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List of contents and author index volume 7 1976
General Pharmacology
EDITOR G, A. KERKUT
(Southampton)
LIST OF CONTENTS AND AUTHOR INDEX VOLUME 7 1976
O PERGAMON PRESS OXFORD
NEW YORK
PARIS
FRANKFURT
General Pharmacology EDITOR
Professor G. A KERKUT, Department of Physiology and Biochemistry, Umverslty of Southampton, Southampton SO9 3TU, England ASSISTANT EDITOR Dr. G. N. WOODRUFF, Department of Physiology and Biochemistry, University of Southampton, Southampton SO9 3TU, England HONORARY EDITORIAL ADVISORY BOARD
M. H. APRISON (Indianapolis) R. W. BRIMBLECOMBE (Welwyn) B. B. BRODIE (Tucson) G. BURNSTOCK (Melbourne) V. ERSPAMER (Rome) E. FLOREY (Konstanz) H. M. GERSCHENFELD (Paris) L. 1. GOLDBERG (Chicago) M. J. GREENBERG (Tallahassee)
G. B. KOELLE (Philadelphia) G. D. H. LEACH (Bradford) L. LYTLE (Cambridge, Mass.) M. J. MICHELSON (Leningrad) G. PETERS (Lausanne) J. W. PHILLIS (Winnipeg) M. ROCHA E SILVA (S~o Paulo) D. W. STRAUGHAN (London) R. WERMAN (Jerusalem)
Published Bi-monthly Copyright © 1976 Pergamon Press No part ol this pubhcatton may be produced, stored In a retrteval system or transmitted in any form or by any means electronic, electrostatic, magnetic tape, mechamcal, photocopying, recording or otherwise, without permission in wrttlng from the pubhshers.
Annual Subscription Rates 1977
For hbraries, university departments, government laboratories, industrml and other multireader institutions $80 per annum (including postage and insurance). Specially Reduced Rates to Individuals In the interests of maximizing the dissemination of the research results published in this important international journal we have established a two-tier price structure. Any individual, whose institution takes out a hbrary subscription, may purchase a second or additional subscription for personal use at the reduced rate of $30.00 per annum. All subscription orders should be addressed to the Subscription Fulfillment Manager, Pergamon Press, Ltd., Headlngton Hill Hall, Oxford OX3 0BW. Microlorm Subscriptions and Back Issues Back issues of all previously published volumes are available in the regular editions and on m~crofilm and microfiche. Current subscriphons are available on microfiche simultaneously with the paper edition, and on microfilm on complehon of the annual index at the end of the subscrlphon year.
PERGAMON PRESS
HEADINGTON HILL HALL, OXFORD OX3 0BW MAXWELL HOUSE, FAIRVIEW PARK, ELMSFORD, NEW YORK 10523
C O N T E N T S OF V O L U M E 7 Vol. 7, No 1 Minireview: I. M WEINER Comparative pharmacology of urlcosurlc drugs Minireview: N. T. Buu, E PuiL and N M VAN GELDER: receptors for amino acids in exotable tissues Minireview: CLIVE R. CALCUTT. The role of histamine in the brain Minireview: KAY BRUNE, MARKUSGLATT and PETER GRAF Mechanisms of action of anti-inflammatory drugs G. M. LEW Clrcadmn rhythms in blood pressure and noreplnephrme in genetically hypertensive and normotensive rats JOHN B. MORGANTI, BRADLEYA. LOWN, PAUL SALVATERRAand EDWARDJ. MASSARO.Effects on open-field behavior of mice exposed to multiple doses of methyl mercury DAVID S MADGE: Polychlorlnated blphenyls and Intestinal absorphon of D-glucose in mice YEu-MING WANG, ERLINDA LANTIN and JAN VAN EYS ErythrocytIc enzyme actlwties and drug induced hemolysis in rabbits HERMAN VAN BELLE. Kinetics and inhibition of rat and avian alkaline phosphatases J. J A HEFFRONand J V McLoUGHLIN' Influence of halothane, pentobarbltal, carbon dioxide and ether anaesthesm on high-energy phosphate levels in mouse and frog skeletal muscle CLIFFORDJ BAILEY,TERENCEW ATKINSand ALLENJ. MATTY: Effect of sodium warfarin on plasma msuhn estimation G TUNNICLIFF, C C WIMER and R E WIMER. Brain ),-amlnobutyrlc acid metabolism and behavlour in the mouse and rat ROBERT E. BUDA and PETER C. BAKER' Effects of mhlbltors during eye lndole-amme maturation PAUL M SALVATERRAand EDWARD J MASSARO The pharmacodynamlcs of methyl mercury in the BALB/c mouse and its hairless homolog, the HRS/J mouse M T. RINAUDO, C. PONZETTO and M CURTO. Effect of some sulfonamldes on anaerobic glycolysls in the rat brain
