YHG=1707>effect YHG=1707>of(-)-epicatechin YHG=1718>on " XBD=1324 XBD=1592XHG=859 XBD=1646 XBD=1843 XBD=1889 XBD=1957 XBD=2069 XHG=1428 XHG=1604 XHG=1659 XHG=1857 XHG=1903 XHG=1970 YBD=1759 YBD=1751 YBD=1758 YBD=1750 YHG=1721>explained YHG=1721>by YHG=1720>differences YHG=1721>in YHG=1730>age YHG=1720>alone. " XBD=432 XBD=582 XBD=733 XBD=781 XBD=884 XBD=987 XBD=1176 XBD=1269 XBD=1323 XHG=187 XHG=447 XHG=597 XHG=748 XHG=796 XHG=900 XHG=1002 XHG=1191 XHG=1288 YBD=1790 YBD=1783 YBD=1782 YBD=1789 YBD=1783 YBD=1782 YHG=1752>streptozotocin YHG=1753>induced YHG=1753>diabetes YHG=1753>in YHG=1752>mice. YHG=1753>Male YHG=1752>C57BL/6J YHG=1753>mice " XBD=2548 XBD=1533 XHG=2514 XBD=1648 XBD=1789 XBD=1911 XBD=2008 XBD=2219 XBD=2310 XBD=2498 XHG=1463 YBD=1796 XHG=1551 XHG=1667 XHG=1805 XHG=1929 XHG=2027 XHG=2236 XHG=2328 YBD=1807 YHG=1754>12 YBD=1797 YHG=1766>The YHG=1767>stable YHG=1767>HbAlc YHG=1767>values YHG=1776>were YHG=1766>determined YHG=1765>after YHG=1767>incubation YHG=1766>of " XBD=2544 XBD=287 XHG=916 XBD=355 XBD=432 XBD=540 XBD=658 XBD=819 XBD=888 XBD=932 XBD=1059 XBD=1163 XBD=1264 XBD=1329 XHG=186 XHG=317 XHG=377 XHG=460 XHG=569 XHG=686 XHG=847 XHG=960YBD=1828 XHG=1087 XHG=1190 XHG=1292 YBD=1829 YBD=1836 YBD=1836 YBD=1836 YBD=1829 YHG=1798>weeks YHG=1798>of YHG=1807>age YHG=1808>were YHG=1799>made YHG=1799>diabetic YHG=1798>by YHG=1808>a YHG=1799>single YHG=1799>high YHG=1799>dose YHG=1798>of " XBD=1525 XBD=1608 XBD=1653 XBD=1865 XBD=1982 XBD=2063 XBD=2184 XBD=2338 XBD=2394 XHG=1430 XHG=1535 XHG=1619 XHG=1662 XHG=1876 XHG=1993 XHG=2073 XHG=2194 XHG=2347 XHG=2403 YBD=1850 YBD=1841 YBD=1842 YHG=1812>blood YHG=1812>cells YHG=1812>in YHG=1811>glucose-free YHG=1812>saline. YHG=1811>The YHG=1812>results YHG=1812>obtained YHG=1821>are YHG=1811>therefore " XBD=431 XBD=644 XBD=851 XBD=922 XBD=1037 XBD=1128 XBD=1272 XHG=187 XHG=439 XHG=652 XHG=932 XHG=1046 XHG=1137 XHG=1284 YBD=1881 YBD=1882 YBD=1880 YBD=1873 YBD=1882 YBD=1882 YBD=1873 YHG=1844>streptozotocin YHG=1844>(Boehringer YHG=1844>Mannheim, YHG=1845>175 YHG=1844>mg/kg YHG=1844>body YHG=1844>weight). YHG=1845>24 " XBD=1322 XBD=1642XHG=866 XBD=1694 XBD=1753 XBD=1892 XBD=1983 XBD=2025 XBD=2091 XBD=2178 XBD=2229 XBD=2395 XHG=1430 XHG=1656 XHG=1700 XHG=1767 XHG=1906 XHG=1997 XHG=2038 XHG=2104 XHG=2191 XHG=2236 YBD=1887 YBD=1895 YHG=1858>independent YHG=1858>glucose YHG=1858>level YHG=1864>at YHG=1857>the YHG=1858>time YHG=1857>of YHG=1858>sampling. " XBD=1323 XBD=209 XHG=876 XBD=310 XBD=578 XBD=851 XBD=934 XBD=1058 XBD=1120 XBD=1267 XHG=187 XHG=232 XHG=334 XHG=602 XHG=959YBD=1919 XHG=1083 XHG=1138 XHG=1291 YBD=1927 YBD=1927 YBD=1919 YBD=1918 YHG=1889>h YHG=1889>after YHG=1890>streptozotocin YHG=1890>administration YHG=1899>one YHG=1899>group YHG=1889>of YHG=1890>animals YHG=1890>in DAVID OWERBACH " XBD=1323 XBD=327 XHG=881 XBD=518 XBD=833 XBD=933 XBD=1099 XBD=1181 XHG=186 XHG=377 XHG=567 XHG=983YBD=1973 XHG=1149 XHG=1229 YBD=1965 YBD=1964 YBD=1974 YBD=1973 YBD=1964YHG=1935>(40 YBD=1965 YHG=1934>addition YHG=1935>received YHG=1934>(-)-epicatechin YHG=1935>mg/kg) YHG=1935>in YHG=1942>water PER BILLESBØLLE " XBD=1322 XBD=474 XHG=832 XBD=586 XBD=693 XBD=765 XBD=807 XBD=915 XBD=1025 XBD=1164 XBD=1226 XHG=186 XHG=497 XHG=611 XHG=717 XHG=788 XHG=942YBD=2019 XHG=1049 XHG=1188 XHG=1244 YBD=2011 YBD=2010 YBD=2010 YBD=2019 YBD=2010 YHG=1981>intraperitoneally YHG=1981>twice YHG=1980>daily YHG=1980>for YHG=1982>4 YHG=1981>days. YHG=1980>Both YHG=1990>groups YHG=1980>of YHG=1981>mice Hagedorn Research Laboratory, SVENN POULSEN Steno Memorial Hospital, "|>"XBD=1322 XBD=334 XBD=515 XBD=799 XBD=892 XBD=950 XBD=1096 XBD=1261 XBD=1206 XHG=186 XHG=350 XHG=532 XHG=815 XHG=908 XHG=967 XHG=1223 XHG=1270 XHG=1113 YBD=2064 YBD=2065 YBD=2056 YBD=2056 YBD=2056 YBD=2056 YHG=2026>acquired YHG=2027>persistent YHG=2026>hyperclycaemia YHG=2026>with YHG=2036>no YHG=2026>obvious YHG=2025>of YHG=2026>the YHG=2026>effect Denmark NERUP DK-2820 Gentofte, JØRN " XBD=456 XBD=266 XHG=353 XBD=340 XHG=186 YBD=2110 XHG=277 YBD=2109 YHG=2072>table). YHG=2071>drug YHG=2072>(see " XBD=1322 XBD=343 XHG=913 XBD=413 XBD=562 XBD=603 XBD=731 XBD=794 XBD=889 XBD=974 XBD=1108 XBD=1240 XHG=221 XHG=367 XHG=438 XHG=587 XHG=627 XHG=756 XHG=813 XHG=998YBD=2146 XHG=1133 XHG=1265 YBD=2155 YBD=2147 YBD=2155 YBD=2147 YBD=2146 YHG=2117>Finally YHG=2127>we YHG=2117>studied YHG=2126>a YHG=2117>model YHG=2116>of YHG=2117>slow YHG=2116>and YHG=2117>partial YHG=2117>B-islet YHG=2117>cell IgG IN BRAIN CELLS IN SLE " XBD=1206 XBD=549 XHG=668 XBD=640 XBD=742 XBD=1014 XHG=186 XHG=580 XHG=771YBD=2193 XHG=1043 YBD=2200 YBD=2192 YBD=2200 YBD=2193YHG=2163>dose YHG=2163>destruction-namely, YHG=2163>low YHG=2163>streptozotocin YHG=2155>diabetes.2 Male with "" XBD=1322 XBD=361 XBD=452 XBD=543 XBD=688 XBD=850 XBD=1026 XBD=1075 XHG=186 XHG=372 XHG=463 XHG=555 XHG=862 XHG=1037 XHG=1080 YBD=2245 YBD=2238 YBD=2237 YBD=2245 YBD=2237 YBD=2246 YHG=2208>C57BL/6J YHG=2208>mice YHG=2217>were YHG=2201>treated3 YHG=2208>five YHG=2208>injections YHG=2208>of YHG=2209>streptozotocin SiR,―The XBD=1785XHG=789 XBD=1841 XBD=1922 XBD=1973 XBD=2043 XBD=2234 XBD=2289 XBD=2386 XBD=2471 XBD=2518 XBD=2548 XHG=1661 XHG=1803 XHG=1854 XHG=1940 XHG=1992 XHG=2063 XHG=2252 XHG=2300 XHG=2403 XHG=2489 XHG=2534 YBD=2255 YBD=2248 YBD=2247 YHG=2217>finding YHG=2217>IgG YHG=2218>the YHG=2218>cytoplasm YHG=2217>of YHG=2218>brain YHG=2218>cells YHG=2218>in YHG=2227>a " XBD=1323 XBD=238 XBD=361 XBD=459 XBD=611 XBD=794 XBD=1079 XBD=1267 XHG=185 XHG=256 XHG=375 XHG=475 XHG=629 XHG=811 XHG=1095 XHG=1282 YBD=2291 YBD=2292 YBD=2283 YBD=2292 YBD=2292 YHG=2254>(40 YHG=2254>mg/kg YHG=2253>body YHG=2253>weight). YHG=2254>Moderate YHG=2254>hyperglycaemia YHG=2254>developed XBD=1550 XHG=2494 XBD=1654 XBD=1825 XBD=1946 XBD=2218 XBD=2283 XBD=2353 XBD=2470 XBD=2548 XHG=1433 YBD=2290 XHG=1577 XHG=1681 XHG=1852 XHG=1973 XHG=2243 XHG=2308 XHG=2378 YBD=2300 YHG=2255>by YBD=2291 YBD=2301 YBD=2299 YHG=2263>patient YHG=2262>with YHG=2263>systemic YHG=2262>lupus YHG=2261>erythematosus YHG=2261>by YHG=2262>Dr YHG=2262>Inoue YHG=2263>and " XBD=2545 XBD=245 XHG=535 XBD=294 XBD=381 XBD=442 XBD=525 XBD=820 XBD=1003 XBD=1084 XBD=1193 XBD=1322 XHG=186 XHG=255 XHG=303 XHG=390 XHG=451 XHG=830YBD=2336 XHG=1014 XHG=1093 XHG=1203 YBD=2337 YBD=2328 YBD=2335 YBD=2328 YBD=2336 YBD=2329 YHG=2299>day YHG=2300>30 YHG=2298>after YHG=2298>the YHG=2305>start YHG=2298>of YHG=2299>injections. YHG=2298>One YHG=2308>group YHG=2299>of streptozotocin mice " XBD=1607 XBD=1721 XBD=1786 XBD=1831 XBD=1920 XBD=2028 XBD=2074 XBD=2125 XBD=2326 XBD=2411 XHG=1433 XHG=1620 XHG=1739 XHG=1802 XHG=1848 XHG=1934 XHG=2041 XHG=2087 XHG=2140 XHG=2338 XHG=2424 YBD=2347 YBD=2344 YBD=2346 YBD=2338 YHG=2309>colleagues YHG=2308>(April YHG=2310>10, YHG=2318>p. YHG=2309>852) YHG=2308>needs