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LB009-SUN: Neutrophil to Lymphocyte Ratio is Associated with Postoperative Survival of Primary Hepatocellular Carcinoma Patients Undergoing Curative Surgery
S242 LB008-SUN SERUM 25-OH VITAMIN D (25OH-VITD) AND PHYSICAL PERFORMANCE IN COMMUNITY-DWELLING OLD MOBILITY LIMITED ADULTS ˚ . von Berens1 , T. Gustafsson2 , D. Kirn3 , A. Koochek1 , A ˚ berg4 , M. Nydahl5 , J. Laussen3 , K. Reid3 , A.C. A T. Cederholm1 , R. Fielding3 . 1 Dept. of Public Health and Caring Sciences/Clinical Nutrition and Metabolism, Uppsala Universitet, Uppsala, 2 Laboratory Medicine, Karolinska institutet, Stockholm, Sweden; 3 Jean Mayer USDA Human Nutrition Research Center on Aging/Nutrition, Exercise, Physiology & Sarcopenia, Tufts University, Boston, United States; 4 Department of Public Health and Caring Sciences/Geriatrics, 5 Department of Food, Nutrition and Dietetics, Uppsala Universitet, Uppsala, Sweden Rationale: Low serum 25OH-VitD may inflict poor physical performance. The aim of this study was to examine the potential association between serum 25OH-VitD and the Short Physical Performance Battery (SPPB) including its subcomponents; e.g. gait speed (GS) and chair stand (ChS) among elderly community-dwelling men and women with mobility limitation. Methods: A cross sectional study was performed among subjects who were screened for a combined exercise/nutrition intervention trial (VIVE2). Community-dwelling old (78±5.3 years) Swedish (n = 118) and American (n = 494) women (57%) and men were examined. SPPB (0 12 p) and its sub-components GS (m/s), 5 timed ChS (s), and balance tests were assessed. Only subjects with SPPB 9 were included. The serum levels of 25OH-was determined by the chemiluminescence method (CLIA) and categorized according to (1) definition by Institute of Medicine (IOM), i.e. deficient (<30 nmol/L), inadequate (30 50) and sufficient (>50 nmol/L) levels, and (2) to quintiles of the 25OH-VitD distribution. Linear regression analyses were performed to relate 25OHVitD to the various functional outcomes. Results: Mean SPPB was 7.5 p. Serum concentrations of 25OH-VitD was 70.1 and 61.3 nmol/l in women and men, respectively (p < 0.01). The US population had higher 25OHVitD compared with the Swedish, i.e. 70.1 vs. 51.1 nmol/l (p < 0.01). No relation was found for 25OH-VitD and any of the SPPB components when categorizing 25OH-VitD according to IOM. In contrast, when quintiles were analyzed serum concentration of 43 56 nmol/L (Q2) appeared to be related to faster ChS in all, and faster GS in the Swedish subjects after adjusting for age and sex. Conclusion: Our findings demonstrated that women had higher serum concentrations of 25OH-VitD than men, and that the American participants had higher levels than the Swedish participants. No relation was observed for physical performance and the IOM recommended cut off points. When using quintile distributions there were some indications that 43 56 nmol/L (Q2) was related to ChS in all subjects and GS in Swedish elderly. ˚ . von Disclosure of Interest: A. Koochek Grant from: NESTEC SA, A Berens Grant from: NESTEC SA, T. Gustafsson Grant from: NESTEC SA, D. Kirn Grant from: NESTEC SA, J. Laussen Grant from: NESTEC SA, ˚ berg Grant from: NESTEC SA, K. Reid Grant from: NESTEC SA, A. C. A M. Nydahl Grant from: NESTEC SA, T. Cederholm Grant from: NESTEC SA, R. Fielding Grant from: NESTEC SA.
Late Breaking Abstracts LB009-SUN NEUTROPHIL TO LYMPHOCYTE RATIO IS ASSOCIATED WITH POSTOPERATIVE SURVIVAL OF PRIMARY HEPATOCELLULAR CARCINOMA PATIENTS UNDERGOING CURATIVE SURGERY Y. Kanno1 , M. Ishizuka1 , K. Kubota1 . 1 Department of Gastroenterology, Dokkyo Medical University, Mibu, Japan Rationale: To investigate the relationship between neutrophil to lymphocyte ratio (NLR) and postoperative survival of primary hepatocellular carcinoma (pHCC) patients undergoing curative resection. Methods: Data from 418 pHCC patients undergoing surgery between 2000 and 2012 were enrolled. Uni-and multivariate analysis using Cox proportional hazard model were performed to investigate the relationship to postoperative survival. All cut-off values were defined by receiver operating characteristic (ROC) curve analysis. Results: The result of multivariate analysis using 9 clinical characteristics which were selected by univariate analyses revealed that NLR (2.05/>2.05) (HR, 1.707; 95% CI, 1.294 2.252; P = 0.040) was associated with overall survival (OS) along with age (65/>65), number of tumors (2/1), maximal tumor size (3.8/>3.8, cm), aspartate aminotransferase (AST) (32/>32, IU/L), a-fetoprotein (AFP) (17/>17, ng/ml) and pathology (well, moderately/others). Kaplan Meier analyses and log rank tests revealed that there was a significant difference between patients with low (2.05) and high NLR (>2.05) in not only cancer-specific (P < 0.001) but also relapse-free survival (P = 0.026) as well as OS (P < 0.001). Conclusion: NLR predicts postoperative survival of patients with pHCC and is able to divide such patients into two independent groups before surgery. Disclosure of Interest: None Declared.