PAGE 1 5 15 27
35 41 45 49 53 59 63 67 71 75 81
Vol 7, No 2/3 PAGE Symposium' Receptors and active centres of enzymes M. ROCHA E SILVA. Pharmacological ways to study pharmacological receptors A JURKmWICZ, A. O ABOO, N. H. JURKmWICZ, A. O GtmDES and C SOUCCAR. Relative responsiveness (p): a critical analysis of a new method in receptor differentiation IVONE BAREICHAand M ROCHA E SILVA' H1- and H2-receptors for histamine in the ileum of the guinea pig EMILIO SANCHEZ, LtrrSKE TAMPIER and JORGE MARDONES: Receptors for morphine and oplolds A. ANTONIO, I. MELITO, A. P. ALMEIDA and A. P. CORRADO' Supersensitivity induced by the toxin of Brazilian scorpion venom (Tttyus serrulatus Lutz e Mello) L. FREIRE-MA1A,J R CUNHA-MELO,H A FUTURO-NETO,A. D AZEVEDOand J WEINBERG:Chohnergle and adrenergic effects of htyustoxin ROCIVAL L ARAUJOand MARCUS V. GOMEZ Potentiation of bradykmln action on smooth muscle by a scorpion venom extract LEA R SIMIONI, ALEXANDREP CORRADO and ARON JURKIEWICZ A comparative study of the effects induced by MCN-A-343 and acetylchohne on the isolated toad rectus abdommls M K. TicKu and D J TRIGGLE. Calcium and the muscarlnlC receptor FERNANDO PIMENTEL-SOuzA' Origins of the spontaneous receptor potential in the tuberous organ in a Mormyrid fish W A SAAD,L. A A CAMARGO,F G GRAEFF,C R SILVA-NETO,J ANTUNES-RODRIGUESand M R. COVIAN' The role of central muscarlmc and nicotinic receptors in the regulation of sodium and potassium renal excretion LEONIDESREZENDE,JR, CARLOSR DINIZ and MARCOSMARES-GUIA:Guanldlnes as analogs of histamme and antihistamines on the isolated guinea-pig ileum M C RUBIO. Regulatory mechanisms for the enzymes involved in the synthesis of noradrenalme under different experimental conditions EDUARDOB OLIVEIRA,ANTt~NIOR MARTINSand ANT~)NIOC M DE CAMARGO"Rabbit brmn thtol-achvated endopeptldase Hydrolysis of bradyklnln and kmlnogen CLAUDIO A M SAMPAIOand ELINE S. PRADO' Active-site labelhng of kalllkrelns by chloromethylketone derivatives MISAKO O. SAMPA10,F GALEMBECK,A. C M PAIVAand ELINE S. PRADO Kinetics of the hydrolysis of synthetic substrates by horse urinary kalhkrem and trypsin HELENA M S BITTENCOURTand HERNAN CHAIMOVICH Effect of salts on the kinetic parameters and thermal stability of bovine brain acid phosphatase JOHN M STEWART,RICHARDJ. FREER, LEONIDESREZENDE,CLARAPE~A and GARY R. MATSUEDA.A pharmacologmal study of the anglotensln receptor and tachyphylaxls In smooth muscle T B PAIVA, J ABOULAFIA,V. L. A NOUAILHETASand A. C. M. PAIVA' Tachyphylaxis and anglotensm receptors L. F. DE OLIVEIRA,A D BRETAS and R T. SUDO 5-hydroxytryptamine and narcotic-analgesics interactions in the Intestine
1 87 93 103 107 111 115 123 127 133 141 145 149 153 159 163 167 173 177 185 189
PAGE
MANASSI~S C FONTELES, A M KAROW, JR and A H JESKE The effect of cold storage on the sensitivity to alpha and beta agomsts in the isolated rabbit kidney Abstracts of other papers presented at the Symposium
195 201
Vol 7, No 4 PAGE
