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P 47 Tick disorders in children and differential diagnosis with progressive diseases of the nervous system
Abstracts / Clinical Neurophysiology 128 (2017) e305–e412
Due to the explorative character of the study, methods to counteract the problem of multiple comparisons were not applied. Conclusion: The ultrasonography can be applied to describe changes in facial muscles characteristic for Parkinson’s disease. Especially the impact of the bradykinesia expressed as the reduced ability to contract can be objectively assessed. After this proof-of principle investigation further longitudinal studies in larger cohorts are necessary to evaluate the dependence between clinical features and ultrasonography. Reference Volk GF. Reference values for dynamic facial muscle ultrasonography in adults. Muscle Nerve 2014;50(3):348–57. doi:10.1016/j.clinph.2017.06.124
Poster P 46 Tourette syndrome and attention deficit hyperactivity disorders—D. Aminova (Tashkent Institute of Postgraduate Medical Education, Tashkent, Uzbekistan)
Background: Tourette syndrome (TS) and related tic disorders are commonly associated with obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD). It has been argued, however, that any observed association between TS and these and other psychopathologies may be due to ascertainment bias in that individuals with multiple problems are more likely to be referred for medical evaluation. A tic is a sudden, uncontrollable movement which can occur anywhere in the body or be vocal. Tics are often very mild and may not be noticeable to others but tics can also be grandiose. It is common for some tics to normally occur in people, particularly children. Methods: In order to overcome the potential confounding by ascertainment bias, we conducted a community-based study of school children using direct interviews to determine the prevalence of tic disorders and any comorbid psychopathology. A standard psychiatric interview and standardized rating scales were utilized to diagnose childhood behavioral disorders. Results: Of the 325 children interviewed, 71 were identified as having tics. The following psychopathologies were found more commonly (p < 0.05) in the children with tics: OCD, ADHD, separation anxiety, overanxious disorder, simple phobia, social phobia, agoraphobia, mania, major depression, and oppositional defiant behavior. Conclusion: The behavioral spectrum of tic disorders includes OCD, other anxiety disorders, a mood disorder, and attention-deficit and disruptive behavior disorders. doi:10.1016/j.clinph.2017.06.125
Poster P 47 Tick disorders in children and differential diagnosis with progressive diseases of the nervous system—D. Aminova (Tashkent Institute of Postgraduate Medical Education, Tashkent, Uzbekistan)
Objective: The study of features of tick disorders and differential diagnosis with progressive diseases of the nervous system.
e353
Background: In the general population the prevalence of ticks is quite large and the statistics of different countries is 1–13%. There are two main theories of ticks: genetic determination and neurogenic stress on the background of residual-organic lesions of various structures of the extra pyramidal system. Methods: We performed a neurological, neurochemical (determination of catecholamines in the urine), neuroimaging (MRI) and psychological examination of children (5–15 years) with chronic tic disorder. total number of 250 children were studied. Results: On the basis of complex neuropsychiatric examination, changes of catecholamines; neuroimaging and follow-up of children with chronic tic disorder evaluated the efficacy of the treatment of chronic tic disorder in children and indications for drug therapy, developed criteria for early diagnostics of ticks in the debut of hereditary degenerative diseases. Conclusion: we did set multifactor genesis of chronic tic disorder, resulting from organic brain damage in childhood and psychological characteristics of the child’s personality and its interaction with other people. At follow-up study we found that chronic tic disorder may be the initial manifestation of progressive diseases of the nervous system. The features of emotional-personal sphere of children with chronic tics and features of the interaction of the child with chronic tics within the family were identified. Thus, the primary tics can be considered typical of neuropsychiatric disorders. In MRI study any specific for chronic tic disorder changes were not found. doi:10.1016/j.clinph.2017.06.126
Poster P 48 The time of the ALSFRS-R to decrease to 50% (D50) in a sigmoidal decay model sufficiently describes the complete disease course of amyotrophic lateral sclerosis—B. Stubendorff 1,*, T. Grehl 2, C. Neuwirth 3, A. Rödiger 1, A. Gunkel 1, M. Radscheidt 1, B. Ilse 1, T. Prell 1, O.W. Witte 1, M. Weber 3, J. Grosskreutz 1 (1 Universitätsklinikum Jena, Hans-Berger Klinik für Neurologie, Jena, Germany, 2 Essen Hospital, Department of Neurology, Essen, Germany, 3 ALS Clinics St. Gallen Hospital, Department of Neuroradiology, St. Gallen, Switzerland) ⇑
Corresponding author.
