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Keratinocyte- And Fibroblast-Specific FAK Signaling Critically Mediate Scar Matrix Remodeling During Supraphysiologic Loading
ASSOCIATION FOR ACADEMIC SURGERY AND SOCIETY OF UNIVERSITY SURGEONS—ABSTRACTS
TRAUMA & CRITICAL CARE 2: BURNS, WOUND HEALING, AND ISCHEMIA-REPERFUSION 12.1. Human Serum Aggravates Injury In A Human Skin Xenograft Scald Burn Injury Model. G. Younan, E. G. Sheu, W. Dagher, S. M. Oakes, F. D. Moore; Brigham and Women’s Hospital, Boston, MA 12.2. A Novel Model For Studying Electrical Injury: Correlating Perturbations In Tissue Properties With Local And Systemic Molecular Markers. J. W. Shupp,1 L. T. Moffatt,1 T. Nguyen,2 J. C. Ramella-Roman,2 J. C. Jeng,1 M. H. Jordan1; 1 The Burn Center, Department of Surgery, Washington Hospital Center, Washington, DC; 2Department of Biomedical Engineering, Catholic University of America, Washington, DC 12.3. Keratinocyte- And Fibroblast-Specific FAK Signaling Critically Mediate Scar Matrix Remodeling During Supraphysiologic Loading. V. W. Wong, S. Akaishi, K. C. Rustad, M. Januszyk, J. P. Glotzbach, M. Sorkin, M. T. Longaker, G. C. Gurtner; Stanford University, Stanford, CA 12.4. Mechanisms In Scar Mechanotransduction: LigandDependent Deletion Of Focal Adhesion Kinase In Adult Dermal Fibroblasts Using The Cre/loxP System. V. W. Wong, K. C. Rustad, S. Akaishi, M. Sorkin, J. P. Glotzbach, M. T. Longaker, G. C. Gurtner; Stanford University, Stanford, CA 12.5. Inhibition Of Unfolded Protein Response Delays Wound Healing. M. C. Tran, Z. Wang, P. D. Butler, M. T. Spiotto, Y. Chen, E. Fattakhov, M. T. Longaker, A. C. Koong, G. P. Yang; Stanford University, Stanford, CA 12.6. Successful Xenografting Of Full-Thickness Human Skin Onto Athymic Rats: An Extended Evaluation Of Vascularization, Epithelial Integrity, And Cellular Proliferation. J. W. Shupp, L. T. Moffatt, B. Amundsen, A. R. Pavlovich, E. Leto, J. C. Jeng, M. H. Jordan; The Burn Center, Department of Surgery, Washington Hospital Center, Washington, DC 12.7. The Role of Retinol Binding Protein In The Inflammatory And Metabolic Response To Severe Burn Injury. R. Kraft,1 A. Al-Mousawi,1 M. G. Jeschke,2 C. C. Finnerty,1 D. N. Herndon1; 1University of Texas Medical Branch, Galveston, Texas; 2University of Toronto, Toronto, Canada 12.8. EGF Regulates NIKS Cell Proliferation Through Notch Signaling. M. Roy,1,2 B. Zarebczan,2 S. J. Schlosser,3 B. Allen-Hoffmann,2,3 T. W. King1,2; 1University of Wisconsin, Madison, WI; 2University of Wisconsin, Madison, WI; 3 University of Wisconsin, Madison, WI 12.9. Gene Expression Profile In Lung Contusion. D. MachadoAranda, B. Yu, K. Raghavendran; University of Michigan, Ann Arbor, MI 12.10. IL6 Knock Out Reduces Performance On Behavioral Tests And Increases IL1B And HSP72 Levels In Mice After Traumatic Brain Injury. M. A. Clond, M. Singer, A. Salim, E. J. Ley; Cedars-Sinai Medical Center, Los Angeles, CA
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12.11. Microarray And Functional Cluster Analysis Implicates Transforming Growth Factor Beta1 In Endothelial Cell Dysfunction In A Swine Hemorrhagic Shock Model. M. W. Causey, S. L. Miller, J. Stallings, Z. Hoffer, L. Houston, M. Martin; Madigan Army Medical Center, Tacoma, WA
12.12. Norepinephine Administration In Patients For Septic Shock Induces Th2 Cytokine Expression In Blood. S. F. Monaghan, R. K. Thakkar, M. L. Tran, A. Ayala, W. G. Cioffi, D. S. Heffernan; Rhode Island Hospital/Alpert Medical School of Brown University, Department of Surgery, Providence, RI
