Long-Term Outcomes Following Lumbar Microendoscopic Decompression for Lumbar Spinal Stenosis with and without Degenerative Spondylolisthesis: Minimum 10-Year Follow-Up

Long-Term Outcomes Following Lumbar Microendoscopic Decompression for Lumbar Spinal Stenosis with and without Degenerative Spondylolisthesis: Minimum 10-Year Follow-Up

Journal Pre-proof Long-term outcomes following lumbar microendoscopic decompression for lumbar spinal stenosis with and without degenerative spondylol...

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Journal Pre-proof Long-term outcomes following lumbar microendoscopic decompression for lumbar spinal stenosis with and without degenerative spondylolisthesis: Minimum 10-year follow-up Takato Aihara, M.D., Ph.D, Kenji Endo, M.D., Ph.D, Hidekazu Suzuki, M.D., Ph.D, Atsushi Kojima, M.D., Ph.D, Yasunobu Sawaji, Ph.D, Makoto Urushibara, M.D., Ph.D, Yuji Matsuoka, M.D., Ph.D, Taichiro Takamatsu, M.D., Ph.D, Kazuma Murata, M.D., Ph.D, Takamitsu Konishi, M.D, Hideya Yamauchi, M.D, Hiroo Endo, M.D, Kengo Yamamoto, M.D., Ph.D PII:

S1878-8750(20)32516-X

DOI:

https://doi.org/10.1016/j.wneu.2020.11.131

Reference:

WNEU 16402

To appear in:

World Neurosurgery

Received Date: 11 August 2020 Revised Date:

21 November 2020

Accepted Date: 23 November 2020

Please cite this article as: Aihara T, Endo K, Suzuki H, Kojima A, Sawaji Y, Urushibara M, Matsuoka Y, Takamatsu T, Murata K, Konishi T, Yamauchi H, Endo H, Yamamoto K, Long-term outcomes following lumbar microendoscopic decompression for lumbar spinal stenosis with and without degenerative spondylolisthesis: Minimum 10-year follow-up, World Neurosurgery (2020), doi: https://doi.org/10.1016/ j.wneu.2020.11.131. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2020 Elsevier Inc. All rights reserved.

Long-term outcomes following lumbar microendoscopic decompression for lumbar spinal stenosis with and without degenerative spondylolisthesis: Minimum 10-year follow-up Takato Aihara1, 2, M.D., Ph.D., Kenji Endo2, M.D., Ph.D., Hidekazu Suzuki2, M.D., Ph.D., Atsushi Kojima1, M.D., Ph.D., Yasunobu Sawaji2, Ph.D., Makoto Urushibara1, M.D., Ph.D., Yuji Matsuoka2, M.D., Ph.D., Taichiro Takamatsu2, M.D., Ph.D., Kazuma Murata2, M.D., Ph.D., Takamitsu Konishi2, M.D., Hideya Yamauchi2, M.D., Hiroo Endo2, M.D., and Kengo Yamamoto2, M.D., Ph.D. Department of Orthopedic Surgery, Funabashi Orthopedic Hospital

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Department of Orthopedic Surgery, Tokyo Medical University

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1

Name and address for correspondence:

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Takato Aihara, M.D., Ph.D.

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Funabashi Orthopedic Hospital

1-833 Hasama, Funabashi-city, Chiba 274-0822, Japan

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E-mail: [email protected]

Fax: 81 / 47-425-6592

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TEL: 81 / 47-425-5585

Key words: Degenerative lumbar spondylolisthesis; Long-term outcomes;

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Lumbar spinal stenosis; Microendoscopic decompression; Minimum 10-year follow-up;

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Patient-based outcome measure; Preoperative radiological predictor Short title: LUMBAR MICROENDOSCOPIC DECOMPRESSION Declarations of interest: none This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Table 1. Patient data (n=80)

DS group (n=34)

SS group (n=46)

Mean age at surgery (years)

63.2

59.8

(standard deviation; range)

(8.76; 43 to 77)

(9.49; 40 to 74)

Female, n (%)

14 (41.2)

9 (19.6)

P value

0.104

of 5

-p

L3/4

ro

Levels of surgery (n)

29

2

5

3

5

1

1

140.8

136.7

lP

na

L3/4 and L4/5

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L4/5 and L5/S1

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Mean follow-up (months)

(standard deviation; range) Follow-up rate (%)

6

23

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L4/5 L5/S1

0.0348*

0.155 (11.5; 120 to 159) (11.6; 120 to 159) 34/41 (82.9)

46/59 (78.0)

* The gender difference between the two groups was significant.

