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Lung cancer differentiation; implications for diagnosis and treatment
Camp. Biochem. Physiol. Vol. 108A, No. I, pp. 143-144. 1994 Copyright 6 1994 Elsevier Science Ltd Printed in Great Britain. All rights reserved 0300-9629/94 $7.00 + 0.00
Pergamon
Book Reviews Gastrointestinal Regulatory Peptides. Edited by D. R. BKOWN. Handbook of Experimental Pharmacology Vol. 106, 446~~. 1993. Springer Verlag, Berlin. DM 480. The GI regulatory peptides (GIRPs) have received increased interest since it was realised that many GIRPs have regulatory roles in the CNS and other body systems. This book deals with; the localization and co-localization of GIRPs; regulation of GIRP gene expression; post translation processing of GIRPs; regulation of peptide secretion of endocrine cells; peptide receptors and signal transduction; proteolytic inactivation of GIRPs; peptidergic regulation of acid secretion; peptides and enteric neural activity; GIRP regulation of smooth muscle contractility; regulation of intestinal electrolyte transport; regulation of Cl blood flow; regulation of cell proliferation through multiple signalling pathways; mucosal immune function; pathophysiology of GIRPs; GIRPs as therapeutic agents. The reviews are of a high standard as to be expected of this series.
oncogenes and growth factors in lung cancer; biochemical markers in lung cancer (neural cell adhesion molecule; use of monoclonal antibodies; overproduction of ACTH, ADH, calcitonin; carcinoembryonic antigen; enolase; CK-BB); screening, diagnosis and monitoring of lung cancer; non-small cell lung cancer; small cell lung cancer. The four main types of lung carcinomas account for 26% (adenocarcinoma), 35% (squamous cell), 20% (small cell) and 15% (large cell) of the tumours. There is some evidence that different cell types respond selectively to chemotherapy and radiation. In the U.S.A. lung cancer accounts for about 100,000 deaths per year. and although smoking is the main cause, other forms of air pollution are also implicated.
Childhood Asthma; Pathophysiology and Treatment. 2nd edition. Edited by D. G. TINKELMAN and C. K. NASPITZ. 618~~. 1992. Marcel Dekker, New York. $135. Asthma is the leading cause of school absenteeism due to illness. It is now considered as a predominantly inflammatory disease with a bronchospastic component. The second edition of this book has been revised and expanded. The topics on asthma include; basic mechanisms; bronchial hyper-responsiveness: lung function; epidemiology; defense mechanisms of the lung; lung injury and repair; morbidity and mortality; viral and bacterial infections; wheezing; chronic cough; treatment of chronic asthma; treatment of acute asthma; asthmatic adolescents; exercise-induced asthma; sinusitis; non-pharmacological management; indoor allergens; food hypersensitivity; psychological impact: self management.
lmmunohistochemistry IL Edited by A. C. CUELLO. IBRO Handbook Methods in the Neurosciences Vol. 14, 456~~. 1993. John Wiley, Chichester, U.K. E45. The first edition was published in 1983 and the present volume is updated and expanded. The methods deal with; synthetic peptides for the production of antibodies; testing antibody specificity; preparation of monoclonal antibodies; avidin-biotin; immuno gold staining; EM silver intensified colloidal gold; in situ hybridization; retrograde neuronal tracing; anterograde PHA-L tracing; Golgi impregnation; ultrastructural immunocytochemistry; confocal microscopy applications; second messenger molecules; formaldehyde fixed cGMP. It gives the basic theory background for each method followed by full practical details on how to carry out the technique.
Microencapsulation of Drugs. Edited by T. L. WHATELEY 306~~. Harwood Academic Publishers, 820 Town Center Drive, Langhorne PA, U.S.A. $70 (to individuals who order direct from the publisher).
Pathophysiology of Hypertension in Blacks. Edited by J. C. S. FRAY and J. 6..DO&AS. Clinical Physiology Serieb; American Physiological Society 299~~. 1993. Oxford University Press, New York. $85.
The novel packaging of a drug in microcapsules (M) to protect it and also to facilitate its transmission to the target organ in the body, has aroused considerable interest, since novel packaging is as patentable as a new drug. A microcapsule has a definite coating or shell encapsulating the contents in the form of a particle in the micrometre size range. A microsphere is a monolithic structure with the therapeutic agent distributed throughout the matrix. This book describes the M of benzalkonium chloride; cross linked starch walled M; release of sodium diclofenac from nylon coated ion exchange resins; erythromycin release from PHBjPHV films; regulation of polyester M morphology; effect of surfactants; modification of surface carboxyl groups; controlled release of water soluble drugs; M Levo-norgestrel; surface polymerization; peptide hormones; 5-fluorouracil liposomes: Zn-phthalocyanine liposomes; sodium stibogluconate M; phenobarbitone M; release kinetics; M enzymes; insulin nanocapsules; M antibodies; liver microsomes: cyclophosphamide M: release of M L-DOPA; colloidal drug targeting; M of mitomycin C.
More than I5 million adult black Americans have hypertension (H). As a result blacks have a higher incidence than whites of stroke (50%), heart disease (30%) and generalised kidney disease (50%). This book deals with; H in blacks; salt sensitive H; PreH in black children; social and cultural dimensions; psychosocial factors; autonomic reactivity; nutrition, calcium and dietary factors; intracellular ions and H; (pro) Renin processing and secretion in essential H; pathogenesis of H: drug therapy.
