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Neuropsychological performance is independent of CSF HVA in unmedicated schizophrenic patients
172S
Poster session m
BIOL. PSYCHIATRY 1997:42:15-2975
165-45 , Context effect on vlsuo-spatlal working memory In schizophrenia R. longevlalle, I. Amado, M.O. Krebs, M.e. Bourdel, A. Galinowskl, M.F. Poirier, H. loo, J.P. Olia. Sts Anne Hospital S.H.V., Paris, Francs The aim Is the Investigation of visuospatial context effects on cognWve processes of schizophrenic patients: representational memory Oeaming, encoding strategy), selective attention. Neuropsychological tests are used to evaluated lhe Interference pr0ce• dures on lhe cognitive strategy 01 schizophrenic patients. The organiza· tion and sttueturation capacities of visual information are tested. Acute schiZophrenic patients (DSMIII·R) are matched with control SUbjects accord• Ing to gender, age, level of intellectual efficiency (048). The study Is perform on two patients groups: lhe first one Is drug free and lhe second one Is a 15 days after neuroleptic Initiation treatment; lhen both groups are tested again after six months. Deficit on visuospatial maintenance context ·target Is analyzed with two valid tests. The influence 01 schizophrenic symptomatology (negative, positive and disorganlzatJon) on cognitive processes Is evaluated. Also effects on neu· roIeptic drugs will be discussed.
165-461 Neuropsychological distinction between the schizophrenic sUbsyndromes e. Gordon, M.D. Lucas, M. Berll. Department of Psychiatry, University of the Witwatersrand. Medical School. Parlctown. South Africa Aim: The aim 01 the present study was to determine whether there is any neuropsychological validity lor a three subsyndrome model 01 schizophrenia. Method: Fifty two SChizophrenic patients were classified Into three sub• syndromes according to their symptomatology using the model proposed by Liddle (1987): A neuropsychological battery was administered. Results Irom this battery were correlated with the three subsyndromes making use 01 the Pearson's Product Moment Coefficient ColTelation method. Results and Conclusion: Pattems 01 deficit emerging from the results indicate a strong colTelation between lhe negative subsyndrome and scores 10/' tests known to assess lunctions of the dorsa-lateral prefrontal area. A similar cooelation was noted between the disorganised subsyndrome and tests 01 medio basallrontal lobe lunctionlng. The positive subsyndrome scores colTelated with those for tests sensitive to medio-temporal functioning.
165-471 Abnormal neurological signs In first-eplsode schizophrenia - relation to clinical featuresT. Okamura, M. Hidari, T. Hanaoka, T. Mizuno, H. Toyoda, H. Vonada, T. Sakai. Department of Neuropsychiatry, Osaka Medical College. Osaka, Japan
We studied the relationship between neurological signs and clinical leatures In first-episode schizophrenic patients. SUbjects and Methods: The subjects were 27 first-episode schizophrenic inpatients diagnosed according to DSM-IV. They had no histories 01 neuro• logical disorder, drug abuse, alcoholism or electroconvulsive therapy. The patients were given a comprehensive neurological examination and as• sessed for symptom profiles using the Positive and Negative Syndrome Scale. The patients were also assessed 10/' drug induced involuntary move• ment using the Abnormal Involuntary Movement Scale (AIMS), fO/' cognitive Impairment using the Minl-Mental State Test (MMS) and lor social and oc• cupational functioning using the General Assessment of Functioning (GAF). Infonned consent was obtained from all patients. Results: Abnormal neurological stgns were significantly related to negative symptoms and poor drug response, but not related to the duration 01 illness, education, daily dose 01 neuroleptic drugs, scores on AIMS, MMS and GAF. Conclusion: Abnormal neurological signs are associated with negative symptoms and poor drug response In first-episode schiZophrenic patients.
165-481 Virtual reality: An useful tool to explore vigilance and attentlonal functions? J.G. Rohmer, B. Kastler, M. Patris. Department of Psychiatry Unit 2. C.H.R.U. 67091 Strasbourg, France It Is more and more admitted that the studies about attention or cognitive funclions Involving treatment 01 Incoming Intormation must take account
very carefully of target Information but also 01 messages generated .... context. "'7 the Lots of works have been done about context and C8pacity of e . pertinent Inlormatlon. But lrom now on little was done to control ~ Input of sensorial messages and the parasite stimuli. the In this study, we tried to enhance lhe control 01 the Stimulus more important, to recreate and control the environment where : -...~ stimulus was delivered. -• We try to isolating totally subjects from environmental stimuli using Yir1UIII reality (VR) hardware and software. We are now trying to interlace VR hardware with known and validated tools exploring various attention modalities. I~ the first step 01 our studies, we will impose to the SUbjed • stalIC enVIronment In a second development phase we plan to render subjects he to explore virtual environments thus allowing us to study the c:ognitiY8 .., psy?hornotor strategies used to collect pertinent lnfonnation in a controlled enVIronment.
