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Initial results with diltiazem in limiting myocardial infarct size (MIS)
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INITIAL RESULTS WITH DILTIAZEM IN LIMITING MYOCARDIAL INFARCT SIZE (MIS). F.Zannad, M. Amor, G.Karcher,A.Lasbenne, A.Bertrand, J.M.Gilgenkrantz, G.Faivre.Departmen[ des Maladies Cardiovasculaires et Service de Pharmacologie.CHU NANCY (FRANCE). Calclum-antagonists had been shown to reduce experimental MIS. We studied the effects of Diltiazem on MIS in man. 18 pts were admitted to the CCU with typical acute MI within 6 hrs after the first symptoms. All pts were untreated and without ~revious MI. MIS was assessed by serial measurements of CPK and MB-CPK plasma evels and b y a tomographic score (perfusion defects) with 201-Th single photon emission computed tomography (SPECT). SPECT was performed on admission, then pts were randomized into 2 equal groups. Group D received Dlltlazem 15 mg/hr IV during 72 hrs followed by 4x60 mg orally ( Diltiazem steady states plasma levels were 274 + 93 nE/ml). Group C was placebo treated in double blind way. SPECT were again performea 48 hrs and 28 days later. Groups were comparabled in terms of a~e, sex, inclusion time (4.7 + 0.9 hrs) and infarct location. Results showed no difference in peak CPK and MB-CPK between the 2 groups. Comparison of SPECTs showed a decrease in the scores assigned to the Diltiazem group ( 48-6 hr : D-1.87 + 2.53 ; C-0.89 + 1.54 NS) ( 28 days-6 hr : D-2.28 + 2.2 ~ C-0.28 + 1.89 p
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W A T E R - M I N E R A L M E T A B O L I S M IN M U S C L E A N D T I S S U E S OF R A B B I T S U N D E R H Y P O K I NESIA. Y. Zorbas, N. A l e k s e y e v . D a n i e l 0 p o l u I n s t i t u t e of P h y s i o l o g y , B u c h a r e s t , Rumania. It is k n o w n that h y p o k i n e s i a (HK) i n d u c e s c h a n g e s in f l u i d - e l e c t r o lyte m e t a b o l i s m of d i f f e r e n t organs a n d systems, i n c l u d i n g c a r d i o v a s c u lar system. A g a i n s t this b a c k g r o u n d the a i m of this s t u d y was to e x a m i n e w a t e r - m i n e r a l m e t a b o l i s m on 68 r a b b i t s u n d e r 5 0 - d a y s of H K . F o r the r e p r o d u c t i o n of HK the e x p e r i m e n t a l a n i m a l s were kept in s m a l l i n d i v i d u a l cages and the c o n t r o l p l a c e d in o r d i n a r y cages. At the i n i t i a l s t a g e s of HI( was o b s e r v e d p l s s m a l i q u e f a c t i o n , a c c o m p a n i e d by a r e d u c t i o n i n the hema~ocrit i n d e x a n d h e m o g l o b i n c o n c e n t r a t i o n . P l a s m a volume i n c r e a s e d by 51.1%. By the 21st day fluid r e d i s t r i b u t i o n w a s d e v e l o p e d b e t w e e n plasma and red blood cells. The p o t a s s i u m and s o d i u m c o n c e n t r a t i o n in the p l a s m a d e c r e a s e d as the d u r a t i o n of H K i n c r e a s e d . The p a t t e r n of c h a n g e s i n the p l a s m a c a l c i u m c o n c e n t r a t i o n w a s c o r r e l a t e d w i t h the v a r i a t i o n s i n t o t a l b l o o d s e r u m protein. The p o t a s s i u m and s o d i u m c o n t e n t in v a r i o u s m y o c a r d i a l p a r t s v a r r i e d i n d i f f e r e n t ways. An a n a l y s i s of v a r i a t i o n s in p o t a s s i u m and s o d i u m c o n t e n t in the f e m u r e x t e n s o r and back long muscle failed to demonstrate s i g n i f i c a n t discrepancies i n the c h a n g e s of elec t r o l y t e content. It was c o n c l u d e d that HK i n d u c e d c h a n g e s in w a t e r - m i n e ral m e t a b o l i s m in the e x a m i n e d p a r a m e t e r s .
