Imaging of small cell tumours with the radiolabelled somatostatin analogue, III in-pentetreotide

78 298

291 Comparison of cbesstx-ray Glms, computerized tomography of thorax, bronchoscopic results, and operative Gndings in patients with suspected lung aodlor mediastinal lesions. Ugur

GnilIIll,

Noman

Nomanoglu,

&em Medical

bdemir,

School

6mer

Altuntag,

Doganay

of Ankara

ismail

Sava~.

SL4LlC ACID, LIPID-BOUND SIALIC ACID, CERULOPL4SMIN, AND FIBRINOGEN LEVELS IN MALIGN AND BENIGN PLEURAL DISEASES

TOTAL

Dr.NumanNumanoglu, Dr.Turan Karayrlanoglu, Dr.Ugur Giiniillii. Dr.i%lem

Alper,

University,

&demir,

Dr.Yddo

Atakwt.

Dr.Doganay

Dept. of Chest Diseases We studied

2.4 patients

with

long

and/or

mediastinal

University.

AU patients plain

manifes~aiions

chest

obtain

and squamous

followed films,

of each patients

We could toners

were x-ray

up to their

CT findings

cell

long

unlike

performing bronchoscopy. Chest x-ray films could not give detailed mediastinal lesions. Thoracic thoracic

cystic

lesions

could be seen readily

benign

lesions

information

accurately

compared

benign

lymph major

bronchoscopic

by

about

malign markers Thirieen

Turkey.

acid (%A),

pleural diseases

ihan the levels

levels

of TSA and LSA of malignant @
cases

were

findings. nodes from

acid

benign effosions

we also measured subjects disease,

from

the same

as a conrrol group. while the remaining

benign patho1ogie.s. We foundsewn andpleural effusion levels ofTSA and EGA in cases with malignant pleurisy significantly higher

node

sialic

and pleural effosions

to differentiate

to the patients,

fmdings.

films.

lipid-bound

in sewn

in the serum of 30 healthy of total cases had malignant

group

lymph

of sialic

cases had

in thorax CT. We showed

the metestatic

and Biostatistics,

of Ankara University,

and fibrinogen

ones. In addition

benign

with operative

pleurisy

of cases with benign

cases

higher

were

Semm than

pleurisy

pleurisy

significantly

ceruloplasmin

above levels

the ceruloplasmin

@cO.Mll).

Serum

cases and TSA levels

of

the levels

of control

01 malipant

pleurisy

levels

of benign

pleurisy

control group@
and

nodes.

CT did not give extra information locared

the levels

ceroloplasmin,

originared

masses

in thorax CT much easier than chest x-ray

Cf could not differentiate

School

vessels end

ThoracicCT was not able10 show hilarlymph involvement

(LSA),

carcinoid

as much detail as in operative

Inourstudy, we found ihat inuabronchial from large bronchi

We detected

of 32 caseswith

with

CT could not reveal the invasion of gxat

wall involvement

We

results.

in patients

cancers

operations.

and bronchoscopic

with the operative

the diagnosis

Medical

mass(a)

School of Ankara

admined toourChest Diseases Depariment, Medical compared

Alper.

Turkey.

bronchi

however

method

for

the

it

except staging about tumors

guided

lesion

in

10 select cases

with

diagnostic

negative

bronchoscopic results.

THE VALUE OF CYTOGENETIC ANALYSIS IN THE DIAGNOSIS

IMAGING OF SHALL

OF MALIGNANTPLEURAL EFFUSIONS

K.J. O'Byme, J.T. Ennis, P.J. Freyne, L.J. Clancy, J.S. Prichard, D.N.

f.Savag,N.fmirzal~oglu,B.S.~ayl~,N.Numano~lu,U. GSniillii,O.Ozdemir,D.Alper,H.Giirses. Departments of Chest Diseases and Genetics,Facultyof Medicine, University of Ankara;Departmentof Genetics,Giilhane Military Medical School,Tiirkiye We examined 34 cases with pleural effusions.Following thoracentesis,chromosomalanalysis of G-banded metaphase plates by direct and culture methods have been performed. Pleural effusions of 11 patients wsre found to be benign and the remaining malignant. No diagnosis was made in 2 cases.1" these instances,no chromosomal abnormality was found in some and culture was not positive in others. The results of chromosomal analjsis were consistent with the diagnosis in benign effusions. In general,diagnosticrate of cytology was 52% and histopathologicexamination 42% in malignant effusions. When the chromosomal analysis was added,the diagnostic rate reached 71%. Chromosomal analysis was not very effective in the diagnosis of metastatic cases while results were contributive for lymphomas.Chromosomalanalysis in lung adenocarcinomawere consistent with the cytology while it was negative for squamous cell carcinoma.These(-) results might be due to paramalignanteffusions and/or technical reasons. We believe that if chromosomal analysis is combined with cytology,mdre information can be gained.

SOMATOSTATIN

CELL

ANALOCUE.

TlJ!JjURS

WITH

THE

RADIOLABELLED

IN-PENTETRBOTIDB.

Carney. Depts. of Oncology & Radiology, Mater Hospital, & Depts. of Diagnostic Imaging & Respiratory Medicine, St. James's Hospital, Dublin, Ireland. Recent work suggests that between 50-75X of small cell lung cancer (SCLC) turnourshave specific high affinity binding sites for somatostatin. This study evaluated the ypjjentialrole of the radiolabelled somatostatin analogue, In-pentetreotide, in the detection of SCLC and extrapulmonary small cell turnours(EPSCC) in patients (pts) prior to and after chemotherapy (CT) using scintigraphic imaging techniques. Results were compared to standard imaging techniques. In all 25 pts were studied. The primary site of disease was detected in 22/23 pts with SCLC and l/2 pts with EPSCC. Furthermore 9/M known metastatic sites of disease were localized in the SCLC pts. Thirteen of the SCLC pts were evaluated prior to CTlll IllFollowing standard staging 6 pts had LD and 7 ED. pentetreotide imaging led to the detection of all primary sites of disease including a primary site of disease not detectable with chest x-ray or CT thorax. All sites of metsstatic disease detected by standard staging, were imaged in 50% of cases. This included an asymptomatic cerebellar metastasis detected in a pt thought to have LD. Following CT scintigraphic imaging of 6 pts detected residual disease in 2/j with complete remissions and in all 3 pts with a partial re~y~nse on standard staging. In-pentetreotide imaging may These results suggest that have a role to play in the clinical evaluation of pts with SCLC and EPSCC. Specifically, this technique may be of particular value in detecting residual intrathoracic disease in pts with SCLC thought to have a complete remission by conventional staging methods.