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Lab unit for crossflow separation
News and Views Richland, WA, USA. T a p e c a s t i n g c a n p r o d u c e t a p e s with 25 m m to 30 m m t h i c k n e s s e s while tape c a l e n d a r i n g p r o d u c e s 50 m m tapes; m u l t i p l e layer tapes (:an bc m a d e with layer t h i c k n e s s e s of 1m m . The m i n i m u m p o s s i b l e layer t h i c k n e s s is the most critical c o n s i d e r a t i o n in choosin,~ b e t w e e n the two processes. Tape c a s l i n g revolves a s l u r r y of c e r a m i c m a t e r i a l s d i s p e r s e d m a liquid c o n t a i n i n g organic b i n d e r s , p l a s t i c i s e r s a n d d i s p e r s a n t s . This is t h e n s p r e a d on a fiat s u r l a c e 1o a controlled t h i c k n e s s . W h e n the s o l v e n t s evaporate, the r e s u l t i n g tape is flexible a n d c a n be stripl)ed from the c a s t i n g s u r f a c e a n d 10rmed bel0re firint~. Tape c a l e n d e r i n g involves m i x i n g oxide powders, b i n d e r a n d p l a s t i c i s e r with c e r a m i c powder. The r e s u l t i n ~ plastic-like m a s s is c a l e n d a r e d into a thin, liar tape u s i n g a two roll mill with c o u n t e r r o l a l i n g roils. This; p r o d u c e s flexible tape t h a t c a n be cut to size, l a m i n a t e d , c o r r u g a t e d or otherwise formed, before lirinK. ForJhrthcr il!fbrmation, conlact: T i m Armstrong, MSIN K2 44. Malecials S c i e n c e s D e p a r t m e n t , Pacific N o r t h w e s t Laboratoqj, Richland, PO B o x 999. Richland, WA 99352, t eSA, Tel: + 1 5 0 9 3 7 5 3938.
Lab u n i t for crossflow separation The new SEPA CF l n e i n b r a n e filtration u n i t from O s m o n i c s users reverse o s m o s i s , n a n o t i l t r a l i o n . u l l r a l i l t r a t i o n a n d microfiltration m e m b r a n e s for a m y r i a d of s e p a r a t i o n s , This l a b - s c a l e u n i t operates in a crossllow filtralion m o d e p e r f o r m i n g s m a l l - s c a l e p r o d u c t i o n icuns a n d p r o v i d i n g c o m p r e h e n s i v e s c a l e - u p data. The SEPA CF u n i t c o n s i s t s of a test cell body a n d rigid holder. The cell body is available in acrylic, p o l y p r o p y l e n c or 316 s l a m l e s s steel, a n d a c c o m m o d a l e s a n y 15 c m x 20 cm (6 i n c h e s x 8 inches) flal sheet i n e m b r a n e . In addition, m e s h or t u b u l a r feed s p a c e r s c a n be loaded in the cell body wiil l m e m b r a n e a n d p e r m e a t e c a r r i e r to s i m u l a l e the a c t u a l llow c h a r a c t e r i s t i c s of a wide variety of commercially available spiral-wound m e m b r a n e e l e m e n t s . The ('ell is c a p a b l e of l a m i n a r a n d t u r b u l e n t flow and operates at pressures up to 69 bar (10()0 psig). The cell h o l d e r ' s p a t e n t e d p i s t o n m e c h a n i s m quickly seals lhc cell a n d provides u n i l o r m p r e s s u r e to a s s u r e a seal -- 'a i m p r o v e m e n t over existing multid~olt l a b - s c a l e u n i t s a n d their i n h e r e n I , u n e v e n torque p r o b l e m s . M e m b r a n e c h a n g e - o u t t a k e s less ( h a l l oIae m i n t d e arid r e q u i r e s no tools. ]'otential SEPA CF a p p l i c a t i o n s include: proWin c o n c e n t r a t i o n a n d ~-nzyme p u r i f i c a t i o n in the b i o t e c h n o l o ~ industry, a n d organic concentration a n d c h e m i c a l f r a c l i o n a t i o n in the c h e m i c a l p r o c e s s i n g
Membrane
T e c h n o l o g y No, 7 2
a n d food i n d u s t r i e s . A d d i t i o n a l u s e s i n c l u d e m e m b r a n e characterization and comparison studies, as well as s l i p s t r e a m m o n i t o r i n g of lar~er m e m b r a n e systems. For f u r t h e r information, contact: Osmonics, Inc.. 5951 C l e a r w a t e r Drive, Minnetonka, MN 5 5 3 4 3 - 8 9 9 5 , USA, Tel: +1 612 9 3 3 2 2 7 7 : f a x : +1 61'2 9 3 3 0141.
