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Induction of mutagenic effects in Salmonella typhimurium by drugs consisting of medicinal plant extracts
321 (SCE) compared with a control group from the same plant. Chromosome analysis for SCE was performed on lymphocytes from 21 workers. An increase in the frequency of SCE ( Y = 8.0) as compared to the control value (Y = 6.0) was observed in the group of exposed workers.
25 Garaj-Vrhovac, V., D. Horvat, V. BrumenMahovid and J. RaEid, Institute for Medical Research and Occupational Health, Zagreb (Yugoslavia) Somatic mutations in persons occupationally exposed to microwave radiation Numerous microwave instruments, which are used in medicine, industry, meteorology, navigation, telecommunications and television, as well as others, covering the frequency range from 300 M H z to 300 GHz, may pose a risk from irradiation to occupationally exposed persons and to population in general. The paper deals with the results of analysis of structural chromosome aberrations in a group of 50 workers operating microwave equipment. A control group was selected among persons who do not get in contact with radioactive sources at work. Standard 48-h cultures of lymphocyte cells from the peripheral blood were used for analysis. The total percentage of chromosome aberrations in occupationally exposed persons varied between 0.5 and 13. The aberrations included deletions: chromosome breaks and acentric fragments, translocations in the form of dicentric chromosomes and changes of ploidy. In control workers mainly chromatid lesions were present. The results, particularly the type of chromosome aberration, point to a connection between long-standing occupational exposure to microwaves and somatic mutations. This fact calls for further investigation and for obligatory and regular control of exposed persons.
26 G0ggelmann, W., A. Koppers and B. Meixelsperger, Institut ffir Toxikologie, G S F Munich, 8042 Neuherberg (F.R.G.)
Induction of mutagenic effects in Salmonella typhimurium by drugs consisting of medicinal plant extracts In Germany during the last decade plant drugs have become more and more popular and self-prepared aqueous or ethanolic suspensions as well as commercial products are used for the treatment of various diseases. However, little information on their toxic potentials is available. Therefore, we studied in the Ames test the mutagenicity of plant drugs which are commonly used in Germany. 40 drugs consisting of one or more plant preparations were examined in Salmonella strains TA98 and TA100 with and without addition of $9 mix. Mutagenic activities could be detected in drugs containing extracts or tinctures of acorus, angelica+ arnica, betula, centaurium, crataegus, gentiana, Humulus lupulus, and hypericum. These drugs are r e c o m m e n d e d to treat disorders of gallbladder, heart+ liver, stomach or urinary tract as well as for the treatment of depressions, phlebitis or rheumatism. Our results indicate that the same amount of plant material in different drugs induces different revertant numbers. Moreover+ mutagenic potency did not correlate with the amount or number of plant preparations present in the different drugs. Therefore, it is not possible to extrapolate from the mutagenicity of a distinct amount of plant material to that of a drug containing the same amount but additional plant material.
27 Della Morte, R., G. Micallo, G. Pagano 1, M. Cipollarol+ G.G. Giordano ~ and N. Staiano, Istituto di Biochimica Cellulare e Molecolare, II Facolt~ di Medicina e Chirurgia, University of Naples, and 1 Istituto Nazionale dei Tumori, Naples (Italy)
Mutagenicity evaluation of diphenyl and diphenyl ether derivatives Diphenyl (DP), diphenyl ether (DPE) and their derivatives are widely used industrial chemicals. In spite of the occupational human exposure to these agents, few data on their uptake, metabolism
25 Garaj-Vrhovac, V., D. Horvat, V. BrumenMahovid and J. RaEid, Institute for Medical Research and Occupational Health, Zagreb (Yugoslavia) Somatic mutations in persons occupationally exposed to microwave radiation Numerous microwave instruments, which are used in medicine, industry, meteorology, navigation, telecommunications and television, as well as others, covering the frequency range from 300 M H z to 300 GHz, may pose a risk from irradiation to occupationally exposed persons and to population in general. The paper deals with the results of analysis of structural chromosome aberrations in a group of 50 workers operating microwave equipment. A control group was selected among persons who do not get in contact with radioactive sources at work. Standard 48-h cultures of lymphocyte cells from the peripheral blood were used for analysis. The total percentage of chromosome aberrations in occupationally exposed persons varied between 0.5 and 13. The aberrations included deletions: chromosome breaks and acentric fragments, translocations in the form of dicentric chromosomes and changes of ploidy. In control workers mainly chromatid lesions were present. The results, particularly the type of chromosome aberration, point to a connection between long-standing occupational exposure to microwaves and somatic mutations. This fact calls for further investigation and for obligatory and regular control of exposed persons.
26 G0ggelmann, W., A. Koppers and B. Meixelsperger, Institut ffir Toxikologie, G S F Munich, 8042 Neuherberg (F.R.G.)
Induction of mutagenic effects in Salmonella typhimurium by drugs consisting of medicinal plant extracts In Germany during the last decade plant drugs have become more and more popular and self-prepared aqueous or ethanolic suspensions as well as commercial products are used for the treatment of various diseases. However, little information on their toxic potentials is available. Therefore, we studied in the Ames test the mutagenicity of plant drugs which are commonly used in Germany. 40 drugs consisting of one or more plant preparations were examined in Salmonella strains TA98 and TA100 with and without addition of $9 mix. Mutagenic activities could be detected in drugs containing extracts or tinctures of acorus, angelica+ arnica, betula, centaurium, crataegus, gentiana, Humulus lupulus, and hypericum. These drugs are r e c o m m e n d e d to treat disorders of gallbladder, heart+ liver, stomach or urinary tract as well as for the treatment of depressions, phlebitis or rheumatism. Our results indicate that the same amount of plant material in different drugs induces different revertant numbers. Moreover+ mutagenic potency did not correlate with the amount or number of plant preparations present in the different drugs. Therefore, it is not possible to extrapolate from the mutagenicity of a distinct amount of plant material to that of a drug containing the same amount but additional plant material.
27 Della Morte, R., G. Micallo, G. Pagano 1, M. Cipollarol+ G.G. Giordano ~ and N. Staiano, Istituto di Biochimica Cellulare e Molecolare, II Facolt~ di Medicina e Chirurgia, University of Naples, and 1 Istituto Nazionale dei Tumori, Naples (Italy)
Mutagenicity evaluation of diphenyl and diphenyl ether derivatives Diphenyl (DP), diphenyl ether (DPE) and their derivatives are widely used industrial chemicals. In spite of the occupational human exposure to these agents, few data on their uptake, metabolism