Review T J MARCZYNSKI and L L BURNS. Reward contingent positive variation (RCPV) and post-reinforcement L E G synchronization (PRS) in the cat: physiological aspects, the effect of m o r p h m e and LSD-25, and a new interpretation of chohnerglc mechanisms Minireview. M ROSEGHINI. Natural histamines FRANK R. GOODMAN and H RICHARD ADAMS Contractile function and 45Ca movements in vascular s m o o t h muscle of n o n h u m a n primates effects of amlnoglycoslde antibiotics S D BOUCHER and N L KATZ Effect of colchlclne and vlnblastlne on crayfish neuromuscular junction EMANUEL J. DILIBERTO, JR, RICHARD DAVIS and GEORGE B KOELLE Locahzatlon of acetylchohnesterase in a crustacean neuromuscular system DAVID S MADGE Polychlorlnated blphenyls (Phenoclor and Pyralene) and intestinal transport of hexoses and amino acids in mice W F GEBER, S S LEEKOWlTZ and C Y HUNG Role of spleen in the interferon-lowering action of morphine G TUNNICLIFF Centrally-acting drugs and the formation of brain 7-ammo-butyrlc acid MATTI LAITINEN Hepatic and duodenal drug metabolism in the rat during fat deficiency PETER KALIX and PHILIPPE ROCH Evidence of depolarization-induced c A M P increase in the superior cervical ganglion of several m a m m a l i a n species D R NELSON and A K HUGGINS The effect of oxygen on the enzymes concerned in the metabolism of 5-hydroxytryptamlne by rat brain and liver preparations C D KARY and W D WOSILAIT Factors affecting the excretion of 14C-dicumarol in the bile of rats P A BAILEY and J W PHILLIS The interaction of four putative glutamate antagonists with glutamate and their effects on the toad spinal cord J C TURNER, R S GREEN and W J KELLY In vttro metabolism of aniline by sheep intestine ELIZABETH PHILLIPS and A LIVINGSTON Accumulation of chlorpromazlne by subcellular fractions of rat brain HENRY W ELLIOT and ARTHUR W MARTIN A comparison of the effect of propylthlouraell on the respiration of thyroid slices from h u m a n s , chickens and rats
211 221 227 233 239 249 255 259 263 267 271 277 283 289 293 299
Vol 7, No 5 Minireview KLAUS STARKE and TAKAHIKO ENDO Presynaptlc ct-adrenoceptors Minireview. P V SULAKHE and P. J ST Louis M e m b r a n e phosphorylatlon and calcium transport in cardiac and skeletal muscle m e m b r a n e s Minlreview MICHAEL J NEAL Amino acid transmitter substances in the vertebrate retina ELIZABETH PHILLIPS and A LIVINGSTON The role of proteollplds in the accumulation of chlorpromazlne in subfractlons of rat brain ELIZABETH PHILLIPS and A. LIVINGSTON. Accumulation of chlorpromazlne by rat brain homogenates RlC CONE, W H HARRISON and D A PETERSON Regional distributions of noradrenahne and dopamlne in marmoset monkey brain CHANA BRODA, EDNA NACHTOMI and EUGENIA ALUMOT (OLOMUCKI) Differences in liver morphology between rats and chicks treated with ethylene dlbromlde ROBERT SCHWARCZ and JOSEPH T COYLE Adenylate cyclase activity in chick retina P J. BENTLEY and THOMAS YORIO Effects of the G r o u p IIB metals (Cd, Zn and Hg) on the permeablhty of the crystalline lens of the toad (Bufo marlnus) R A GREEN, J J A. HEFFRON and G MITCHELL. Effects of potassium, procaine and dantrolene on the calcium-dependent and "basal" ATPase activities of sarcoplasmlc retlculum of skeletal muscle JANUSZ BYCZKOWSKI and RYSZARD BORYSEWICZ Action of some neurotroplc drugs and Cu 2 + cations on mltoehondrial m e m b r a n e permeability DENNIS W WILSON and LARRY G HANSEN Comparative kinetics and inhibition of swine and sheep liver mlcrosomal enzymes
PAGE 307
313 321 333 337 341 345 349 355 361 365 371
Vol 7, No 6 PAGE