165-49 , Psychopharmacological therapy and Its effects as transitional object F. Gabrielli, P. Fornaro, L Luise. Clinics Psichiatrica dellVniversitf cf Genova, Italy The authors underilne lhe importance 01 the Integrated 8ppl'Oach chotherapy and pharmacotherapy combined) to the treatment of (Psy• psychiatric patients. This approach is based on a bio-psycho-SOCiaI S8YerIlI disease and on lhe understanding 01 patienrs real and concreta ITlOdel cI al~ his intrapsychi~ and relational dynamics. Therefore, from a ::::::: ~ of VIew. understanding the psychological meaning of the Ps~ logical treatment Is essential as well as lhe InffuellC8S on the ~ relationship 01 the pharmacotherapy Itself. The authors especially emphasize: 1) the meaning 01 the dn.tg transition~ object; 2) the role of the drug not only as chemical and :.:. machologlcal substance, but also as a vehicle 01 PSychological eft such as placebo-nocebo; 3) tranquillizing Influences of lhe presajplion; ~ compliance problems as an index of positive or negative translEll'al
arrea:.
I CSF HVA In unmedicated schizophrenic patients
165-50 Neuropsychological performance Is Independent or W.O. Faustman. J.A. Moses, A. Pfefferbaum, K.F. Fault. StanbQVA Mental Health Clinical Research Center, Department 01 Vetemns AIIU$ Health Care System. Palo Alto. California, USA Prior works examining relationships between cerebrospinal fluid
centr~.tions 01 ~o":,ovanillic
acid (HVA, the major dopamine meta~ ~ cogOlllve lunctlonlng have yielded both positive (Kahn et aJ 1 ) and negativelindings (Nyman et al., 1986). We examined these re~~L ancI a relatively large sample 01 unmedicated schiZophrenics. - - _ ., Methods: RDC-
c::
165-51
I Laterality on human visuospatial recognition
K. Gegeshidze. M.G. Tsagareli. Lab NeuroPSyhophysioiogy, A.sa . Institute of Psychiatry Tbilisl. Georgia • 1iarai The present study was designed to investigate the ability f mind ordinary geometric ligures In backward masking ~t~ II subjects and patients with chronic alCOholism. ..... OS in "-lrf Methods: Two parts 01 simple geometric ligures are . sented In the left and right visuallields; the subjects have ~ pit" mentally and decided whether these ligures's parts I ~ 1Nlll
_
standans
~
Poster session m
BIOL. PSYCHIATRY 1997:42:15-2975
165-45 , Context effect on vlsuo-spatlal working memory In schizophrenia R. longevlalle, I. Amado, M.O. Krebs, M.e. Bourdel, A. Galinowskl, M.F. Poirier, H. loo, J.P. Olia. Sts Anne Hospital S.H.V., Paris, Francs The aim Is the Investigation of visuospatial context effects on cognWve processes of schizophrenic patients: representational memory Oeaming, encoding strategy), selective attention. Neuropsychological tests are used to evaluated lhe Interference pr0ce• dures on lhe cognitive strategy 01 schizophrenic patients. The organiza· tion and sttueturation capacities of visual information are tested. Acute schiZophrenic patients (DSMIII·R) are matched with control SUbjects accord• Ing to gender, age, level of intellectual efficiency (048). The study Is perform on two patients groups: lhe first one Is drug free and lhe second one Is a 15 days after neuroleptic Initiation treatment; lhen both groups are tested again after six months. Deficit on visuospatial maintenance context ·target Is analyzed with two valid tests. The influence 01 schizophrenic symptomatology (negative, positive and disorganlzatJon) on cognitive processes Is evaluated. Also effects on neu· roIeptic drugs will be discussed.
165-461 Neuropsychological distinction between the schizophrenic sUbsyndromes e. Gordon, M.D. Lucas, M. Berll. Department of Psychiatry, University of the Witwatersrand. Medical School. Parlctown. South Africa Aim: The aim 01 the present study was to determine whether there is any neuropsychological validity lor a three subsyndrome model 01 schizophrenia. Method: Fifty two SChizophrenic patients were classified Into three sub• syndromes according to their symptomatology using the model proposed by Liddle (1987): A neuropsychological battery was administered. Results Irom this battery were correlated with the three subsyndromes making use 01 the Pearson's Product Moment Coefficient ColTelation method. Results and Conclusion: Pattems 01 deficit emerging from the results indicate a strong colTelation between lhe negative subsyndrome and scores 10/' tests known to assess lunctions of the dorsa-lateral prefrontal area. A similar cooelation was noted between the disorganised subsyndrome and tests 01 medio basallrontal lobe lunctionlng. The positive subsyndrome scores colTelated with those for tests sensitive to medio-temporal functioning.