P value

Preoperative

42.4±32.3

39.1±30.3

0.693

Postoperative

76.1±28.1

75.8±35.1

0.563

Preoperative

51.7±32.3

Postoperative

77.9±24.4

80.8±25.8

0.477

Preoperative

23.3±19.8

30.3±21.6

0.172

66.0±33.0

67.7±33.7

0.775

28.7±20.9

35.3±21.7

0.166

Postoperative

62.8±26.5

66.5±25.4

0.573

Preoperative

42.5±17.5

42.7±16.0

0.793

Postoperative

58.3±19.8

56.6±20.1

0.830

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lP

na

Gait disturbance

ur

Postoperative

Preoperative

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Social life disturbance

Psychological disorders

50.2±28.5

0.777

ro

Lumbar spine dysfunction

SS group (n=46)

of

Pain-related disorders

DS group (n=34)

re

Table 2. Preoperative and postoperative JOABPEQ scores in DS and SS groups

Values are expressed as mean ± standard deviation.

Table 3. Preoperative and postoperative VAS scores in DS and SS groups

Preoperative

51.3±30.6

46.8±27.1

0.501

Postoperative

32.9±31.7

29.9±27.9

0.661

Preoperative

70.7±23.8

67.3±23.6

Postoperative

30.4±34.1

Preoperative

29.4±28.2

0.884

70.3±24.2

59.5±27.6

0.0780

30.5±31.6

28.6±30.1

0.781

ro

0.532

na

lP

Postoperative

of

Leg numbness

P value

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Leg pain

SS group (n=46)

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Low back pain

DS group (n=34)

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Values are expressed as mean ± standard deviation.

Table 4. Degrees of improvement and intensities of improvement in DS and SS groups

SS group (n=46)

P value

Pain-related disorders

36.9±34.4

38.3±40.4

0.872

Lumbar spine dysfunction

27.9±37.8

31.8±35.9

0.644

Gait disturbance

42.6±38.9

Social life disturbance Psychological disorders

0.567

34.1±34.1

31.2±34.7

0.710

15.8±26.9

13.9±21.8

0.731

20.8±36.3

18.1±32.7

0.729

Leg pain

42.0±40.6

38.9±37.2

0.726

39.6±40.6

32.0±41.3

0.422

re

lP

na

ur

Low back pain

-p

37.4±41.1

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ro

of

DS group (n=34)

Leg numbness

Values are expressed as mean ± standard deviation. Degree of improvement was calculated by the following formula: postoperative score − preoperative score of JOABPEQ Intensity of improvement was calculated by the following formula: preoperative score − postoperative score of VAS

Table 5. Preoperative radiographic measurements in E and I groups concerning JOABPEQ Pain-related

Lumbar spine

Gait

Social life

Psychological

disorders

dysfunction

disturbance

disturbance

disorders

E group

12.3±5.66%

13.1±6.23%

13.1±5.23%

12.0±4.50%

12.5±5.15%

I group

12.6±6.88%

12.4±6.67%

13.1±8.44%

14.8±8.31%

13.4±6.87%

E group

15.3±7.32%

16.3±7.65%

15.9±6.82%

I group

15.3±8.37%

15.0±7.58%

E group

5.59±3.92%

I group

5.12±4.15%

Percentage of slipping in neutral position

slipping

15.4±5.60%

16.8±6.19%

16.1±9.53%

16.9±10.2%

15.6±8.33%

5.88±3.77%

5.95±3.28%

6.93±2.95%

3.87±5.14%

4.18±3.75%

4.35±4.40%

4.62±3.95%

-1.89±4.24°

-1.38±5.51°

-2.86±4.66°

-4.06±4.99°

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E group

-1.08±5.45°

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at flexion

Intervertebral range of motion

Disc height ratio

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re

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flexion-extension

Intervertebral angle

6.19±2.81%

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translation during

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at flexion

Percentage

of

Percentage of

I group

-2.79±4.42°

-2.60±7.30°

-3.70±4.85°

-1.08±6.27°

-1.33±5.38°

E group

11.0±5.22°

11.4±4.74°

12.2±4.87°

12.5±4.74°

13.4±5.59°

I group

11.1±5.08°

10.8±6.03°

9.65±5.20°

9.63±5.18°

10.5±4.65°

E group

0.270±0.055

0.257±0.052

0.275±0.052

0.269±0.046

0.276±0.043

I group

0.252±0.064

0.267±0.052

0.241±0.056

0.256±0.068

0.258±0.059

Values are expressed as mean ± standard deviation.