Minireview PARV1Z MALEK-AHMADI and JAMES L CHAPEL Tolerance to phenothlazmes In schizophrenic patients Minireview. JEROME A. ROTH Multiple forms of m o n o a m l n e oxldase and their interaction with tracyclic psychomlmetic drugs Minireview M A BISBY Axonal transport KENNETH M HOFF Effects of prenatal and postnatal exposure to LSD on brain maturation I N STOYANOV, Y B LOUKANOV, P V VASSILEVA and V I VASSILEV: Comparative studies of the alpha and beta adrenergxc receptors in the longitudinal and circular smooth muscle layers of the simple and complex stomach D G SMITH The lnnervation of the cutaneous artery in the toad Bufo marmus
377 381 387 395 399 405
PAGE B S R SASTRYand J. W PHILLIS: Antagonism of glutamate and acetylchohne excitation of rat cerebral cortical neurones by dlphenylhydantoln MATTI LANG Depression of drug metabolism in liver mlcrosomes after treating rats with unsaturated fatty acids P. A. BAILEY,J. W PHILLIS and B S R SASTRY' Further studies on glutamate antagomsts m the central nervous system CLARA TORDA. Effect of stress on newborn hypothalamic phenylethanolamlne-N-methyltransferase S. KACEW, Z MERALIand R L SINGHAL Cadmium. sequential changes in nucleic acid synthesis as well as polyamines and cychc AMP levels of rat pancreas
411 415 421 427 433
AUTHOR INDEX Vol 7, Nos l ~
ABDO, A O 93 ABOULAFIA, J 185 ADAMS, H R 227 ALMEIDA, A P 111 ALUMOT (OLOMUCKI) E 345 ANTONIO, A 111 ANTUNES~RODRIGUES J 145 ARAUJO, R L 123 ATKINS, T W 63 AZEVEDO, A D 115 BAILEY, C J 63 BAILEY, P A 283, 421 BAKER, P. C 71 BAREICHA 1 103 BENTLEY P J 355 BISBY M A 387 BITTENCOURT, H M S 173 BORYSEWlCZ R 365 BOUCHER, S D 233 BRETAS, A D 189 BRODA, C 345 BRUNE, K 27 (MR) BUDA, R E 71 BURNS, L L 211 (R) Buu, N T 5(MR) BYCZKOWSKI, J 365 CALCUTT, C R 15 (MR) CAMARGO, L A A 145 CEIAIMOVlCH, H 173 CHAPEL, J L 377 (MR) CONE, R 341 CORRADO, A P 111, 127 COVIAN, M R 145 COYLE, J T 349 CUNHA-MELo, J R 115 CURTO, M 81 DAVIS, R 239 DE CAMARGO,A C M 159 DE OLIVEIRA L F 189 DILIBERTO E J, JR 239 DINIZ, C R 149 ELLIOTT, H W 299 ENDO, T 307 (MR) FONTELES, M C 195 FREER, R J 177 FRIERE-MAIA, L 115 FUTURO-NETO, H A 115 GALEMB1ECK,F 167 GEBER, W F 255 GLATT, M 27 (MR) GOMEZ, M V 123 GOODMAN, F R 227 GRAEFE, F G 145 R = Review, MR = Minlrevlew
GRAF, P 27 (MR) GREEN, R A 361 GREEN, R S 289 GUEDES, A O 93 HANSEN, L G 371 HARRISON, W H 341 HEFFRON, J J A 59, 361 HOFF, K M 395 HUGGINS, A K 271 HUNG, C Y 255 JESKE, A H 195 JURKIEWICZ A 93, 127 JURKIEWlCZ, N H 93
ROCH, P 267 ROCHA E SILVA M 87, 103 ROSEGHINI, M 221 (MR) ROTH, J A 381 (MR) PAIVA, A C M. 167, 185 PAIVA, T B 185 PLea, C 177 PETERSON,D A 341 PHILLIPS, E 293, 333, 337 PHILLIS, J W 283, 411,421 PIMENTEL-SOUZA, F 141 PONZETTO C 81 PRADO, E S 163, 167 PULL, E 5 (MR) Rumo, M. C 153
KACEW S 433 KALIX, P 267 KAROW, A M, JR 195 KARY, C D 277 KATZ, N L 233 KELLY, W J 289 KOELLE, G B 239 LAITINEN, M 263 LANG, M 415 LANTIN, E 49 LEFKOWITZ, S S 255 LEW, G M 35 LIVINGSTON A 293, 333, 337 LOUKANOV, Y B 399 LOWN, B A 41 MADGE, D S 45, 249 MALEK-AHMADI,P 377 (MR) MARCZYNSKI, T J 211 (R) MARDONES, J 107 MARES-GUIA, M 149 MARTIN, A W 299 MARTINS, A R 159 MASSARO, E J 41, 75 MATSUEDA, G R !77 MATTY, A J 63 McLOUGHLIN, J V 59 MELITO, I 111 MERALI, Z 433 MITCHELL, G 361 MORGANTI, J B 41 NACHTOMI, E 345 NEAL, M J 321 (MR) NELSON, D R 271 NOUAILHETAS, V L A 185 OLIVE1RA, E B 159 REZENDE, L 177 REZENDE, L, JR 149 RINAUOO, M T 81
SAAD, W A 145 SALVATERRA,P 41 SALVATERRA,P M 75 SAMPAIO, C A M 163 SAMPAIO, M U 167 S~,NCHEZ, E 107 SASTRY, B S R 411, 421 Scr~WARCZ, R 349 SILVA-NETO C R 145 SIMIONI,L R 127 SINGHAL,R L 433 SMITH, D G 405 SOUCCAR, C 93 STARKE, K 307 (MR) STEWART, J M 177 ST LOUIS, P J 313 (MR) STOYANOV, I N 399 Suoo, R T 189 SULAKHE, P V 313 (MR) TAMPIER, L 107 TICKU, M K 133 TORDA, C 427 TRIGGLE, D J 133 TUNNICL1FF, G 67, 259 TURNER, J C 289 VAN BELLE. H 53 VAN EYS J 49 VAN GELDER, N M 5 (MR) VASSILEV,V I 399 VASSILEVAP V 399
WANG, Y-M 49 WEINBERG, J 115 WEiNER, I M. 1 (MR) WILSON, D W 371 WIMER, C C 67 WIMER, R E 67 WOSILAIT, W D 277 YoaiO, T 355
