Key to headings: Ion channels

Nomenclature

most commonly used nomenclature

Current

the name of the current associated with the channel opening

Conductance

the conductance of the open channel (in pS)

Openers or agonist ligands

compounds that act at sites within, or close to, the channel to open the channel or to change modal gating and increase channel open time

Blockers

compounds that act at sites within, or close to, the channel to inhibit opening or block the channel in either the open or closed state

Regulation

voltage-dependence, endogenous ligands, or secondary ions that modulate channel activity

Structural information

subunit composition and assembly; cloned subunits are represented by Greek letters