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Interactions of surfactants with polymers and proteins
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lipoproteins and discusses the effects of chemical modification. Chapter 9 discusses pharmacological evaluations of sterylglucoside-lipoprotein complexes as drug carriers for in vivo applications. For the first time the authors have demonstrated the potential of applying in vivo lipoprotein carriers using p-sitosteryl-/3-D-glycoside as pharmacological agents. The following chapter ( 10) describes key issues of lipoprotein delivery as well as design of synthetic peptide-lipid carrier systems. This chapter reviews the main principles in designing lipoproteins for use as controlled release devices. Overall, the information derived from studying lipoproteins as potential carriers of drugs and diagnostic agents may be useful in improving the design of natural and synthetic carriers for drug delivery systems, considering the complex interactions and transport pathways they must pass through to reach their target when administered parenterally. This book is well referenced and makes generous use of diagrams, tables and chemical structures. Readers from a variety of disciplines should find the text of interest since numerous topics in biological, physical, medical and pharmacological sciences are described. We believe it will serve as a valuable reference for industrial, biomedical and pharmaceutical scientists, advanced undergraduate and graduate courses, and academic research teams involved in lipoproteins as targeted drug delivery systems. S. Shefer and R. Langer
Department of Chemical Engineering MIT, Cambridge, MA, USA E.D. Goddard and K.P. Ananthapadmanabhan, Eds., Interactions of Surfactants with Polymers and Proteins. CRC Press, Boca Raton, FL, 1993, 427 pages. This book is an updated expansion and addition to a review that E.D. Goddard prepared in 1986; prepared in part because of the significant increase in research activity in polymer/surfactant interactions in recent years and also in part to add
the growing field of protein/surfactant interactions which was not included in the 1986 book. There are ten chapters: (i) Introduction, (ii) Surfactant solutions: adsorption and aggregation properties, (iii) Fundamentals of polymer science, (iv ) Polymer-surfactant interaction (uncharged water-soluble polymers and charged surfactants as well as polymer and surfactant of opposite charge), (v) Polymer-surfactant interactions-recent developments, (vi ) Hydrophobemodified polymers, (vii ) Proteins in solution and at interfaces, (viii ) Protein-surfactant interactions, (ix) Applications of fluorescence spectroscopy to the study of polymer-surfactant interactions and (x) Applications of polymer-surfactant systems. There is a comprehensive subject index for the entire book as well. The sub-section on ‘control of drug delivery’ in the last chapter does not do justice to the parts of this book which could be of interest to scientists working in the field of controlled release. It is obvious that the author of this chapter has very little knowledge of controlled release as the only specific formulation mentioned is an oral tablet with hydroxypropyl cellulose with SDS which showed longer drug release with SDS than without. Just a few examples of where knowledge contained in this volume would be helpful are: preparation of biodegradable microparticles by emulsion or suspension techniques; preparation of any formulation containing protein(s) and liquid (s); analytical analysis of protein solutions as standards or after release; and surface structure of polymers resulting from surfactant interactions during formulation. Scientists working in the formulation of drugs, whether in controlled delivery or not, will find this book extremely interesting and useful, if they keep an open mind. It is up to the individual scientist to determine which information is most pertinent to their formulations of interest, since the chapters have been written with no view as to their utility for the controlled delivery scientist. Lisa Brannon-Peppas
Biogel Technology, Inc. Indianapolis, IN, US4
lipoproteins and discusses the effects of chemical modification. Chapter 9 discusses pharmacological evaluations of sterylglucoside-lipoprotein complexes as drug carriers for in vivo applications. For the first time the authors have demonstrated the potential of applying in vivo lipoprotein carriers using p-sitosteryl-/3-D-glycoside as pharmacological agents. The following chapter ( 10) describes key issues of lipoprotein delivery as well as design of synthetic peptide-lipid carrier systems. This chapter reviews the main principles in designing lipoproteins for use as controlled release devices. Overall, the information derived from studying lipoproteins as potential carriers of drugs and diagnostic agents may be useful in improving the design of natural and synthetic carriers for drug delivery systems, considering the complex interactions and transport pathways they must pass through to reach their target when administered parenterally. This book is well referenced and makes generous use of diagrams, tables and chemical structures. Readers from a variety of disciplines should find the text of interest since numerous topics in biological, physical, medical and pharmacological sciences are described. We believe it will serve as a valuable reference for industrial, biomedical and pharmaceutical scientists, advanced undergraduate and graduate courses, and academic research teams involved in lipoproteins as targeted drug delivery systems. S. Shefer and R. Langer
Department of Chemical Engineering MIT, Cambridge, MA, USA E.D. Goddard and K.P. Ananthapadmanabhan, Eds., Interactions of Surfactants with Polymers and Proteins. CRC Press, Boca Raton, FL, 1993, 427 pages. This book is an updated expansion and addition to a review that E.D. Goddard prepared in 1986; prepared in part because of the significant increase in research activity in polymer/surfactant interactions in recent years and also in part to add
the growing field of protein/surfactant interactions which was not included in the 1986 book. There are ten chapters: (i) Introduction, (ii) Surfactant solutions: adsorption and aggregation properties, (iii) Fundamentals of polymer science, (iv ) Polymer-surfactant interaction (uncharged water-soluble polymers and charged surfactants as well as polymer and surfactant of opposite charge), (v) Polymer-surfactant interactions-recent developments, (vi ) Hydrophobemodified polymers, (vii ) Proteins in solution and at interfaces, (viii ) Protein-surfactant interactions, (ix) Applications of fluorescence spectroscopy to the study of polymer-surfactant interactions and (x) Applications of polymer-surfactant systems. There is a comprehensive subject index for the entire book as well. The sub-section on ‘control of drug delivery’ in the last chapter does not do justice to the parts of this book which could be of interest to scientists working in the field of controlled release. It is obvious that the author of this chapter has very little knowledge of controlled release as the only specific formulation mentioned is an oral tablet with hydroxypropyl cellulose with SDS which showed longer drug release with SDS than without. Just a few examples of where knowledge contained in this volume would be helpful are: preparation of biodegradable microparticles by emulsion or suspension techniques; preparation of any formulation containing protein(s) and liquid (s); analytical analysis of protein solutions as standards or after release; and surface structure of polymers resulting from surfactant interactions during formulation. Scientists working in the formulation of drugs, whether in controlled delivery or not, will find this book extremely interesting and useful, if they keep an open mind. It is up to the individual scientist to determine which information is most pertinent to their formulations of interest, since the chapters have been written with no view as to their utility for the controlled delivery scientist. Lisa Brannon-Peppas
Biogel Technology, Inc. Indianapolis, IN, US4