EDITOR G, A. KERKUT
(Southampton)
LIST OF CONTENTS AND AUTHOR INDEX VOLUME 7 1976
O PERGAMON PRESS OXFORD
NEW YORK
PARIS
FRANKFURT
General Pharmacology EDITOR
Professor G. A KERKUT, Department of Physiology and Biochemistry, Umverslty of Southampton, Southampton SO9 3TU, England ASSISTANT EDITOR Dr. G. N. WOODRUFF, Department of Physiology and Biochemistry, University of Southampton, Southampton SO9 3TU, England HONORARY EDITORIAL ADVISORY BOARD
M. H. APRISON (Indianapolis) R. W. BRIMBLECOMBE (Welwyn) B. B. BRODIE (Tucson) G. BURNSTOCK (Melbourne) V. ERSPAMER (Rome) E. FLOREY (Konstanz) H. M. GERSCHENFELD (Paris) L. 1. GOLDBERG (Chicago) M. J. GREENBERG (Tallahassee)
G. B. KOELLE (Philadelphia) G. D. H. LEACH (Bradford) L. LYTLE (Cambridge, Mass.) M. J. MICHELSON (Leningrad) G. PETERS (Lausanne) J. W. PHILLIS (Winnipeg) M. ROCHA E SILVA (S~o Paulo) D. W. STRAUGHAN (London) R. WERMAN (Jerusalem)
Published Bi-monthly Copyright © 1976 Pergamon Press No part ol this pubhcatton may be produced, stored In a retrteval system or transmitted in any form or by any means electronic, electrostatic, magnetic tape, mechamcal, photocopying, recording or otherwise, without permission in wrttlng from the pubhshers.
Annual Subscription Rates 1977
For hbraries, university departments, government laboratories, industrml and other multireader institutions $80 per annum (including postage and insurance). Specially Reduced Rates to Individuals In the interests of maximizing the dissemination of the research results published in this important international journal we have established a two-tier price structure. Any individual, whose institution takes out a hbrary subscription, may purchase a second or additional subscription for personal use at the reduced rate of $30.00 per annum. All subscription orders should be addressed to the Subscription Fulfillment Manager, Pergamon Press, Ltd., Headlngton Hill Hall, Oxford OX3 0BW. Microlorm Subscriptions and Back Issues Back issues of all previously published volumes are available in the regular editions and on m~crofilm and microfiche. Current subscriphons are available on microfiche simultaneously with the paper edition, and on microfilm on complehon of the annual index at the end of the subscrlphon year.
PERGAMON PRESS
HEADINGTON HILL HALL, OXFORD OX3 0BW MAXWELL HOUSE, FAIRVIEW PARK, ELMSFORD, NEW YORK 10523
C O N T E N T S OF V O L U M E 7 Vol. 7, No 1 Minireview: I. M WEINER Comparative pharmacology of urlcosurlc drugs Minireview: N. T. Buu, E PuiL and N M VAN GELDER: receptors for amino acids in exotable tissues Minireview: CLIVE R. CALCUTT. The role of histamine in the brain Minireview: KAY BRUNE, MARKUSGLATT and PETER GRAF Mechanisms of action of anti-inflammatory drugs G. M. LEW Clrcadmn rhythms in blood pressure and noreplnephrme in genetically hypertensive and normotensive rats JOHN B. MORGANTI, BRADLEYA. LOWN, PAUL SALVATERRAand EDWARDJ. MASSARO.Effects on open-field behavior of mice exposed to multiple doses of methyl mercury DAVID S MADGE: Polychlorlnated blphenyls and Intestinal absorphon of D-glucose in mice YEu-MING WANG, ERLINDA LANTIN and JAN VAN EYS ErythrocytIc enzyme actlwties and drug induced hemolysis in rabbits HERMAN VAN BELLE. Kinetics and inhibition of rat and avian alkaline phosphatases J. J A HEFFRONand J V McLoUGHLIN' Influence of halothane, pentobarbltal, carbon dioxide and ether anaesthesm on high-energy phosphate levels in mouse and frog skeletal muscle CLIFFORDJ BAILEY,TERENCEW ATKINSand ALLENJ. MATTY: Effect of sodium warfarin on plasma msuhn estimation G TUNNICLIFF, C C WIMER and R E WIMER. Brain ),-amlnobutyrlc acid metabolism and behavlour in the mouse and rat ROBERT E. BUDA and PETER C. BAKER' Effects of mhlbltors during eye lndole-amme maturation PAUL M SALVATERRAand EDWARD J MASSARO The pharmacodynamlcs of methyl mercury in the BALB/c mouse and its hairless homolog, the HRS/J mouse M T. RINAUDO, C. PONZETTO and M CURTO. Effect of some sulfonamldes on anaerobic glycolysls in the rat brain
