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Iotaderma #207
IOTADERMA #207 What is a Brauer nevus, what is its other name, where would it be found, and what would be evident clinically and pathologically? Robert I. Rudolph, MD, FACP Answer will appear in the JAAD Online section of the May issue of the Journal.
MARCH IOTADERMA (#206) What is Haxthausen disease? What other name is usually applied to it, and what are two other diseases that have the same pathophysiology? Answer: Haxthausen disease (more popularly known as ‘‘popsicle panniculitis’’) is a panniculitis occurring predominantly in infants that manifests as red indurated plaques or nodules on the face, and ensues after exposure to localized and severe cold. Histopathologically, cold panniculitis shows a mostly lobular panniculitis, which consists of an infiltrate of lymphocytes and histiocytes in the fat lobules. Inflammation is most intense at the dermalesubcutaneous junction. Some other cold-induced panniculitides include ‘‘equestrian cold panniculitis’’ (perniosis), a condition occurring in (usually) young women who ride horses in cold, damp weather and who thereafter develop a distinctive red tender eruption on the outer thighs and the unusual condition reported as ‘‘cold-induced scrotal panniculitis’’ of children. REFERENCES Beacham BE, Cooper PH, Buchanan CS, Weary PE. Equestrian cold panniculitis in women. Arch Dermatol 1980;116:1025-7. Rajkumar SV, Laude TA, Russo RM, Gururaj VJ. Popsicle panniculitis of the cheeks. A diagnostic entity caused by sucking on cold objects. Clin Pediatr 1976;15:619-21. Versini P, Varlet F, Blanc P, Poulard G, Chavrier Y, Boucheron S. Scrotal panniculitis due to cold: a pseudotumoral lesion in the prepubertal child. Report of a case. Ann Pathol 1996;16:282-4.
Robert I. Rudolph, MD, FACP
e63
MARCH IOTADERMA (#206) What is Haxthausen disease? What other name is usually applied to it, and what are two other diseases that have the same pathophysiology? Answer: Haxthausen disease (more popularly known as ‘‘popsicle panniculitis’’) is a panniculitis occurring predominantly in infants that manifests as red indurated plaques or nodules on the face, and ensues after exposure to localized and severe cold. Histopathologically, cold panniculitis shows a mostly lobular panniculitis, which consists of an infiltrate of lymphocytes and histiocytes in the fat lobules. Inflammation is most intense at the dermalesubcutaneous junction. Some other cold-induced panniculitides include ‘‘equestrian cold panniculitis’’ (perniosis), a condition occurring in (usually) young women who ride horses in cold, damp weather and who thereafter develop a distinctive red tender eruption on the outer thighs and the unusual condition reported as ‘‘cold-induced scrotal panniculitis’’ of children. REFERENCES Beacham BE, Cooper PH, Buchanan CS, Weary PE. Equestrian cold panniculitis in women. Arch Dermatol 1980;116:1025-7. Rajkumar SV, Laude TA, Russo RM, Gururaj VJ. Popsicle panniculitis of the cheeks. A diagnostic entity caused by sucking on cold objects. Clin Pediatr 1976;15:619-21. Versini P, Varlet F, Blanc P, Poulard G, Chavrier Y, Boucheron S. Scrotal panniculitis due to cold: a pseudotumoral lesion in the prepubertal child. Report of a case. Ann Pathol 1996;16:282-4.
Robert I. Rudolph, MD, FACP
e63