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P.1.k.025 Are obstetrical complications really involved in the aetiology and outcome of psychotic and mood disorders?
P.1.k. Basic and clinical neuroscience − Epidemiology 5 may increase the occurrence of insomnia more than twice. The number of PLMS has been shown to vary from night to night, particularly in individuals with less severe sleep complaints. To further elucidate the clinical significance of PLMS, more participants with 2 consecutive nights PSG might be needed. References [1] Ancoli-Israel S, Kripke DF, Klauber MR, Mason WJ, Fell R, Kaplan O.,1991. Periodic limb movements in sleep in community-dwelling elderly. Sleep 14(6),496–500.
P.1.k.025 Are obstetrical complications really involved in the aetiology and outcome of psychotic and mood disorders? V. Bertino1 ° , A. Caldiroli1 , C. Dobrea1 , V. Ciappolino1 , M. Serati1 , M. Buoli1 , A. Altamura1 1 University of Milan, Department of Psychiatry, Milan, Italy Purpose of the study: Several studies show that the impact of stressful experiences during pregnancy or early life lead to enhanced susceptibility to psychiatric diseases [1], but just few of those are focused on the correlation between Obstetrical Complications (OCs) and the later development of psychotic symptoms. Clinical experience shows that many psychotic patients experienced OCs on birth. Aims of the study are: 1) assess the rate of OCs in patients affected by mood and psychotic disorders; 2) investigate the impact of OCs in the risk of future mood and psychotic diagnosis; 3) evaluate the effects of OCs on patients’ outcome. Methods: Obstetrical data were extrapolated through a retrospective review of the clinical documentation and, when necessary, through interviews with relatives, about patients treated at the Department of Psychiatry of University of Milan in a period from 2010 to 2013 with the following diagnosis: schizophrenia; bipolar disorder; unipolar major depressive disorder; not otherwise specified psychotic disorders. OCs were evaluated through the Lewis and Murray Scale. Global Assessment of Functioning (GAF) at the moment of hospitalization was considered as measurement of outcome. Descriptive statistical analysis of the whole sample was performed. c2 tests were performed to evaluate if obstetrical complications were related to lifetime psychotic symptoms in the whole sample. c2 tests (including Bonferroni’s post-hoc tests) were performed to compare the groups, classified according to diagnosis, in terms of overall or specific obstetrical complications. Finally GAF scores were compared between classified patients according to the presence of overall or specific obstetrical complications through one way analysis of covariance (ANCOVAs) (covariates: diagnosis and duration of illness). Results: The total sample (N = 545) was distributed according to the following diagnoses (schizophrenia 9.6%, bipolar disorder 49.4%, major depression 14.2% and otherwise specified psychotic disorders 26.8%). Ninety-nine patients (18.2%) presented at least one obstetrical complication. In the whole sample, overall or specific obstetrical complications were not more frequent in patients with lifetime psychotic symptoms (p > 0.05). On the contrary, patients with otherwise specified psychotic disorders presented more frequently obstetrical complications when compared to major depressed patients (p < 0.05). In addition, schizophrenia patients were found to be born more frequently by forceps compared to patients with otherwise specified psychotic disorders (p < 0.05).