PAGE 1 5 15 27
35 41 45 49 53 59 63 67 71 75 81
Vol 7, No 2/3 PAGE Symposium' Receptors and active centres of enzymes M. ROCHA E SILVA. Pharmacological ways to study pharmacological receptors A JURKmWICZ, A. O ABOO, N. H. JURKmWICZ, A. O GtmDES and C SOUCCAR. Relative responsiveness (p): a critical analysis of a new method in receptor differentiation IVONE BAREICHAand M ROCHA E SILVA' H1- and H2-receptors for histamine in the ileum of the guinea pig EMILIO SANCHEZ, LtrrSKE TAMPIER and JORGE MARDONES: Receptors for morphine and oplolds A. ANTONIO, I. MELITO, A. P. ALMEIDA and A. P. CORRADO' Supersensitivity induced by the toxin of Brazilian scorpion venom (Tttyus serrulatus Lutz e Mello) L. FREIRE-MA1A,J R CUNHA-MELO,H A FUTURO-NETO,A. D AZEVEDOand J WEINBERG:Chohnergle and adrenergic effects of htyustoxin ROCIVAL L ARAUJOand MARCUS V. GOMEZ Potentiation of bradykmln action on smooth muscle by a scorpion venom extract LEA R SIMIONI, ALEXANDREP CORRADO and ARON JURKIEWICZ A comparative study of the effects induced by MCN-A-343 and acetylchohne on the isolated toad rectus abdommls M K. TicKu and D J TRIGGLE. Calcium and the muscarlnlC receptor FERNANDO PIMENTEL-SOuzA' Origins of the spontaneous receptor potential in the tuberous organ in a Mormyrid fish W A SAAD,L. A A CAMARGO,F G GRAEFF,C R SILVA-NETO,J ANTUNES-RODRIGUESand M R. COVIAN' The role of central muscarlmc and nicotinic receptors in the regulation of sodium and potassium renal excretion LEONIDESREZENDE,JR, CARLOSR DINIZ and MARCOSMARES-GUIA:Guanldlnes as analogs of histamme and antihistamines on the isolated guinea-pig ileum M C RUBIO. Regulatory mechanisms for the enzymes involved in the synthesis of noradrenalme under different experimental conditions EDUARDOB OLIVEIRA,ANTt~NIOR MARTINSand ANT~)NIOC M DE CAMARGO"Rabbit brmn thtol-achvated endopeptldase Hydrolysis of bradyklnln and kmlnogen CLAUDIO A M SAMPAIOand ELINE S. PRADO' Active-site labelhng of kalllkrelns by chloromethylketone derivatives MISAKO O. SAMPA10,F GALEMBECK,A. C M PAIVAand ELINE S. PRADO Kinetics of the hydrolysis of synthetic substrates by horse urinary kalhkrem and trypsin HELENA M S BITTENCOURTand HERNAN CHAIMOVICH Effect of salts on the kinetic parameters and thermal stability of bovine brain acid phosphatase JOHN M STEWART,RICHARDJ. FREER, LEONIDESREZENDE,CLARAPE~A and GARY R. MATSUEDA.A pharmacologmal study of the anglotensln receptor and tachyphylaxls In smooth muscle T B PAIVA, J ABOULAFIA,V. L. A NOUAILHETASand A. C. M. PAIVA' Tachyphylaxis and anglotensm receptors L. F. DE OLIVEIRA,A D BRETAS and R T. SUDO 5-hydroxytryptamine and narcotic-analgesics interactions in the Intestine
1 87 93 103 107 111 115 123 127 133 141 145 149 153 159 163 167 173 177 185 189
PAGE
MANASSI~S C FONTELES, A M KAROW, JR and A H JESKE The effect of cold storage on the sensitivity to alpha and beta agomsts in the isolated rabbit kidney Abstracts of other papers presented at the Symposium
195 201
Vol 7, No 4 PAGE