Lung Cancer Differentiation; Implications for Diagnosis and Treatment. Edited by S. D. BERNAL and P. J. HESKETH. 488~~. 1992. Marcel Dekker, New York. $175. The 27 chapters of this book are grouped into sections on; differentiation of normal and neoplastic lung epithelial cells; 143
Pergamon
Book Reviews Gastrointestinal Regulatory Peptides. Edited by D. R. BKOWN. Handbook of Experimental Pharmacology Vol. 106, 446~~. 1993. Springer Verlag, Berlin. DM 480. The GI regulatory peptides (GIRPs) have received increased interest since it was realised that many GIRPs have regulatory roles in the CNS and other body systems. This book deals with; the localization and co-localization of GIRPs; regulation of GIRP gene expression; post translation processing of GIRPs; regulation of peptide secretion of endocrine cells; peptide receptors and signal transduction; proteolytic inactivation of GIRPs; peptidergic regulation of acid secretion; peptides and enteric neural activity; GIRP regulation of smooth muscle contractility; regulation of intestinal electrolyte transport; regulation of Cl blood flow; regulation of cell proliferation through multiple signalling pathways; mucosal immune function; pathophysiology of GIRPs; GIRPs as therapeutic agents. The reviews are of a high standard as to be expected of this series.
oncogenes and growth factors in lung cancer; biochemical markers in lung cancer (neural cell adhesion molecule; use of monoclonal antibodies; overproduction of ACTH, ADH, calcitonin; carcinoembryonic antigen; enolase; CK-BB); screening, diagnosis and monitoring of lung cancer; non-small cell lung cancer; small cell lung cancer. The four main types of lung carcinomas account for 26% (adenocarcinoma), 35% (squamous cell), 20% (small cell) and 15% (large cell) of the tumours. There is some evidence that different cell types respond selectively to chemotherapy and radiation. In the U.S.A. lung cancer accounts for about 100,000 deaths per year. and although smoking is the main cause, other forms of air pollution are also implicated.
Childhood Asthma; Pathophysiology and Treatment. 2nd edition. Edited by D. G. TINKELMAN and C. K. NASPITZ. 618~~. 1992. Marcel Dekker, New York. $135. Asthma is the leading cause of school absenteeism due to illness. It is now considered as a predominantly inflammatory disease with a bronchospastic component. The second edition of this book has been revised and expanded. The topics on asthma include; basic mechanisms; bronchial hyper-responsiveness: lung function; epidemiology; defense mechanisms of the lung; lung injury and repair; morbidity and mortality; viral and bacterial infections; wheezing; chronic cough; treatment of chronic asthma; treatment of acute asthma; asthmatic adolescents; exercise-induced asthma; sinusitis; non-pharmacological management; indoor allergens; food hypersensitivity; psychological impact: self management.
lmmunohistochemistry IL Edited by A. C. CUELLO. IBRO Handbook Methods in the Neurosciences Vol. 14, 456~~. 1993. John Wiley, Chichester, U.K. E45. The first edition was published in 1983 and the present volume is updated and expanded. The methods deal with; synthetic peptides for the production of antibodies; testing antibody specificity; preparation of monoclonal antibodies; avidin-biotin; immuno gold staining; EM silver intensified colloidal gold; in situ hybridization; retrograde neuronal tracing; anterograde PHA-L tracing; Golgi impregnation; ultrastructural immunocytochemistry; confocal microscopy applications; second messenger molecules; formaldehyde fixed cGMP. It gives the basic theory background for each method followed by full practical details on how to carry out the technique.
Microencapsulation of Drugs. Edited by T. L. WHATELEY 306~~. Harwood Academic Publishers, 820 Town Center Drive, Langhorne PA, U.S.A. $70 (to individuals who order direct from the publisher).
Pathophysiology of Hypertension in Blacks. Edited by J. C. S. FRAY and J. 6..DO&AS. Clinical Physiology Serieb; American Physiological Society 299~~. 1993. Oxford University Press, New York. $85.
The novel packaging of a drug in microcapsules (M) to protect it and also to facilitate its transmission to the target organ in the body, has aroused considerable interest, since novel packaging is as patentable as a new drug. A microcapsule has a definite coating or shell encapsulating the contents in the form of a particle in the micrometre size range. A microsphere is a monolithic structure with the therapeutic agent distributed throughout the matrix. This book describes the M of benzalkonium chloride; cross linked starch walled M; release of sodium diclofenac from nylon coated ion exchange resins; erythromycin release from PHBjPHV films; regulation of polyester M morphology; effect of surfactants; modification of surface carboxyl groups; controlled release of water soluble drugs; M Levo-norgestrel; surface polymerization; peptide hormones; 5-fluorouracil liposomes: Zn-phthalocyanine liposomes; sodium stibogluconate M; phenobarbitone M; release kinetics; M enzymes; insulin nanocapsules; M antibodies; liver microsomes: cyclophosphamide M: release of M L-DOPA; colloidal drug targeting; M of mitomycin C.
More than I5 million adult black Americans have hypertension (H). As a result blacks have a higher incidence than whites of stroke (50%), heart disease (30%) and generalised kidney disease (50%). This book deals with; H in blacks; salt sensitive H; PreH in black children; social and cultural dimensions; psychosocial factors; autonomic reactivity; nutrition, calcium and dietary factors; intracellular ions and H; (pro) Renin processing and secretion in essential H; pathogenesis of H: drug therapy.
Lung Cancer Differentiation; Implications for Diagnosis and Treatment. Edited by S. D. BERNAL and P. J. HESKETH. 488~~. 1992. Marcel Dekker, New York. $175. The 27 chapters of this book are grouped into sections on; differentiation of normal and neoplastic lung epithelial cells; 143