YHG=2316>to YHG=2309>be YHG=2309>interpreted YHG=2309>with YHG=2309>caution. " XBD=1322 XBD=248 XBD=341 XBD=477 XBD=583 XBD=684 XBD=778 XBD=1060 XBD=1125 XBD=1182 XBD=1273 XHG=186 XHG=266 XHG=359 XHG=494 XHG=602 XHG=794 XHG=1077 XHG=1147 XHG=1200 XHG=1291 YBD=2374 YBD=2382 YBD=2373 YBD=2382 YBD=2382 YBD=2374 YHG=2353>was YHG=2344>then YHG=2344>treated YHG=2344>twice YHG=2344>daily YHG=2344>with YHG=2344>(-)-epicatechin YHG=2344>for YHG=2345>10 YHG=2345>days YHG=2354>as XBD=1552XHG=701 XBD=1708 XBD=1793 XBD=1940 XBD=2049 XBD=2214 XBD=2271 XBD=2347 XBD=2474 XBD=2548 XHG=1434 XHG=1575 XHG=1729 XHG=1814 XHG=1961 XHG=2070 XHG=2234 XHG=2286 XHG=2367 XHG=2495 YBD=2384 YBD=2390 YBD=2383 YHG=2355>Frozen YHG=2355>sections YHG=2354>will YHG=2355>contain YHG=2354>small YHG=2361>amounts YHG=2354>of YHG=2354>free YHG=2364>serum, YHG=2354>and " XBD=348 XBD=480 XBD=587 XBD=670 XBD=744 XBD=873 XBD=1021 XBD=1140 XBD=1243 XHG=186 XHG=372 XHG=505 XHG=612 XHG=695 XHG=896 XHG=1047 XHG=1164 XHG=1269 YBD=2425 YBD=2427 YBD=2418 YBD=2419 YBD=2426 YBD=2419 YHG=2389>described YHG=2389>above, YHG=2389>until YHG=2389>day YHG=2390>40. YHG=2389>Blood YHG=2389>glucose YHG=2390>levels YHG=2399>were YHG=2397>not " XBD=1322 XBD=1548XHG=771 XBD=1624 XBD=1848 XBD=1970 XBD=2167 XBD=2314 XBD=2405 XBD=2499 XBD=2548 XHG=1433 XHG=1571 XHG=1650 XHG=1875 XHG=1995 XHG=2192 XHG=2338 XHG=2428 XHG=2520 YBD=2436 YBD=2437 YBD=2438 YBD=2429 YHG=2400>during YHG=2400>the YHG=2399>&dquo;pre-wash&dquo; YHG=2400>phase YHG=2400>antibodies YHG=2407>present YHG=2409>may YHG=2400>bind YHG=2407>to |>" " XBD=398 XBD=632 XBD=747 XBD=557 XHG=186 XHG=569 XHG=645 XHG=410 YBD=2472 YBD=2464 YHG=2434>significantly YHG=2435>(see YHG=2434>table). YHG=2434>different " XBD=1570 XBD=1776 XBD=1848 XBD=1963 XBD=2079 XBD=2193 XBD=2250 XBD=2473 XBD=2547 XHG=1434 XHG=1603 XHG=1810 XHG=1875 XHG=1996 XHG=2115 XHG=2225 XHG=2283 XHG=2501 YBD=2475 YBD=2483 YBD=2474 YHG=2446>exposed YHG=2445>cytoplasm YHG=2444>of YHG=2445>brain YHG=2445>cells. YHG=2444>This YHG=2445>is YHG=2445>presumably YHG=2445>the |>" " XBD=277 XBD=408 XBD=559 XBD=614 XBD=829 XBD=992 XBD=1266 XBD=1323 XBD=937 XHG=221 XHG=294 XHG=424 XHG=575 XHG=630 XHG=954 XHG=1001 XHG=1282 XHG=845 YBD=2508 YBD=2510 YBD=2509 YBD=2518 YBD=2509 YHG=2479>We YHG=2486>cannot YHG=2479>confirm YHG=2489>an YHG=2480>antidiabetic YHG=2480>of YHG=2479>effect YHG=2480>(-)-epicatechin YHG=2490>on " XBD=1633 XBD=1690 XBD=1752 XBD=1888 XBD=2033 XBD=2218 XBD=2374 XBD=2414 XBD=2486 XBD=2549 XHG=1434 XHG=1642 XHG=1699 XHG=1762 XHG=1897 XHG=2042 XHG=2228 XHG=2383 XHG=2423 XHG=2495 YBD=2529 YBD=2528 YBD=2520 YHG=2491>explanation YHG=2490>for YHG=2491>the YHG=2491>nuclear YHG=2491>staining YHG=2490>sometimes YHG=2491>observed YHG=2491>in YHG=2490>skin YHG=2490>and " XBD=369 XBD=528 XBD=688 XBD=745 XBD=905 XBD=991 XBD=1038 XBD=1086 XBD=1163 XBD=1269 XHG=186 XHG=393 XHG=551 XHG=713 XHG=768 XHG=1015 XHG=1062 XHG=1110 XHG=1186 XHG=1291 YBD=2562 YBD=2560 YBD=2554 YBD=2554 YBD=2563 YBD=2555 YHG=2524>chemically YHG=2524>induced YHG=2525>diabetes YHG=2525>in YHG=2525>rodents; YHG=2525>and YHG=2525>it YHG=2526>is YHG=2532>too YHG=2525>early YHG=2532>to " XBD=1323 XBD=1519XHG=930 XBD=1652 XBD=1756 XBD=1911 XBD=2009 XBD=2175 XBD=2298 XBD=2368 XBD=2476 XBD=2547 XHG=1434 XHG=1540 XHG=1673 XHG=1777 XHG=1932 XHG=2031 XHG=2197 XHG=2321 XHG=2389 XHG=2493 YBD=2574 YBD=2566 YBD=2565 YHG=2537>renal YHG=2537>biopsy YHG=2536>from YHG=2537>patients YHG=2536>with YHG=2536>systemic YHG=2536>lupus. YHG=2537>To YHG=2536>avoid YHG=2536>this " XBD=387 XBD=461 XBD=554 XBD=615 XBD=700 XBD=727 XBD=877 XBD=924 XBD=1018 XHG=186 XHG=400 XHG=475 XHG=567 XHG=627 XHG=715 XHG=741 XHG=891 XHG=937 YBD=2606 YBD=2608 YBD=2599 YBD=2598 YBD=2599 YHG=2569>recommend YHG=2569>this YHG=2569>drug YHG=2569>for YHG=2577>type YHG=2570>I YHG=2570>diabetes YHG=2569>in YHG=2579>man. " XBD=2547 XBD=1554 XHG=2518 XBD=1587 XBD=1703 XBD=1750 XBD=1923 XBD=1965 XBD=2167 XBD=2228 XBD=2324 XBD=2405 XBD=2510 XHG=1434 YBD=2610 XHG=1564 XHG=1597 XHG=1712 XHG=1761 XHG=1932 XHG=1975 XHG=2176 XHG=2237 XHG=2333 XHG=2414 YBD=2612 YHG=2590>or YBD=2619 YBD=2611 YHG=2582>artifact YHG=2582>it YHG=2582>would YHG=2582>be YHG=2591>necessary YHG=2588>to YHG=2581>pre-perfuse YHG=2582>the YHG=2582>brain YHG=2582>with YHG=2581>buffer
H. KOLB " XBD=1540 XHG=1434 YBD=2657 YHG=2628>saline. U. KIESEL Diabetes Research Institute, B. GREULICH University of Düsseldorf, D-4000 Düsseldorf, West Germany J. VAN DER BOSCH
"" " " " " " " " " " " " "
Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0HS
DAVID J. EVANS
GLUCOSE REGULATION AND THE INSULIN GENE
XBD=2546 XBD=1555 XBD=1678 XBD=1767 XBD=1879 XBD=2023 XBD=2087 XBD=2167 XBD=2305 XBD=2438 XHG=1433 XHG=1589 XHG=1712 XHG=1800 XHG=1913 XHG=2055 XHG=2120 XHG=2199 XHG=2338 XHG=2469 YBD=2923 YBD=2917 YBD=2918 YBD=2925 YBD=2919 YBD=2927 YHG=2887>**This YHG=2888>letter YHG=2888>has YHG=2888>been YHG=2888>shown YHG=2896>to YHG=2889>Dr YHG=2889>Inoue, YHG=2890>whose YHG=2889>reply S[R,―The XBD=482 XBD=531 XBD=587 XBD=671 XBD=865 XBD=971 XBD=1022 XBD=1079 XBD=1262 XBD=1333 XHG=415 XHG=492 XHG=534 XHG=597 XHG=682 XHG=875 XHG=980 XHG=1032 XHG=1088 XHG=1273 YBD=2941 YBD=2949 YBD=2949 YBD=2941 YBD=2940 YHG=2912>title YHG=2911>of YHG=2912>the YHG=2921>very YHG=2912>interesting YHG=2921>paper YHG=2912>by YHG=2912>Dr YHG=2912>Owerbach YHG=2912>and XBD=1698 XHG=1664 YBD=2960 YHG=2932>L. XBD=369 XHG=900 XBD=492 XBD=565 XBD=619 XBD=718 XBD=877 XBD=966 XBD=1050 XBD=1164 XBD=1224 XBD=1333 XHG=194 XHG=391 XHG=518 XHG=589 XHG=644 XHG=740 XHG=989YBD=2985 XHG=1072 XHG=1186 XHG=1240 YBD=2993 YBD=2991 YBD=2994 YBD=2993 YBD=2985 YHG=2956>colleagues YHG=2956>(April YHG=2957>17, YHG=2966>p. YHG=2957>880) YHG=2966>assumes YHG=2956>that YHG=2965>any YHG=2956>effect YHG=2955>of YHG=2956>DNA XBD=346 XBD=525 XBD=697 XBD=924 XBD=1027 XBD=1088 XBD=1332 XHG=195 XHG=356 XHG=535 XHG=939 XHG=1036 XHG=1098 YBD=3032 YBD=3038 YBD=3030 YBD=3030 YHG=3001>insertion YHG=3010>sequences YHG=3001>of YHG=3002>11 YHG=3001>the YHG=3001>concentration human on XBD=1693XHG=707 XBD=1753 XBD=1827 XBD=2010 XBD=2123 XBD=2188 XBD=2278 XBD=2471 XBD=2546 XHG=1607YBD=3031 XHG=1703 XHG=1763 XHG=1837 XHG=2019 XHG=2132 XHG=2198 XHG=2288 XHG=2478 YBD=3036YHG=3001>chromosome YBD=3037 YBD=3046 YBD=3038 YHG=3006>there YHG=3016>are YHG=3006>free YHG=3007>antibodies YHG=3007>which YHG=3017>can YHG=3015>react YHG=3008>sufficiently YHG=3008>with XBD=233 XHG=669 XBD=435 XBD=658 XBD=890 XBD=1042 XBD=1141 XBD=1288 XBD=1332 XHG=195 XHG=240 XHG=448 XHG=903YBD=3084 XHG=1054 XHG=1154 XHG=1300 YBD=3077 YBD=3085 YBD=3084 YBD=3075 YHG=3047>of YHG=3047>erythrocyte YHG=3046>glycosylated YHG=3046>haemoglobin YHG=3046>depends YHG=3055>upon YHG=3046>changes YHG=3047>in XBD=1578 XBD=1665 XBD=1711 XBD=1776 XBD=1888 XBD=1997 XBD=2125 