Review T J MARCZYNSKI and L L BURNS. Reward contingent positive variation (RCPV) and post-reinforcement L E G synchronization (PRS) in the cat: physiological aspects, the effect of m o r p h m e and LSD-25, and a new interpretation of chohnerglc mechanisms Minireview. M ROSEGHINI. Natural histamines FRANK R. GOODMAN and H RICHARD ADAMS Contractile function and 45Ca movements in vascular s m o o t h muscle of n o n h u m a n primates effects of amlnoglycoslde antibiotics S D BOUCHER and N L KATZ Effect of colchlclne and vlnblastlne on crayfish neuromuscular junction EMANUEL J. DILIBERTO, JR, RICHARD DAVIS and GEORGE B KOELLE Locahzatlon of acetylchohnesterase in a crustacean neuromuscular system DAVID S MADGE Polychlorlnated blphenyls (Phenoclor and Pyralene) and intestinal transport of hexoses and amino acids in mice W F GEBER, S S LEEKOWlTZ and C Y HUNG Role of spleen in the interferon-lowering action of morphine G TUNNICLIFF Centrally-acting drugs and the formation of brain 7-ammo-butyrlc acid MATTI LAITINEN Hepatic and duodenal drug metabolism in the rat during fat deficiency PETER KALIX and PHILIPPE ROCH Evidence of depolarization-induced c A M P increase in the superior cervical ganglion of several m a m m a l i a n species D R NELSON and A K HUGGINS The effect of oxygen on the enzymes concerned in the metabolism of 5-hydroxytryptamlne by rat brain and liver preparations C D KARY and W D WOSILAIT Factors affecting the excretion of 14C-dicumarol in the bile of rats P A BAILEY and J W PHILLIS The interaction of four putative glutamate antagonists with glutamate and their effects on the toad spinal cord J C TURNER, R S GREEN and W J KELLY In vttro metabolism of aniline by sheep intestine ELIZABETH PHILLIPS and A LIVINGSTON Accumulation of chlorpromazlne by subcellular fractions of rat brain HENRY W ELLIOT and ARTHUR W MARTIN A comparison of the effect of propylthlouraell on the respiration of thyroid slices from h u m a n s , chickens and rats
211 221 227 233 239 249 255 259 263 267 271 277 283 289 293 299
Vol 7, No 5 Minireview KLAUS STARKE and TAKAHIKO ENDO Presynaptlc ct-adrenoceptors Minireview. P V SULAKHE and P. J ST Louis M e m b r a n e phosphorylatlon and calcium transport in cardiac and skeletal muscle m e m b r a n e s Minlreview MICHAEL J NEAL Amino acid transmitter substances in the vertebrate retina ELIZABETH PHILLIPS and A LIVINGSTON The role of proteollplds in the accumulation of chlorpromazlne in subfractlons of rat brain ELIZABETH PHILLIPS and A. LIVINGSTON. Accumulation of chlorpromazlne by rat brain homogenates RlC CONE, W H HARRISON and D A PETERSON Regional distributions of noradrenahne and dopamlne in marmoset monkey brain CHANA BRODA, EDNA NACHTOMI and EUGENIA ALUMOT (OLOMUCKI) Differences in liver morphology between rats and chicks treated with ethylene dlbromlde ROBERT SCHWARCZ and JOSEPH T COYLE Adenylate cyclase activity in chick retina P J. BENTLEY and THOMAS YORIO Effects of the G r o u p IIB metals (Cd, Zn and Hg) on the permeablhty of the crystalline lens of the toad (Bufo marlnus) R A GREEN, J J A. HEFFRON and G MITCHELL. Effects of potassium, procaine and dantrolene on the calcium-dependent and "basal" ATPase activities of sarcoplasmlc retlculum of skeletal muscle JANUSZ BYCZKOWSKI and RYSZARD BORYSEWICZ Action of some neurotroplc drugs and Cu 2 + cations on mltoehondrial m e m b r a n e permeability DENNIS W WILSON and LARRY G HANSEN Comparative kinetics and inhibition of swine and sheep liver mlcrosomal enzymes
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Vol 7, No 6 PAGE
Minireview PARV1Z MALEK-AHMADI and JAMES L CHAPEL Tolerance to phenothlazmes In schizophrenic patients Minireview. JEROME A. ROTH Multiple forms of m o n o a m l n e oxldase and their interaction with tracyclic psychomlmetic drugs Minireview M A BISBY Axonal transport KENNETH M HOFF Effects of prenatal and postnatal exposure to LSD on brain maturation I N STOYANOV, Y B LOUKANOV, P V VASSILEVA and V I VASSILEV: Comparative studies of the alpha and beta adrenergxc receptors in the longitudinal and circular smooth muscle layers of the simple and complex stomach D G SMITH The lnnervation of the cutaneous artery in the toad Bufo marmus