Australian process yields b e t t e r beer At the Q u e e n s l a n d University of Technology. c h e m i s t Dr Bob J o h n s o n h a s developed a m e t h o d to p r o d u c e preservative-free beer, u s i n g a m e m b r a n e . J o h n s o n ' s technology strips oxygen from water, e.liminating the need to i n t r o d u c e preservatives, w h o s e sole role is to stop oxidisation. In this process, the b e e r is p a s s e d over a hydrophilic m e m b r a n e , w h i c h s e p a r a t e s it from a s o d i u m s u l p h i t e s o l u t i o n o n the o t h e r side. T h e dissolved oxygen d e s o r b s from the waler, p a s s e s t h r o u g h the m e m b r a n e into the s u l p h i t e s o l u t i o n , where it is destroyed - it is c o n v e r l e d into s u l p h a t e a n d c a n n o t p a s s b a c k t h r o u g h the m e m b r a n e . Since lhe m e m b r a n e is hydrophilic, a n y t h i n g t h a t is dissolved in w a t e r c a n n o t p a s s t h r o u g h . This way, the beer is kept s e p a r a t e from the active m g r e d i e n t s . ForJurther inJormation, contact: Dr R J o h n s o n , GP E420, Q u e e n s l a n d University o]Technology, 2 George Street. B r i s b a n e QLD 4000, Auslralia. Tel: +61 7 386.4 2016.
Microfiltration for m a m m a l i a n cell h a r v e s t A series of cross flow hollow fibre m i c r o f i l t r a t i o n cartridges for efficient h a r v e s t i n g ot m a m m a l i a n cells h a s b e e n l a u n c h e d by A / G Technolo~y. M e m b r a n e s e p a r a t i o n offers a d v a n t a g e s over c o n v e n t i o n a l m e t h o d s s u c h as flocculation, centrilut{alion a n d dead e n d filtration w h i c h c a n be c u m b e r s o m e , slow a n d m a y r e s u l t in u n a c c e p t a b l e cell d a m a g e . Crossflow microfiltration a c c o m p l i s h e s comple.te, gentle cell s e p a r a t i o n at high p r o c e s s i n g rates with Kood recoveries of a sterilised p r o t e i n p r o d u c t . A m o n g the v a r i o u s crossflow a l t e r n a t i v e s , the c o n s i s t e n t d i a m e t e r a n d open feed c h a n n e l s , a n d low cost c o m p a r e d to plate a n d frame devices, favours the u s e of the hollow fibre c o n f i g u r a t i o n .