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Finally, patients presenting obstetrical complications were found to have higher GAF scores than patients without these complications, even when the results were scored for duration of illness and diagnosis (F = 4.9, p = 0.027). Conclusions: Obstetrical complications are frequently registered in patients with mood or psychotic disorder. This study reveals that these complications have a major role in the aetiology of otherwise specified psychotic disorders more than in mood disorders/schizophrenia. Specific obstetrical complications (forceps) might be associated with schizophrenia. Otherwise, Obstetrical complications do not seem to have a major role in influencing long-term outcome of patients: the “toxic effects” of duration of illness are probably more relevant [2]. Limits of the present study include retrospective design and the possibility that GAF scores has been influenced by pharmacological treatment, presence of social support and patients’ compliance. References [1] Kotlicka-Antczak, M., Pawelczyk, A., Rabe-Jablonska, J., Smigielski, J., Pawelczyk, T., 2014. Obstetrical complications and Apgar score in subjects at risk of psychosis. Journal of Psychiatric Research; 48, 79−85 [2] Altamura, A.C., Serati, M., Buoli, M., 2015. Is duration of illness really influencing outcome in major psychoses? Nord J Psychiatry; online
P.1.k.026 The sociodemographic characteristics, habits, trends and forensic aspects of young male soldiers who applied to psychiatry clinic O. Ozmut1 ° , R. Tutuncu1 , H. Balibey1 , M. Ates1 , A. Algul1 , S. Ebrinc1 , C. Basoglu1 1 GATA Haydarpasha training hospital, Department of Psychiatry, Istanbul, Turkey Aim: The purpose of this study is to examine patients,who consulted thr private soldier outpatient unit in GATA Haydarpasa Training and Research Hospital, sociodemographic characteristics, habits, trends and criminal aspects. This study expected that psychiatric problems are closely related to sociodemographic characteristics and this information would affect the prevention and treatment to the psychiatric problems in terms of preventive medicine. The current tren toward cost effciency, in which the use of hospitalization should be limited, there is a new priority on developing strategies for managing violence risk in the community [1]. Strategies that may be effective include specific assessment procedures [1]. Method: The group of patients, who applied in the last two years (1 January 2013 to 31 December 2014), were given a questionnaire to determin demographic information. It is a singlecenter study which compared of urban and rural areas. Findings: This study reviewed 624 patients who applied to the private soldier outpatient. The age of the study subjects ranged between 18 and 25 years (59.2%). Participants were from urban areas were single (61.9%), the avarage number of substance users who live in urban areas was 82.1%. The avarage number of siblings was of 5 (SD±3). The average of educational levels were determined (70.2%) both as primary school and as high school drop out. The drugs used by patients in order of substance cannabis (49.5%), ecstasy (20.7%), heroin (10.8%), synthetic cannabis (9.9%) and cocaine (3.2%). The average forensic aspects were determined as (33.3%) in order of injuring (13.1%), drug traffic (7.0%), thieving (4.9%) and other crimes (15.4%). The average of the patient self-mutilation behavior was confirmed
P.1.k.025 Are obstetrical complications really involved in the aetiology and outcome of psychotic and mood disorders? V. Bertino1 ° , A. Caldiroli1 , C. Dobrea1 , V. Ciappolino1 , M. Serati1 , M. Buoli1 , A. Altamura1 1 University of Milan, Department of Psychiatry, Milan, Italy Purpose of the study: Several studies show that the impact of stressful experiences during pregnancy or early life lead to enhanced susceptibility to psychiatric diseases [1], but just few of those are focused on the correlation between Obstetrical Complications (OCs) and the later development of psychotic symptoms. Clinical experience shows that many psychotic patients experienced OCs on birth. Aims of the study are: 1) assess the rate of OCs in patients affected by mood and psychotic disorders; 2) investigate the impact of OCs in the risk of future mood and psychotic diagnosis; 3) evaluate the effects of OCs on patients’ outcome. Methods: Obstetrical data were extrapolated through a retrospective review of the clinical documentation and, when necessary, through interviews with relatives, about patients treated at the Department of Psychiatry of University of Milan in a period from 2010 to 2013 with the following diagnosis: schizophrenia; bipolar disorder; unipolar major depressive disorder; not otherwise specified psychotic disorders. OCs were evaluated through the Lewis and Murray Scale. Global Assessment of Functioning (GAF) at the moment of hospitalization was considered as measurement of outcome. Descriptive statistical analysis of the whole sample was performed. c2 tests were performed to evaluate if obstetrical complications were related to lifetime psychotic symptoms in the whole sample. c2 tests (including Bonferroni’s post-hoc tests) were performed to compare the groups, classified according to diagnosis, in terms of overall or specific obstetrical complications. Finally GAF scores were compared between classified patients according to the presence of overall or specific obstetrical complications through one way analysis of covariance (ANCOVAs) (covariates: diagnosis and duration of illness). Results: The total sample (N = 545) was distributed according to the following diagnoses (schizophrenia 9.6%, bipolar disorder 49.4%, major depression 14.2% and otherwise specified psychotic disorders 26.8%). Ninety-nine patients (18.2%) presented at least one obstetrical complication. In the whole sample, overall or specific obstetrical complications were not more frequent in patients with lifetime psychotic symptoms (p > 0.05). On the contrary, patients with otherwise specified psychotic disorders presented more frequently obstetrical complications when compared to major depressed patients (p < 0.05). In addition, schizophrenia patients were found to be born more frequently by forceps compared to patients with otherwise specified psychotic disorders (p < 0.05).
