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Incidence of narcolepsy before and after the pandemic influenza a (H1N1) vaccination in the Korean military
Abstracts/Sleep Medicine 16 (2015) S2–S199
duration (r = −0.34), Benton test and number of awakenings (r = −0.53) and verbal fluency test and insomnia duration (r = −0.45). Mann–Whitney U test also revealed significant differences between results of Benton tests in patients with frequent (10.9 ± 2.2) and episodic (11.9 ± 2.1) night awakenings. Conclusion: We found very weak and inconsistent connection between the presence of any sleep disturbances in chronic insomnia patients and the results of cognitive function tests. http://dx.doi.org/10.1016/j.sleep.2015.02.1541
Clinical manifestation of narcoleptic patients with family history D. Xiaosong, X. Liyue, L. Qinghua, H. Yan, L. Xiao, L. Jing, A. Pei, Z. Long, Z. Xueli, H. Fang Peking University People’s Hospital, China
Introduction: Narcolepsy has been recognized as a genetic sleep disorder. However, only 1–2% of the cases had family history with definite narcolepsy–cataplexy. The current study aims to explore the clinical presentation of familial cases with narcolepsy–cataplexy in a large Chinese narcoleptic sample, as a phenotype study for genetic research. Materials and methods: The study groups included 66 probands with narclepsy–cataplexy had definite family history of narcolepsy with cataplexy (group 1), 194 type I narcolepsy proband with family history of excessive daytime sleepiness only (group 2), and 212 sporadic patients diagnosed with narcolepsy with cataplexy but no indication of EDS family history (group 3). All patients underwent a standardized questionnaire for clinical evaluation on narcolepsy. Nocturnal polysomnogram (PSG), followed by a daytime multiple sleep latency test (MSLT), HLA typing for DQ0602 were carried out. Results: Group 1 had similar proportion of male with 2.4:1 as the other two groups (2.13:1 for group 2) and (2.65:1 for group 3). Patients in group 1 had a younger disease onset age (10.09 ± 7.00 years) than the other two groups (11.07 ± 5.49 years for group 2) and (12.42 ± 4.86 years for group 3). There are no significant difference among three groups as to clinical symptoms including hallucination, sleep paralysis and nocturnal disturbed sleep. Group 1 had higher proportion of narcolepsy tetrad. However, there were no significant difference in sleep latency, REM latency and SOREM times among three groups on MSLT. Conclusion: Type 1 narcolepsy, i.e. hypocretin deficiency indicated by CSF hypocretin measurement or predicted by the occurrence of narcolepsy cataplexy and positive HLADQB1*06:02 with family history of narcolepsy with cataplexy had earlier disease onset age compared with type1 narcolespy with excessive daytime sleepiness family history and those without family history. Acknowledgements: The study was supported by research grants from National Natural Science Foundation of China (NSFC) (81300061). http://dx.doi.org/10.1016/j.sleep.2015.02.1542
Incidence of narcolepsy before and after the pandemic influenza a (H1N1) vaccination in the Korean military W. Kim 1, S. Lee 2, E. Lee 1, K. Namkoong 1, K. Choe 3, J. Song 4, H. Cheong 4, H. Jeong 5, J. Heo 5 1 Department of Psychiatry and Institute of Behavioral Science In Medicine, Yonsei University College of Medicine, Sleep Health Center, Severance Hospital, Korea
S165
2
Department of Psychiatry, Armed Forces Capital Hospital, Korea Department of Internal Medicine, Armed Forces Capital Hospital, Korea 4 Department of Internal Medicine, Korea University College of Medicine, Korea 5 Department of Internal Medicine, Chungbuk National University, Korea 3