XBD=2176 XBD=2265 XBD=2363 XBD=2464 XBD=2542 XHG=1428 XHG=1592 XHG=1679 XHG=1724 XHG=1788 XHG=1901 XHG=2010 XHG=2138 XHG=2182 XHG=2276 XHG=2374 XHG=2476 YBD=3084 YBD=3089 YBD=3083 YHG=3054>neuronal YHG=3054>cells YHG=3054>in YHG=3055>the YHG=3055>brain, YHG=3055>eluates YHG=3054>of YHG=3054>fresh YHG=3054>brain YHG=3055>tissue YHG=3054>with XBD=290 XBD=440 XBD=701 XBD=829 XBD=928 XBD=985 XBD=1243 XBD=1331 XHG=194 XHG=315 XHG=465 XHG=726 XHG=852 XHG=1011 XHG=1269 YBD=3122 YBD=3129 YBD=3121 YBD=3120 YBD=3121 YBD=3126 YHG=3093>blood YHG=3093>glucose YHG=3092>concentration YHG=3092>rather YHG=3092>than YHG=3092>in YHG=3092>red-blood-cell YHG=3091>life, XBD=1607XHG=953 XBD=1773 XBD=1890 XBD=2040 XBD=2123 XBD=2291 XBD=2432 XBD=2481 XBD=2545 XHG=1432 XHG=1629 XHG=1794 XHG=1912 XHG=2047 XHG=2145 XHG=2312 XHG=2451 XHG=2500 YBD=3134 YBD=3135 YBD=3127 YBD=3128 YHG=3096>phosphate YHG=3096>buffered YHG=3097>saline YHG=3097>should. YHG=3098>have YHG=3098>antibody YHG=3099>activity YHG=3105>to YHG=3099>the XBD=395 XHG=888 XBD=552 XBD=664 XBD=861 XBD=938 XBD=1047 XBD=1105 XBD=1185 XBD=1332 XHG=196 XHG=420 XHG=578 XHG=691 XHG=965YBD=3166 XHG=1074 XHG=1132 XHG=1212 YBD=3175 YBD=3174 YBD=3165 YBD=3166 YBD=3165 YBD=3173 YHG=3137>presumably YHG=3137>because YHG=3136>these YHG=3146>sequences YHG=3146>are YHG=3137>close YHG=3143>to YHG=3136>the YHG=3136>genetic XBD=1582 XBD=1689 XBD=1774 XBD=1848 XBD=2002 XBD=2373 XBD=2481 XBD=2545 XHG=1432 XHG=1605 XHG=1713 XHG=1795 XHG=1871 XHG=2024 XHG=2394 XHG=2499 YBD=3176 YBD=3171 YBD=3179 YBD=3172 YHG=3142>neuronal YHG=3142>cells, YHG=3142>and YHG=3142>the YHG=3142>indirect YHG=3142>immunofluorescence YHG=3143>using YHG=3143>the XBD=334 XHG=868 XBD=537 XBD=671 XBD=851 XBD=948 XBD=1160 XBD=1280 XBD=1332 XHG=196 XHG=350 XHG=554 XHG=686 XHG=964YBD=3211 XHG=1174 XHG=1294 YBD=3218 YBD=3220 YBD=3219 YBD=3211 YHG=3182>material YHG=3182>controlling YHG=3181>insulin YHG=3182>synthesis. YHG=3181>This YHG=3182>assumption YHG=3182>would YHG=3182>be XBD=1531 XBD=1650 XBD=1699 XBD=1854 XBD=1911 XBD=1970 XBD=2153 XBD=2218 XBD=2324 XBD=2395 XBD=2544 XHG=1432 XHG=1543 XHG=1661 XHG=1712 XHG=1869 XHG=1924 XHG=1983 XHG=2166 XHG=2231 XHG=2337 XHG=2407 YBD=3224 YBD=3216 YBD=3222 YBD=3217 YBD=3225 YHG=3187>eluate YHG=3187>would YHG=3187>be YHG=3187>positive. YHG=3187>As YHG=3196>we YHG=3187>described, YHG=3188>the YHG=3188>result YHG=3197>was YHG=3189>negative, XBD=248 XBD=354 XBD=529 XBD=580 XBD=681 XBD=764 XBD=864 XBD=901 XBD=1107 XBD=1161 XBD=1235 XBD=1331 XHG=194 XHG=269 XHG=376 XHG=550 XHG=594 XHG=703 XHG=784 XHG=923 XHG=1129 XHG=1183 XHG=1257 YBD=3265 YBD=3257 YBD=3256 YBD=3256 YBD=3256 YHG=3228>the YHG=3236>more YHG=3227>plausible YHG=3227>if YHG=3228>there YHG=3227>had YHG=3228>been YHG=3237>a YHG=3227>correlation YHG=3227>in YHG=3227>the YHG=3236>nonXBD=1493XHG=885 XBD=1641 XBD=2016 XBD=2095 XBD=2243 XBD=2334 XBD=2423 XBD=2545 XHG=1431 XHG=1510 XHG=1659 XHG=2033 XHG=2113 XHG=2261 XHG=2350 XHG=2439 YBD=3262 YBD=3261 YBD=3269 YBD=3270 YBD=3263 YHG=3233>and YHG=3232>indirect YHG=3232>immunofluorescence YHG=3242>was YHG=3232>positive YHG=3233>only YHG=3233>after YHG=3233>elution XBD=344 XHG=660 XBD=486 XBD=642 XBD=756 XBD=1009 XBD=1088 XBD=1203 XBD=1333 XHG=195 XHG=361 XHG=500 XHG=904YBD=3301 XHG=1027 XHG=1104 XHG=1219 YBD=3301 YBD=3301YHG=3272>stable YBD=3308 YHG=3272>diabetics YHG=3272>studied YHG=3272>between YHG=3272>values YHG=3272>and YHG=3272>either YHG=3272>fasting HbA1c XBD=1508 XBD=1629 XBD=1758 XBD=1880 XBD=2034 XBD=2182 XBD=2262 XBD=2362 XBD=2423 XBD=2476 XBD=2545 XHG=1430 XHG=1522 XHG=1644 XHG=1775 XHG=1895 XHG=2050 XHG=2197 XHG=2278 XHG=2376 XHG=2438 XHG=2490 YBD=3314 YBD=3306 YBD=3307 YHG=3278>with YHG=3277>citrate YHG=3277>buffer. YHG=3277>These YHG=3277>findings YHG=3277>indicate YHG=3278>that YHG=3278>there YHG=3287>are YHG=3288>no YHG=3278>free XBD=290 XHG=896 XBD=427 XBD=476 XBD=507 XBD=609 XBD=666 XBD=750 XBD=832 XBD=884 XBD=949 XBD=1052 XHG=194 XHG=302 XHG=440 XHG=488 XHG=520 XHG=622 XHG=680 XHG=763 XHG=845 XHG=962YBD=3346 YBD=3347 YBD=3353 YBD=3355 YBD=3354 YBD=3345 YBD=3354 YHG=3318>blood YHG=3317>glucose YHG=3326>or YHG=3317>k YHG=3318>value YHG=3317>(as YHG=3326>may YHG=3317>well YHG=3316>be YHG=3317>the YHG=3317>case). XBD=1615 XBD=1704 XBD=1794 XBD=1879 XBD=2037 XBD=2254 XBD=2413 XBD=2490 XBD=2544 XHG=1431 XHG=1643 XHG=1729 XHG=1821 XHG=1905 XHG=2063 XHG=2280 XHG=2438 XHG=2512 YBD=3358 YBD=3351 YBD=3359 YBD=3352 YHG=3322>antibodies, YHG=3323>and YHG=3323>that YHG=3332>our YHG=3322>positive YHG=3322>fluoresence YHG=3322>findings YHG=3332>can YHG=3324>be XBD=297 XBD=375 XBD=424 XBD=605 XBD=801 XBD=844 XBD=906 XBD=971 XBD=1116 XBD=1266 XBD=1329 XHG=228 XHG=308 XHG=385 XHG=428 XHG=616 XHG=812 XHG=854 XHG=980 XHG=1126 XHG=1276 YBD=3399 YBD=3391 YBD=3389 YBD=3388 YBD=3397 YBD=3389 YBD=3396 YHG=3362>The YHG=3362>lack YHG=3360>of YHG=3360>significant YHG=3362>correlation YHG=3361>in YHG=3362>the YHG=3361>LL YHG=3361>subjects YHG=3361>between YHG=3369>age XBD=1622XHG=917 XBD=1678 XBD=1849 XBD=1938 XBD=2180 XBD=2373 XBD=2455 XBD=2544 XHG=1431 XHG=1646 XHG=1703 XHG=1873 XHG=1964 XHG=2205 XHG=2397 XHG=2476 YBD=3405 YBD=3404 YBD=3397 YBD=3398 YHG=3368>interpreted YHG=3377>as YHG=3368>meaning YHG=3368>that YHG=3368>antineuronal YHG=3368>antibodies YHG=3368>had YHG=3369>been XBD=257 XBD=365 XBD=491 XBD=596 XBD=732 XBD=777 XBD=807 XBD=906 XBD=952 XBD=1045 XBD=1174 XBD=1331 XHG=194 XHG=267 XHG=376 XHG=500 XHG=606 XHG=743 XHG=787 XHG=817 XHG=962 XHG=1056 XHG=1184 YBD=3439 YBD=3437 YBD=3440 YBD=3436 YBD=3444 YBD=3436 YBD=3443 YHG=3408>and YHG=3407>either YHG=3407>fasting YHG=3407>blood YHG=3408>glucose YHG=3417>or YHG=3407>k YHG=3407>value YHG=3416>or YHG=3407>early YHG=3407>insulin YHG=3416>response XBD=1555XHG=917 XBD=1601 XBD=1666 XBD=1814 XBD=1915 XBD=2011 XBD=2066 XBD=2131 XBD=2280 XBD=2323 XHG=1431 XHG=1569 XHG=1614 XHG=1680 XHG=1825 XHG=1927 XHG=2026 XHG=2078 XHG=2145 XHG=2292 YBD=3447 YBD=3450 YBD=3442 YBD=3441 YHG=3419>present YHG=3412>affected YHG=3413>brain YHG=3412>cells, YHG=3413>by YHG=3413>the YHG=3413>reaction YHG=3413>in 2. Like
AA, Rossini AA. Streptozotocin-induced pancreatic insulitis; new model of diabetes mellitus Science 1976; 193: 415-18. 3 Kiesel U, Freytag G, Biener J, Kolb H. Transfer of experimental autoimmune insulitis by spleen cells in mice. Diabetologia 1980; 19: 516-20
follows.-ED
SiR,―If
situ. First Department of Internal Medicine, Oska City University Medical School,
1-5-7, Asahimachi, Abenoku,
Osaka 545, Japan
TAKATOSHI INOUE