165-471 Abnormal neurological signs In first-eplsode schizophrenia - relation to clinical featuresT. Okamura, M. Hidari, T. Hanaoka, T. Mizuno, H. Toyoda, H. Vonada, T. Sakai. Department of Neuropsychiatry, Osaka Medical College. Osaka, Japan
We studied the relationship between neurological signs and clinical leatures In first-episode schizophrenic patients. SUbjects and Methods: The subjects were 27 first-episode schizophrenic inpatients diagnosed according to DSM-IV. They had no histories 01 neuro• logical disorder, drug abuse, alcoholism or electroconvulsive therapy. The patients were given a comprehensive neurological examination and as• sessed for symptom profiles using the Positive and Negative Syndrome Scale. The patients were also assessed 10/' drug induced involuntary move• ment using the Abnormal Involuntary Movement Scale (AIMS), fO/' cognitive Impairment using the Minl-Mental State Test (MMS) and lor social and oc• cupational functioning using the General Assessment of Functioning (GAF). Infonned consent was obtained from all patients. Results: Abnormal neurological stgns were significantly related to negative symptoms and poor drug response, but not related to the duration 01 illness, education, daily dose 01 neuroleptic drugs, scores on AIMS, MMS and GAF. Conclusion: Abnormal neurological signs are associated with negative symptoms and poor drug response In first-episode schiZophrenic patients.
165-481 Virtual reality: An useful tool to explore vigilance and attentlonal functions? J.G. Rohmer, B. Kastler, M. Patris. Department of Psychiatry Unit 2. C.H.R.U. 67091 Strasbourg, France It Is more and more admitted that the studies about attention or cognitive funclions Involving treatment 01 Incoming Intormation must take account
very carefully of target Information but also 01 messages generated .... context. "'7 the Lots of works have been done about context and C8pacity of e . pertinent Inlormatlon. But lrom now on little was done to control ~ Input of sensorial messages and the parasite stimuli. the In this study, we tried to enhance lhe control 01 the Stimulus more important, to recreate and control the environment where : -...~ stimulus was delivered. -• We try to isolating totally subjects from environmental stimuli using Yir1UIII reality (VR) hardware and software. We are now trying to interlace VR hardware with known and validated tools exploring various attention modalities. I~ the first step 01 our studies, we will impose to the SUbjed • stalIC enVIronment In a second development phase we plan to render subjects he to explore virtual environments thus allowing us to study the c:ognitiY8 .., psy?hornotor strategies used to collect pertinent lnfonnation in a controlled enVIronment.
165-49 , Psychopharmacological therapy and Its effects as transitional object F. Gabrielli, P. Fornaro, L Luise. Clinics Psichiatrica dellVniversitf cf Genova, Italy The authors underilne lhe importance 01 the Integrated 8ppl'Oach chotherapy and pharmacotherapy combined) to the treatment of (Psy• psychiatric patients. This approach is based on a bio-psycho-SOCiaI S8YerIlI disease and on lhe understanding 01 patienrs real and concreta ITlOdel cI al~ his intrapsychi~ and relational dynamics. Therefore, from a ::::::: ~ of VIew. understanding the psychological meaning of the Ps~ logical treatment Is essential as well as lhe InffuellC8S on the ~ relationship 01 the pharmacotherapy Itself. The authors especially emphasize: 1) the meaning 01 the dn.tg transition~ object; 2) the role of the drug not only as chemical and :.:. machologlcal substance, but also as a vehicle 01 PSychological eft such as placebo-nocebo; 3) tranquillizing Influences of lhe presajplion; ~ compliance problems as an index of positive or negative translEll'al
arrea:.
I CSF HVA In unmedicated schizophrenic patients
165-50 Neuropsychological performance Is Independent or W.O. Faustman. J.A. Moses, A. Pfefferbaum, K.F. Fault. StanbQVA Mental Health Clinical Research Center, Department 01 Vetemns AIIU$ Health Care System. Palo Alto. California, USA Prior works examining relationships between cerebrospinal fluid
centr~.tions 01 ~o":,ovanillic
acid (HVA, the major dopamine meta~ ~ cogOlllve lunctlonlng have yielded both positive (Kahn et aJ 1 ) and negativelindings (Nyman et al., 1986). We examined these re~~L ancI a relatively large sample 01 unmedicated schiZophrenics. - - _ ., Methods: RDC-
c::
165-51
I Laterality on human visuospatial recognition
K. Gegeshidze. M.G. Tsagareli. Lab NeuroPSyhophysioiogy, A.sa . Institute of Psychiatry Tbilisl. Georgia • 1iarai The present study was designed to investigate the ability f mind ordinary geometric ligures In backward masking ~t~ II subjects and patients with chronic alCOholism. ..... OS in "-lrf Methods: Two parts 01 simple geometric ligures are . sented In the left and right visuallields; the subjects have ~ pit" mentally and decided whether these ligures's parts I ~ 1Nlll
_
standans
~