Introduction: Narcolepsy is hypothesized to be caused by autoimmune-mediated process. Previous reports suggested association between occurrence of narcolepsy and the influenza A(H1N1)pdm09 vaccine adjuvanted with AS03. During the 2009 H1N1 pandemic, the Korean military performed a vaccination campaign with one type of influenza vaccine containing the MF59-adjuvants. Materials and methods: Our aim was to investigate the background incidence rate of narcolepsy in the Korean military and the association of the vaccination using the MF59-adjuvanted vaccine with the occurrence of narcolepsy in a young adult group. We conducted a retrospective chart review of narcolepsy or hypersomnia cases in 2007–2013 to assess the incidence of narcolepsy in the Korean military, using the computerized disease registry and the medical record system of the Korean armed forces. The screened cases of narcolepsy were classified by two sleep specialists according to the Brighton Collaboration case definition of narcolepsy. Results: A total of 41 cases were finally diagnosed with narcolepsy in 2007–2013 (male sex, 95%; median age, 21 years). The average background incidence rate of narcolepsy in Korean soldiers was 0.91 cases per 100,000 person-years. During the prior 9 months before the implementation of the vaccination (April– December 2009), six narcolepsy cases occurred, while during the next 9 months (January–September 2010) including the 3-month vaccination campaign, five cases occurred. Conclusion: The incidence of narcolepsy in Korean soldiers was not increased after the pandemic vaccination campaign using the MF59-adjuvanted vaccine. Our result suggests that the MF59adjuvanted H1N1 vaccine did not contribute to the occurrence of narcolepsy in a young adult male group. http://dx.doi.org/10.1016/j.sleep.2015.02.1543
Coping strategies in patients with narcolepsy: Another focus of cognitive behavioral intervention in narcolepsy H. Marín Agudelo 1, U. Jiménez Correa 2, R. Haro Valencia 3, S. Tufik 4 1 Facultad de Psicología, Universidad Coperativa de Colombia, Colombia 2 Clínica de Trastornos del Sueño, Universidad Nacional Autónoma de México, Mexico 3 Instituto Méxicano de Medicina Integral del Sueño, Mexico 4 Universidade Federal de Sao Paulo, Brazil
Introduction: Given a single stressful event, people react in different ways, as also occurs in patients with narcolepsy, which react with different intensity. The aim of this work, was to relate coping strategies, in a sample of patients with Narcolepsy, not just pharmacological treatment. Materials and methods: Cross-sectional study where Ullanlina Narcolepsy Scale were applied, The Stanford cataplexy scale, Multiple Sleep Latency Test and Narcolepsy Coping Strategies Questionnaire, in a sample of 22 patients diagnosed with narcolepsy, among 25 and 42 years of age, prior informed consent.
duration (r = −0.34), Benton test and number of awakenings (r = −0.53) and verbal fluency test and insomnia duration (r = −0.45). Mann–Whitney U test also revealed significant differences between results of Benton tests in patients with frequent (10.9 ± 2.2) and episodic (11.9 ± 2.1) night awakenings. Conclusion: We found very weak and inconsistent connection between the presence of any sleep disturbances in chronic insomnia patients and the results of cognitive function tests. http://dx.doi.org/10.1016/j.sleep.2015.02.1541
Clinical manifestation of narcoleptic patients with family history D. Xiaosong, X. Liyue, L. Qinghua, H. Yan, L. Xiao, L. Jing, A. Pei, Z. Long, Z. Xueli, H. Fang Peking University People’s Hospital, China
Introduction: Narcolepsy has been recognized as a genetic sleep disorder. However, only 1–2% of the cases had family history with definite narcolepsy–cataplexy. The current study aims to explore the clinical presentation of familial cases with narcolepsy–cataplexy in a large Chinese narcoleptic sample, as a phenotype study for genetic research. Materials and methods: The study groups included 66 probands with narclepsy–cataplexy had definite family history of narcolepsy with cataplexy (group 1), 194 type I narcolepsy proband with family history of excessive daytime sleepiness only (group 2), and 212 sporadic patients diagnosed with narcolepsy with cataplexy but no indication of EDS family history (group 3). All patients underwent a standardized questionnaire for clinical evaluation on narcolepsy. Nocturnal polysomnogram (PSG), followed by a daytime multiple sleep latency test (MSLT), HLA typing for DQ0602 were carried out. Results: Group 1 had similar proportion of male with 2.4:1 as the other two groups (2.13:1 for group 2) and (2.65:1 for group 3). Patients in group 1 had a younger disease onset age (10.09 ± 7.00 years) than the other two groups (11.07 ± 5.49 years for group 2) and (12.42 ± 4.86 years for group 3). There are no significant difference among three groups as to clinical symptoms