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Lab u n i t for crossflow separation The new SEPA CF l n e i n b r a n e filtration u n i t from O s m o n i c s users reverse o s m o s i s , n a n o t i l t r a l i o n . u l l r a l i l t r a t i o n a n d microfiltration m e m b r a n e s for a m y r i a d of s e p a r a t i o n s , This l a b - s c a l e u n i t operates in a crossllow filtralion m o d e p e r f o r m i n g s m a l l - s c a l e p r o d u c t i o n icuns a n d p r o v i d i n g c o m p r e h e n s i v e s c a l e - u p data. The SEPA CF u n i t c o n s i s t s of a test cell body a n d rigid holder. The cell body is available in acrylic, p o l y p r o p y l e n c or 316 s l a m l e s s steel, a n d a c c o m m o d a l e s a n y 15 c m x 20 cm (6 i n c h e s x 8 inches) flal sheet i n e m b r a n e . In addition, m e s h or t u b u l a r feed s p a c e r s c a n be loaded in the cell body wiil l m e m b r a n e a n d p e r m e a t e c a r r i e r to s i m u l a l e the a c t u a l llow c h a r a c t e r i s t i c s of a wide variety of commercially available spiral-wound m e m b r a n e e l e m e n t s . The ('ell is c a p a b l e of l a m i n a r a n d t u r b u l e n t flow and operates at pressures up to 69 bar (10()0 psig). The cell h o l d e r ' s p a t e n t e d p i s t o n m e c h a n i s m quickly seals lhc cell a n d provides u n i l o r m p r e s s u r e to a s s u r e a seal -- 'a i m p r o v e m e n t over existing multid~olt l a b - s c a l e u n i t s a n d their i n h e r e n I , u n e v e n torque p r o b l e m s . M e m b r a n e c h a n g e - o u t t a k e s less ( h a l l oIae m i n t d e arid r e q u i r e s no tools. ]'otential SEPA CF a p p l i c a t i o n s include: proWin c o n c e n t r a t i o n a n d ~-nzyme p u r i f i c a t i o n in the b i o t e c h n o l o ~ industry, a n d organic concentration a n d c h e m i c a l f r a c l i o n a t i o n in the c h e m i c a l p r o c e s s i n g
Membrane
T e c h n o l o g y No, 7 2
a n d food i n d u s t r i e s . A d d i t i o n a l u s e s i n c l u d e m e m b r a n e characterization and comparison studies, as well as s l i p s t r e a m m o n i t o r i n g of lar~er m e m b r a n e systems. For f u r t h e r information, contact: Osmonics, Inc.. 5951 C l e a r w a t e r Drive, Minnetonka, MN 5 5 3 4 3 - 8 9 9 5 , USA, Tel: +1 612 9 3 3 2 2 7 7 : f a x : +1 61'2 9 3 3 0141.
Australian process yields b e t t e r beer At the Q u e e n s l a n d University of Technology. c h e m i s t Dr Bob J o h n s o n h a s developed a m e t h o d to p r o d u c e preservative-free beer, u s i n g a m e m b r a n e . J o h n s o n ' s technology strips oxygen from water, e.liminating the need to i n t r o d u c e preservatives, w h o s e sole role is to stop oxidisation. In this process, the b e e r is p a s s e d over a hydrophilic m e m b r a n e , w h i c h s e p a r a t e s it from a s o d i u m s u l p h i t e s o l u t i o n o n the o t h e r side. T h e dissolved oxygen d e s o r b s from the waler, p a s s e s t h r o u g h the m e m b r a n e into the s u l p h i t e s o l u t i o n , where it is destroyed - it is c o n v e r l e d into s u l p h a t e a n d c a n n o t p a s s b a c k t h r o u g h the m e m b r a n e . Since lhe m e m b r a n e is hydrophilic, a n y t h i n g t h a t is dissolved in w a t e r c a n n o t p a s s t h r o u g h . This way, the beer is kept s e p a r a t e from the active m g r e d i e n t s . ForJurther inJormation, contact: Dr R J o h n s o n , GP E420, Q u e e n s l a n d University o]Technology, 2 George Street. B r i s b a n e QLD 4000, Auslralia. Tel: +61 7 386.4 2016.
Microfiltration for m a m m a l i a n cell h a r v e s t A series of cross flow hollow fibre m i c r o f i l t r a t i o n cartridges for efficient h a r v e s t i n g ot m a m m a l i a n cells h a s b e e n l a u n c h e d by A / G Technolo~y. M e m b r a n e s e p a r a t i o n offers a d v a n t a g e s over c o n v e n t i o n a l m e t h o d s s u c h as flocculation, centrilut{alion a n d dead e n d filtration w h i c h c a n be c u m b e r s o m e , slow a n d m a y r e s u l t in u n a c c e p t a b l e cell d a m a g e . Crossflow microfiltration a c c o m p l i s h e s comple.te, gentle cell s e p a r a t i o n at high p r o c e s s i n g rates with Kood recoveries of a sterilised p r o t e i n p r o d u c t . A m o n g the v a r i o u s crossflow a l t e r n a t i v e s , the c o n s i s t e n t d i a m e t e r a n d open feed c h a n n e l s , a n d low cost c o m p a r e d to plate a n d frame devices, favours the u s e of the hollow fibre c o n f i g u r a t i o n .
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