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XBD=2539 XBD=1473 XBD=1527 XBD=1601 XBD=1653 XBD=1751 XBD=1825 XBD=1991 XBD=2041 XBD=2106 XBD=2210 XBD=2259 XBD=2367 XBD=2442 XBD=2501 XBD=1475 XBD=1569 XBD=1716 XBD=1793 XBD=1904 XBD=2054 XBD=2147 XBD=2237 XBD=2463 XBD=2539 XBD=1496 XBD=1670 XBD=1751 XBD=1886 XBD=1951 XBD=2022 XBD=2232 XBD=2408 XBD=2458 XBD=2539 XBD=1589 XBD=1650 XBD=1731 XBD=1875 XBD=2036 XBD=2247 XBD=2314 XBD=2393 XBD=2501 XBD=2538 XBD=1593 XBD=1641 XBD=1707 XBD=1954 XBD=2000 XBD=2154 XBD=2232 XBD=2306 XBD=2386 XBD=2539 XBD=1497 XBD=1559 XBD=1589 XBD=1709 XBD=1822 XBD=1910 XBD=1975 XBD=2157 XBD=1549 XBD=1614 XBD=1738 XBD=1799 XBD=2177 XBD=2310 XBD=2424 XBD=2539 XBD=1457 XBD=1725 XBD=1771 XBD=1857 XBD=1928 XBD=2051 XBD=2191 XBD=2232 XBD=2293 XBD=2375 XBD=2421 XBD=2538 XBD=1589 XBD=1682 XBD=1754 XBD=1965 XBD=2039 XBD=2168 XBD=2407 XBD=2494 XBD=2538 XBD=1765 XBD=1911 XBD=1956 XBD=2029 XBD=2177 XBD=1510
XHG=2511 XHG=1424 XHG=1492 XHG=1539 XHG=1614 XHG=1664 XHG=1763 XHG=1838 XHG=2002 XHG=2052 XHG=2118 XHG=2221 XHG=2268 XHG=2379 XHG=2454 XHG=1423 XHG=1488 XHG=1581 XHG=1727 XHG=1805 XHG=1915 XHG=2066 XHG=2157 XHG=2248 XHG=2476 XHG=1422 XHG=1523 XHG=1696 XHG=1778 XHG=1912 XHG=1970 XHG=2050 XHG=2256 XHG=2435 XHG=2482 XHG=1423 XHG=1618 XHG=1678 XHG=1759 XHG=1902 XHG=2064 XHG=2275 XHG=2341 XHG=2420 XHG=2525 XHG=1423 XHG=1607 XHG=1654 XHG=1849 XHG=1969 XHG=2014 XHG=2167 XHG=2246 XHG=2319 XHG=2401 XHG=1423 XHG=1510 XHG=1572 XHG=1601 XHG=1722 XHG=1835 XHG=1923 XHG=1988 XHG=1458 XHG=1561 XHG=1627 XHG=1750 XHG=1939 XHG=2189 XHG=2322 XHG=2436 XHG=1423 XHG=1468 XHG=1737 XHG=1781 XHG=1868 XHG=1937 XHG=2062 XHG=2200 XHG=2241 XHG=2303 XHG=2385 XHG=2425 XHG=1423 XHG=1609 XHG=1701 XHG=1775 XHG=1985 XHG=2058 XHG=2188 XHG=2426 XHG=2511 XHG=1647 XHG=1776 XHG=1923 XHG=1968 XHG=2042 XHG=1423
YBD=453 YBD=462 YBD=461 YBD=452 YBD=451 YBD=459 YBD=460 YBD=499 YBD=500 YBD=507 YBD=498 YBD=504 YBD=496 YBD=553 YBD=552 YBD=551 YBD=544 YBD=550 YBD=541 YBD=543 YBD=598 YBD=590 YBD=596 YBD=589 YBD=587 YBD=588 YBD=635 YBD=634 YBD=639 YBD=641 YBD=690 YBD=688 YBD=681 YBD=680 YBD=726 YBD=727 YBD=725 YBD=734 YBD=781 YBD=780 YBD=772 YBD=771 YBD=778 YBD=824 YBD=817 YBD=826 YBD=825 YBD=818 YBD=872 YBD=863 YBD=871
YHG=422>in YHG=433>no. YHG=424>19 YHG=433>was YHG=425>77 YHG=433>years YHG=424>old, YHG=423>implying YHG=432>an YHG=431>age YHG=432>range YHG=422>of YHG=423>10-77 YHG=421>(not YHG=421>57) YHG=470>the YHG=469>table YHG=469>(though YHG=469>that YHG=478>seems YHG=468>unlikely YHG=467>from YHG=468>their YHG=466>relationship). YHG=466>The YHG=525>very YHG=514>different YHG=524>age YHG=524>ranges YHG=514>of YHG=514>the YHG=514>&dquo;unrelated YHG=512>subjects&dquo; YHG=512>is YHG=513>also YHG=560>worrying, YHG=570>as YHG=560>the YHG=560>related YHG=560>subjects YHG=559>themselves YHG=558>do YHG=565>not YHG=557>show YHG=568>a YHG=605>difference YHG=606>in YHG=605>the YHG=605>values YHG=615>as YHG=605>between YHG=604>UU YHG=604>and YHG=603>UL, YHG=603>although YHG=651>they YHG=660>are YHG=660>a YHG=651>bigger YHG=660>group YHG=651>than YHG=651>the YHG=650>unrelated. YHG=696>Were YHG=696>the YHG=696>bloods YHG=696>for YHG=697>determination YHG=696>usually YHG=696>drawn YHG=694>fasting YHG=751>or YHG=742>postprandially, YHG=752>or YHG=742>with YHG=752>any YHG=742>special YHG=742>relation YHG=748>to YHG=742>the YHG=741>time YHG=740>of YHG=741>glucose YHG=788>injection? YHG=788>Was YHG=788>the YHG=788>81-year-old YHG=788>LL YHG=788>female YHG=787>(contributing YHG=787>only YHG=795>to YHG=833>values) YHG=834>unusual YHG=834>in YHG=833>this YHG=834>respect? YHG=833>these
HbAlc HbAlc HbA1c Radcliffe Infirmary, Oxford OX2 6HE
XBD=2542 XHG=2373 XBD=1553 XBD=1655 XBD=1724 XBD=1816 XBD=1940 XBD=1985 XBD=2044 XBD=2229 XBD=2302 XBD=2361 XHG=1430 XHG=1566 XHG=1669 XHG=1737 XHG=1831 XHG=1952 XHG=1998 XHG=2058 XHG=2242 XHG=2314 YBD=1045 YHG=1015>colleagues, YBD=1046 YBD=1053 YHG=1016>** This YHG=1016>letter YHG=1016>has YHG=1016>been YHG=1017>shown YHG=1023>to YHG=1016>Dr YHG=1016>Owerbach YHG=1016>and YHG=1016>his n= 10YBD=1083 mice; XBD=274 XBD=513 XBD=558 XBD=646 XBD=847 XHG=190 XHG=472 XHG=523 XHG=569 YBD=1076 YBD=1077 YHG=1052>*n=9 YHG=1050>for YHG=1051>all YHG=1051>other YHG=1051>experiments. XBD=1534XHG=657 XBD=1635 XBD=1876 XBD=1925 XHG=1429 XHG=1547 XHG=1646 XHG=1890 YBD=1099 YBD=1091 YBD=1092 YHG=1062>whose YHG=1061>reply YHG=1061>follows.-ED. YHG=1061>L. XBD=294 XHG=883 XBD=453 XBD=548 XBD=777 XBD=851 XBD=936 XBD=1156 XBD=1326 XHG=193 XHG=327 XHG=487 XHG=583 XHG=809 XHG=969YBD=1151 XHG=1190 YBD=1152 YBD=1160 YBD=1159 YBD=1151 YBD=1151 YHG=1122>Blood YHG=1122>glucose YHG=1130>was YHG=1121>determined YHG=1121>by YHG=1121>the YHG=1121>hexokinase YHG=1121>method. XBD=1707 XBD=1755 XBD=1849 XBD=1890 XBD=1956 XBD=2060 XBD=2110 XBD=2150 XBD=2230 XBD=2309 XBD=2405 XBD=2464 XBD=2507 XBD=2543 XHG=1682 XHG=1717 XHG=1765 XHG=1858 XHG=1899 XHG=1965 XHG=2068 XHG=2119 XHG=2161 XHG=2241 XHG=2318 XHG=2414 XHG=2473 XHG=2510 YBD=1166 YBD=1165 YBD=1157 YBD=1158 YHG=1128>is YHG=1138>an YHG=1137>error YHG=1127>in YHG=1137>our YHG=1137>paper YHG=1137>on YHG=1138>p. YHG=1128>882. YHG=1127>The YHG=1137>mean YHG=1137>age YHG=1127>of YHG=1129>all XBD=474 XBD=687 XBD=758 XBD=838 XBD=939 XBD=1089 XBD=1169 XBD=1330 XHG=194 XHG=513 XHG=726 XHG=798 XHG=978 XHG=1130 XHG=1208 YBD=1206 YBD=1204 YBD=1196 YBD=1197 YBD=1196 YBD=1197 YHG=1167>Hyperglycaemia YHG=1166>developed YHG=1167>in YHG=1167>all YHG=1173>rats YHG=1167>within YHG=1167>24 YHG=1167>h XBD=1485XHG=878 XBD=1631 XBD=1703 XBD=1806 XBD=1994 XBD=2055 XBD=2107 XBD=2178 XBD=2265 XBD=2322 XBD=2379 XBD=2544 XHG=1430 XHG=1495 XHG=1642 XHG=1716 XHG=1819 XHG=2005 XHG=2072 XHG=2117 XHG=2189 XHG=2275 XHG=2335 XHG=2389 YBD=1210 YBD=1211 YBD=1203 YBD=1202 YBD=1212 YHG=1173>LLand YHG=1173>subjects YHG=1174>36-9. YHG=1173>Individual YHG=1183>no. YHG=1174>19 YHG=1183>was YHG=1173>aged YHG=1174>31. YHG=1173>Dr YHG=1173>Hockaday 2 XBD=975 XBD=1155 XBD=1329 XHG=989 XHG=1167 YBD=1250 YBD=1250 YBD=1242 YHG=1211>4 YHG=1212>Complete YHG=1212>remission days. XBD=476 XBD=592 XBD=751 XBD=794 XHG=194 XHG=486 XHG=603 XHG=761 YBD=1251 YBD=1241 YBD=1242 YHG=1212>normoglycaemic YHG=1212>values YHG=1212>returned YHG=1212>in XBD=1571XHG=861 XBD=1651 XBD=1718 XBD=1799 XBD=1852 XBD=2036 XBD=2234 XBD=2279 XBD=2344 XBD=2409 XBD=2544 XHG=1430 XHG=1585 XHG=1665 XHG=1733 XHG=1813 XHG=1860 XHG=2051 XHG=2248 XHG=2292 XHG=2357 XHG=2422 YBD=1250 YBD=1257 YBD=1249 YBD=1248 YBD=1256 YHG=1225>suggests YHG=1219>that YHG=1218>the YHG=1219>lack YHG=1219>of YHG=1218>significant YHG=1219>correlation YHG=1219>in YHG=1219>the YHG=1219>LL YHG=1219>subjects XBD=268 XBD=457 XBD=530 XBD=647 XBD=803 XBD=905 XBD=1005 XBD=1257 XBD=1333 XHG=194 XHG=307 XHG=497 XHG=570 XHG=687 XHG=843 XHG=943 XHG=1046 XHG=1297 YBD=1288 YBD=1287 YBD=1295 YBD=1286 YBD=1287 YBD=1295 YBD=1288 YHG=1259>thus YHG=1258>occurred YHG=1258>in YHG=1257>both YHG=1266>groups YHG=1257>and YHG=1267>was YHG=1257>independent YHG=1257>of XBD=1570 XHG=2471 XBD=1643 XBD=1722 XBD=1836 XBD=1968 XBD=2079 XBD=2219 XBD=2270 XBD=2305 