including hallucination, sleep paralysis and nocturnal disturbed sleep. Group 1 had higher proportion of narcolepsy tetrad. However, there were no significant difference in sleep latency, REM latency and SOREM times among three groups on MSLT. Conclusion: Type 1 narcolepsy, i.e. hypocretin deficiency indicated by CSF hypocretin measurement or predicted by the occurrence of narcolepsy cataplexy and positive HLADQB1*06:02 with family history of narcolepsy with cataplexy had earlier disease onset age compared with type1 narcolespy with excessive daytime sleepiness family history and those without family history. Acknowledgements: The study was supported by research grants from National Natural Science Foundation of China (NSFC) (81300061). http://dx.doi.org/10.1016/j.sleep.2015.02.1542
Incidence of narcolepsy before and after the pandemic influenza a (H1N1) vaccination in the Korean military W. Kim 1, S. Lee 2, E. Lee 1, K. Namkoong 1, K. Choe 3, J. Song 4, H. Cheong 4, H. Jeong 5, J. Heo 5 1 Department of Psychiatry and Institute of Behavioral Science In Medicine, Yonsei University College of Medicine, Sleep Health Center, Severance Hospital, Korea
S165
2
Department of Psychiatry, Armed Forces Capital Hospital, Korea Department of Internal Medicine, Armed Forces Capital Hospital, Korea 4 Department of Internal Medicine, Korea University College of Medicine, Korea 5 Department of Internal Medicine, Chungbuk National University, Korea 3
Introduction: Narcolepsy is hypothesized to be caused by autoimmune-mediated process. Previous reports suggested association between occurrence of narcolepsy and the influenza A(H1N1)pdm09 vaccine adjuvanted with AS03. During the 2009 H1N1 pandemic, the Korean military performed a vaccination campaign with one type of influenza vaccine containing the MF59-adjuvants. Materials and methods: Our aim was to investigate the background incidence rate of narcolepsy in the Korean military and the association of the vaccination using the MF59-adjuvanted vaccine with the occurrence of narcolepsy in a young adult group. We conducted a retrospective chart review of narcolepsy or hypersomnia cases in 2007–2013 to assess the incidence of narcolepsy in the Korean military, using the computerized disease registry and the medical record system of the Korean armed forces. The screened cases of narcolepsy were classified by two sleep specialists according to the Brighton Collaboration case definition of narcolepsy. Results: A total of 41 cases were finally diagnosed with narcolepsy in 2007–2013 (male sex, 95%; median age, 21 years). The average background incidence rate of narcolepsy in Korean soldiers was 0.91 cases per 100,000 person-years. During the prior 9 months before the implementation of the vaccination (April– December 2009), six narcolepsy cases occurred, while during the next 9 months (January–September 2010) including the 3-month vaccination campaign, five cases occurred. Conclusion: The incidence of narcolepsy in Korean soldiers was not increased after the pandemic vaccination campaign using the MF59-adjuvanted vaccine. Our result suggests that the MF59adjuvanted H1N1 vaccine did not contribute to the occurrence of narcolepsy in a young adult male group. http://dx.doi.org/10.1016/j.sleep.2015.02.1543
Coping strategies in patients with narcolepsy: Another focus of cognitive behavioral intervention in narcolepsy H. Marín Agudelo 1, U. Jiménez Correa 2, R. Haro Valencia 3, S. Tufik 4 1 Facultad de Psicología, Universidad Coperativa de Colombia, Colombia 2 Clínica de Trastornos del Sueño, Universidad Nacional Autónoma de México, Mexico 3 Instituto Méxicano de Medicina Integral del Sueño, Mexico 4 Universidade Federal de Sao Paulo, Brazil
Introduction: Given a single stressful event, people react in different ways, as also occurs in patients with narcolepsy, which react with different intensity. The aim of this work, was to relate coping strategies, in a sample of patients with Narcolepsy, not just pharmacological treatment. Materials and methods: Cross-sectional study where Ullanlina Narcolepsy Scale were applied, The Stanford cataplexy scale, Multiple Sleep Latency Test and Narcolepsy Coping Strategies Questionnaire, in a sample of 22 patients diagnosed with narcolepsy, among 25 and 42 years of age, prior informed consent.