INITIAL RESULTS WITH DILTIAZEM IN LIMITING MYOCARDIAL INFARCT SIZE (MIS). F.Zannad, M. Amor, G.Karcher,A.Lasbenne, A.Bertrand, J.M.Gilgenkrantz, G.Faivre.Departmen[ des Maladies Cardiovasculaires et Service de Pharmacologie.CHU NANCY (FRANCE). Calclum-antagonists had been shown to reduce experimental MIS. We studied the effects of Diltiazem on MIS in man. 18 pts were admitted to the CCU with typical acute MI within 6 hrs after the first symptoms. All pts were untreated and without ~revious MI. MIS was assessed by serial measurements of CPK and MB-CPK plasma evels and b y a tomographic score (perfusion defects) with 201-Th single photon emission computed tomography (SPECT). SPECT was performed on admission, then pts were randomized into 2 equal groups. Group D received Dlltlazem 15 mg/hr IV during 72 hrs followed by 4x60 mg orally ( Diltiazem steady states plasma levels were 274 + 93 nE/ml). Group C was placebo treated in double blind way. SPECT were again performea 48 hrs and 28 days later. Groups were comparabled in terms of a~e, sex, inclusion time (4.7 + 0.9 hrs) and infarct location. Results showed no difference in peak CPK and MB-CPK between the 2 groups. Comparison of SPECTs showed a decrease in the scores assigned to the Diltiazem group ( 48-6 hr : D-1.87 + 2.53 ; C-0.89 + 1.54 NS) ( 28 days-6 hr : D-2.28 + 2.2 ~ C-0.28 + 1.89 p
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W A T E R - M I N E R A L M E T A B O L I S M IN M U S C L E A N D T I S S U E S OF R A B B I T S U N D E R H Y P O K I NESIA. Y. Zorbas, N. A l e k s e y e v . D a n i e l 0 p o l u I n s t i t u t e of P h y s i o l o g y , B u c h a r e s t , Rumania. It is k n o w n that h y p o k i n e s i a (HK) i n d u c e s c h a n g e s in f l u i d - e l e c t r o lyte m e t a b o l i s m of d i f f e r e n t organs a n d systems, i n c l u d i n g c a r d i o v a s c u lar system. A g a i n s t this b a c k g r o u n d the a i m of this s t u d y was to e x a m i n e w a t e r - m i n e r a l m e t a b o l i s m on 68 r a b b i t s u n d e r 5 0 - d a y s of H K . F o r the r e p r o d u c t i o n of HK the e x p e r i m e n t a l a n i m a l s were kept in s m a l l i n d i v i d u a l cages and the c o n t r o l p l a c e d in o r d i n a r y cages. At the i n i t i a l s t a g e s of HI( was o b s e r v e d p l s s m a l i q u e f a c t i o n , a c c o m p a n i e d by a r e d u c t i o n i n the hema~ocrit i n d e x a n d h e m o g l o b i n c o n c e n t r a t i o n . P l a s m a volume i n c r e a s e d by 51.1%. By the 21st day fluid r e d i s t r i b u t i o n w a s d e v e l o p e d b e t w e e n plasma and red blood cells. The p o t a s s i u m and s o d i u m c o n c e n t r a t i o n in the p l a s m a d e c r e a s e d as the d u r a t i o n of H K i n c r e a s e d . The p a t t e r n of c h a n g e s i n the p l a s m a c a l c i u m c o n c e n t r a t i o n w a s c o r r e l a t e d w i t h the v a r i a t i o n s i n t o t a l b l o o d s e r u m protein. The p o t a s s i u m and s o d i u m c o n t e n t in v a r i o u s m y o c a r d i a l p a r t s v a r r i e d i n d i f f e r e n t ways. An a n a l y s i s of v a r i a t i o n s in p o t a s s i u m and s o d i u m c o n t e n t in the f e m u r e x t e n s o r and back long muscle failed to demonstrate s i g n i f i c a n t discrepancies i n the c h a n g e s of elec t r o l y t e content. It was c o n c l u d e d that HK i n d u c e d c h a n g e s in w a t e r - m i n e ral m e t a b o l i s m in the e x a m i n e d p a r a m e t e r s .