at flexion

Percentage translation

13.7±6.63%

12.8±5.73%

I group

13.5±6.47%

12.8±5.75%

14.3±7.10%

E group

16.2±8.75%

16.1±7.75%

15.2±7.45%

I group

16.6±7.02%

E group

4.70±4.43%

4.43±3.61%

5.41±4.05%

I group

5.80±3.49%

6.95±3.93%

5.14±3.72%

E group

-1.62±6.23°

-1.74±5.84°

-2.00±6.01°

-2.37±4.53°

-2.20±4.11°

-1.75±4.15°

E group

10.5±4.45°

10.7±3.91°

10.9±4.89°

I group

12.2±5.58°

12.3±6.93°

11.7±5.55°

E group

0.257±0.060

0.258±0.052

0.263±0.057

I group

0.278±0.049

0.280±0.061

0.269±0.055

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Intervertebral angle

13.6±6.39%

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during flexion-extension

E group

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at flexion

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I group

Intervertebral range of motion

Disc height ratio

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Percentage of slipping

Leg numbness

16.2±8.12%

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in neutral position

Leg pain

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Percentage of slipping

Low back pain

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Table 6. Preoperative radiographic measurements in E and I groups concerning VAS

Values are expressed as mean ± standard deviation.

17.5±8.25%

DS group 80

SS group

%

f

70

epr

oo

60

Pr

50

rn

al

40

Jo u

30 20 10 0

Pain-related disorders

Lumbar spine dysfunction

Gait disturbance

Social life disturbance

Psychological disorders

Figure 1. Effectiveness rates in the DS and SS groups

Preoperative

Postoperative

*P<0.05 80





70

* oo

f

60

epr

50

al rn Jo u

30 20

Pr

40

10 0

Low back pain

Leg pain

Leg numbness

Figure 2. Mean preoperative and postoperative VAS scores in the DS group

Preoperative

Postoperative

*P<0.05 70

* *

60

oo

f

* epr

50

Pr

40

rn Jo u

20

al

30

10 0

Low back pain

Leg pain

Leg numbness

Figure 3. Mean preoperative and postoperative VAS scores in the SS group

Abbreviations

DOI: Degree of improvement DS: Degenerative lumbar spondylolisthesis E (group): Effective (group) I (group): Ineffective (group) IOI: Intensity of improvement

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JOABPEQ: Japanese Orthopaedic Association Back Pain Evaluation Questionnaire

MED: Microendoscopic decompression

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SS: Lumbar spinal stenosis

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MCID: Minimal clinically important difference

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VAS: Visual analogue scale

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LBP: Low back pain

OBJECTIVE: To determine whether preoperative presence of degenerative lumbar spondylolisthesis (DS) worsens the minimum 10-year outcome of patients undergoing microendoscopic decompression (MED) for lumbar spinal stenosis (SS). METHODS: Eighty patients undergoing MED were classified into two groups: DS group (34 SS with DS patients) and SS group (46 SS without DS patients). The degrees of improvement (DOIs) by the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) and intensities of improvement (IOIs) by visual analogue scale (VAS) at 120~159 (mean, 138.4) months after MED of the DS and SS groups were statistically compared. Patients with DS were classified into two groups based on the effectiveness by VAS or JOABPEQ: effective group (E group: IOI or DOI ≥20) and ineffective group (I group).

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All preoperative radiological measurements were statistically compared between the E and I

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groups.

RESULTS: Significant decreases in low back pain (LBP), leg pain and numbness, as

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measured by VAS, were noted at follow-up in the DS and SS groups. The effectiveness rates

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of pain-related disorders, lumbar spine dysfunction, and gait disturbance by JOABPEQ were almost equally high in the DS and SS groups. Statistical comparisons of the DOIs in all five

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functional scores and IOIs in LBP, leg pain and numbness showed no significant differences between the DS and SS groups. No significant differences were confirmed between the E and

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I groups concerning preoperative spondylolisthesis and instability. CONCLUSIONS: Our study indicated that preoperative DS did not worsen the outcome of

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patients with SS undergoing MED.

Declaration of interests ☒ The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

☐ The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:

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Declarations of interest: none