A R R SIM O RI S O A A CO D L E O C f I F’ O E N LO CS N O N N A I I O TL N TI W R N E L Y E CE E R O I E EH S S SP NUT T TV N E EV I S R AI RE TO EM * YO uK T a sa am a A taW Fi & M K aS A rM n R mt O a z Mk I tAhk E h nr MM H Cy K u Cp H e e e ok r i B n A t s n H Ke ~ E tas p B nFn t SI u si fei a m in u r t s k o rl I H J t y a a o W pm og U H A e l o t n Hmi loa a i e e ev, i C R Ar c f r e (o e dr l Pso u c h n ie i c F l aoe a r e S d nr r e i t a e o e c pb p a v o io s c r rr h e a o te r n t n ed c ai d d W i i nn ow v as t m e r e s I Cs t h avh s i ay ad gs ip a mi nee a t v ta c . u s i r ah caeeba c d o elr C ti p i wee a r n t o ei i c am c e rt an t ntt e- lS (in iFuV i aun en o d e m d oi u W e e h s (y ps 5 e x eH r im o i el oce t mT aro ni A aA is pn riamf ) l nd m a nft u e n h ms (y m a e2 p s de eV cri e adt r3 e r n nyi t ri l s a a ei d w n tbca p a ialn a tm a e i tt w m a 5 + 9 oy A p w e ma g 4rm e Te. ii ps a r l eo o . ossn e a u ) knr : lr e ra cc e t f r oa now to dc p t e daf r i rrpa d d m r oAi m t A oa i g / nm ee f r m l aaa drpa nao s h teec ye r a t en c ga d x oi W i o f cr w sg i a o lrwi e l s v a on m aseu b p e t di m oa tW o c h s h rd i n a t w rs ( o af s b se al h sni oi oy id t Ra pen uo e gsi d ~ t i l ou dg r U l sd u ti an asar l blood p omr i d n t ( mp rl i yy a ru - o v m i T i cPde d 3 women,with ( 5m a 2 m a d ai s p fu y r aob 1 ir n 4 ai0s i t a 6 sd1 e ny d a -7 q eims1 - u n o at 3 e i et o g a ri t k n s t (mo h l o uR d ine r l rt u en TIi a am n o C W dj ta e tcM Fr r eu u l a ma n r tt s i i de ovi t dg n f ai ii s anr v t(hn f aen ali isp napnsr a as s i sur , a sy h i wu l g s in eo r s ec l l e n f veh, a b Wn a v es a a a a l l t r e t a f o e pi b t m acdSLC n sM y and tk v m ei ( an r w t Lnt ra h id Vci a aassay c nu (VA l 2-D a e a n i lIc t r ( e c ch b op c( al r r e l d e iB i L ov gs w o t r n wa P s h p h ou i y b t e ai P a st 2 a B tm c l bha f 4 ou o aml le -s on t v a tn dt bo t e c aea r s ir pe hc o to A g l 1 W w ls eai n ug e n v c e cgi f a oi n v n ec et Se n o Etm cn v e r o isa hl e e o L 2 m r d B v e a n b t a ct et r l e r o di c o R r e L l m a w a s n h L av y e r mw e i s vr c r ( p M f oa d rl bo h tt w u et i a t R a 2 m d B w i i h n a 4 d et I W e s anm e pi f e t hr V t ( ta t e V c v- n oa wL e odn r ral a n c e t W (o Pg a tr a r Cb s t n b e .l v o1 n e = 0 s t 0t l t. ea da pi y (h saa= l n L R w m c c t W oTl f r o o i ( r W h t a V n=es a rC lt t rdRs a eet o i. a e t l nl i l,T 4 i 0 B gm c s 1 ueW a =naai t s0 s t t i iu R an i d hi h( e sa s. rGe on 5 en2 thl d r gat O a C i e t h s tay t e ps e s e $ e np @r F @ ehn tu( s( cdeF t an f E- ni W Oi t f s a . Sav M ia5 e- l o L g ( h he c i yt o o ap no c e m i cc r ns nr gatr h to rri nm e ac h e ei t t p tm re h p m i p m o i r o C m p oe po aA r i i fs m ts a r ai aomt n gR rei o t Ad wF t cr S u
C R
p d K
w
c w e
f r
r t
eoo
s a
e
rr
h
a
hypertension, s
vr sa
s
IMPAIREDELASTINSYNTHESISIN E A AC O A H YA Q
a
M a S
S
E
eo ,
w h i w
r ef c f m
h i e
a n o re
d id n p y r ao i s d o c $ do m ’ a a ui h t l o i A o f m r am n t i
l
A
r
oid n i e a r nu u u
6 e
h
P a
i i a f
a
b l
r
w r
a v r p c f w w t s d
o r t f
c h I
W
a
T
a
R
L
e
MS M
H K D
S N
w
s
o
s
p
b
f
d
o
l a e
c
va e r o
r
a w k ( g
P u
d w w a M
im
L g nl Ct
(
r
L
a
i
p
s y m r w a c w a cs s a m a y so t li m g l ahi di i ( e ai i e i o oa s g t u n m l rh Ca ro t a iw o t a I e e
1
k
d
d v
g l a ir t o l e m i ( g g 1: e ur ne ran i n zl a L z 1 g m a z 1 t i h t r e i 1 w L ( B g b s I
6 s
g
w
t
g
0
d
L
d
. 1
m
T
m
Wa e k v
L L
c
)
U ( T
r
(
M e 1
( a
L l a m h a
C
I ( ee
g t
t
g
n m tm e s t
oc a
v
s
t e
h
g
s
i l s
t
1 w p
F IS n
nK
l sci b dat c i r( 1 v u it r Itsa ai g irs r en d h a t ct g r n ue I l(tn h ag U r( g e tg e p t r l sd io L e( l p ai t o r i gre a i r2 i me r ht s n ms n a i ox tI ( h ei
s p
L
i
5
C P b p
I
r
y
SN C
H
H
w v i t e a sr a be O a t p g w v ei h e p w hl b i s bo T e g c a a f c b p H v a a ei uo r n l a a od e T o c o l moc a pi m l a o l r ap t c uo e - al o n s h ko c cn e o s s m yi t hp a p a n e s l n T f s w g r t i t e d ac e p b v T r d k a t a e l c a w r p a m b p O t t a i r t s w t a t i b p p l v h a d (
s w p w
c m
s
TS
R H
U
rm o 1
l a
k
HO
U a
D
m n l bb
t
S
J oE T h b q t i I v h ( ‘ s L m i a w t i u ev t en ce p d s h ii e t d a e i r n c a s e i a i w w r sr b v h t s a - sa h o a ( lo i w t l m c t p w ve d i t s h ( sw u r s a s a e n roa 7 y wd m t re q ue n o c gh 6r l
B
M
p s
, U
y m
t
S O IL M TR I I A A W E A UT H S E T Y IS NN S P IL I S E E UR M D T EL VA Q E U T N Y P E R T