Outcomes with ambulatory anaesthesia delivered in an oral and maxillofacial surgery training program

348 subject. We investigated the similarity of CT images of the phantom with the patient images. In order to determine the spatial accuracy of the printed “soft tissue”, “bone”, “airways” and “blood vessels/outer lung structure”, and “tumours”, a surface comparison was performed between the virtual 3D models obtained from the phantom and the virtual 3D models used for printing. Findings and Conclusions: This study demonstrated that the dimensional accuracy of the two printed phantoms was high and therefore such models can be used for wide range of ex vivo applications. http://dx.doi.org/10.1016/j.ijom.2017.02.1171 Outcomes with ambulatory anaesthesia delivered in an oral and maxillofacial surgery training program J. Lyu ∗ , B. Voegele, B. Springer, J. Barclay, L. Christensen University of Minnesota, Minneapolis, MN, United States Background: Oral and maxillofacial surgeons (OMFS) in the United States have the ability to provide intravenous anaesthesia while simultaneously performing the surgical procedure in a clinic setting. Objectives: The objective of this study is to examine the anaesthesia techniques utilised in an OMFS program and assess both intra- and postoperative adverse events and/or complications. Methods: Trainees in the OMFS program at the University of Minnesota will perform intravenous anaesthesia and demographics, medications, and intra- and postoperative complications information are collected. The patient is asked to fill out a survey 2 and 14 days after with questions about his/her postoperative condition and complications experienced. Findings: Of the patients sedated, mean age of patient is 24.8 years old who had no to mild systemic medical conditions. All patients received midazolam during the sedation with an average dose of 4.01 mg. Most patients (87.65%) received fentanyl with an average dose of 46.20 mcg. Propofol (42% with mean dose of 57.65 mg) and/or ketamine (60.5% with a mean dose of 27.14 mg) were used. The only reported adverse events intra and postoperatively by the surgeon was nausea and vomiting. To date, patients have not reported complications. Conclusion: There is a variety of intravenous anaesthesia techniques being delivered by OMFS residents. There appears to be very little to no intraoperative nor acute postoperative complications associated with providing intravenous anaesthesia while performing surgical procedure simultaneously by the same provider. This may be associated to the patient risk assessment and selection process for safe delivery of intravenous anaesthesia prior to the procedure. http://dx.doi.org/10.1016/j.ijom.2017.02.1172

Retrograde endodontic treatment in patients receiving high dose antiresorptive medication – an alternative treatment to surgical removal due to apical periodontitis in orthograde endodontic treated teeth S.W. Madsen ∗ , M. Schiodt Department of Oral and Maxillofacial Surgery, Rigshospitalet, Copenhagen University Hospital, Denmark Background: Root resection and retrograde root filling on an endodontic treated tooth is a well-documented treatment. Oral surgery and/or periapical infection has been regarded a possible risk factor for precipitating osteonecrosis of the jaws in patients on antiresorptive treatment (ART). The possible effect of periapical surgery and/or the possible risk has not yet been described in the literature. Objectives: Present three patients on high-dose ART receiving root resection due to apical periodontitis as an alternative to surgical removal. Methods: Case series, short-term follow-up. Medical history, clinical and radiological findings, surgery procedure and images are presented. Findings: Three patients referred for apical periodontitis where previous orthograde endodontic treatment had a negative outcome. The patients signed an informed consent. During local anaesthesia apicoectomy and retrograde root filling with zinc oxide eugenol was performed. All patients received prophylactic antibiotic, Amoxicillin 500 mg + clavulanic acid 125 mg × 3 starting one day preoperative and seven days postoperative. The patients were examined clinical and radiographically at one, three and six months postoperatively. Conclusions: Patients on high-dose ART with apical periodontitis are usually having revision of orthograde root canal filling or surgically removal. Retrograde root resection might be a possibility, which may save the tooth. So far we treated three patients with successful healing. There is a need to perform a larger systematic study. http://dx.doi.org/10.1016/j.ijom.2017.02.1173 Pin1 and Par14 prolyl isomerase inhibitors block oral cancer cell proliferation H. Miyashita ∗ , S. Mori, T. Takahashi, T. Uchida Tohoku University, Sendai, Japan Background: A central common signalling mechanism in activations of heterogeneous oncogenic pathways are often largely cause of ineffectiveness against cancer treatment. One of them is proline-directed phosphorylation, and phosphorylated proteins are controlled by a single proline isomerase: Pin1. Pin1 regulates cell cycle progression, and has been reported as a regulator of p53 in genotoxic response. In human cancer, Pin1 is overactivated and it promotes cancer and cancer stem cells by disrupting the balance of oncogenes and tumour suppressors. Objectives: Since Pin1 inhibitor would be expected to block cell proliferation, the objectives of this study are to identify such inhibitors. Methods: We screened a chemical compound library for molecules that inhibited human Pin1 PPIase activity in vitro. We found a set of compounds that inhibited Pin1 PPIase