XBD=2406 XBD=2455 XBD=2544 XHG=1429 YBD=1304 XHG=1589 XHG=1661 XHG=1739 XHG=1854 XHG=1984 XHG=2095 XHG=2236 XHG=2287 XHG=2320 XHG=2423 YBD=1302 YHG=1265>early YBD=1294 YHG=1265>between YHG=1274>age YHG=1265>and YHG=1265>either YHG=1264>fasting YHG=1265>blood YHG=1265>glucose YHG=1264>k YHG=1265>value YHG=1274>or XBD=468 XBD=517 XBD=543 XBD=670 XBD=871 XBD=1146 XBD=1216 XBD=1328 XHG=193 XHG=480 XHG=527 XHG=554 XHG=880 XHG=1155 XHG=1226 YBD=1342 YBD=1332 YBD=1333 YBD=1341 YBD=1340 YBD=1333 YBD=1340 YHG=1303>(-)-epicatechin. YHG=1303>In YHG=1313>a YHG=1303>second YHG=1303>experiment YHG=1302>(-)-epicatechin YHG=1312>was YHG=1304>given, XBD=1548XHG=679 XBD=1709 XBD=1792 XBD=1843 XBD=1972 XBD=2015 XBD=2080 XBD=2214 XBD=2279 XBD=2382 XBD=2504 XBD=2544 XHG=1431 XHG=1561 XHG=1722 XHG=1804 XHG=1856 XHG=1983 XHG=2027 XHG=2093 XHG=2226 XHG=2292 XHG=2393 XHG=2516 YBD=1339 YBD=1347 YBD=1348 YHG=1310>insulin YHG=1319>response YHG=1320>may YHG=1310>be YHG=1310>related YHG=1317>to YHG=1310>the YHG=1310>smaller YHG=1319>age YHG=1320>range YHG=1310>(10-57 YHG=1321>vs XBD=226 XHG=775 XBD=355 XBD=433 XBD=543 XBD=647 XBD=715 XBD=754 XBD=860 XBD=1012 XBD=1048 XBD=1131 XBD=1257 XBD=1329 XHG=194 XHG=248 XHG=376 XHG=454 XHG=565 XHG=667 XHG=736 XHG=882YBD=1387 XHG=1036 XHG=1072 XHG=1150 XHG=1277 YBD=1384 YBD=1379 YBD=1378 YBD=1386 YBD=1378 YBD=1387 YBD=1379 YHG=1359>as YHG=1349>above, YHG=1348>but YHG=1349>twice YHG=1349>daily YHG=1348>for YHG=1350>6 YHG=1349>days, YHG=1349>starting YHG=1350>1 28 YHG=1349>day YHG=1348>before YHG=1349>the XBD=1560 XBD=1737 XBD=1821 XBD=1848 XBD=1912 XBD=2002 XBD=2076 XBD=2119 XBD=2186 XBD=2377 XBD=2460 XBD=2544 XHG=1435 XHG=1571 XHG=1747 XHG=1831 XHG=1858 XHG=1922 XHG=2012 XHG=2084 XHG=2127 XHG=2194 XHG=2384 XHG=2468 YBD=1393 YBD=1391 YBD=1394 YBD=1384 YBD=1385 YBD=1386 YHG=1356>10-74). YHG=1355>However, YHG=1356>only YHG=1356>3 YHG=1362>out YHG=1355>of YHG=1356>UU YHG=1365>or YHG=1355>UL YHG=1356>individuals YHG=1365>were YHG=1356>older XBD=1506 XBD=1569 XHG=1430 XHG=1521 YBD=1431 YBD=1430 YHG=1401>than YHG=1402>57. XBD=443 XHG=924 XBD=499 XBD=642 XBD=790 XBD=907 XBD=963 XBD=1035 XBD=1193 XBD=1329 XHG=194 XHG=460 XHG=509 XHG=660 XHG=807 XHG=974YBD=1424 XHG=1052 XHG=1209 YBD=1425 YBD=1429 YBD=1432 YBD=1425 YBD=1424 YHG=1394>administration YHG=1394>alloxan; YHG=1394>another YHG=1404>group YHG=1393>of YHG=1401>rats YHG=1394>received YHG=1394>alloxan XBD=277 XBD=585 XBD=783 XBD=839 XBD=942 XBD=1083 XBD=1219 XBD=1284 XBD=1330 XHG=194 XHG=305 XHG=610 XHG=807 XHG=864 XHG=967 XHG=1108 XHG=1244 XHG=1308 YBD=1479 YBD=1478 YBD=1470 YBD=1478 YBD=1471 YBD=1469 YHG=1441>only. YHG=1440>Hyperglycaemia YHG=1440>developed YHG=1440>in YHG=1440>both YHG=1449>groups YHG=1440>within YHG=1440>24 XBD=1552 XHG=2445 XBD=1681 XBD=1723 XBD=1783 XBD=1977 XBD=2153 XBD=2214 XBD=2310 XBD=2371 XBD=2438 XBD=2544 XHG=1465 YBD=1485 XHG=1561 XHG=1690 XHG=1731 XHG=1793 XHG=1984 XHG=2162 XHG=2222 XHG=2319 XHG=2379 YBD=1484 YHG=1440>h YBD=1476 YBD=1477 YBD=1486 YBD=1478 YHG=1447>With YHG=1453>respect YHG=1454>to YHG=1447>&dquo;unrelated YHG=1446>subjects&dquo;, YHG=1447>the YHG=1456>mean YHG=1457>age YHG=1457>was YHG=1448>higher
T. D. R. HOCKADAY
SIR,-There
274±83 XBD=333 XHG=847 XBD=442 XBD=579 XBD=833 XBD=895 XBD=1330 XHG=193 XHG=346 XHG=454 XHG=737 XHG=906YBD=1516 YBD=1525 YBD=1524 YBD=1523 YBD=1524 YHG=1486>(average YHG=1486>blood YHG=1486>glucose YHG=1485>mg/dl YHG=1485>for YHG=1485>(-)-epicatechin + alloxan (34 - 0) (43 - 4) " XBD=2542 XBD=2074 XBD=2132 XBD=2198 XBD=2353 XBD=2421 XHG=1998 XHG=2085 XHG=2144 XHG=2322 XHG=2363 XHG=2433 YBD=1521 YBD=1522 YBD=1523 YBD=1532 YHG=1493>than YHG=1493>for YHG=1492>LL YHG=1502>as YHG=1502>was YHG=1493>HbAlc XBD=1476 XBD=1539 XBD=1616 XBD=1688 XBD=1759 XBD=1870 XHG=1428 XHG=1487 XHG=1551 XHG=1627 XHG=1699 XHG=1770 YBD=1530 YHG=1494>the YHG=1493>UU YHG=1493>and YHG=1492>UL YHG=1502>group 309±80 XBD=224 XHG=839 XBD=480 XBD=542 XBD=678 XBD=790 XBD=825 XBD=913 XBD=1002 XBD=1101 XBD=1326 XHG=190 XHG=383 XHG=494 XHG=556 XHG=691 XHG=807 XHG=926YBD=1569 XHG=1016 XHG=1115 YBD=1568 YBD=1561 YBD=1560 YBD=1560 YBD=1560 YHG=1542>vs YHG=1531>mg/dl YHG=1531>for YHG=1531>alloxan YHG=1531>alone. YHG=1533>6 YHG=1531>days YHG=1531>later YHG=1540>some YHG=1537>spontaneous (5 - 74% 8107o). " XBD=2542 XBD=1642 XBD=1852 XBD=1913 XBD=2094 XBD=2164 XBD=2340 XBD=2425 XHG=1608 XHG=1758 XHG=1860 XHG=1922 XHG=2103 XHG=2173 XHG=2348 XHG=2433 YBD=1566 YBD=1567 YBD=1575 YBD=1568 YBD=1578 YHG=1539>4 YHG=1538>From YHG=1538>the YHG=1538>regression YHG=1538>line YHG=1538>calculated YHG=1538>from YHG=1538>HbA - lc ( -)-epicatechin+alloxan " XBD=895 XBD=354 XBD=425 XBD=583 XBD=839 XHG=190 XHG=363 XHG=433 XHG=742 YBD=1607 YBD=1614 YBD=1606 (292±78 YHG=1576>remission YHG=1577>had YHG=1577>occurred YHG=1576>mg/dl YHG=1576>for XBD=1596XHG=848 XBD=1681 XBD=1746 XBD=1804 XBD=1880 XBD=1951 XBD=2020 XBD=2137 XBD=2308 XBD=2369 XBD=2506 XBD=2548 XHG=1428 XHG=1605 XHG=1691 XHG=1756 XHG=1814 XHG=1889 XHG=1960 XHG=2029 XHG=2145 XHG=2318 XHG=2379 XHG=2514 YBD=1621 YBD=1613 YBD=1622 YBD=1619 YBD=1614 YHG=1584>compared YHG=1583>with YHG=1593>age YHG=1583>for YHG=1583>UU YHG=1584>and YHG=1583>UL YHG=1583>family YHG=1584>members, YHG=1584>the YHG=1584>increase YHG=1583>of 229±60 <0’2%. " XBD=1326 XBD=224 XBD=479 XBD=540 XBD=675 XBD=799 XBD=905 XBD=934 XBD=1110 XBD=1216 XBD=1268 XHG=191 XHG=382 XHG=493 XHG=554 XHG=688 XHG=814 XHG=918 XHG=946 XHG=1124 XHG=1230 XHG=1274 YBD=1660 YBD=1653 YBD=1661 YBD=1652 YBD=1652 YBD=1651 YHG=1633>vs YHG=1623>mg/dl YHG=1622>for YHG=1623>alloxan YHG=1622>alone). YHG=1622>Thus YHG=1632>a YHG=1621>beneficial YHG=1621>effect YHG=1621>of YHG=1622>the XBD=1550 XHG=2496 XBD=1642 XBD=1711 XBD=1809 XBD=1863 XBD=1911 XBD=1966 XBD=2069 XBD=2123 XBD=2185 XBD=2226 XBD=2482 XBD=2542 XHG=1429 YBD=1660 XHG=1565 XHG=1658 XHG=1728 XHG=1825 XHG=1879 XHG=1926 XHG=1982 XHG=2084 XHG=2131 XHG=2201 XHG=2387 YBD=1669 YHG=1630>the YBD=1667 YBD=1668 YBD=1659 YBD=1666 YHG=1629>HbA 1c YHG=1630>with YHG=1629>from YHG=1630>35 YHG=1637>to YHG=1630>45 YHG=1639>years YHG=1629>of YHG=1639>age YHG=1630>is YHG=1630>Thus, XBD=274 XHG=820 XBD=327 XBD=462 XBD=611 XBD=657 XBD=732 XBD=806 XBD=874 XBD=1047 XHG=193 XHG=285 XHG=340 XHG=475 XHG=625 XHG=671 XHG=745 XHG=888YBD=1698 YBD=1706 YBD=1699 YBD=1698 YHG=1669>drug YHG=1679>on YHG=1669>alloxan YHG=1669>diabetes YHG=1670>in YHG=1677>rats YHG=1678>was YHG=1668>observed. " XBD=2543 XBD=1597 XBD=1760 XBD=1803 XBD=1936 XBD=2062 XBD=2231 XBD=2373 XBD=2407 XHG=1428 XHG=1609 XHG=1771 XHG=1815 XHG=1948 XHG=2071 XHG=2242 XHG=2383 XHG=2416 YBD=1715YHG=1675>not YBD=1713 YBD=1712 YBD=1705 YBD=1714 YHG=1675>difference YHG=1676>observed YHG=1676>in YHG=1676>HbAlc YHG=1685>among YHG=1675>unrelated YHG=1676>subjects YHG=1676>is YHG=1676>unlikely " XBD=260 XBD=393 XBD=613 