Introduction: The progression of ALSFRS-R is not linear (Gordon et al., 2010; Proudfoot et al., 2016); the often used calculated progression rate using PR = ((48-ALSFRS-R)/disease duration) presents the progression at a certain time point rather than reflecting the entire disease course. A model describing the disease progression at different time points would facilitate the stratification of ALS patients according to disease severity and progression type and will in combination with other biomarkers enable identification of effective drugs in clinical trials. Objectives: The aim of our study was to develop a model that describes the disease course mathematically for each individual ALS patient which can be estimated from regularly ascertained ALSFRS-R scores. Methods: The model is based on the observation that after symptom onset the ALSFRS-R does not drop immediately but decays slowly first followed by a period of uniform progression which is captured in most clinical trials due to a relatively late inclusion requiring at least laboratory supported ALS according to EL Escorial/Awaji criteria. With increasing disability, ALSFRS-R seems to reach a plateau again. Thus we used a function which describes the transition between two states, i.e. full health to maximum
Due to the explorative character of the study, methods to counteract the problem of multiple comparisons were not applied. Conclusion: The ultrasonography can be applied to describe changes in facial muscles characteristic for Parkinson’s disease. Especially the impact of the bradykinesia expressed as the reduced ability to contract can be objectively assessed. After this proof-of principle investigation further longitudinal studies in larger cohorts are necessary to evaluate the dependence between clinical features and ultrasonography. Reference Volk GF. Reference values for dynamic facial muscle ultrasonography in adults. Muscle Nerve 2014;50(3):348–57. doi:10.1016/j.clinph.2017.06.124
Poster P 46 Tourette syndrome and attention deficit hyperactivity disorders—D. Aminova (Tashkent Institute of Postgraduate Medical Education, Tashkent, Uzbekistan)
Background: Tourette syndrome (TS) and related tic disorders are commonly associated with obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD). It has been argued, however, that any observed association between TS and these and other psychopathologies may be due to ascertainment bias in that individuals with multiple problems are more likely to be referred for medical evaluation. A tic is a sudden, uncontrollable movement which can occur anywhere in the body or be vocal. Tics are often very mild and may not be noticeable to others but tics can also be grandiose. It is common for some tics to normally occur in people, particularly children. Methods: In order to overcome the potential confounding by ascertainment bias, we conducted a community-based study of school children using direct interviews to determine the prevalence of tic disorders and any comorbid psychopathology. A standard psychiatric interview and standardized rating scales were utilized to diagnose childhood behavioral disorders. Results: Of the 325 children interviewed, 71 were identified as having tics. The following psychopathologies were found more commonly (p < 0.05) in the children with tics: OCD, ADHD, separation anxiety, overanxious disorder, simple phobia, social phobia, agoraphobia, mania, major depression, and oppositional defiant behavior. Conclusion: The behavioral spectrum of tic disorders includes OCD, other anxiety disorders, a mood disorder, and attention-deficit and disruptive behavior disorders. doi:10.1016/j.clinph.2017.06.125
Poster P 47 Tick disorders in children and differential diagnosis with progressive diseases of the nervous system—D. Aminova (Tashkent Institute of Postgraduate Medical Education, Tashkent, Uzbekistan)
Objective: The study of features of tick disorders and differential diagnosis with progressive diseases of the nervous system.
e353
Background: In the general population the prevalence of ticks is quite large and the statistics of different countries is 1–13%. There are two main theories of ticks: genetic determination and neurogenic stress on the background of residual-organic lesions of various structures of the extra pyramidal system. Methods: We performed a neurological, neurochemical (determination of catecholamines in the urine), neuroimaging (MRI) and psychological examination of children (5–15 years) with chronic tic disorder. total number of 250 children were studied. Results: On the basis of complex neuropsychiatric examination, changes of catecholamines; neuroimaging and follow-up of children with chronic tic disorder evaluated the efficacy of the treatment of chronic tic disorder in children and indications for drug therapy, developed criteria for early diagnostics of ticks in the debut of hereditary degenerative diseases. Conclusion: we did set multifactor genesis of chronic tic disorder, resulting from organic brain damage in childhood and psychological characteristics of the child’s personality and its interaction with other people. At follow-up study we found that chronic tic disorder may be the initial manifestation of progressive diseases of the nervous system. The features of emotional-personal sphere of children with chronic tics and features of the interaction of the child with chronic tics within the family were identified. Thus, the primary tics can be considered typical of neuropsychiatric disorders. In MRI study any specific for chronic tic disorder changes were not found. doi:10.1016/j.clinph.2017.06.126
Poster P 48 The time of the ALSFRS-R to decrease to 50% (D50) in a sigmoidal decay model sufficiently describes the complete disease course of amyotrophic lateral sclerosis—B. Stubendorff 1,*, T. Grehl 2, C. Neuwirth 3, A. Rödiger 1, A. Gunkel 1, M. Radscheidt 1, B. Ilse 1, T. Prell 1, O.W. Witte 1, M. Weber 3, J. Grosskreutz 1 (1 Universitätsklinikum Jena, Hans-Berger Klinik für Neurologie, Jena, Germany, 2 Essen Hospital, Department of Neurology, Essen, Germany, 3 ALS Clinics St. Gallen Hospital, Department of Neuroradiology, St. Gallen, Switzerland) ⇑
Corresponding author.
Introduction: The progression of ALSFRS-R is not linear (Gordon et al., 2010; Proudfoot et al., 2016); the often used calculated progression rate using PR = ((48-ALSFRS-R)/disease duration) presents the progression at a certain time point rather than reflecting the entire disease course. A model describing the disease progression at different time points would facilitate the stratification of ALS patients according to disease severity and progression type and will in combination with other biomarkers enable identification of effective drugs in clinical trials. Objectives: The aim of our study was to develop a model that describes the disease course mathematically for each individual ALS patient which can be estimated from regularly ascertained ALSFRS-R scores. Methods: The model is based on the observation that after symptom onset the ALSFRS-R does not drop immediately but decays slowly first followed by a period of uniform progression which is captured in most clinical trials due to a relatively late inclusion requiring at least laboratory supported ALS according to EL Escorial/Awaji criteria. With increasing disability, ALSFRS-R seems to reach a plateau again. Thus we used a function which describes the transition between two states, i.e. full health to maximum