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Laser methods in mass spectrometry
trends in analytical chemistry, vol. 13, no. 6, 1994
251
[41 C. Koster, MS. Kahr, J.A. Castor0 and C.L. Wilkins, Mass Spectrom. Rev., 11 (1992) 4955 12; and references cited therein. [51 R.T. McIver, Jr., R.L. Hunter and W.D. Bowers, Int. J. Mass Spectrom. Ion Processes, 64 (1985) 67-77. [61 P. Kofel, M. Alleman, Hp. Kellerhals and K.P. Wanczek, lnt. J. Mass Spectrom. Ion Processes, 65 (1985) 97-103. [71 J.M. Alford, P.E. Williams, D.J. Trevor and R.E. Smalley, Int. J. Mass Spectrom. Ion Processes, 72 (1986) 33-51. [81 R.T. McIver, Jr., ht. J. Mass Spectrom. Zen Processes, 98 ( 1990) 35-50. [9 K.D. Henry, E.R. Williams, B.H. Wang, F.W. McLafferty, J. Shabanowitz and D.F. Hunt, Proc. Natl. Acad. Sci. USA, 86 (1989) 9075-9078. [lo SC. Beu, M.W. Senko, J.P. Quinn, F.M. Wampler, III and F.W. McLafferty, J. Am. Sot. Mass Spectrom., 4 (1993) 557-565. B.W. Winger, S.A. Hofstadler, J.E. Bruce, H.R. [111 Udseth and R.D. Smith, J. Am. Sot. Mass Spectrom., 4 ( 1993) 566-577. [I21 L. Voress, Anal. Chem., 66 ( 1994) 481486A. [I31 S.A. Hofstadler and D.A. Laude, Jr., Anal. Chem., 64 (1992) 569-572. [ 141 S.A. Hofstadler and D.A. Laude, Jr., J. Am. Sot. Mass Spectrom., 3 ( 1992) 615-623.
[ 151 E.R. Williams, K.D. Henry and F.W. McLafferty, J. Am. Chem. Sot., 1 I2 (1990) 6157-6162. [ 161 Z. Guan, S.A. Hofstadler and D.A. Laude, Jr., Anal. Chem., 65 (1993) 1588-1593. [ 171 S.C. Beu, M.W. Senko, J.P. Quinn and F.W. McLafferty, J. Am. Sot. Mass Spectrom., 4 (1993) 190-192. [I81 S.A. Hofstadler, J.H. Wahl, J.E. Bruce and R.D. Smith, J. Am. Chem. Sot., 115 ( 1993) 69836984. [I91 R.D. Smith, J.H. Wahl, D.R. Goodlett and S.A. Hofstadler, Anal. Chem., 65 ( 1993) 574584A. 1201 K.D. Henry and F.W. McLafferty, Org. Mass Spectrom., 25 ( 1990) 490-492. [211 M.W. Senko, S.C. Beu and F.W. McLafferty, Anal. Chem., 66 ( 1994) 415417. [221 D. Suckau, Y. Shi, S.C. Beu, M.W. Senko, J.P. Quinn, F.M. Wampler, III and F.W. McLafferty, Proc. Natl. Acad. Sci. USA, 90 ( 1993) 790-793. ~231 B.E. Winger, K.J. Light-Wahl, A.L. Rockwood and R.D. Smith, J. Am. Chem. Sot., 114 ( 1992) 5897-5898. v41 D.S. Gross and E.R. Williams, J. Am. Chem. Sot., submitted for publication. Evan R. Williams is an Assistant Professor of Chemistry in the Chemistry Department at the University of California, Berkeley, CA 94720- 1460, USA.
Laser methods in mass spectrometry Laser Ionization Mass Analysis, edited by A. Vertes, R. Gijbels and F. Adams, Wiley, Chichester, 1993, f 79.00 (xviii + 3 18 pages), ISBN O-471 -536-733
In recent years, the application of lasers in the field of mass spectrometry has led to a dramatic increase in the range of molecular masses that can be measured using this technique. This success has established laser methods in an area in which they had previously occupied only a peripheral role. Further advances are to be expected from current research into the practical and theoretical problems that arise from studies of how intense laser beams interact with organic and inorganic
compounds within a mass spectrometer. It is to those engaged in this research that this book is recommended. The book is divided into five chapters, the first of which is a brief introduction by the editors who also make other contributions later on. The remaining four chapters are lengthy and are the work of a total of thirteen authors. Generally, the quality of presentation is high and uniform in style. However, an anomaly is to be found in the title which refers only to laser ionization. Fortunately, the book is as much concerned with laser desorption. Chapter 2 gives a comprehensive survey of early work and describes ways in which lasers have been interfaced to magnetic sector instru-
ments, time-of-flight, quadrupole and, more recently, Fourier transform and ion trap mass analysers. Both prototype and commercially available instruments are described and the results obtained at different laser wavelengths and irradiances are discussed. Chapter 3 is subdivided into three sections each with its own list of references at the end. This chapter is concerned with work done at low and medium laser irradiance. Section A discusses desorption/ionization mechanisms and includes a description of work done on the matrix assisted laser desorption of proteins, DNA, carbohydrates and synthetic polymers. Section B describes work done on relatively small organic molecules including