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Finally, patients presenting obstetrical complications were found to have higher GAF scores than patients without these complications, even when the results were scored for duration of illness and diagnosis (F = 4.9, p = 0.027). Conclusions: Obstetrical complications are frequently registered in patients with mood or psychotic disorder. This study reveals that these complications have a major role in the aetiology of otherwise specified psychotic disorders more than in mood disorders/schizophrenia. Specific obstetrical complications (forceps) might be associated with schizophrenia. Otherwise, Obstetrical complications do not seem to have a major role in influencing long-term outcome of patients: the “toxic effects” of duration of illness are probably more relevant [2]. Limits of the present study include retrospective design and the possibility that GAF scores has been influenced by pharmacological treatment, presence of social support and patients’ compliance. References [1] Kotlicka-Antczak, M., Pawelczyk, A., Rabe-Jablonska, J., Smigielski, J., Pawelczyk, T., 2014. Obstetrical complications and Apgar score in subjects at risk of psychosis. Journal of Psychiatric Research; 48, 79−85 [2] Altamura, A.C., Serati, M., Buoli, M., 2015. Is duration of illness really influencing outcome in major psychoses? Nord J Psychiatry; online
P.1.k.026 The sociodemographic characteristics, habits, trends and forensic aspects of young male soldiers who applied to psychiatry clinic O. Ozmut1 ° , R. Tutuncu1 , H. Balibey1 , M. Ates1 , A. Algul1 , S. Ebrinc1 , C. Basoglu1 1 GATA Haydarpasha training hospital, Department of Psychiatry, Istanbul, Turkey Aim: The purpose of this study is to examine patients,who consulted thr private soldier outpatient unit in GATA Haydarpasa Training and Research Hospital, sociodemographic characteristics, habits, trends and criminal aspects. This study expected that psychiatric problems are closely related to sociodemographic characteristics and this information would affect the prevention and treatment to the psychiatric problems in terms of preventive medicine. The current tren toward cost effciency, in which the use of hospitalization should be limited, there is a new priority on developing strategies for managing violence risk in the community [1]. Strategies that may be effective include specific assessment procedures [1]. Method: The group of patients, who applied in the last two years (1 January 2013 to 31 December 2014), were given a questionnaire to determin demographic information. It is a singlecenter study which compared of urban and rural areas. Findings: This study reviewed 624 patients who applied to the private soldier outpatient. The age of the study subjects ranged between 18 and 25 years (59.2%). Participants were from urban areas were single (61.9%), the avarage number of substance users who live in urban areas was 82.1%. The avarage number of siblings was of 5 (SD±3). The average of educational levels were determined (70.2%) both as primary school and as high school drop out. The drugs used by patients in order of substance cannabis (49.5%), ecstasy (20.7%), heroin (10.8%), synthetic cannabis (9.9%) and cocaine (3.2%). The average forensic aspects were determined as (33.3%) in order of injuring (13.1%), drug traffic (7.0%), thieving (4.9%) and other crimes (15.4%). The average of the patient self-mutilation behavior was confirmed