377 381 387 395 399 405
PAGE B S R SASTRYand J. W PHILLIS: Antagonism of glutamate and acetylchohne excitation of rat cerebral cortical neurones by dlphenylhydantoln MATTI LANG Depression of drug metabolism in liver mlcrosomes after treating rats with unsaturated fatty acids P. A. BAILEY,J. W PHILLIS and B S R SASTRY' Further studies on glutamate antagomsts m the central nervous system CLARA TORDA. Effect of stress on newborn hypothalamic phenylethanolamlne-N-methyltransferase S. KACEW, Z MERALIand R L SINGHAL Cadmium. sequential changes in nucleic acid synthesis as well as polyamines and cychc AMP levels of rat pancreas
411 415 421 427 433
AUTHOR INDEX Vol 7, Nos l ~
ABDO, A O 93 ABOULAFIA, J 185 ADAMS, H R 227 ALMEIDA, A P 111 ALUMOT (OLOMUCKI) E 345 ANTONIO, A 111 ANTUNES~RODRIGUES J 145 ARAUJO, R L 123 ATKINS, T W 63 AZEVEDO, A D 115 BAILEY, C J 63 BAILEY, P A 283, 421 BAKER, P. C 71 BAREICHA 1 103 BENTLEY P J 355 BISBY M A 387 BITTENCOURT, H M S 173 BORYSEWlCZ R 365 BOUCHER, S D 233 BRETAS, A D 189 BRODA, C 345 BRUNE, K 27 (MR) BUDA, R E 71 BURNS, L L 211 (R) Buu, N T 5(MR) BYCZKOWSKI, J 365 CALCUTT, C R 15 (MR) CAMARGO, L A A 145 CEIAIMOVlCH, H 173 CHAPEL, J L 377 (MR) CONE, R 341 CORRADO, A P 111, 127 COVIAN, M R 145 COYLE, J T 349 CUNHA-MELo, J R 115 CURTO, M 81 DAVIS, R 239 DE CAMARGO,A C M 159 DE OLIVEIRA L F 189 DILIBERTO E J, JR 239 DINIZ, C R 149 ELLIOTT, H W 299 ENDO, T 307 (MR) FONTELES, M C 195 FREER, R J 177 FRIERE-MAIA, L 115 FUTURO-NETO, H A 115 GALEMB1ECK,F 167 GEBER, W F 255 GLATT, M 27 (MR) GOMEZ, M V 123 GOODMAN, F R 227 GRAEFE, F G 145 R = Review, MR = Minlrevlew
GRAF, P 27 (MR) GREEN, R A 361 GREEN, R S 289 GUEDES, A O 93 HANSEN, L G 371 HARRISON, W H 341 HEFFRON, J J A 59, 361 HOFF, K M 395 HUGGINS, A K 271 HUNG, C Y 255 JESKE, A H 195 JURKIEWICZ A 93, 127 JURKIEWlCZ, N H 93
ROCH, P 267 ROCHA E SILVA M 87, 103 ROSEGHINI, M 221 (MR) ROTH, J A 381 (MR) PAIVA, A C M. 167, 185 PAIVA, T B 185 PLea, C 177 PETERSON,D A 341 PHILLIPS, E 293, 333, 337 PHILLIS, J W 283, 411,421 PIMENTEL-SOUZA, F 141 PONZETTO C 81 PRADO, E S 163, 167 PULL, E 5 (MR) Rumo, M. C 153
KACEW S 433 KALIX, P 267 KAROW, A M, JR 195 KARY, C D 277 KATZ, N L 233 KELLY, W J 289 KOELLE, G B 239 LAITINEN, M 263 LANG, M 415 LANTIN, E 49 LEFKOWITZ, S S 255 LEW, G M 35 LIVINGSTON A 293, 333, 337 LOUKANOV, Y B 399 LOWN, B A 41 MADGE, D S 45, 249 MALEK-AHMADI,P 377 (MR) MARCZYNSKI, T J 211 (R) MARDONES, J 107 MARES-GUIA, M 149 MARTIN, A W 299 MARTINS, A R 159 MASSARO, E J 41, 75 MATSUEDA, G R !77 MATTY, A J 63 McLOUGHLIN, J V 59 MELITO, I 111 MERALI, Z 433 MITCHELL, G 361 MORGANTI, J B 41 NACHTOMI, E 345 NEAL, M J 321 (MR) NELSON, D R 271 NOUAILHETAS, V L A 185 OLIVE1RA, E B 159 REZENDE, L 177 REZENDE, L, JR 149 RINAUOO, M T 81
SAAD, W A 145 SALVATERRA,P 41 SALVATERRA,P M 75 SAMPAIO, C A M 163 SAMPAIO, M U 167 S~,NCHEZ, E 107 SASTRY, B S R 411, 421 Scr~WARCZ, R 349 SILVA-NETO C R 145 SIMIONI,L R 127 SINGHAL,R L 433 SMITH, D G 405 SOUCCAR, C 93 STARKE, K 307 (MR) STEWART, J M 177 ST LOUIS, P J 313 (MR) STOYANOV, I N 399 Suoo, R T 189 SULAKHE, P V 313 (MR) TAMPIER, L 107 TICKU, M K 133 TORDA, C 427 TRIGGLE, D J 133 TUNNICL1FF, G 67, 259 TURNER, J C 289 VAN BELLE. H 53 VAN EYS J 49 VAN GELDER, N M 5 (MR) VASSILEV,V I 399 VASSILEVAP V 399
WANG, Y-M 49 WEINBERG, J 115 WEiNER, I M. 1 (MR) WILSON, D W 371 WIMER, C C 67 WIMER, R E 67 WOSILAIT, W D 277 YoaiO, T 355