251
[41 C. Koster, MS. Kahr, J.A. Castor0 and C.L. Wilkins, Mass Spectrom. Rev., 11 (1992) 4955 12; and references cited therein. [51 R.T. McIver, Jr., R.L. Hunter and W.D. Bowers, Int. J. Mass Spectrom. Ion Processes, 64 (1985) 67-77. [61 P. Kofel, M. Alleman, Hp. Kellerhals and K.P. Wanczek, lnt. J. Mass Spectrom. Ion Processes, 65 (1985) 97-103. [71 J.M. Alford, P.E. Williams, D.J. Trevor and R.E. Smalley, Int. J. Mass Spectrom. Ion Processes, 72 (1986) 33-51. [81 R.T. McIver, Jr., ht. J. Mass Spectrom. Zen Processes, 98 ( 1990) 35-50. [9 K.D. Henry, E.R. Williams, B.H. Wang, F.W. McLafferty, J. Shabanowitz and D.F. Hunt, Proc. Natl. Acad. Sci. USA, 86 (1989) 9075-9078. [lo SC. Beu, M.W. Senko, J.P. Quinn, F.M. Wampler, III and F.W. McLafferty, J. Am. Sot. Mass Spectrom., 4 (1993) 557-565. B.W. Winger, S.A. Hofstadler, J.E. Bruce, H.R. [111 Udseth and R.D. Smith, J. Am. Sot. Mass Spectrom., 4 ( 1993) 566-577. [I21 L. Voress, Anal. Chem., 66 ( 1994) 481486A. [I31 S.A. Hofstadler and D.A. Laude, Jr., Anal. Chem., 64 (1992) 569-572. [ 141 S.A. Hofstadler and D.A. Laude, Jr., J. Am. Sot. Mass Spectrom., 3 ( 1992) 615-623.
[ 151 E.R. Williams, K.D. Henry and F.W. McLafferty, J. Am. Chem. Sot., 1 I2 (1990) 6157-6162. [ 161 Z. Guan, S.A. Hofstadler and D.A. Laude, Jr., Anal. Chem., 65 (1993) 1588-1593. [ 171 S.C. Beu, M.W. Senko, J.P. Quinn and F.W. McLafferty, J. Am. Sot. Mass Spectrom., 4 (1993) 190-192. [I81 S.A. Hofstadler, J.H. Wahl, J.E. Bruce and R.D. Smith, J. Am. Chem. Sot., 115 ( 1993) 69836984. [I91 R.D. Smith, J.H. Wahl, D.R. Goodlett and S.A. Hofstadler, Anal. Chem., 65 ( 1993) 574584A. 1201 K.D. Henry and F.W. McLafferty, Org. Mass Spectrom., 25 ( 1990) 490-492. [211 M.W. Senko, S.C. Beu and F.W. McLafferty, Anal. Chem., 66 ( 1994) 415417. [221 D. Suckau, Y. Shi, S.C. Beu, M.W. Senko, J.P. Quinn, F.M. Wampler, III and F.W. McLafferty, Proc. Natl. Acad. Sci. USA, 90 ( 1993) 790-793. ~231 B.E. Winger, K.J. Light-Wahl, A.L. Rockwood and R.D. Smith, J. Am. Chem. Sot., 114 ( 1992) 5897-5898. v41 D.S. Gross and E.R. Williams, J. Am. Chem. Sot., submitted for publication. Evan R. Williams is an Assistant Professor of Chemistry in the Chemistry Department at the University of California, Berkeley, CA 94720- 1460, USA.
Laser methods in mass spectrometry Laser Ionization Mass Analysis, edited by A. Vertes, R. Gijbels and F. Adams, Wiley, Chichester, 1993, f 79.00 (xviii + 3 18 pages), ISBN O-471 -536-733
In recent years, the application of lasers in the field of mass spectrometry has led to a dramatic increase in the range of molecular masses that can be measured using this technique. This success has established laser methods in an area in which they had previously occupied only a peripheral role. Further advances are to be expected from current research into the practical and theoretical problems that arise from studies of how intense laser beams interact with organic and inorganic
compounds within a mass spectrometer. It is to those engaged in this research that this book is recommended. The book is divided into five chapters, the first of which is a brief introduction by the editors who also make other contributions later on. The remaining four chapters are lengthy and are the work of a total of thirteen authors. Generally, the quality of presentation is high and uniform in style. However, an anomaly is to be found in the title which refers only to laser ionization. Fortunately, the book is as much concerned with laser desorption. Chapter 2 gives a comprehensive survey of early work and describes ways in which lasers have been interfaced to magnetic sector instru-
ments, time-of-flight, quadrupole and, more recently, Fourier transform and ion trap mass analysers. Both prototype and commercially available instruments are described and the results obtained at different laser wavelengths and irradiances are discussed. Chapter 3 is subdivided into three sections each with its own list of references at the end. This chapter is concerned with work done at low and medium laser irradiance. Section A discusses desorption/ionization mechanisms and includes a description of work done on the matrix assisted laser desorption of proteins, DNA, carbohydrates and synthetic polymers. Section B describes work done on relatively small organic molecules including