XBD=671 XBD=783 XBD=846 XBD=951 XBD=1271 XHG=223 XHG=272 XHG=405 XHG=624 XHG=683 XHG=794 XHG=963 XHG=1283 YBD=1736 YBD=1745 YBD=1737 YBD=1746 YBD=1737 YHG=1707>In YHG=1707>further YHG=1708>experiments YHG=1717>we YHG=1707>tested YHG=1708>the YHG=1707>effect YHG=1707>of(-)-epicatechin YHG=1718>on " XBD=1324 XBD=1592XHG=859 XBD=1646 XBD=1843 XBD=1889 XBD=1957 XBD=2069 XHG=1428 XHG=1604 XHG=1659 XHG=1857 XHG=1903 XHG=1970 YBD=1759 YBD=1751 YBD=1758 YBD=1750 YHG=1721>explained YHG=1721>by YHG=1720>differences YHG=1721>in YHG=1730>age YHG=1720>alone. " XBD=432 XBD=582 XBD=733 XBD=781 XBD=884 XBD=987 XBD=1176 XBD=1269 XBD=1323 XHG=187 XHG=447 XHG=597 XHG=748 XHG=796 XHG=900 XHG=1002 XHG=1191 XHG=1288 YBD=1790 YBD=1783 YBD=1782 YBD=1789 YBD=1783 YBD=1782 YHG=1752>streptozotocin YHG=1753>induced YHG=1753>diabetes YHG=1753>in YHG=1752>mice. YHG=1753>Male YHG=1752>C57BL/6J YHG=1753>mice " XBD=2548 XBD=1533 XHG=2514 XBD=1648 XBD=1789 XBD=1911 XBD=2008 XBD=2219 XBD=2310 XBD=2498 XHG=1463 YBD=1796 XHG=1551 XHG=1667 XHG=1805 XHG=1929 XHG=2027 XHG=2236 XHG=2328 YBD=1807 YHG=1754>12 YBD=1797 YHG=1766>The YHG=1767>stable YHG=1767>HbAlc YHG=1767>values YHG=1776>were YHG=1766>determined YHG=1765>after YHG=1767>incubation YHG=1766>of " XBD=2544 XBD=287 XHG=916 XBD=355 XBD=432 XBD=540 XBD=658 XBD=819 XBD=888 XBD=932 XBD=1059 XBD=1163 XBD=1264 XBD=1329 XHG=186 XHG=317 XHG=377 XHG=460 XHG=569 XHG=686 XHG=847 XHG=960YBD=1828 XHG=1087 XHG=1190 XHG=1292 YBD=1829 YBD=1836 YBD=1836 YBD=1836 YBD=1829 YHG=1798>weeks YHG=1798>of YHG=1807>age YHG=1808>were YHG=1799>made YHG=1799>diabetic YHG=1798>by YHG=1808>a YHG=1799>single YHG=1799>high YHG=1799>dose YHG=1798>of " XBD=1525 XBD=1608 XBD=1653 XBD=1865 XBD=1982 XBD=2063 XBD=2184 XBD=2338 XBD=2394 XHG=1430 XHG=1535 XHG=1619 XHG=1662 XHG=1876 XHG=1993 XHG=2073 XHG=2194 XHG=2347 XHG=2403 YBD=1850 YBD=1841 YBD=1842 YHG=1812>blood YHG=1812>cells YHG=1812>in YHG=1811>glucose-free YHG=1812>saline. YHG=1811>The YHG=1812>results YHG=1812>obtained YHG=1821>are YHG=1811>therefore " XBD=431 XBD=644 XBD=851 XBD=922 XBD=1037 XBD=1128 XBD=1272 XHG=187 XHG=439 XHG=652 XHG=932 XHG=1046 XHG=1137 XHG=1284 YBD=1881 YBD=1882 YBD=1880 YBD=1873 YBD=1882 YBD=1882 YBD=1873 YHG=1844>streptozotocin YHG=1844>(Boehringer YHG=1844>Mannheim, YHG=1845>175 YHG=1844>mg/kg YHG=1844>body YHG=1844>weight). YHG=1845>24 " XBD=1322 XBD=1642XHG=866 XBD=1694 XBD=1753 XBD=1892 XBD=1983 XBD=2025 XBD=2091 XBD=2178 XBD=2229 XBD=2395 XHG=1430 XHG=1656 XHG=1700 XHG=1767 XHG=1906 XHG=1997 XHG=2038 XHG=2104 XHG=2191 XHG=2236 YBD=1887 YBD=1895 YHG=1858>independent YHG=1858>glucose YHG=1858>level YHG=1864>at YHG=1857>the YHG=1858>time YHG=1857>of YHG=1858>sampling. " XBD=1323 XBD=209 XHG=876 XBD=310 XBD=578 XBD=851 XBD=934 XBD=1058 XBD=1120 XBD=1267 XHG=187 XHG=232 XHG=334 XHG=602 XHG=959YBD=1919 XHG=1083 XHG=1138 XHG=1291 YBD=1927 YBD=1927 YBD=1919 YBD=1918 YHG=1889>h YHG=1889>after YHG=1890>streptozotocin YHG=1890>administration YHG=1899>one YHG=1899>group YHG=1889>of YHG=1890>animals YHG=1890>in DAVID OWERBACH " XBD=1323 XBD=327 XHG=881 XBD=518 XBD=833 XBD=933 XBD=1099 XBD=1181 XHG=186 XHG=377 XHG=567 XHG=983YBD=1973 XHG=1149 XHG=1229 YBD=1965 YBD=1964 YBD=1974 YBD=1973 YBD=1964YHG=1935>(40 YBD=1965 YHG=1934>addition YHG=1935>received YHG=1934>(-)-epicatechin YHG=1935>mg/kg) YHG=1935>in YHG=1942>water PER BILLESBØLLE " XBD=1322 XBD=474 XHG=832 XBD=586 XBD=693 XBD=765 XBD=807 XBD=915 XBD=1025 XBD=1164 XBD=1226 XHG=186 XHG=497 XHG=611 XHG=717 XHG=788 XHG=942YBD=2019 XHG=1049 XHG=1188 XHG=1244 YBD=2011 YBD=2010 YBD=2010 YBD=2019 YBD=2010 YHG=1981>intraperitoneally YHG=1981>twice YHG=1980>daily YHG=1980>for YHG=1982>4 YHG=1981>days. YHG=1980>Both YHG=1990>groups YHG=1980>of YHG=1981>mice Hagedorn Research Laboratory, SVENN POULSEN Steno Memorial Hospital, "|>"XBD=1322 XBD=334 XBD=515 XBD=799 XBD=892 XBD=950 XBD=1096 XBD=1261 XBD=1206 XHG=186 XHG=350 XHG=532 XHG=815 XHG=908 XHG=967 XHG=1223 XHG=1270 XHG=1113 YBD=2064 YBD=2065 YBD=2056 YBD=2056 YBD=2056 YBD=2056 YHG=2026>acquired YHG=2027>persistent YHG=2026>hyperclycaemia YHG=2026>with YHG=2036>no YHG=2026>obvious YHG=2025>of YHG=2026>the YHG=2026>effect Denmark NERUP DK-2820 Gentofte, JØRN " XBD=456 XBD=266 XHG=353 XBD=340 XHG=186 YBD=2110 XHG=277 YBD=2109 YHG=2072>table). YHG=2071>drug YHG=2072>(see " XBD=1322 XBD=343 XHG=913 XBD=413 XBD=562 XBD=603 XBD=731 XBD=794 XBD=889 XBD=974 XBD=1108 XBD=1240 XHG=221 XHG=367 XHG=438 XHG=587 XHG=627 XHG=756 XHG=813 XHG=998YBD=2146 XHG=1133 XHG=1265 YBD=2155 YBD=2147 YBD=2155 YBD=2147 YBD=2146 YHG=2117>Finally YHG=2127>we YHG=2117>studied YHG=2126>a YHG=2117>model YHG=2116>of YHG=2117>slow YHG=2116>and YHG=2117>partial YHG=2117>B-islet YHG=2117>cell IgG IN BRAIN CELLS IN SLE " XBD=1206 XBD=549 XHG=668 XBD=640 XBD=742 XBD=1014 XHG=186 XHG=580 XHG=771YBD=2193 XHG=1043 YBD=2200 YBD=2192 YBD=2200 YBD=2193YHG=2163>dose YHG=2163>destruction-namely, YHG=2163>low YHG=2163>streptozotocin YHG=2155>diabetes.2 Male with "" XBD=1322 XBD=361 XBD=452 XBD=543 XBD=688 XBD=850 XBD=1026 XBD=1075 XHG=186 XHG=372 XHG=463 XHG=555 XHG=862 XHG=1037 XHG=1080 YBD=2245 YBD=2238 YBD=2237 YBD=2245 YBD=2237 YBD=2246 YHG=2208>C57BL/6J YHG=2208>mice YHG=2217>were YHG=2201>treated3 YHG=2208>five YHG=2208>injections YHG=2208>of YHG=2209>streptozotocin SiR,―The XBD=1785XHG=789 XBD=1841 XBD=1922 XBD=1973 XBD=2043 XBD=2234 XBD=2289 XBD=2386 XBD=2471 XBD=2518 XBD=2548 XHG=1661 XHG=1803 XHG=1854 XHG=1940 XHG=1992 XHG=2063 XHG=2252 XHG=2300 XHG=2403 XHG=2489 XHG=2534 YBD=2255 YBD=2248 YBD=2247 YHG=2217>finding YHG=2217>IgG YHG=2218>the YHG=2218>cytoplasm YHG=2217>of YHG=2218>brain YHG=2218>cells YHG=2218>in YHG=2227>a " XBD=1323 XBD=238 XBD=361 XBD=459 XBD=611 XBD=794 XBD=1079 XBD=1267 XHG=185 XHG=256 XHG=375 XHG=475 XHG=629 XHG=811 XHG=1095 XHG=1282 YBD=2291 YBD=2292 YBD=2283 YBD=2292 YBD=2292 YHG=2254>(40 YHG=2254>mg/kg YHG=2253>body YHG=2253>weight). YHG=2254>Moderate YHG=2254>hyperglycaemia YHG=2254>developed XBD=1550 XHG=2494 XBD=1654 XBD=1825 XBD=1946 XBD=2218 XBD=2283 XBD=2353 XBD=2470 XBD=2548 XHG=1433 YBD=2290 XHG=1577 XHG=1681 XHG=1852 XHG=1973 XHG=2243 XHG=2308 XHG=2378 YBD=2300 YHG=2255>by YBD=2291 YBD=2301 YBD=2299 YHG=2263>patient YHG=2262>with YHG=2263>systemic YHG=2262>lupus YHG=2261>erythematosus YHG=2261>by YHG=2262>Dr YHG=2262>Inoue YHG=2263>and " XBD=2545 XBD=245 XHG=535 XBD=294 XBD=381 XBD=442 XBD=525 XBD=820 XBD=1003 XBD=1084 XBD=1193 XBD=1322 XHG=186 XHG=255 XHG=303 XHG=390 XHG=451 XHG=830YBD=2336 XHG=1014 XHG=1093 XHG=1203 YBD=2337 YBD=2328 YBD=2335 YBD=2328 YBD=2336 YBD=2329 YHG=2299>day YHG=2300>30 YHG=2298>after YHG=2298>the YHG=2305>start YHG=2298>of YHG=2299>injections. YHG=2298>One YHG=2308>group YHG=2299>of streptozotocin mice " XBD=1607 XBD=1721 XBD=1786 XBD=1831 XBD=1920 XBD=2028 XBD=2074 XBD=2125 