12.13. Monocyte Deactivation Correlates With Injury Severity Score, But Not With Heme-oxygenase 1 Levels In Trauma Patients. S. D. West1 C. Mold2; 1University of New Mexico Health Sciences Center, Albuquerque, NM; 2University of New Mexico Health Sciences Center, Albuquerque, NM
12.14. Myelopoiesis And Lymphopoiesis Differ In Sepsis Versus Trauma-Hemorrhagic Shock. P. A. Efron, D. C. Nacioncales, A. G. Cuenca, M. J. Delano, D. N. Ang, L. L. Moldawer; University of Florida, Department of Surgery, Gainesville, FL
12.15. CD177 Expression Is Upregulated In Neutrophils Of Patients With Major Injury. B. Chung, R. Sleem, S. Banerjee, M. De, A. K. De, P. E. Bankey; Department of Surgery, University of Rochester Medical Center, Rochester, NY
12.16. Effect Of Protein C Gene Mutation On Activated Protein C, Coagulation And Inflammatory Mediators In Hemorrhagic Shock. S. K. Burruss, A. Andakyan, S. Romanov, J. Hiatt, N. Semiletova, H. Cryer; University of California, Los Angeles Department of Surgery, Los Angeles, CA
12.17. Arteriole Vasospasm, Capillary Flow And Cell Death In Skeletal Muscle Ischemia-Reperfusion. K. K. Kao, J. C. Jimenez, M. G. Stelzner, J. E. Thompson, D. J. Saltzman; Department of Surgery, David Geffen School of Medicine At UCLA, Los Angeles, CA
12.18. The Effects Of Aging On Mitochondrial Manganese Superoxide Dismutase Expression In Ischemic Rat Skin. E. K. Tummel L. J. Gould; University of South Florida College of Medicine, Tampa, Florida
12.19. Pharmacologic Pre-conditioning With The Gasotransmitter Hydrogen Sulfide Confers Protection Through An Increase In Reactive Oxygen Species. N. Jimenez, A. J. Reiffel, E. Israely, P. W. Henderson, J. A. Spector; Weill Cornell Medical College, New York, New York
12.20. Staurosporine Induces Brain Microvascular Endothelial Cell Hyperpermeability Through Intrinsic Apoptotic Signaling Pathway. J. R. McKenzie, B. Tharakan, D. A. Sawant, J. G. Whaley, F. A. Hunter, E. W. Childs; Texas A&M Health Science Centre College of Medicine and Scott and White Memorial Hospital, Temple, TX
TRAUMA & CRITICAL CARE 2: BURNS, WOUND HEALING, AND ISCHEMIA-REPERFUSION 12.1. Human Serum Aggravates Injury In A Human Skin Xenograft Scald Burn Injury Model. G. Younan, E. G. Sheu, W. Dagher, S. M. Oakes, F. D. Moore; Brigham and Women’s Hospital, Boston, MA 12.2. A Novel Model For Studying Electrical Injury: Correlating Perturbations In Tissue Properties With Local And Systemic Molecular Markers. J. W. Shupp,1 L. T. Moffatt,1 T. Nguyen,2 J. C. Ramella-Roman,2 J. C. Jeng,1 M. H. Jordan1; 1 The Burn Center, Department of Surgery, Washington Hospital Center, Washington, DC; 2Department of Biomedical Engineering, Catholic University of America, Washington, DC 12.3. Keratinocyte- And Fibroblast-Specific FAK Signaling Critically Mediate Scar Matrix Remodeling During Supraphysiologic Loading. V. W. Wong, S. Akaishi, K. C. Rustad, M. Januszyk, J. P. Glotzbach, M. Sorkin, M. T. Longaker, G. C. Gurtner; Stanford University, Stanford, CA 12.4. Mechanisms In Scar Mechanotransduction: LigandDependent Deletion Of Focal Adhesion Kinase In Adult Dermal Fibroblasts Using The Cre/loxP System. V. W. Wong, K. C. Rustad, S. Akaishi, M. Sorkin, J. P. Glotzbach, M. T. Longaker, G. C. Gurtner; Stanford University, Stanford, CA 12.5. Inhibition Of Unfolded Protein Response Delays Wound Healing. M. C. Tran, Z. Wang, P. D. Butler, M. T. Spiotto, Y. Chen, E. Fattakhov, M. T. Longaker, A. C. Koong, G. P. Yang; Stanford University, Stanford, CA 12.6. Successful Xenografting Of Full-Thickness Human Skin Onto Athymic Rats: An Extended Evaluation Of Vascularization, Epithelial Integrity, And Cellular Proliferation. J. W. Shupp, L. T. Moffatt, B. Amundsen, A. R. Pavlovich, E. Leto, J. C. Jeng, M. H. Jordan; The