LB010-SUN MAIL-BASED INTERVENTION FOR SARCOPENIA PREVENTION INCREASED SKELETAL MUSCLE MASS, VITAMIN D AND IGF-1 IN COMMUNITY-DWELLING JAPANESE OLDER ADULTS INE STUDY M. Yamada1 , H. Arai2 . 1 University of Tsukuba, Bunkyo-ku, 2 Kyoto University, Kyoto, Japan Rationale: Sarcopenia, the age-dependent loss of skeletal muscle mass. The aim of this study was to investigate the effects of a mail-based intervention for sarcopenia prevention on muscle mass and anabolic hormones in community-dwelling older adults. This intervention is the combination of a stepwise approach to increase physical activity and nutritional supplementation. Methods: This trial was conducted in community-dwelling Japanese older adults. A participants were divided into the exercise group with nutritional supplementation (S/Ex group), the exercise group (Ex group) and the control group, and were followed for 6 months. A stepwise approach to increase physical activity indicates that the participants were instructed to increase the number of daily steps by 10% each month. Participants were also asked to record the steps taken at the end of each day on a calendar. A sheet for brief feedback and setting the number of daily steps was mailed to all participants to evaluate the recorded step counts each month. Nutritional supplementation indicates that a
Late Breaking Abstracts LB009-SUN NEUTROPHIL TO LYMPHOCYTE RATIO IS ASSOCIATED WITH POSTOPERATIVE SURVIVAL OF PRIMARY HEPATOCELLULAR CARCINOMA PATIENTS UNDERGOING CURATIVE SURGERY Y. Kanno1 , M. Ishizuka1 , K. Kubota1 . 1 Department of Gastroenterology, Dokkyo Medical University, Mibu, Japan Rationale: To investigate the relationship between neutrophil to lymphocyte ratio (NLR) and postoperative survival of primary hepatocellular carcinoma (pHCC) patients undergoing curative resection. Methods: Data from 418 pHCC patients undergoing surgery between 2000 and 2012 were enrolled. Uni-and multivariate analysis using Cox proportional hazard model were performed to investigate the relationship to postoperative survival. All cut-off values were defined by receiver operating characteristic (ROC) curve analysis. Results: The result of multivariate analysis using 9 clinical characteristics which were selected by univariate analyses revealed that NLR (2.05/>2.05) (HR, 1.707; 95% CI, 1.294 2.252; P = 0.040) was associated with overall survival (OS) along with age (65/>65), number of tumors (2/1), maximal tumor size (3.8/>3.8, cm), aspartate aminotransferase (AST) (32/>32, IU/L), a-fetoprotein (AFP) (17/>17, ng/ml) and pathology (well, moderately/others). Kaplan Meier analyses and log rank tests revealed that there was a significant difference between patients with low (2.05) and high NLR (>2.05) in not only cancer-specific (P < 0.001) but also relapse-free survival (P = 0.026) as well as OS (P < 0.001). Conclusion: NLR predicts postoperative survival of patients with pHCC and is able to divide such patients into two independent groups before surgery. Disclosure of Interest: None Declared.
LB010-SUN MAIL-BASED INTERVENTION FOR SARCOPENIA PREVENTION INCREASED SKELETAL MUSCLE MASS, VITAMIN D AND IGF-1 IN COMMUNITY-DWELLING JAPANESE OLDER ADULTS INE STUDY M. Yamada1 , H. Arai2 . 1 University of Tsukuba, Bunkyo-ku, 2 Kyoto University, Kyoto, Japan Rationale: Sarcopenia, the age-dependent loss of skeletal muscle mass. The aim of this study was to investigate the effects of a mail-based intervention for sarcopenia prevention on muscle mass and anabolic hormones in community-dwelling older adults. This intervention is the combination of a stepwise approach to increase physical activity and nutritional supplementation. Methods: This trial was conducted in community-dwelling Japanese older adults. A participants were divided into the exercise group with nutritional supplementation (S/Ex group), the exercise group (Ex group) and the control group, and were followed for 6 months. A stepwise approach to increase physical activity indicates that the participants were instructed to increase the number of daily steps by 10% each month. Participants were also asked to record the steps taken at the end of each day on a calendar. A sheet for brief feedback and setting the number of daily steps was mailed to all participants to evaluate the recorded step counts each month. Nutritional supplementation indicates that a