XBD=2326 XBD=2411 XHG=1433 XHG=1620 XHG=1739 XHG=1802 XHG=1848 XHG=1934 XHG=2041 XHG=2087 XHG=2140 XHG=2338 XHG=2424 YBD=2347 YBD=2344 YBD=2346 YBD=2338 YHG=2309>colleagues YHG=2308>(April YHG=2310>10, YHG=2318>p. YHG=2309>852) YHG=2308>needs YHG=2316>to YHG=2309>be YHG=2309>interpreted YHG=2309>with YHG=2309>caution. " XBD=1322 XBD=248 XBD=341 XBD=477 XBD=583 XBD=684 XBD=778 XBD=1060 XBD=1125 XBD=1182 XBD=1273 XHG=186 XHG=266 XHG=359 XHG=494 XHG=602 XHG=794 XHG=1077 XHG=1147 XHG=1200 XHG=1291 YBD=2374 YBD=2382 YBD=2373 YBD=2382 YBD=2382 YBD=2374 YHG=2353>was YHG=2344>then YHG=2344>treated YHG=2344>twice YHG=2344>daily YHG=2344>with YHG=2344>(-)-epicatechin YHG=2344>for YHG=2345>10 YHG=2345>days YHG=2354>as XBD=1552XHG=701 XBD=1708 XBD=1793 XBD=1940 XBD=2049 XBD=2214 XBD=2271 XBD=2347 XBD=2474 XBD=2548 XHG=1434 XHG=1575 XHG=1729 XHG=1814 XHG=1961 XHG=2070 XHG=2234 XHG=2286 XHG=2367 XHG=2495 YBD=2384 YBD=2390 YBD=2383 YHG=2355>Frozen YHG=2355>sections YHG=2354>will YHG=2355>contain YHG=2354>small YHG=2361>amounts YHG=2354>of YHG=2354>free YHG=2364>serum, YHG=2354>and " XBD=348 XBD=480 XBD=587 XBD=670 XBD=744 XBD=873 XBD=1021 XBD=1140 XBD=1243 XHG=186 XHG=372 XHG=505 XHG=612 XHG=695 XHG=896 XHG=1047 XHG=1164 XHG=1269 YBD=2425 YBD=2427 YBD=2418 YBD=2419 YBD=2426 YBD=2419 YHG=2389>described YHG=2389>above, YHG=2389>until YHG=2389>day YHG=2390>40. YHG=2389>Blood YHG=2389>glucose YHG=2390>levels YHG=2399>were YHG=2397>not " XBD=1322 XBD=1548XHG=771 XBD=1624 XBD=1848 XBD=1970 XBD=2167 XBD=2314 XBD=2405 XBD=2499 XBD=2548 XHG=1433 XHG=1571 XHG=1650 XHG=1875 XHG=1995 XHG=2192 XHG=2338 XHG=2428 XHG=2520 YBD=2436 YBD=2437 YBD=2438 YBD=2429 YHG=2400>during YHG=2400>the YHG=2399>&dquo;pre-wash&dquo; YHG=2400>phase YHG=2400>antibodies YHG=2407>present YHG=2409>may YHG=2400>bind YHG=2407>to |>" " XBD=398 XBD=632 XBD=747 XBD=557 XHG=186 XHG=569 XHG=645 XHG=410 YBD=2472 YBD=2464 YHG=2434>significantly YHG=2435>(see YHG=2434>table). YHG=2434>different " XBD=1570 XBD=1776 XBD=1848 XBD=1963 XBD=2079 XBD=2193 XBD=2250 XBD=2473 XBD=2547 XHG=1434 XHG=1603 XHG=1810 XHG=1875 XHG=1996 XHG=2115 XHG=2225 XHG=2283 XHG=2501 YBD=2475 YBD=2483 YBD=2474 YHG=2446>exposed YHG=2445>cytoplasm YHG=2444>of YHG=2445>brain YHG=2445>cells. YHG=2444>This YHG=2445>is YHG=2445>presumably YHG=2445>the |>" " XBD=277 XBD=408 XBD=559 XBD=614 XBD=829 XBD=992 XBD=1266 XBD=1323 XBD=937 XHG=221 XHG=294 XHG=424 XHG=575 XHG=630 XHG=954 XHG=1001 XHG=1282 XHG=845 YBD=2508 YBD=2510 YBD=2509 YBD=2518 YBD=2509 YHG=2479>We YHG=2486>cannot YHG=2479>confirm YHG=2489>an YHG=2480>antidiabetic YHG=2480>of YHG=2479>effect YHG=2480>(-)-epicatechin YHG=2490>on " XBD=1633 XBD=1690 XBD=1752 XBD=1888 XBD=2033 XBD=2218 XBD=2374 XBD=2414 XBD=2486 XBD=2549 XHG=1434 XHG=1642 XHG=1699 XHG=1762 XHG=1897 XHG=2042 XHG=2228 XHG=2383 XHG=2423 XHG=2495 YBD=2529 YBD=2528 YBD=2520 YHG=2491>explanation YHG=2490>for YHG=2491>the YHG=2491>nuclear YHG=2491>staining YHG=2490>sometimes YHG=2491>observed YHG=2491>in YHG=2490>skin YHG=2490>and " XBD=369 XBD=528 XBD=688 XBD=745 XBD=905 XBD=991 XBD=1038 XBD=1086 XBD=1163 XBD=1269 XHG=186 XHG=393 XHG=551 XHG=713 XHG=768 XHG=1015 XHG=1062 XHG=1110 XHG=1186 XHG=1291 YBD=2562 YBD=2560 YBD=2554 YBD=2554 YBD=2563 YBD=2555 YHG=2524>chemically YHG=2524>induced YHG=2525>diabetes YHG=2525>in YHG=2525>rodents; YHG=2525>and YHG=2525>it YHG=2526>is YHG=2532>too YHG=2525>early YHG=2532>to " XBD=1323 XBD=1519XHG=930 XBD=1652 XBD=1756 XBD=1911 XBD=2009 XBD=2175 XBD=2298 XBD=2368 XBD=2476 XBD=2547 XHG=1434 XHG=1540 XHG=1673 XHG=1777 XHG=1932 XHG=2031 XHG=2197 XHG=2321 XHG=2389 XHG=2493 YBD=2574 YBD=2566 YBD=2565 YHG=2537>renal YHG=2537>biopsy YHG=2536>from YHG=2537>patients YHG=2536>with YHG=2536>systemic YHG=2536>lupus. YHG=2537>To YHG=2536>avoid YHG=2536>this " XBD=387 XBD=461 XBD=554 XBD=615 XBD=700 XBD=727 XBD=877 XBD=924 XBD=1018 XHG=186 XHG=400 XHG=475 XHG=567 XHG=627 XHG=715 XHG=741 XHG=891 XHG=937 YBD=2606 YBD=2608 YBD=2599 YBD=2598 YBD=2599 YHG=2569>recommend YHG=2569>this YHG=2569>drug YHG=2569>for YHG=2577>type YHG=2570>I YHG=2570>diabetes YHG=2569>in YHG=2579>man. " XBD=2547 XBD=1554 XHG=2518 XBD=1587 XBD=1703 XBD=1750 XBD=1923 XBD=1965 XBD=2167 XBD=2228 XBD=2324 XBD=2405 XBD=2510 XHG=1434 YBD=2610 XHG=1564 XHG=1597 XHG=1712 XHG=1761 XHG=1932 XHG=1975 XHG=2176 XHG=2237 XHG=2333 XHG=2414 YBD=2612 YHG=2590>or YBD=2619 YBD=2611 YHG=2582>artifact YHG=2582>it YHG=2582>would YHG=2582>be YHG=2591>necessary YHG=2588>to YHG=2581>pre-perfuse YHG=2582>the YHG=2582>brain YHG=2582>with YHG=2581>buffer
H. KOLB " XBD=1540 XHG=1434 YBD=2657 YHG=2628>saline. U. KIESEL Diabetes Research Institute, B. GREULICH University of Düsseldorf, D-4000 Düsseldorf, West Germany J. VAN DER BOSCH
"" " " " " " " " " " " " "
Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0HS
DAVID J. EVANS
GLUCOSE REGULATION AND THE INSULIN GENE
XBD=2546 XBD=1555 XBD=1678 XBD=1767 XBD=1879 XBD=2023 XBD=2087 XBD=2167 XBD=2305 XBD=2438 XHG=1433 XHG=1589 XHG=1712 XHG=1800 XHG=1913 XHG=2055 XHG=2120 XHG=2199 XHG=2338 XHG=2469 YBD=2923 YBD=2917 YBD=2918 YBD=2925 YBD=2919 YBD=2927 YHG=2887>**This YHG=2888>letter YHG=2888>has YHG=2888>been YHG=2888>shown YHG=2896>to YHG=2889>Dr YHG=2889>Inoue, YHG=2890>whose YHG=2889>reply S[R,―The XBD=482 XBD=531 XBD=587 XBD=671 XBD=865 XBD=971 XBD=1022 XBD=1079 XBD=1262 XBD=1333 XHG=415 XHG=492 XHG=534 XHG=597 XHG=682 XHG=875 XHG=980 XHG=1032 XHG=1088 XHG=1273 YBD=2941 YBD=2949 YBD=2949 YBD=2941 YBD=2940 YHG=2912>title YHG=2911>of YHG=2912>the YHG=2921>very YHG=2912>interesting YHG=2921>paper YHG=2912>by YHG=2912>Dr YHG=2912>Owerbach YHG=2912>and XBD=1698 XHG=1664 YBD=2960 YHG=2932>L. XBD=369 XHG=900 XBD=492 XBD=565 XBD=619 XBD=718 XBD=877 XBD=966 XBD=1050 XBD=1164 XBD=1224 XBD=1333 XHG=194 XHG=391 XHG=518 XHG=589 XHG=644 XHG=740 XHG=989YBD=2985 XHG=1072 XHG=1186 XHG=1240 YBD=2993 YBD=2991 YBD=2994 YBD=2993 YBD=2985 YHG=2956>colleagues YHG=2956>(April YHG=2957>17, YHG=2966>p. YHG=2957>880) YHG=2966>assumes YHG=2956>that YHG=2965>any YHG=2956>effect YHG=2955>of YHG=2956>DNA XBD=346 XBD=525 XBD=697 XBD=924 XBD=1027 XBD=1088 XBD=1332 XHG=195 XHG=356 XHG=535 XHG=939 XHG=1036 XHG=1098 YBD=3032 YBD=3038 YBD=3030 YBD=3030 YHG=3001>insertion YHG=3010>sequences YHG=3001>of YHG=3002>11 YHG=3001>the YHG=3001>concentration human on XBD=1693XHG=707 XBD=1753 XBD=1827 XBD=2010 XBD=2123 XBD=2188 XBD=2278 XBD=2471 XBD=2546 XHG=1607YBD=3031 XHG=1703 XHG=1763 XHG=1837 XHG=2019 XHG=2132 XHG=2198 XHG=2288 XHG=2478 YBD=3036YHG=3001>chromosome YBD=3037 YBD=3046 YBD=3038 YHG=3006>there YHG=3016>are YHG=3006>free YHG=3007>antibodies YHG=3007>which YHG=3017>can YHG=3015>react YHG=3008>sufficiently YHG=3008>with XBD=233 XHG=669 XBD=435 XBD=658 XBD=890 XBD=1042 XBD=1141 XBD=1288 XBD=1332 XHG=195 XHG=240 XHG=448 XHG=903YBD=3084 XHG=1054 XHG=1154 