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Overview of food and mood disorders
S30
Abstracts / Journal of Affective Disorders 107 (2008) S21–S52
Aims: To test for interaction between genetic and environmental factors in an homogeneous subgroup of patients with bipolar affective disorder (BPAD) characterized by an early age at onset. Background: BPAD is known to be a multifactorial heterogeneous disorder. The identification of homogeneous subgroups through a candidate symptom approach may help the identification of genetic vulnerability factors. Early onset BPAD is one of this subgroup of interest. Personal history of childhood trauma is supposed to be a risk factor for BPAD. Methods: A genome-wide scan of early onset BPAD (87 affected sib pairs with 387 microsatellite markers) has been performed. History of childhood trauma was studied in a sample of 206 bipolar patients regardless their age at onset. Results: Suggestive linkage was obtained to several genome regions (2p21, 2q14.3, 3p14, 5q33, 7q36, 10q23, 16q23 and 20p12). Among different kind of trauma, past emotional abuse was over represented in BP patients by comparison with controls. Presence of personal history of childhood trauma was associated with an earlier age at onset of BPAD. This association was biased by the serotonin transporter gene promoter marker. Conclusions: These very preliminary results suggest the existence of genetic–environment interaction in a specific subgroup of patient with BPAD (i.e. early onset). Conflict of Interest: No conflict declared. References: Etain, B. et al., 2006 Jul. Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I earlyonset proband: supportive evidence for linkage at 3p14. Mol. Psychiatry. 11 (7), 685–94. doi:10.1016/j.jad.2007.12.172
psychiatric disorders, the possible mood elevating effects of chocolate, and the protective effect of alcohol on cognition are examples of how food and drink can influence affect. This symposium will address these issues, and present the latest available evidence indicating that normal mood is very much dependent upon proper nutrition. doi:10.1016/j.jad.2007.12.173
5.1 Overview of food and mood disorders Mike Isaac South London & Maudsley NHS Trust, UK Institute of Psychiatry, UK The importance of diet has been integral to medicine for millennia. It is an enduring preoccupation among people of all walks of life. Only relatively recently, however, have we been able to make more direct associations between specific nutrients and food. Indeed, one can scarcely escape such comparisons even after the most superficial contact with the mass media. Moreover, given that in most jurisdictions there is little or no regulation of nutritional therapy or nutritional therapists, there has in many countries been an explosion of practitioners some of whom are little more than quacks. Because robust scientific studies in the area are challenging to design, there is also an element of scepticism about the value of nutrition at all. My overview today is intended to illustrate the range of issues that have arisen in this field, together with an introduction to the more robust findings of the relationship between food and mood. I shall also touch on the possible therapeutic role of dietary interventions in specific classes of individual, including patients with serious mental illness and in children.
Symposium 5
doi:10.1016/j.jad.2007.12.174
Mood and food: The impact of diet on affective disorders
5.2 Nutrition, diet and mood
Symposium Leader: Maria Isaac Institute of Psychiatry, UK 5 (overview) Food and drink have a major influence on the workings of the brain, both in the short and long term. The effects of diet on the behaviour of children, the influence of fish oils and its major constituents the omega-3 fatty acids on
E.A. Malta,b,c,⁎, U.F. Maltc, H. Müllerc, J.I. Pedersenc a Rikshopitalet University Hospital, Norway b Pfizer AS, Norway c University of Oslo, Norway Introduction: To which extent diet may influence mood is from an empirical point of view insufficiently studied. In
Abstracts / Journal of Affective Disorders 107 (2008) S21–S52
Aims: To test for interaction between genetic and environmental factors in an homogeneous subgroup of patients with bipolar affective disorder (BPAD) characterized by an early age at onset. Background: BPAD is known to be a multifactorial heterogeneous disorder. The identification of homogeneous subgroups through a candidate symptom approach may help the identification of genetic vulnerability factors. Early onset BPAD is one of this subgroup of interest. Personal history of childhood trauma is supposed to be a risk factor for BPAD. Methods: A genome-wide scan of early onset BPAD (87 affected sib pairs with 387 microsatellite markers) has been performed. History of childhood trauma was studied in a sample of 206 bipolar patients regardless their age at onset. Results: Suggestive linkage was obtained to several genome regions (2p21, 2q14.3, 3p14, 5q33, 7q36, 10q23, 16q23 and 20p12). Among different kind of trauma, past emotional abuse was over represented in BP patients by comparison with controls. Presence of personal history of childhood trauma was associated with an earlier age at onset of BPAD. This association was biased by the serotonin transporter gene promoter marker. Conclusions: These very preliminary results suggest the existence of genetic–environment interaction in a specific subgroup of patient with BPAD (i.e. early onset). Conflict of Interest: No conflict declared. References: Etain, B. et al., 2006 Jul. Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I earlyonset proband: supportive evidence for linkage at 3p14. Mol. Psychiatry. 11 (7), 685–94. doi:10.1016/j.jad.2007.12.172
psychiatric disorders, the possible mood elevating effects of chocolate, and the protective effect of alcohol on cognition are examples of how food and drink can influence affect. This symposium will address these issues, and present the latest available evidence indicating that normal mood is very much dependent upon proper nutrition. doi:10.1016/j.jad.2007.12.173
5.1 Overview of food and mood disorders Mike Isaac South London & Maudsley NHS Trust, UK Institute of Psychiatry, UK The importance of diet has been integral to medicine for millennia. It is an enduring preoccupation among people of all walks of life. Only relatively recently, however, have we been able to make more direct associations between specific nutrients and food. Indeed, one can scarcely escape such comparisons even after the most superficial contact with the mass media. Moreover, given that in most jurisdictions there is little or no regulation of nutritional therapy or nutritional therapists, there has in many countries been an explosion of practitioners some of whom are little more than quacks. Because robust scientific studies in the area are challenging to design, there is also an element of scepticism about the value of nutrition at all. My overview today is intended to illustrate the range of issues that have arisen in this field, together with an introduction to the more robust findings of the relationship between food and mood. I shall also touch on the possible therapeutic role of dietary interventions in specific classes of individual, including patients with serious mental illness and in children.
Symposium 5
doi:10.1016/j.jad.2007.12.174
Mood and food: The impact of diet on affective disorders
5.2 Nutrition, diet and mood
Symposium Leader: Maria Isaac Institute of Psychiatry, UK 5 (overview) Food and drink have a major influence on the workings of the brain, both in the short and long term. The effects of diet on the behaviour of children, the influence of fish oils and its major constituents the omega-3 fatty acids on
E.A. Malta,b,c,⁎, U.F. Maltc, H. Müllerc, J.I. Pedersenc a Rikshopitalet University Hospital, Norway b Pfizer AS, Norway c University of Oslo, Norway Introduction: To which extent diet may influence mood is from an empirical point of view insufficiently studied. In