Burn Center, Department of Surgery, Washington Hospital Center, Washington, DC 12.7. The Role of Retinol Binding Protein In The Inflammatory And Metabolic Response To Severe Burn Injury. R. Kraft,1 A. Al-Mousawi,1 M. G. Jeschke,2 C. C. Finnerty,1 D. N. Herndon1; 1University of Texas Medical Branch, Galveston, Texas; 2University of Toronto, Toronto, Canada 12.8. EGF Regulates NIKS Cell Proliferation Through Notch Signaling. M. Roy,1,2 B. Zarebczan,2 S. J. Schlosser,3 B. Allen-Hoffmann,2,3 T. W. King1,2; 1University of Wisconsin, Madison, WI; 2University of Wisconsin, Madison, WI; 3 University of Wisconsin, Madison, WI 12.9. Gene Expression Profile In Lung Contusion. D. MachadoAranda, B. Yu, K. Raghavendran; University of Michigan, Ann Arbor, MI 12.10. IL6 Knock Out Reduces Performance On Behavioral Tests And Increases IL1B And HSP72 Levels In Mice After Traumatic Brain Injury. M. A. Clond, M. Singer, A. Salim, E. J. Ley; Cedars-Sinai Medical Center, Los Angeles, CA
183
12.11. Microarray And Functional Cluster Analysis Implicates Transforming Growth Factor Beta1 In Endothelial Cell Dysfunction In A Swine Hemorrhagic Shock Model. M. W. Causey, S. L. Miller, J. Stallings, Z. Hoffer, L. Houston, M. Martin; Madigan Army Medical Center, Tacoma, WA
12.12. Norepinephine Administration In Patients For Septic Shock Induces Th2 Cytokine Expression In Blood. S. F. Monaghan, R. K. Thakkar, M. L. Tran, A. Ayala, W. G. Cioffi, D. S. Heffernan; Rhode Island Hospital/Alpert Medical School of Brown University, Department of Surgery, Providence, RI
12.13. Monocyte Deactivation Correlates With Injury Severity Score, But Not With Heme-oxygenase 1 Levels In Trauma Patients. S. D. West1 C. Mold2; 1University of New Mexico Health Sciences Center, Albuquerque, NM; 2University of New Mexico Health Sciences Center, Albuquerque, NM
12.14. Myelopoiesis And Lymphopoiesis Differ In Sepsis Versus Trauma-Hemorrhagic Shock. P. A. Efron, D. C. Nacioncales, A. G. Cuenca, M. J. Delano, D. N. Ang, L. L. Moldawer; University of Florida, Department of Surgery, Gainesville, FL
12.15. CD177 Expression Is Upregulated In Neutrophils Of Patients With Major Injury. B. Chung, R. Sleem, S. Banerjee, M. De, A. K. De, P. E. Bankey; Department of Surgery, University of Rochester Medical Center, Rochester, NY
12.16. Effect Of Protein C Gene Mutation On Activated Protein C, Coagulation And Inflammatory Mediators In Hemorrhagic Shock. S. K. Burruss, A. Andakyan, S. Romanov, J. Hiatt, N. Semiletova, H. Cryer; University of California, Los Angeles Department of Surgery, Los Angeles, CA
12.17. Arteriole Vasospasm, Capillary Flow And Cell Death In Skeletal Muscle Ischemia-Reperfusion. K. K. Kao, J. C. Jimenez, M. G. Stelzner, J. E. Thompson, D. J. Saltzman; Department of Surgery, David Geffen School of Medicine At UCLA, Los Angeles, CA
12.18. The Effects Of Aging On Mitochondrial Manganese Superoxide Dismutase Expression In Ischemic Rat Skin. E. K. Tummel L. J. Gould; University of South Florida College of Medicine, Tampa, Florida
12.19. Pharmacologic Pre-conditioning With The Gasotransmitter Hydrogen Sulfide Confers Protection Through An Increase In Reactive Oxygen Species. N. Jimenez, A. J. Reiffel, E. Israely, P. W. Henderson, J. A. Spector; Weill Cornell Medical College, New York, New York
12.20. Staurosporine Induces Brain Microvascular Endothelial Cell Hyperpermeability Through Intrinsic Apoptotic Signaling Pathway. J. R. McKenzie, B. Tharakan, D. A. Sawant, J. G. Whaley, F. A. Hunter, E. W. Childs; Texas A&M Health Science Centre College of Medicine and Scott and White Memorial Hospital, Temple, TX