XHG=1300 YBD=3077 YBD=3085 YBD=3084 YBD=3075 YHG=3047>of YHG=3047>erythrocyte YHG=3046>glycosylated YHG=3046>haemoglobin YHG=3046>depends YHG=3055>upon YHG=3046>changes YHG=3047>in XBD=1578 XBD=1665 XBD=1711 XBD=1776 XBD=1888 XBD=1997 XBD=2125 XBD=2176 XBD=2265 XBD=2363 XBD=2464 XBD=2542 XHG=1428 XHG=1592 XHG=1679 XHG=1724 XHG=1788 XHG=1901 XHG=2010 XHG=2138 XHG=2182 XHG=2276 XHG=2374 XHG=2476 YBD=3084 YBD=3089 YBD=3083 YHG=3054>neuronal YHG=3054>cells YHG=3054>in YHG=3055>the YHG=3055>brain, YHG=3055>eluates YHG=3054>of YHG=3054>fresh YHG=3054>brain YHG=3055>tissue YHG=3054>with XBD=290 XBD=440 XBD=701 XBD=829 XBD=928 XBD=985 XBD=1243 XBD=1331 XHG=194 XHG=315 XHG=465 XHG=726 XHG=852 XHG=1011 XHG=1269 YBD=3122 YBD=3129 YBD=3121 YBD=3120 YBD=3121 YBD=3126 YHG=3093>blood YHG=3093>glucose YHG=3092>concentration YHG=3092>rather YHG=3092>than YHG=3092>in YHG=3092>red-blood-cell YHG=3091>life, XBD=1607XHG=953 XBD=1773 XBD=1890 XBD=2040 XBD=2123 XBD=2291 XBD=2432 XBD=2481 XBD=2545 XHG=1432 XHG=1629 XHG=1794 XHG=1912 XHG=2047 XHG=2145 XHG=2312 XHG=2451 XHG=2500 YBD=3134 YBD=3135 YBD=3127 YBD=3128 YHG=3096>phosphate YHG=3096>buffered YHG=3097>saline YHG=3097>should. YHG=3098>have YHG=3098>antibody YHG=3099>activity YHG=3105>to YHG=3099>the XBD=395 XHG=888 XBD=552 XBD=664 XBD=861 XBD=938 XBD=1047 XBD=1105 XBD=1185 XBD=1332 XHG=196 XHG=420 XHG=578 XHG=691 XHG=965YBD=3166 XHG=1074 XHG=1132 XHG=1212 YBD=3175 YBD=3174 YBD=3165 YBD=3166 YBD=3165 YBD=3173 YHG=3137>presumably YHG=3137>because YHG=3136>these YHG=3146>sequences YHG=3146>are YHG=3137>close YHG=3143>to YHG=3136>the YHG=3136>genetic XBD=1582 XBD=1689 XBD=1774 XBD=1848 XBD=2002 XBD=2373 XBD=2481 XBD=2545 XHG=1432 XHG=1605 XHG=1713 XHG=1795 XHG=1871 XHG=2024 XHG=2394 XHG=2499 YBD=3176 YBD=3171 YBD=3179 YBD=3172 YHG=3142>neuronal YHG=3142>cells, YHG=3142>and YHG=3142>the YHG=3142>indirect YHG=3142>immunofluorescence YHG=3143>using YHG=3143>the XBD=334 XHG=868 XBD=537 XBD=671 XBD=851 XBD=948 XBD=1160 XBD=1280 XBD=1332 XHG=196 XHG=350 XHG=554 XHG=686 XHG=964YBD=3211 XHG=1174 XHG=1294 YBD=3218 YBD=3220 YBD=3219 YBD=3211 YHG=3182>material YHG=3182>controlling YHG=3181>insulin YHG=3182>synthesis. YHG=3181>This YHG=3182>assumption YHG=3182>would YHG=3182>be XBD=1531 XBD=1650 XBD=1699 XBD=1854 XBD=1911 XBD=1970 XBD=2153 XBD=2218 XBD=2324 XBD=2395 XBD=2544 XHG=1432 XHG=1543 XHG=1661 XHG=1712 XHG=1869 XHG=1924 XHG=1983 XHG=2166 XHG=2231 XHG=2337 XHG=2407 YBD=3224 YBD=3216 YBD=3222 YBD=3217 YBD=3225 YHG=3187>eluate YHG=3187>would YHG=3187>be YHG=3187>positive. YHG=3187>As YHG=3196>we YHG=3187>described, YHG=3188>the YHG=3188>result YHG=3197>was YHG=3189>negative, XBD=248 XBD=354 XBD=529 XBD=580 XBD=681 XBD=764 XBD=864 XBD=901 XBD=1107 XBD=1161 XBD=1235 XBD=1331 XHG=194 XHG=269 XHG=376 XHG=550 XHG=594 XHG=703 XHG=784 XHG=923 XHG=1129 XHG=1183 XHG=1257 YBD=3265 YBD=3257 YBD=3256 YBD=3256 YBD=3256 YHG=3228>the YHG=3236>more YHG=3227>plausible YHG=3227>if YHG=3228>there YHG=3227>had YHG=3228>been YHG=3237>a YHG=3227>correlation YHG=3227>in YHG=3227>the YHG=3236>nonXBD=1493XHG=885 XBD=1641 XBD=2016 XBD=2095 XBD=2243 XBD=2334 XBD=2423 XBD=2545 XHG=1431 XHG=1510 XHG=1659 XHG=2033 XHG=2113 XHG=2261 XHG=2350 XHG=2439 YBD=3262 YBD=3261 YBD=3269 YBD=3270 YBD=3263 YHG=3233>and YHG=3232>indirect YHG=3232>immunofluorescence YHG=3242>was YHG=3232>positive YHG=3233>only YHG=3233>after YHG=3233>elution XBD=344 XHG=660 XBD=486 XBD=642 XBD=756 XBD=1009 XBD=1088 XBD=1203 XBD=1333 XHG=195 XHG=361 XHG=500 XHG=904YBD=3301 XHG=1027 XHG=1104 XHG=1219 YBD=3301 YBD=3301YHG=3272>stable YBD=3308 YHG=3272>diabetics YHG=3272>studied YHG=3272>between YHG=3272>values YHG=3272>and YHG=3272>either YHG=3272>fasting HbA1c XBD=1508 XBD=1629 XBD=1758 XBD=1880 XBD=2034 XBD=2182 XBD=2262 XBD=2362 XBD=2423 XBD=2476 XBD=2545 XHG=1430 XHG=1522 XHG=1644 XHG=1775 XHG=1895 XHG=2050 XHG=2197 XHG=2278 XHG=2376 XHG=2438 XHG=2490 YBD=3314 YBD=3306 YBD=3307 YHG=3278>with YHG=3277>citrate YHG=3277>buffer. YHG=3277>These YHG=3277>findings YHG=3277>indicate YHG=3278>that YHG=3278>there YHG=3287>are YHG=3288>no YHG=3278>free XBD=290 XHG=896 XBD=427 XBD=476 XBD=507 XBD=609 XBD=666 XBD=750 XBD=832 XBD=884 XBD=949 XBD=1052 XHG=194 XHG=302 XHG=440 XHG=488 XHG=520 XHG=622 XHG=680 XHG=763 XHG=845 XHG=962YBD=3346 YBD=3347 YBD=3353 YBD=3355 YBD=3354 YBD=3345 YBD=3354 YHG=3318>blood YHG=3317>glucose YHG=3326>or YHG=3317>k YHG=3318>value YHG=3317>(as YHG=3326>may YHG=3317>well YHG=3316>be YHG=3317>the YHG=3317>case). XBD=1615 XBD=1704 XBD=1794 XBD=1879 XBD=2037 XBD=2254 XBD=2413 XBD=2490 XBD=2544 XHG=1431 XHG=1643 XHG=1729 XHG=1821 XHG=1905 XHG=2063 XHG=2280 XHG=2438 XHG=2512 YBD=3358 YBD=3351 YBD=3359 YBD=3352 YHG=3322>antibodies, YHG=3323>and YHG=3323>that YHG=3332>our YHG=3322>positive YHG=3322>fluoresence YHG=3322>findings YHG=3332>can YHG=3324>be XBD=297 XBD=375 XBD=424 XBD=605 XBD=801 XBD=844 XBD=906 XBD=971 XBD=1116 XBD=1266 XBD=1329 XHG=228 XHG=308 XHG=385 XHG=428 XHG=616 XHG=812 XHG=854 XHG=980 XHG=1126 XHG=1276 YBD=3399 YBD=3391 YBD=3389 YBD=3388 YBD=3397 YBD=3389 YBD=3396 YHG=3362>The YHG=3362>lack YHG=3360>of YHG=3360>significant YHG=3362>correlation YHG=3361>in YHG=3362>the YHG=3361>LL YHG=3361>subjects YHG=3361>between YHG=3369>age XBD=1622XHG=917 XBD=1678 XBD=1849 XBD=1938 XBD=2180 XBD=2373 XBD=2455 XBD=2544 XHG=1431 XHG=1646 XHG=1703 XHG=1873 XHG=1964 XHG=2205 XHG=2397 XHG=2476 YBD=3405 YBD=3404 YBD=3397 YBD=3398 YHG=3368>interpreted YHG=3377>as YHG=3368>meaning YHG=3368>that YHG=3368>antineuronal YHG=3368>antibodies YHG=3368>had YHG=3369>been XBD=257 XBD=365 XBD=491 XBD=596 XBD=732 XBD=777 XBD=807 XBD=906 XBD=952 XBD=1045 XBD=1174 XBD=1331 XHG=194 XHG=267 XHG=376 XHG=500 XHG=606 XHG=743 XHG=787 XHG=817 XHG=962 XHG=1056 XHG=1184 YBD=3439 YBD=3437 YBD=3440 YBD=3436 YBD=3444 YBD=3436 YBD=3443 YHG=3408>and YHG=3407>either YHG=3407>fasting YHG=3407>blood YHG=3408>glucose YHG=3417>or YHG=3407>k YHG=3407>value YHG=3416>or YHG=3407>early YHG=3407>insulin YHG=3416>response XBD=1555XHG=917 XBD=1601 XBD=1666 XBD=1814 XBD=1915 XBD=2011 XBD=2066 XBD=2131 XBD=2280 XBD=2323 XHG=1431 XHG=1569 XHG=1614 XHG=1680 XHG=1825 XHG=1927 XHG=2026 XHG=2078 XHG=2145 XHG=2292 YBD=3447 YBD=3450 YBD=3442 YBD=3441 YHG=3419>present YHG=3412>affected YHG=3413>brain YHG=3412>cells, YHG=3413>by YHG=3413>the YHG=3413>reaction YHG=3413>in 2. Like
AA, Rossini AA. Streptozotocin-induced pancreatic insulitis; new model of diabetes mellitus Science 1976; 193: 415-18. 3 Kiesel U, Freytag G, Biener J, Kolb H. Transfer of experimental autoimmune insulitis by spleen cells in mice. Diabetologia 1980; 19: 516-20
follows.-ED
SiR,―If
situ. First Department of Internal Medicine, Oska City University Medical School,
1-5-7, Asahimachi, Abenoku,
Osaka 545, Japan
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